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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 LBnX+qJPBSxXa+44uQj6S1ni/Zt8WFCM3SWQSC0iOJ+zGcwNtMtnn0Kc2PoPChAO
 WEVmfJxrVXs3mA6SVA6MIg==

<SEC-DOCUMENT>0001209191-07-008199.txt : 20070207
<SEC-HEADER>0001209191-07-008199.hdr.sgml : 20070207
<ACCEPTANCE-DATETIME>20070207125022
ACCESSION NUMBER:		0001209191-07-008199
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20070205
FILED AS OF DATE:		20070207
DATE AS OF CHANGE:		20070207

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BOSTON LIFE SCIENCES INC /DE
		CENTRAL INDEX KEY:			0000094784
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				870277826
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		20 NEWBURY STREET
		STREET 2:		5TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		6174250200

	MAIL ADDRESS:	
		STREET 1:		20 NEWBURY STREET
		STREET 2:		5TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GREENWICH PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	STRATEGIC MEDICAL RESEARCH CORP /DE
		DATE OF NAME CHANGE:	19790521

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			FRASHIER GARY E
		CENTRAL INDEX KEY:			0001215914

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-06533
		FILM NUMBER:		07587090

	MAIL ADDRESS:	
		STREET 1:		C/O MANAGEMENT ASSOCIATES
		STREET 2:		PMB 264 28295 IH-10 WEST SUITE 4
		CITY:			BOERNE
		STATE:			TX
		ZIP:			78006 6515
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>b64009f3.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2007-02-05</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000094784</issuerCik>
        <issuerName>BOSTON LIFE SCIENCES INC /DE</issuerName>
        <issuerTradingSymbol>BLSI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001215914</rptOwnerCik>
            <rptOwnerName>FRASHIER GARY E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O BOSTON LIFE SCIENCES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>85 MAIN STREET</rptOwnerStreet2>
            <rptOwnerCity>HOPKINTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>01748</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <ownerSignature>
        <signatureName>/s/ Gary E Frashier</signatureName>
        <signatureDate>2007-02-06</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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