BERTHELSEN SPENCER R (0001181548)

| State of Inc.: DE | Fiscal Year End: 1231 Mailing Address 2855 GAZELLE COURT CARLSBAD CA 92010 Ownership Reports for Issuers: (Click on issuer name to see other owners for the issuer, or CIK for issuer filings.) Issuer Filings Transaction Date Type of Owner ISIS PHARMACEUTICALS INC Current Name:IONIS PHARMACEUTICALS INC 0000874015 2003-07-01 director

Items 1 - 80

The information presented below contains only portions of the information presented in the referenced filing or filings.
You should consult the original filing for complete information. Hyperlinks to the forms are provided for your convenience.

Acquistion or Disposition	Transaction Date	Deemed Execution Date	Issuer	Form	Transaction Type	Direct or Indirect Ownership	Number of Securities Transacted	Number of Securities Owned	Line Number	Issuer CIK	Security Name
D	2024-07-15		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	4677.0000	4079.0000	3	0000874015	Restricted Stock Unit
A	2024-07-15		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	4677.0000	151934.0000	1	0000874015	Common Stock
A	2024-07-01		IONIS PHARMACEUTICALS INC	4	A-Award	--D	4079.0000	8756.0000	2	0000874015	Restricted Stock Unit
A	2024-07-01		IONIS PHARMACEUTICALS INC	4	A-Award	--D	10111.0000	10111.0000	1	0000874015	Non-Qualified Stock Option (right to buy)
D	2024-06-17		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	16000.0000	0.0000	4	0000874015	Non-Qualified Stock Option (right to buy)
D	2024-06-17		IONIS PHARMACEUTICALS INC	4	S-Sale	--D	16000.0000	147257.0000	2	0000874015	Common Stock
A	2024-06-17		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	16000.0000	163257.0000	1	0000874015	Common Stock
D	2023-07-17		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	5333.0000	4677.0000	5	0000874015	Restricted Stock Unit
D	2023-07-17		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	1777.0000	10010.0000	4	0000874015	Restricted Stock Unit
A	2023-07-17		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	5333.0000	147257.0000	2	0000874015	Common Stock
A	2023-07-17		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	1777.0000	141924.0000	1	0000874015	Common Stock
A	2023-07-03		IONIS PHARMACEUTICALS INC	4	A-Award	--D	4677.0000	11787.0000	2	0000874015	Restricted Stock Unit
A	2023-07-03		IONIS PHARMACEUTICALS INC	4	A-Award	--D	10321.0000	10321.0000	1	0000874015	Non-Qualified Stock Option (right to buy)
D	2023-06-20		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	11250.0000	0.0000	3	0000874015	Non-Qualified Stock Option (right to buy)
A	2023-06-20		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	11250.0000	140147.0000	1	0000874015	Common Stock
D	2022-07-15		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	2665.0000	7110.0000	5	0000874015	Restricted Stock Unit
D	2022-07-15		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	5333.0000	9775.0000	4	0000874015	Restricted Stock Unit
A	2022-07-15		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	2665.0000	128897.0000	2	0000874015	Common Stock
A	2022-07-15		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	5333.0000	126232.0000	1	0000874015	Common Stock
A	2022-07-01		IONIS PHARMACEUTICALS INC	4	A-Award	--D	5333.0000	15108.0000	2	0000874015	Restricted Stock Unit
A	2022-07-01		IONIS PHARMACEUTICALS INC	4	A-Award	--D	12000.0000	12000.0000	1	0000874015	Non-Qualified Stock Option (right to buy)
D	2022-06-07		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	11250.0000	0.0000	3	0000874015	Non-Qualified Stock Option (right to buy)
A	2022-06-07		IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	11250.0000	120899.0000	1	0000874015	Common Stock
D	2021-07-15	2021-07-15	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	1778.0000	9775.0000	9	0000874015	Restricted Stock Unit
D	2021-07-15	2021-07-15	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	666.0000	11553.0000	8	0000874015	Restricted Stock Unit
D	2021-07-15	2021-07-15	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	889.0000	12219.0000	7	0000874015	Restricted Stock Unit
D	2021-07-15	2021-07-15	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	5333.0000	13108.0000	6	0000874015	Restricted Stock Unit
A	2021-07-15	2021-07-15	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	1778.0000	109649.0000	4	0000874015	Common Stock
A	2021-07-15	2021-07-15	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	666.0000	107871.0000	3	0000874015	Common Stock
A	2021-07-15	2021-07-15	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	889.0000	107205.0000	2	0000874015	Common Stock
A	2021-07-15	2021-07-15	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	5333.0000	106316.0000	1	0000874015	Common Stock
A	2021-07-01	2021-07-01	IONIS PHARMACEUTICALS INC	4	A-Award	--D	5333.0000	18441.0000	2	0000874015	Restricted Stock Unit
A	2021-07-01	2021-07-01	IONIS PHARMACEUTICALS INC	4	A-Award	--D	12000.0000	12000.0000	1	0000874015	Non-Qualified Stock Option (right to buy)
D	2021-06-23	2021-06-23	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	15000.0000	0.0000	4	0000874015	Non-Qualified Stock Option (right to buy)
D	2021-06-23	2021-06-23	IONIS PHARMACEUTICALS INC	4	S-Sale	--D	15000.0000	100983.0000	2	0000874015	Common Stock
A	2021-06-23	2021-06-23	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	15000.0000	115983.0000	1	0000874015	Common Stock
D	2020-07-06	2020-07-06	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	667.0000	666.0000	9	0000874015	Restricted Stock Units
A	2020-07-06	2020-07-06	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	667.0000	100983.0000	4	0000874015	Common Stock
D	2020-07-02	2020-07-02	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	889.0000	1777.0000	8	0000874015	Restricted Stock Units
A	2020-07-02	2020-07-02	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	889.0000	100316.0000	3	0000874015	Common Stock
A	2020-07-01	2020-07-01	IONIS PHARMACEUTICALS INC	4	A-Award	--D	12000.0000	12000.0000	11	0000874015	Director Stock Option (right to buy)
A	2020-07-01	2020-07-01	IONIS PHARMACEUTICALS INC	4	A-Award	--D	5333.0000	5333.0000	10	0000874015	Restricted Stock Units
D	2020-07-01	2020-07-01	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	1778.0000	5332.0000	7	0000874015	Restricted Stock Units
D	2020-07-01	2020-07-01	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	666.0000	0.0000	6	0000874015	Restricted Stock Units
A	2020-07-01	2020-07-01	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	1778.0000	99427.0000	2	0000874015	Common Stock
A	2020-07-01	2020-07-01	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	666.0000	97649.0000	1	0000874015	Common Stock
D	2020-06-23	2020-06-23	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	15000.0000	0.0000	4	0000874015	Director Stock Option (right to buy)
D	2020-06-23	2020-06-23	IONIS PHARMACEUTICALS INC	4	S-Sale	--D	15000.0000	96983.0000	2	0000874015	Common Stock
A	2020-06-23	2020-06-23	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	15000.0000	111983.0000	1	0000874015	Common Stock
D	2019-07-03	2019-07-03	IONIS PHARMACEUTICALS INC	4/A	M-Exempt	--D	667.0000	1333.0000	9	0000874015	Restricted Stock Units
A	2019-07-03	2019-07-03	IONIS PHARMACEUTICALS INC	4/A	M-Exempt	--D	667.0000	96983.0000	4	0000874015	Common Stock
D	2019-07-02	2019-07-02	IONIS PHARMACEUTICALS INC	4/A	M-Exempt	--D	889.0000	2666.0000	8	0000874015	Restricted Stock Units
A	2019-07-02	2019-07-02	IONIS PHARMACEUTICALS INC	4/A	M-Exempt	--D	889.0000	96316.0000	3	0000874015	Common Stock
A	2019-07-01	2019-07-01	IONIS PHARMACEUTICALS INC	4/A	A-Award	--D	16000.0000	16000.0000	11	0000874015	Director Stock Option (right to buy)
A	2019-07-01	2019-07-01	IONIS PHARMACEUTICALS INC	4/A	A-Award	--D	7110.0000	7110.0000	10	0000874015	Restricted Stock Units
D	2019-07-01	2019-07-01	IONIS PHARMACEUTICALS INC	4/A	M-Exempt	--D	667.0000	666.0000	7	0000874015	Restricted Stock Units
D	2019-07-01	2019-07-01	IONIS PHARMACEUTICALS INC	4/A	M-Exempt	--D	666.0000	0.0000	6	0000874015	Restricted Stock Units
A	2019-07-01	2019-07-01	IONIS PHARMACEUTICALS INC	4/A	M-Exempt	--D	667.0000	95427.0000	2	0000874015	Common Stock
A	2019-07-01	2019-07-01	IONIS PHARMACEUTICALS INC	4/A	M-Exempt	--D	666.0000	94760.0000	1	0000874015	Common Stock
D	2019-06-24	2019-06-24	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	15000.0000	0.0000	6	0000874015	Director Stock Option (right to buy)
D	2019-06-24	2019-06-24	IONIS PHARMACEUTICALS INC	4	S-Sale	--D	9690.0000	94094.0000	4	0000874015	Common Stock
A	2019-06-24	2019-06-24	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	9690.0000	103784.0000	3	0000874015	Common Stock
D	2019-06-24	2019-06-24	IONIS PHARMACEUTICALS INC	4	S-Sale	--D	5310.0000	94094.0000	2	0000874015	Common Stock
A	2019-06-24	2019-06-24	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	5310.0000	99404.0000	1	0000874015	Common Stock
D	2018-07-03	2018-07-03	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	667.0000	2000.0000	5	0000874015	Restricted Stock Units
A	2018-07-03	2018-07-03	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	667.0000	94094.0000	2	0000874015	Common Stock
A	2018-07-02	2018-07-02	IONIS PHARMACEUTICALS INC	4	A-Award	--D	16000.0000	16000.0000	7	0000874015	Director Stock Option (right to buy)
A	2018-07-02	2018-07-02	IONIS PHARMACEUTICALS INC	4	A-Award	--D	3555.0000	3555.0000	6	0000874015	Restricted Stock Units
D	2018-07-01	2018-07-01	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	2000.0000	1999.0000	4	0000874015	Restricted Stock Units
A	2018-07-01	2018-07-01	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	2000.0000	93427.0000	1	0000874015	Common Stock
D	2018-06-25	2018-06-25	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	15000.0000	0.0000	6	0000874015	Director Stock Option (right to buy)
D	2018-06-25	2018-06-25	IONIS PHARMACEUTICALS INC	4	S-Sale	--D	9300.0000	91427.0000	4	0000874015	Common Stock
A	2018-06-25	2018-06-25	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	9300.0000	100727.0000	3	0000874015	Common Stock
D	2018-06-25	2018-06-25	IONIS PHARMACEUTICALS INC	4	S-Sale	--D	5700.0000	91427.0000	2	0000874015	Common Stock
A	2018-06-25	2018-06-25	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	5700.0000	97127.0000	1	0000874015	Common Stock
A	2017-07-03	2017-07-03	IONIS PHARMACEUTICALS INC	4	A-Award	--D	16000.0000	16000.0000	5	0000874015	Director Stock Option (right to buy)
A	2017-07-03	2017-07-03	IONIS PHARMACEUTICALS INC	4	A-Award	--D	2667.0000	2667.0000	4	0000874015	Restricted Stock Units
A	2017-07-01	2017-07-01	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	2469.0000	91427.0000	1	0000874015	Common Stock
D	2017-07-01	2017-07-01	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	2469.0000	3999.0000	3	0000874015	Restricted Stock Units
D	2017-02-24	2017-02-24	IONIS PHARMACEUTICALS INC	4	M-Exempt	--D	12500.0000	0.0000	3	0000874015	Director Stock Option (right to buy)

http://www.sec.gov/cgi-bin/own-disp

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