UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
SCHEDULE TO-C
(Rule 14d-100)
TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR (13)(E)(1)
OF THE SECURITIES EXCHANGE ACT OF 1934
Patheon N.V.
(Name of Subject Company (Issuer))
Thermo Fisher (CN) Luxembourg S.à r.l.
(Offeror)
a wholly owned subsidiary of
Thermo Fisher Scientific Inc.
(Ultimate Parent of Offeror)
Ordinary Shares, 0.01 par value per share
(Title of Class of Securities)
N6865W105
(CUSIP Number of Class of Securities)
Seth H. Hoogasian
Senior Vice President and General Counsel
Thermo Fisher Scientific Inc.
168 Third Avenue
Waltham, Massachusetts 02451
Telephone: (781) 622-1198
(Name, Address, and Telephone Numbers of Person Authorized to Receive Notices and Communications on Behalf of Filing Persons)
Copies to:
Matthew M. Guest, Esq.
Wachtell, Lipton, Rosen & Katz
51 West 52nd Street
New York, New York 10019
Telephone: (212) 403-1000
CALCULATION OF FILING FEE
Transaction Valuation | Amount of Filing Fee* | |
Not applicable | Not applicable |
* | Pursuant to General Instruction D to Schedule TO, a filing fee is not required in connection with this filing because it relates solely to preliminary communications made before the commencement of a tender offer. |
☐ | Check the box if any part of the fee is offset as provided by Rule 0-11(a)(2) and identify the filing with which the offsetting fee was previously paid. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing. |
Amount Previously Paid: None | Filing Party: N/A | |
Form of Registration.: N/A | Date Filed: N/A |
☒ | Check the box if the filing relates solely to preliminary communications made before the commencement of a tender offer. |
Check the appropriate boxes below to designate any transactions to which the statement relates:
☒ | Third-party tender offer subject to Rule 14d-1. |
☐ | Issuer tender offer subject to Rule 13e-4. |
☐ | Going-private transaction subject to Rule 13e-3. |
☐ | Amendment to Schedule 13D under Rule 13d-2. |
Check the following box if the filing is a final amendment reporting the results of the tender offer: ☐
If applicable, check the appropriate box(es) below to designate the appropriate rule provision(s) relied upon:
☐ | Rule 13e-4(i) (Cross-Border Issuer Tender Offer) |
☐ | Rule 14d-1(d) (Cross-Border Third-Party Tender Offer) |
This Tender Offer Statement on Schedule TO-C (Schedule TO-C) relates solely to preliminary communications made before the commencement of a planned tender offer by Thermo Fisher (CN) Luxembourg S.à r.l. (Purchaser), a private limited liability company (société à responsabilité limiteé) organized under the laws of the Grand Duchy of Luxembourg and a wholly owned subsidiary of Thermo Fisher Scientific Inc., a Delaware corporation (Thermo Fisher), to acquire all of the issued and outstanding ordinary shares, par value EUR 0.01 per share, of Patheon N.V., a public limited liability company (naamloze vennootschap) organized under the laws of The Netherlands registered with the trade register in The Netherlands under file number 59564903 (Patheon), at a price of $35.00 per share, in cash, without interest, subject to any required applicable withholding of taxes, pursuant to a Purchase Agreement, dated as of May 15, 2017, by and between Purchaser, Thermo Fisher and Patheon.
Forward-Looking Statements
This communication contains forward-looking statements that involve a number of risks and uncertainties. Words such as believes, anticipates, plans, expects, seeks, estimates, and similar expressions are intended to identify forward-looking statements, but other statements that are not historical facts may also be deemed to be forward-looking statements. Important factors that could cause actual results to differ materially from those indicated by forward-looking statements include risks and uncertainties relating to: the need to develop new products and adapt to significant technological change; implementation of strategies for improving growth; general economic conditions and related uncertainties; dependence on customers capital spending policies and government funding policies; the effect of exchange rate fluctuations on international operations; use and protection of intellectual property; the effect of changes in governmental regulations; and the effect of laws and regulations governing government contracts, as well as the possibility that expected benefits related to recent and pending acquisitions, including the proposed transaction, may not materialize as expected; the proposed transaction not being timely completed, if completed at all; prior to the completion of the transaction, Patheons business experiencing disruptions due to transaction-related uncertainty or other factors making it more difficult to maintain relationships with employees, customers, licensees, other business partners or governmental entities; difficulty retaining key employees; the outcome of any legal proceedings related to the proposed transaction; and the parties being unable to successfully implement integration strategies or to achieve expected synergies and operating efficiencies within the expected time-frames or at all. Additional important factors that could cause actual results to differ materially from those indicated by such forward-looking statements are set forth in Thermo Fishers Annual Report on Form 10-K for the year ended December 31, 2016, which is on file with the U.S. Securities and Exchange Commission (SEC) and available in the Investors section of Thermo Fishers website, ir.thermofisher.com, under the heading SEC Filings, and in any subsequent Quarterly Reports on Form 10-Q and other documents Thermo Fisher files with the SEC, and in Patheons Annual Report on Form 10-K for the year ended October 31, 2016 and its subsequent Quarterly Reports on Form 10-Q, including its Quarterly Report on Form 10-Q for the quarter ended January 31, 2017, each of which is on file with the SEC and available in the Investor Relations section of Patheons website, ir.patheon.com, under the heading SEC Filings, and in other documents Patheon files with the SEC. While Thermo Fisher or Patheon may elect to update forward-looking statements at some point in the future, Thermo Fisher and Patheon specifically disclaim any obligation to do so, even if estimates change and, therefore, you should not rely on these forward-looking statements as representing either Thermo Fishers or Patheons views as of any date subsequent to today.
Additional Information and Where to Find It
The tender offer referenced herein has not yet commenced. This communication is for informational purposes only and is neither an offer to purchase nor a solicitation of an offer to sell any ordinary shares of Patheon or any other securities, nor is it a substitute for the tender offer materials that Thermo Fisher and its acquisition subsidiary will file with the SEC. On the commencement date of the tender offer, a tender offer statement on Schedule TO, including an offer to purchase, a letter of transmittal and related documents, will be filed with the SEC by Thermo Fisher and/or its acquisition subsidiary and a solicitation/recommendation statement on Schedule 14D-9 will be filed with the SEC by Patheon with respect to the tender offer. The offer to purchase all of the outstanding ordinary shares of Patheon will only be made pursuant to the offer to purchase, the letter of transmittal and related documents filed as a part of the Schedule TO. Patheon will also file a proxy statement with the SEC in connection with the extraordinary general meeting of shareholders of Patheon at which the Patheon shareholders will vote on certain proposed resolutions in connection with the transaction (the EGM Proposals).
THE TENDER OFFER MATERIALS (INCLUDING AN OFFER TO PURCHASE, A RELATED LETTER OF TRANSMITTAL AND CERTAIN OTHER TENDER OFFER DOCUMENTS), THE SOLICITATION/RECOMMENDATION STATEMENT ON SCHEDULE 14D-9 AND THE PROXY STATEMENT WILL CONTAIN IMPORTANT INFORMATION. INVESTORS AND SHAREHOLDERS OF PATHEON ARE URGED TO READ THESE DOCUMENTS CAREFULLY WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION THAT SUCH PERSONS SHOULD CONSIDER BEFORE MAKING ANY DECISION REGARDING TENDERING THEIR ORDINARY SHARES OR MAKING ANY VOTING DECISION.
The tender offer materials (including the offer to purchase and the related letter of transmittal and certain other tender offer documents), the solicitation/recommendation statement and the proxy statement (when they become available) and other documents filed with the SEC by Thermo Fisher or Patheon, may be obtained free of charge at the SECs website at www.sec.gov or at Patheons website at www.patheon.com or by contacting Patheons investor relations department at 919-226-3165 or at Thermo Fishers website at www.thermofisher.com or by contacting Thermo Fishers investor relations department at 781-622-1111. In addition, investors and shareholders of Patheon may obtain free copies of the tender offer materials by contacting the information agent for the tender offer that will be named in the tender offer statement on Schedule TO.
Participants in the Solicitation
Patheon, its directors and executive officers and other members of its management and employees, as well as Thermo Fisher and its directors and executive officers, may be deemed to be participants in the solicitation of proxies from Patheons shareholders in connection with the EGM Proposals. Information about Patheons directors and executive officers and their ownership of Patheon ordinary shares is set forth in the proxy statement for Patheons 2017 annual general meeting of shareholders, which was filed with the SEC on January 26, 2017.
Information about Thermo Fishers directors and executive officers is set forth in the proxy statement for Thermo Fishers 2017 annual meeting of stockholders, which was filed with the SEC on April 4, 2017. Shareholders may obtain additional information regarding the direct and indirect interests of the participants in the solicitation of proxies in connection with the EGM Proposals, including the interests of Patheons directors and executive officers in the transaction, which may be different than those of Patheons shareholders generally, by reading the proxy statement and other relevant documents regarding the transaction which will be filed with the SEC.
EXHIBIT INDEX
Exhibit |
Description | |
99.1 | Letter to Thermo Fisher Employees from Marc Casper, Chief Executive Officer of Thermo Fisher Scientific Inc., dated May 15, 2017 | |
99.2 | Transcript of Joint Investor Conference Call held by Thermo Fisher Scientific Inc. and Patheon N.V. on May 15, 2017 |
Exhibit 99.1
MAY 15, 2017
Dear Colleague,
I am very pleased to share the news that Thermo Fisher has taken another significant step toward achieving our Vision. Today, we announced our agreement to acquire Patheon, a leading global provider of high-quality drug development and delivery solutions that help pharmaceutical and biotech customers bring new drugs to market faster and more cost effectively.
Patheon is a contract development and manufacturing organization (CDMO) that offers pharmaceutical and biotech companies a comprehensive range of services from development and production of active pharmaceutical ingredients to contract manufacturing of drugs that are ready for commercialization.
Patheon operates a network of state-of-the-art facilities primarily in North America and Europe, and has more than 9,000 employees worldwide. The business, which had revenue of $1.9 billion in 2016, will become part of Thermo Fishers Laboratory Products and Services Segment.
Both of our companies serve a similar base of customers. Today, we provide a range products and services for the biopharma industry through a number of our businesses that support research, clinical trials logistics and production. Adding Patheons highly complementary development and manufacturing services will significantly strengthen our unique value proposition for these customers and allow us to further accelerate our growth.
Patheon has built a reputation for scientific and technical excellence. Their team shares our commitment to flawless quality and exceptional service, and I look forward to welcoming our new colleagues to Thermo Fisher.
Im very excited about this acquisition because it provides us with a new platform for growth in the $40 billion CDMO market, which is fueled by growing customer demand for outsourcing services that reduce the time and cost of drug development. The addition of Patheons capabilities will allow us to offer a more comprehensive portfolio to help our pharmaceutical and biotech customers accelerate innovation and enhance productivity.
We expect the acquisition to be completed by the end of 2017. Until then, Thermo Fisher and Patheon will continue to operate as separate companies. Consistent with our company policy, if you receive any inquiries from members of the media, please forward them to Karen Kirkwood, Vice President of Corporate Communications. If you receive any investor inquiries, please forward them to Ken Apicerno, Vice President of Investor Relations.
This is an exciting time for our company, as we continue to strengthen our industry leadership. I am grateful to all of you for your contributions to our growth, which enable us to invest in strategic acquisitions like Patheon that will position our company for an even brighter future.
Sincerely,
©2017 Thermo Fisher Scientific Inc. All rights reserved.
This publication may contain sensitive company information not intended for an external audience. It is intended solely for internal distribution and under no circumstances should it or any of the information contained within it be forwarded to our customers, vendors or any parties not employed by Thermo Fisher Scientific.
Questions? Comments? Contact us.
168 Third Avenue | Waltham, Massachusetts 02451
Exhibit 99.2
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CORPORATE PARTICIPANTS
James C. Mullen Patheon N.V. - CEO and Executive Director
Kenneth J. Apicerno Thermo Fisher Scientific Inc. - VP of IR and Treasurer
Marc N. Casper Thermo Fisher Scientific Inc. - CEO, President and Director
Stephen Williamson Thermo Fisher Scientific Inc. - CFO and SVP
CONFERENCE CALL PARTICIPANTS
Derik De Bruin BofA Merrill Lynch, Research Division - MD of Equity Research
Douglas Anthony Schenkel Cowen and Company, LLC, Research Division - MD and Senior Research Analyst
Isaac Ro Goldman Sachs Group Inc., Research Division - VP
Jack Meehan Barclays PLC, Research Division - VP and Senior Research Analyst
Matthew Ian Mishan KeyBanc Capital Markets Inc., Research Division - VP and Senior Equity Research Analyst
Ross Jordan Muken Evercore ISI, Research Division - Senior MD, Head of Healthcare Services and Technology and Fundamental Research Analyst
Timothy Cameron Evans Wells Fargo Securities, LLC, Research Division - VP and Senior Equity Analyst
Tycho W. Peterson JP Morgan Chase & Co, Research Division - Senior Analyst
PRESENTATION
Operator
Ladies and gentlemen, thank you for standing by. Welcome to todays conference call and webcast to discuss Thermo Fisher Scientifics Acquisition of Patheon. (Operator Instructions)
I would now like to turn the conference over to Mr. Ken Apicerno, Vice President of Investor Relations at Thermo Fisher Scientific. Please go ahead, sir.
Kenneth J. Apicerno - Thermo Fisher Scientific Inc. - VP of IR and Treasurer
Thank you, and good morning, everyone. Welcome to our conference call to discuss Thermo Fishers acquisition of Patheon, which we announced earlier today.
On the call with me today is Marc Casper, our President and Chief Executive Officer; Stephen Williamson, our Chief Financial Officer; and Jim Mullen, CEO of Patheon. Youll find a brief slide presentation in the Investors section of our website, thermofisher.com, under the section titled, Webcasts and Presentations. And well walk through that deck this morning. After the prepared comments, well open it up for Q&A.
Before we begin, let me briefly cover our safe harbor statement. Various remarks that we may make about the future expectations, plans and prospects constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors as set forth in Thermo Fisher and Patheons most recent annual reports and current reports, which are on file with the SEC and available on our respective websites; as well as the possibility that expected benefits related to the transaction may not materialize as expected; the transaction not being timely completed, if completed at all; prior to the completion of the transaction, Patheons business experiencing disruptions due to transaction-related uncertainty or other factors, making it more difficult to maintain relationships with employees, customers, licensees, other business partners or governmental entities and difficulty retaining employees; the outcome of any legal proceedings related to the proposed transactions and the parties being unable to successfully implement integration strategies or to achieve expected synergies and operating efficiencies within the
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expected time frames or at all. While Thermo Fisher or Patheon may elect to update forward-looking statements at some point in the future, we specifically disclaim any obligation to do so even if our estimates change. And therefore, you should not rely on these forward-looking statements as representing our views as of any date subsequent to today.
Also during the call, well be referring to certain financial measures not prepared in accordance with generally accepted accounting principles, or GAAP, such as adjusted EPS and adjusted operating income. We believe that the use of non-GAAP measures helps investors to gain a better understanding of our core operating results and future prospects consistent with how management measures and forecasts the companys performance, especially when comparing such results to previous periods or forecasts.
On Slide 3, youll see references to where you can find additional information on the transaction, which is also outlined in our press release.
So with that, I will now turn the call over to Marc. Marc?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Thank you, Ken. Good morning, everyone, and thank you for joining us.
Turning to Slide 4 in the presentation. Were really excited to announce our agreement to acquire Patheon. As you know, were the leading supplier to the pharmaceutical and biotech industry. In fact, its our largest and fastest-growing end market.
Today, we support our customers in research, clinical trials logistics services and production. Patheons capabilities are highly complementary and will considerably strengthen our unique value proposition for these customers.
Patheon gives us entry into the contract development and manufacturing services market. Ill cover this in a bit more detail in a few minutes. But this is a large and high-growth market that opens up new growth opportunities for us. This transaction is compelling from a financial perspective.
A quick snapshot on the deal: This is an all-cash transaction, and were paying $35 per share. We expect it to be immediately and significantly accretive to our adjusted EPS. It has an attractive return on investment profile, and we expect to complete the transaction by the end of 2017.
Before I get into the details, Id like to turn it over to Jim to make a few comments about the transaction. Jim?
James C. Mullen - Patheon N.V. - CEO and Executive Director
Thank you, Marc. I share your excitement about the combination of Patheon with Thermo Fisher. I would like to take a moment to highlight the tremendous value this transaction brings to all of our stakeholders.
First, it offers immediate and significant value for our shareholders, who will receive $35 per share in cash for each share of Patheon they own. Over the past 6 years, weve built a leading company in the CDMO space with exciting growth prospects. This combination is all about continuing that momentum.
Joining Thermo Fishers leading global organization will enable us to expand our reach and capitalize on the tremendous success Patheon has achieved in recent years. Together, both companies will be better positioned to add scale and new value chain capabilities to expand our offerings to our biopharma customers.
I have to point out that this transaction would not have been possible without the hard work of our talented team. They displayed an unwavering commitment to providing innovative solutions and expertise that help our customers deliver the highest-quality medicines to patients.
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Importantly, Thermo Fishers mission to enable its customers to make the world healthier, cleaner and safer is very much aligned with our commitment to a healthier world delivered.
We believe this transaction is an ideal fit and the logical next step in the evolution of our company. We will create more value for all of our key stakeholders as part of Thermo Fisher.
With that, Ill turn it back over to Marc. Thank you.
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Thanks, Jim. Turning back to the presentation. Slide 5 gives you an overview of the CDMO market. Its a very attractive $40 billion market thats growing in the mid-single to high single digits.
The growth is driven by 2 key industry trends. First is the increase in demand from smaller biotech companies that are rapidly growing in number. They dont have the in-house capability, so they need outsourced support to advance their molecules from research to the commercial marketplace.
And the second is growing demand from larger biopharma companies that are increasing their outsourcing activities so they can focus on their core business. Theyre also consolidating the number of outsourced providers to fewer trusted partners like Thermo Fisher and Patheon.
This is a highly fragmented industry with the top 10 players, including Patheon, addressing roughly 35% of the market today. Some of the other players in this market would include Lonza and Catalent. As you see, the trend is increasingly moving towards leveraging outsourcing, and Patheon has a strong competitive position.
The slide also shows the 3 key market segments that comprise the CDMO space. Development services is about a $2 billion market. Patheon has a very strong position here and offers a full spectrum of services. The largest market is the manufacturing of active pharmaceutical ingredients or APIs, and thats about $24 billion. Patheon is a focused player here. It provides a range of services to support the fast-growing market for biologics as well as strong expertise in complex chemistries used in small molecule drugs. The third piece is the manufacturing of finished dosage forms, which is about a $15 billion segment. This covers production and packaging of drugs that are ready for commercialization, including solid, liquid and injectable forms. Patheon has built a scale position here, covering a wide range of finished dosage forms. So to summarize, this is an exciting high-growth market, driven by customer demand for services and expertise that help to reduce the time and cost of drug development.
Slide 6 provides a quick snapshot of Patheon, which is a leading global provider of contract development and manufacturing services. The company has revenues of $1.9 billion and adjusted operating margin of 17%. Patheon will become part of Thermo Fishers Laboratory Products and Services segment. The business has a very strong North American and European network to serve the biotech and pharmaceutical industry, with opportunities over time to expand further in Asia Pacific. Weve included a couple of pie charts that give you a breakdown of the business by capability and geography.
Turning to Slide 7. Patheon is a great strategic fit with our company. The strategic rationale for this transaction is as follows: First, it gives us entry into the large and fast-growing CDMO market. It also makes our unique value proposition for our biopharma customers even stronger by adding highly complementary development and manufacturing capabilities that will allow us to further accelerate growth. Third, as you know, we have a proven track record in successfully integrating acquisitions and our ability to leverage that playbook is extremely powerful in generating revenue synergies as youve seen in other transactions. With Patheon, well be able to leverage our industry-leading scale and commercial infrastructure to expand their customer reach. And finally, this transaction offers attractive financial benefits to create value for our shareholders.
On Slide 8. As you know, 1 of the 3 key criteria in our M&A strategy is that it has to create value for our customers. In addition to giving us the opportunity to leverage our commercial scale, which I mentioned on the last slide, this slide shows you the significant customer benefits that the combination will bring.
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This is probably one of the most important points in my presentation. As you know, our clinical trials logistics business and our bioproduction business have historically been our fastest-growing businesses within the company. And between the two of them, they represent about $2.25 billion of our revenue. If you look at the fit between these businesses and Patheon, it is compelling.
Starting with bioproduction. You know that Thermo Fisher is a clear leader in this space. With seamless access to our bioproduction capabilities, Patheons biologics development and manufacturing capabilities will provide even greater benefit for customers. Thermo Fishers bioproduction business will also benefit from having an in-house world-class showcase for our technologies.
Turning to clinical trials. Youre familiar with our leading BioPharma Services business, which provides packaging and logistics services to efficiently and safely get clinical trial drugs to patients. Adding Patheons formulation services, as well as clinical trials manufacturing capabilities, will significantly enhance our ability to help our biopharma customers accelerate innovation and enhance productivity. This is an area where the 2 companies have been exploring a collaboration for some time because the customer benefits are powerful. These 2 examples, plus the significant cross-selling opportunities well have with our biotech and pharmaceutical customers, will drive substantial revenue synergies from this transaction.
Let me remind you that over time, weve established our BioPharma Services business as the leading player in the industry. Over the past decade, its become the trusted outsource provider for clinical trials logistics with clearly differentiated capabilities. We see the opportunity to do that again with Patheon.
Let me now turn it over to Stephen, who will discuss how we think about the opportunities this transaction creates from a financial perspective.
Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
Thanks, Marc. Im also very excited about the transaction, so Im happy to review some of the financial aspects with all of you today.
Turning to Slide 9. As you saw in our press release this morning, were paying $35 per Patheon share. The transaction represents a purchase price of approximately $7.2 billion, which includes the assumption of $2 billion of net debt.
The transaction delivers attractive financial returns. It will be immediately accretive to adjusted earnings per share, and we expect to deliver $0.30 of accretion in the first full year. We expect to generate a total of $120 million of adjusted operating income synergies by year 3 following the close. This includes $90 million of cost synergies and $30 million of adjusted operating income benefit from revenue-related synergies. Cost synergies will come from eliminating redundant public company expenses and deploying our PPI Business System. In terms of revenue synergies, Marc just outlined the compelling opportunities well have by combining our highly complementary capabilities for biopharma customers. As Im sure youre aware, we have a strong track record of efficiently and effectively integrating businesses, and well follow that prudent playbook.
And finally in terms of tax. As weve done in the past, we expect to significantly benefit from leveraging our combined global structure and anticipate materially lowering Patheons tax rates. Expect that we can very quickly reduce that tax rate from approximately 25% to 10% as a result of this transaction. So all in all, the financial profile for this transaction is very strong.
Moving to Slide 10. Let me review some of the important transaction details. In terms of financing, we have a fully committed bridge in place to support our all-cash offer. Permanent financing will be put in place nearer the close date, and we expect that to be a combination of our available cash plus the issuance of new debt and approximately $2 billion of new equity.
In terms of leverage, assuming no further capital deployment in 2017, we expect a pro forma leverage ratio of about 4x total debt to combined adjusted EBITDA at the closing date. And given the strength of our free cash flow, we would expect to reduce that significantly over the course of 2018.
We discussed the proposed permanent financing structure with the ratings agencies, and we fully expect to retain our investment-grade rating. In terms of next steps, we will commence a tender offer. Its worth noting that we already have an agreement with the 2 largest shareholders, who represent 73% of the 80% required to complete the transaction. Well also need to obtain customary regulatory approvals, as well as other closing conditions. We expect to complete the acquisition by the end of 2017.
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So closing with the last slide. We think this transaction is a great fit for our 2 companies. Its highly complementary to our offering for biopharma customers and gives us access to the large and high-growth CDMO market. Its financially compelling with great short-term benefits and a long runway to drive substantial share gain opportunities that will further accelerate our growth. This transaction is another great example of our proven capital deployment strategy at work. It strengthens our strategic position, enhances our customer offering and creates significant value for our shareholders.
With that, Ill turn it back over to Ken.
Kenneth J. Apicerno - Thermo Fisher Scientific Inc. - VP of IR and Treasurer
Thanks, Stephen. Operator, were ready to take questions.
QUESTIONS AND ANSWERS
Operator
(Operator Instructions) And your first question comes from the line of Ross Muken with Evercore ISI.
Ross Jordan Muken - Evercore ISI, Research Division - Senior MD, Head of Healthcare Services and Technology and Fundamental Research Analyst
So obviously, great deal. As you thought about sort of different verticals [of this thing], Marc, that you can enter, this is obviously one that has really nice growth metrics, and theres a lot of attractive roll-up opportunity. How are you thinking about within LPS, sort of this piece as it evolves for Thermo over time and whether this will be an area, one, obviously, that could grow above, it seems, like the corporate average, or at least at the upper end; and then two, how are you thinking about sort of the other assets that are available outside of this in terms of the runway that you have here, not just organically but inorganically?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
So Ross, thanks, great question or questions. So let me start from the high level about how we think about this transaction and the space that it serves, right? When you think about Patheon and the position in the CDMO market, it fits right in the sweet spot of what our bioproduction business does and what our clinical trials logistics what we call, BioPharma Services does. So if you think historically over the last number of years, those 2 businesses represent about $2.25 billion of our revenue and have been growing the fastest growing within the whole company. And this business really is hand-in-glove fit with it. So from that perspective, we see it as very much a natural part of our offering. So thats kind of how it fits. In terms of the organic prospects for the business, this is a mid-single digit to high single-digit growth business. And therefore, it will be accretive to the organic growth rate of Thermo Fisher over time as well, once we anniversary the first year because it doesnt count in organic, as you know, in the first year. So thats, obviously, a strong positive that goes with it. And in terms of the broader landscape, as you and others have heard or say many times, our industry is quite fragmented. And over time, theres opportunities to continue to build out the life science tools and diagnostics market. And theres opportunities to continue to expand on Patheons leadership in the CDMO space. And right now, the team is fully focused on working through the integration planning, closing the transaction and executing well. And over time, youll see us continue to add to our capabilities.
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Ross Jordan Muken - Evercore ISI, Research Division - Senior MD, Head of Healthcare Services and Technology and Fundamental Research Analyst
Now just quickly as a follow up. And normally, in this type of transactions, the risk is always sort of on the transition in terms of customer reaction. My guess is given your relationship, particularly with the biopharma space, while Patheon, obviously, has a great reputation, you do obviously as well. And my guess is therell be quite a bunch of enthusiasm on sort of theyou now owning the assets. Talk to us about some of the outreach youll do over the next months after you close, or I guess, next year in terms of how youll communicate kind of the breadth now of your BioPharma Service offering versus kind of where you were before and what you expect the customer feedback to be.
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Yes. So short the short term and then mid-term. From a very short-term perspective, as soon as the press release went out this morning, thats when I spent from 7:15 to 8:00 was literally sending notes to our customers. And Ill continue to do that during the course of the day, as well, I know Jim and the teams around the world because its a very exciting transaction. Right now, obviously, were 2 separate companies. But once we close, we will look to leverage the strengths of each company to accelerate growth, right? And there are companies or customers that Patheon has incredibly strong positions with, and that will create new opportunities for our BioPharma Services business or our bioproduction business or any part of Thermo Fisher and vice versa. Just given the scale of our thousands of sales reps around the world, just opening doors more seamlessly for Patheon will be a great opportunity. So it will play out over time. And from a commercial reach and cross-selling, we think it will be a terrific opportunity from that perspective.
Operator
Your next question comes from the line of Tycho Peterson with JP Morgan.
Tycho W. Peterson - JP Morgan Chase & Co, Research Division - Senior Analyst
Marc, wondering if you can talk a little more on the revenue synergy opportunity. How much of this is on the development side of the business with some of your existing pharma services businesses? And are there advantages here to adding a longer-cycle business here with typically 5- to 7-year manufacturing contracts, maybe for other parts of the existing Thermo business?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Yes, so when I think about the revenue synergies, the cross-selling will fall in both companies, right? So if you think about the cross-selling piece of the $90 million of revenue and $30 million of adjusted operating income that comes from it, you have a certain portion that just comes across our portfolio. But the vast majority of the synergies that are going to come within both for Patheons CDMO offering as well as for our clinical trials logistics business. When I think about it, the smaller customers, the biopharma customers that are or the biotech customers that dont have these capabilities, its incredibly compelling. Because were in at the earliest stage from the research side, so the ability to help the customer go from research all the way through manufacturing, thats going to be a big part of the synergies. So the exact numbers on each is probably a level of detail we wont get into today. But with a very large opportunity and obviously, long term, the geographic footprint is an opportunity. We actually didnt put it into the model in terms of Asian expansion, but we see that as an interesting upside longer term.
Tycho W. Peterson - JP Morgan Chase & Co, Research Division - Senior Analyst
And then can you talk on the cash flow side of things for Patheon? Do you see an opportunity to improve that? Its obviously a CapEx-intensive business in terms of adding new capacity. But are there opportunities from your perspective that you flag to maybe improve the cash flow?
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Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Ill start, and then Stephen may comment. But the PPI Business System that weve employed here for the last 15 years has done a really, really strong job of improving the working capital management within the company. I had the opportunity to visit some of the Patheon plants. And obviously, the team visited the network. And this is a well-run company. And where Im excited is that clearly, PPI will be a benefit for Patheon. But the Patheon way will bring some new tools to our toolkit as well, and the combination will be incredibly compelling. So I see this as one where well take the best thinking from both companies and improve the cash flow characteristics of the combined business.
Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
Sure. And just to add to that, Patheons made some significant capital investments over time. And its also done some great transactions to bringing capacity to help fuel the growth. And well continue to look for opportunity
(technical difficulty)
things like that, to expand the capacity footprint for the business.
Tycho W. Peterson - JP Morgan Chase & Co, Research Division - Senior Analyst
Okay. And then just one last one. Can you give us a sense of how large Patheon is as a customer for Thermo today, just in terms of supplying bioproduction services and equipment?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Order of magnitude is about a $50 million customer, 5-0.
Operator
Your next question comes from the line of Derik De Bruin of Bank of America.
Your next question comes from the line of Jack Meehan with Barclays.
Jack Meehan - Barclays PLC, Research Division - VP and Senior Research Analyst
Marc, I was hoping you could elaborate a little bit more on the biologics opportunities. You sized up the options on the market. What was it about Patheons capabilities that drew you to the portfolio? And how do you see that where youre going to be able to generate the opportunity with your bioproduction assets?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Yes. So when you think about the biologics market, obviously, we are a leader in the single-use technologies for the small to mid-scale production of biologics. And that is Patheons strategy in terms of where they are strong in the marketplace. So that relationship that Tycho just asked about is a big part of that is the relationship in bioproduction. And the companies collaborate well, and that will create new opportunities. Because effectively, well become smarter as a bioproduction producer by having a sister business that is doing this every day. Well have a showcase facility to demonstrate for customers. And the biologics business will have access to our technologies and capabilities to make sure that they are most competitive in the market. So its a really unique opportunity. And obviously, that will play out over time.
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Jack Meehan - Barclays PLC, Research Division - VP and Senior Research Analyst
Great. And then you hinted at the opportunity around Asia-Pac. Can you just talk about how you execute upon that? Is that something where you think its just a market maturity, where the region is at this point? And how do you see it fitting in with your broader strategy in the region?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
So Jack, in terms of Asia Pacific, the way to think about it is, its very logical on why Patheons network is set up the way it is because the vast majority of the pharmaceutical and biotech market today is in the U.S. and then Europe. Theres a lot of growth in Asia Pacific. Its very hard for a company to get started without any scale, right? And weve been in the markets there for 30-plus years, so the ability to build a facility or scale up a facility is much easier when you are licensed to operate, have a team, know how to do the business practice at all legal entities. So we are a tremendous accelerator. Were trusted by our customers from that perspective. And its just a question of where it is on the priority list. Its certainly not a day 1 priority. But over time, when we pick the right geography, well be able to scale up in that region and leverage our infrastructure to do so.
Operator
Your next question comes from the line of Tim Evans with Wells Fargo.
Timothy Cameron Evans - Wells Fargo Securities, LLC, Research Division - VP and Senior Equity Analyst
Marc, you talked a little bit about the working capital plan. Wanted to talk about the CapEx plan a little bit. I mean your CapEx is just shy of $500 million, but Patheons much smaller business is up there, $200 million-ish. Does this change your capital deployment outlook where theres going to be more investment in the business and maybe less return of capital to shareholders or anything like that?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
From a capital investment standpoint, the business is fairly similar to our bio basically, to our bioproduction business and our BioPharma Services business. So we have a mix of businesses in terms of capital intensity. And a lot of what we observed over this period is that a lot of the network has been built out and the capacitys there. Theres still going to be many investments to make, but a lot of the big investments that Patheon was making has already been done. So I dont think it changes our strategy whatsoever from a return of capital in the mid-term. Obviously, between now and through 2018, were going to be focusing on executing this transaction and delevering. So other than our dividend, were not going to be focused on return of capital in the next 18 months. But after that, itll be back to return to normal.
Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
And Tim, that $200 million, roughly $50 million of that is customer funded, so thats a gross number in terms of how Patheons been running the business.
Timothy Cameron Evans - Wells Fargo Securities, LLC, Research Division - VP and Senior Equity Analyst
Right, fair enough. And then lastly, on you said Patheons tax rate was going to be 10%. What would the combined company tax rate be after this deal closes?
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Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
Its so were at 13.3% for the rest of the company, so it will come down slightly, probably 20 basis points.
Operator
Your next question comes from the line of Derik De Bruin with Bank of America.
Derik De Bruin - BofA Merrill Lynch, Research Division - MD of Equity Research
Hey, Marc, the CDMO business is a lot lumpier. And youre subject to the timing of commercial launches and changes in customers. Also you it exposes Thermo to more developmental risk and manufacturing risk. I guess how do you think about the risk profile of Patheon versus your traditional businesses and how do you look to sort of mitigate that?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Derik, thats a great question. So when you think about the risk profile of the business, I put them into 2 different buckets, right? The development side of the equation, the business gets paid for, meaning the plan for all of these products is that they make it to market. But if they dont, the business makes money along the way. So thats the nature of the development side of it. So theres not really a risk there other than on a particular project, you may not get all the growth, but you get paid for the work that youve done. In terms of lumpiness, this is a business that is pretty predictable on the annual cycle. And certainly, things are lumpy within quarters. And we have a number of businesses within the company thats like that. And it kind of levels out when you get to the scale of Thermo Fisher, right? This business represents roughly 10% of our total company sales. So from that perspective, we always think about the revenue line on a really on an annual basis and understand that quarter-to-quarter, as you know how we think about guidance, we dont get too focused on the movements in between quarters from that perspective. The other areas you have to be great at, managing quality and regulatory landscape. The industry expects it. The production of biotech and pharmaceutical products are highly regulated. Obviously, Thermo Fisher as well is highly regulated in our BioPharma Services business, as well as in our Specialty Diagnostics business. And youll see a continued, incredibly focused commitment to doing a great job from a quality and regulatory perspective. So our commitment is there as has Patheons commitment been over the years.
Derik De Bruin - BofA Merrill Lynch, Research Division - MD of Equity Research
Great, and just one follow up, if I can.
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Of course.
Derik De Bruin - BofA Merrill Lynch, Research Division - MD of Equity Research
Yes, how do your how do sort of your PPI initiatives sort of play into the manufacturing business, and also making sure that youve sort of retained the people that you need to at Patheon, just given that its a different channel than what youre normally used to doing in terms of, like selling of instruments and reagents?
Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
Sure. Ill cover the PPI one, Derik. I think about the BioPharma Services business, weve been able to take the PPI Business System and methodology, which weve used largely in more manufacturing type of operations, and bring that to bear to a service business in a very impactful way. So weve seen that translate incredibly well. And its not just in the manufacturing and packaging side, but I think just in terms of the back-office piece as well. So I think thats going to translate very well.
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Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Yes, I think the thing thats interesting, and Stephens going to talk about it Wednesday when we have our Analyst Day a little bit, is the better run an operation is, the bigger the impact is from the PPI Business System. When we went to the manufacturing plants at Life Technologies at the operations level, actually they were quite well run back in 2013 at the factory floor. If you look at how rapidly they adopted the methodology and the impact that they drove, its really incredible. And Stephen will highlight a little bit in a couple of days. Thats how I would think about Patheon, right? Its basically giving a skill team additional tools, and theyll be able to apply them very aggressively. And I think its very, very powerful from that perspective.
Operator
Our next question comes from the line of Doug Schenkel with Cowen.
Douglas Anthony Schenkel - Cowen and Company, LLC, Research Division - MD and Senior Research Analyst
So I guess a few financial questions. Youve had a few on the CapEx profile of the business. Could you give us an update on your free cash flow conversion target subsequent to close? And yes, Im not sure how you want to answer this one. But how long until you can get back to a debt-to-EBITDA ratio of 3x? Really, what Im trying to get at there is when do you think you would be back at an acceptable leverage level to deploy capital pursuant to additional M&A?
Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
So in terms of the leverage ratio, its going to be 4x at close and then very rapidly paying that down over the course of 18. So I dont think it precludes us from M&A in terms of additional small bolt-ons. The other question was around...
Douglas Anthony Schenkel - Cowen and Company, LLC, Research Division - MD and Senior Research Analyst
Free cash flow conversion.
Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
Free cash flow conversion, yes, so when I think about this business and the company going forward, after integration, well be operating at 90% conversion of adjusted free cash flowof adjusted net income into free cash flow. So (inaudible) in line with the rest of the company.
Douglas Anthony Schenkel - Cowen and Company, LLC, Research Division - MD and Senior Research Analyst
Okay. And then another one, Stephen. We mathematically can get to $0.30 in year 1 accretion with no sales synergies, under 9% of target OpEx, cost synergies, which usually we can get to with just looking at overlapping public company and administrative costs and then the improved tax rate. The point is it seems like you can get to your $0.30 accretion target in year 1 without doing a whole lot differently operationally in the first year. Again, just kind of cutting out overlapping cost and layering in the tax. Is that the right way to think about this, at least in the context of your guidance?
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Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
So the exact timing in terms of the accretion, year 1 accretion of $0.30 is yes, theres an element of the public company clearly, public company cost going away straight away, the tax rate happening very soon. Synergies ramp. its approximately $30 million of synergies in year 1 and they ramp over the 3-year period fairly linearly, so costs coming in and getting executed a little quicker and revenue being more back-end loaded in that 3-year period. And then exact accretion coming up in 18, well let you know when we produce guidance for 18 in terms of the full impact.
Douglas Anthony Schenkel - Cowen and Company, LLC, Research Division - MD and Senior Research Analyst
Okay. And last one, you indicated that you expect the deal to close by year-end. Given the concentrated ownership of Patheon and the fact that you have most of those folks, if not all of those folks onboard with the deal, it would seem on the surface that this could get done sooner than late in the year. Can you just walk us through the logic and maybe you could comment on the possibility that this gets done a bit more quickly than say, 7, 8 months from now?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
So Doug, the key thing from the regulatory pathway is the EU from a regulatory review perspective. And we have the summer holiday that may -our experience is things in May dont make it through the funnel through the summer holiday. Thats been our historical experience, so thats one of the gating factors here. And then from the tender offer, its a Dutch transaction, its a little more complicated. But nonetheless, the 2 main shareholders have signed up for the transaction, so well go through that process and targeting to be done by year-end.
Douglas Anthony Schenkel - Cowen and Company, LLC, Research Division - MD and Senior Research Analyst
Okay. Last one, could you just comment on when you would expect to raise I think you have to do is there a $2 billion equity raise component? I guess, is there I guess in terms of going to the market to raise additional capital, any thoughts anything you can share on timing there?
Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
So yes, theres an assumption of a $2 billion equity component to this in terms of the [favorable] funding. Still looking at our different alternatives in terms of equity raise or placements, so well finalize that over the coming weeks.
Operator
Your next question comes from the line of Matthew Mishan with KeyBanc.
Matthew Ian Mishan - KeyBanc Capital Markets Inc., Research Division - VP and Senior Equity Research Analyst
On the API business, I think thats one of the big differentiators for Patheon versus its peers. And its a sizable piece of the CDMO market. How do you kind of view their exposure there? And do you view that as something youre looking to add to or be a little bit more careful with?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
So Jim, maybe spend a moment just kind of framing it and then I can add some comments.
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James C. Mullen - Patheon N.V. - CEO and Executive Director
Sure. Matthew, youre right. The API, the small molecule API is a big segment. We have focused our business on the most complex chemistry in the most regulated parts of the value chain, so were typically working on either very complex chemistries that fewer others will work on or very newly launched or late-stage clinical development molecules. And then what we do is we have a whole global network of suppliers underneath that, that we use for acquiring common intermediates or any kind of commoditized product. And so what you will see us do, which is what weve done over the past couple of years, is as the product matures, well take the opportunity to really outsource some of the earlier parts of the chemistry, while we continue to do the finishing chemistry, if you will, of the regulated steps. And that allows us really to stay in the highest-value part of that pyramid.
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
And thats been as we looked at the strategy, it makes sense on what Patheons doing because certain parts of that value chain are on the lower end that doesnt make a lot of sense to be for us to be producing. So we like the space that theyve carved out.
Matthew Ian Mishan - KeyBanc Capital Markets Inc., Research Division - VP and Senior Equity Research Analyst
Okay, great. And then last quarter, Patheon had to lowest had to lower guidance for organic growth from like high single digit, double digit to like a mid-single-digit rate. First off, has some of those headwinds for Patheon abated as its kind of moved through the year? And then secondly, what do you kind of view as like the long-term growth target for this business now?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Yes. In terms of the trajectory for the business, weve had good visibility through the diligence process, both to what was going on in the first quarter, whats happening currently and what the outlook is for the year. So we understand the dynamics there. From an organic perspective, this should be a consistent mid-single digit to high single-digit organic growth business going forward. Thats how we think about the outlook, Matt.
Operator
Your final question comes from the line of Isaac Ro with Goldman Sachs.
Isaac Ro - Goldman Sachs Group Inc., Research Division - VP
So Marc, quick question on just the structure of the industry. Can you give us a sense of what percent of the market is currently outsourced? And if we look over maybe 5 or 10 years, what that number can be?
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Yes. So today, about 30% of the market is outsourced. And its probably going to 50% over the long term is where its going, which creates, obviously, meaningful growth opportunities. Thats not going to happen overnight, but the trends clearly in the favor of moving towards more outsourcing. And thats over the last decade, we played that trend out within the BioPharma Services. And what weve seen is actually the trends accelerating. So we went from a relatively low penetration of outsourced to a much higher. And actually, if I look at the speed of where customers are looking today, its actually picking up. So we think that plays out in the CDMO market as well. Were obviously an incredibly trusted partner of our customers, which is why we really truly are dominant #1 in the BioPharma Services business. And we see over time, the opportunity to expand Patheons market position.
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Isaac Ro - Goldman Sachs Group Inc., Research Division - VP
Got it. And then just a follow-up for Steve. What are you guys assuming for cost of debt?
Stephen Williamson - Thermo Fisher Scientific Inc. - CFO and SVP
Cost of debt, assuming 2.5% in terms of the permanent financing.
Marc N. Casper - Thermo Fisher Scientific Inc. - CEO, President and Director
Thanks, Isaac, and thanks, everyone, for joining us today. Its clearly very exciting news for Thermo Fisher and Patheon. We look forward to working with Jim and the Patheon team to kick off the integration planning and officially and efficiently complete the transaction. And of course, we look forward to seeing you in New York for our Analyst Day meeting on Wednesday. Thank you, everyone.
Operator
This concludes todays conference call. You may now disconnect, and have a wonderful day.
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