-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001470418-09-000002.txt : 20090821
<SEC-HEADER>0001470418-09-000002.hdr.sgml : 20090821
<ACCEPTANCE-DATETIME>20090821100336
ACCESSION NUMBER:		0001470418-09-000002
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090821
DATE AS OF CHANGE:		20090821
EFFECTIVENESS DATE:		20090821

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ALSERES PHARMACEUTICALS INC /DE
		CENTRAL INDEX KEY:			0000094784
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				870277826
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-09478-4B
		FILM NUMBER:		091027742

	BUSINESS ADDRESS:	
		STREET 1:		239 SOUTH STREET
		CITY:			HOPKINTON
		STATE:			MA
		ZIP:			01748
		BUSINESS PHONE:		508-497-2360

	MAIL ADDRESS:	
		STREET 1:		239 SOUTH STREET
		CITY:			HOPKINTON
		STATE:			MA
		ZIP:			01748

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BOSTON LIFE SCIENCES INC /DE
		DATE OF NAME CHANGE:	19950706

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GREENWICH PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	STRATEGIC MEDICAL RESEARCH CORP /DE
		DATE OF NAME CHANGE:	19790521
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0502</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000094784</cik>
        <entityName>ALSERES PHARMACEUTICALS INC /DE</entityName>
        <issuerAddress>
            <street1>239 SOUTH STREET</street1>
            <street2></street2>
            <city>HOPKINTON</city>
            <stateOrCountry>MA</stateOrCountry>
            <zipCode>01748</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>508-497-2360</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>BOSTON LIFE SCIENCES INC /DE</previousName>
            <previousName>GREENWICH PHARMACEUTICALS INC</previousName>
            <previousName>STRATEGIC MEDICAL RESEARCH CORP /DE</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <middleName>G.</middleName>
                <lastName>Savas</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>239 South Street</street1>
                <street2></street2>
                <city>Hopkinton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>01748</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <middleName></middleName>
                <lastName>Pykett</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>239 South Street</street1>
                <street2></street2>
                <city>Hopkinton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>01748</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kenneth</firstName>
                <middleName>L.</middleName>
                <lastName>Rice, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>239 South Street</street1>
                <street2></street2>
                <city>Hopkinton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>01748</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>J.</middleName>
                <lastName>Mullen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>239 South Street</street1>
                <street2></street2>
                <city>Hopkinton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>01748</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>T.</middleName>
                <lastName>Preston</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>239 South Street</street1>
                <street2></street2>
                <city>Hopkinton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>01748</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>L.S.</middleName>
                <lastName>Guinness</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>239 South Street</street1>
                <street2></street2>
                <city>Hopkinton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>01748</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Henry</firstName>
                <middleName></middleName>
                <lastName>Brem</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>239 South Street</street1>
                <street2></street2>
                <city>Hopkinton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>01748</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gary</firstName>
                <middleName>E.</middleName>
                <lastName>Frashier</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>239 South Street</street1>
                <street2></street2>
                <city>Hopkinton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>01748</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName></middleName>
                <lastName>Langer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>239 South Street</street1>
                <street2></street2>
                <city>Hopkinton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>01748</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0000094784-09-000002</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-03-19</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5000000</totalOfferingAmount>
            <totalAmountSold>3900000</totalAmountSold>
            <totalRemaining>1100000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ALSERES PHARMACEUTICALS INC /DE</issuerName>
                <signatureName>/s/ Kenneth L. Rice, Jr.</signatureName>
                <nameOfSigner>Kenneth L. Rice, Jr.</nameOfSigner>
                <signatureTitle>EVP -- Finance and Administration and CFO</signatureTitle>
                <signatureDate>2009-08-20</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----