Wedel Mark K (0001321261)

Mailing Address 1896 RUTHERFORD ROAD CARLSBAD CA 92008 Ownership Reports for Issuers: (Click on issuer name to see other owners for the issuer, or CIK for issuer filings.) Issuer Filings Transaction Date Type of Owner ISIS PHARMACEUTICALS INC Current Name:IONIS PHARMACEUTICALS INC 0000874015 2005-05-25 officer: VP & Chief Medical Officer

Items 1 - 31

The information presented below contains only portions of the information presented in the referenced filing or filings.
You should consult the original filing for complete information. Hyperlinks to the forms are provided for your convenience.

Acquistion or Disposition	Transaction Date	Deemed Execution Date	Issuer	Form	Transaction Type	Direct or Indirect Ownership	Number of Securities Transacted	Number of Securities Owned	Line Number	Issuer CIK	Security Name
D	2007-07-06	2007-07-06	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	3305.0000	17543.0000	5	0000874015	Employee Stock Option (right to buy)
D	2007-07-06	2007-07-06	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	1895.0000	18264.0000	4	0000874015	Employee Stock Option (right to buy)
D	2007-07-06	2007-07-06	ISIS PHARMACEUTICALS INC	4	S-Sale	--D	5200.0000	6603.0000	3	0000874015	Common Stock
A	2007-07-06	2007-07-06	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	3305.0000	11803.0000	2	0000874015	Common Stock
A	2007-07-06	2007-07-06	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	1895.0000	8498.0000	1	0000874015	Common Stock
D	2007-07-02	2007-07-02	ISIS PHARMACEUTICALS INC	4	S-Sale	--D	902.0000	6603.0000	2	0000874015	Common Stock
A	2007-07-01	2007-07-01	ISIS PHARMACEUTICALS INC	4	J-Other	--D	902.0000	7505.0000	1	0000874015	Common Stock
D	2007-05-09	2007-05-09	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	2800.0000	5700.0000	3	0000874015	Employee Stock Purchase (right to buy)
D	2007-05-09	2007-05-09	ISIS PHARMACEUTICALS INC	4	S-Sale	--D	2800.0000	6603.0000	2	0000874015	Common Stock
A	2007-05-09	2007-05-09	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	2800.0000	9403.0000	1	0000874015	Common Stock
D	2007-05-02	2007-05-02	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	2000.0000	8500.0000	3	0000874015	Employee Stock Option (right to buy)
D	2007-05-02	2007-05-02	ISIS PHARMACEUTICALS INC	4	S-Sale	--D	2000.0000	6603.0000	2	0000874015	Common Stock
A	2007-05-02	2007-05-02	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	2000.0000	8603.0000	1	0000874015	Common Stock
D	2007-04-25	2007-04-25	ISIS PHARMACEUTICALS INC	4	S-Sale	--D	13711.0000	6603.0000	3	0000874015	Common Stock
D	2007-04-25	2007-04-25	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	4375.0000	5625.0000	5	0000874015	Employee Stock Option (right to buy)
D	2007-04-25	2007-04-25	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	5625.0000	20159.0000	4	0000874015	Employee Stock Option (right to buy)
A	2007-04-25	2007-04-25	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	4375.0000	20317.0000	2	0000874015	Common Stock
A	2007-04-25	2007-04-25	ISIS PHARMACEUTICALS INC	4	M-Exempt	--D	5625.0000	15939.0000	1	0000874015	Common Stock
A	2007-01-02	2007-01-02	ISIS PHARMACEUTICALS INC	4	A-Award	--D	37535.0000	37535.0000	2	0000874015	Employee Stock Option (right to buy)
A	2007-01-01	2007-01-01	ISIS PHARMACEUTICALS INC	4	J-Other	--D	698.0000	10314.0000	1	0000874015	Common Stock
A	2006-07-01	2006-07-01	ISIS PHARMACEUTICALS INC	4	J-Other	--D	1162.0000	9616.0000	1	0000874015	Common Stock
A	2006-01-03	2006-01-03	ISIS PHARMACEUTICALS INC	4	A-Award	--D	25784.0000	25784.0000	2	0000874015	Employee Stock Option (right to buy)
A	2006-01-01	2006-01-01	ISIS PHARMACEUTICALS INC	4	J-Other	--D	394.0000	8454.0000	1	0000874015	Common Stock
A	2005-07-01	2005-07-01	ISIS PHARMACEUTICALS INC	4	J-Other	--D	856.0000	8060.0000	1	0000874015	Common Stock
A	2005-05-25	2005-05-25	ISIS PHARMACEUTICALS INC	4	A-Award	--D	10000.0000	10000.0000	1	0000874015	Common Stock
-	-		ISIS PHARMACEUTICALS INC	3	-	--D		7204.0000	1	0000874015	Common Stock
-	-		ISIS PHARMACEUTICALS INC	3	-	--D			6	0000874015	Employee Stock Option (right to buy)
-	-		ISIS PHARMACEUTICALS INC	3	-	--D			5	0000874015	Employee Stock Option (right to buy)
-	-		ISIS PHARMACEUTICALS INC	3	-	--D			4	0000874015	Employee Stock Option (right to buy)
-	-		ISIS PHARMACEUTICALS INC	3	-	--D			3	0000874015	Employee Stock Option (right to buy)
-	-		ISIS PHARMACEUTICALS INC	3	-	--D			2	0000874015	Employee Stock Option (right to buy)

http://www.sec.gov/cgi-bin/own-disp

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