Consolidated Statements of Stockholders' (Deficit) Equity (USD $)	Total	Preferred Stock [Member]	Common Stock [Member]	Additional Paid-In Capital [Member]	Deferred Compensation [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Deficit Accumulated During Development Stage [Member]
Beginning Balance at Oct. 16, 1992
Beginning Balance, Shares at Oct. 16, 1992
Issuance of common stock	48,725		3,040	45,685
Issuance of common stock, shares			304,009
Exercise of warrants and stock options	7,596,439		11,850	7,584,589
Exercise of warrants and stock options, shares			1,185,039
Issuance of common stock and warrants, net of issuance costs	56,458,546		115,168	56,343,378
Issuance of common stock and warrants, net of issuance costs, shares			11,516,790
Issuance of common stock and warrants upon Merger	14,603,948		7,239	14,596,709
Issuance of common stock and warrants upon Merger, shares			723,947
Conversion of convertible debentures	988,591		313	988,278
Conversion of convertible debentures, shares			31,321
Issuance of warrants related to debentures, net of issuance costs	3,632,632			3,632,632
Issuance of warrants related to preferred series C stock and BCF, net of issuance costs	3,736,789			3,736,789
Preferred stock, net of issuance costs	25,584,456	2,296,355		23,288,101
Preferred stock, net of issuance costs, shares		240,711
Conversion of Preferred Stock K and payment of interest, net of issuance costs	6,179,186	(1,491,474)	15,538	7,655,122
Accretion of preferred stock	(4,327,679)			(4,327,679)
Conversion of Preferred Stock K and payment of interest, net of issuance costs, shares		(240,149.7)	1,553,749.0
Conversion of debentures and payment of interest, net of issuance costs	4,847,420		3,171	4,844,249
Conversion of debentures and payment of interest, net of issuance costs, shares			317,083
Conversion of preferred stock and modification of warrants		(3,501,539)	9,006	3,492,533
Conversion of preferred stock and modification of warrants, shares		(561.3)	900,646.0
Preferred stock conversion inducement	(600,564)			(600,564)
Amortization of preferred stock Series E BCF		2,696,658		(2,696,658)
Issuance of warrants related to Series E Stock, net of issuance costs	2,049,297			2,049,297
Issuance of common stock and cancellation of warrants			427	(427)
Issuance of common stock and cancellation of warrants, shares			42,667
Dividend accrual preferred Series E	(573,597)			(573,597)
BCF on convertible notes payable	558,000			558,000
Deferred compensation- stock options and warrants				804,607	(804,607)
Share-based compensation	4,274,806			3,470,199	804,607
Modification of options and warrants	1,804,694			1,804,694
Other	69,933		8	69,925
Other, shares			783
Net income (loss)	(143,503,529)						(143,503,529)
Ending Balance at Dec. 31, 2006
Exercise of warrants and stock options	145,705		2,022	143,683
Exercise of warrants and stock options, shares			202,183
Conversion of convertible debentures	10,000,000		40,000	9,960,000
Conversion of convertible debentures, shares			4,000,000
BCF on convertible notes payable	1,880,000			1,880,000
Share-based compensation	1,665,155			1,665,155
Modification of options and warrants	5,614			5,614
Net income (loss)	(19,548,348)						(19,548,348)
Net Unrealized gain (loss) on marketable securities	9,310					9,310
Ending Balance at Dec. 31, 2007	(22,414,471)		207,782	140,420,314		9,310	(163,051,877)
Ending Balance, shares at Dec. 31, 2007			20,778,217
Issuance of common stock	1,085,275		5,718	1,079,557
Issuance of common stock, shares			571,806
Exercise of warrants and stock options	2,541		11	2,530
Exercise of warrants and stock options, shares			1,100
Conversion of convertible debentures	120,000		480	119,520
Conversion of convertible debentures, shares			48,000
BCF on convertible notes payable	380,000			380,000
Share-based compensation	1,670,063			1,670,063
Net income (loss)	(20,847,459)						(20,847,459)
Net Unrealized gain (loss) on marketable securities	(9,310)					(9,310)
Ending Balance at Dec. 31, 2008	(40,013,361)		213,991	143,671,984			(183,899,336)
Ending Balance, shares at Dec. 31, 2008			21,399,123
Issuance of common stock	2,002,000		41,565	1,960,435
Issuance of common stock, shares			4,156,522
Accretion of convertible redeemable preferred stock	(194,107)			(192,107)			(2,000)
Share-based compensation	1,473,083			1,473,083
Net income (loss)	(10,776,937)						(10,776,937)
Ending Balance at Dec. 31, 2009	(47,509,322)		255,556	146,913,395			(194,678,273)
Ending Balance, shares at Dec. 31, 2009			25,555,645
Issuance of common stock	0		15,000	(15,000)
Issuance of common stock, shares			1,500,000
Accretion of preferred stock	(343,000)			(343,000)
Share-based compensation	61,722			61,722
Buyback of common stock	(8,100)		(2,700)	(5,400)
Buyback of common stock, shares			(270,000)
Net income (loss)	512,419						512,419
Ending Balance at Dec. 31, 2010	(47,286,281)		267,856	146,611,717			(194,165,854)
Ending Balance, shares at Dec. 31, 2010			26,785,645
Conversion of convertible debentures	7,172,412		28,690	7,143,722
Conversion of convertible debentures, shares			2,868,965
Accretion of preferred stock	486,663			486,663
Issuance of common stock-debt forgiveness	28,680		3,585	25,095
Issuance of common stock-debt forgiveness, shares			358,500
Share-based compensation	834			834
Buyback of common stock per share	(7,172)		(28,690)	21,518
Buyback of common stock per share, shares			(2,868,965)
Buyback of common stock	(11,084)		(11,084)
Buyback of common stock, shares			(1,108,425)
Forgiveness of accrued interest on convertible debt	6,132,499			6,132,499
Conversion of Series F Preferred to common stock			46,000	4,554,000
Conversion of Series F Preferred to common stock, shares			4,600,000
Forgiveness of accrued interest on note payable	195,807			195,807
Settlement of note payable	999,000			999,000
Net income (loss)	(2,882,214)						(2,882,214)
Net Unrealized gain (loss) on marketable securities	(31,367)					(31,367)
Ending Balance at Dec. 31, 2011	(30,602,223)		306,357	166,170,855		(31,367)	(197,048,068)
Ending Balance, shares at Dec. 31, 2011			30,635,720
Conversion of convertible debentures	5,827,588		23,311	5,804,277
Conversion of convertible debentures, shares			2,331,035
Accretion of preferred stock	(21,057)			(21,057)
Buyback of common stock per share	(1,866)		(23,311)	21,445
Buyback of common stock per share, shares			(2,331,035)
Net income (loss)	(1,645,476)						(1,645,476)
Net Unrealized gain (loss) on marketable securities	(277,837)					(277,837)
Ending Balance at Dec. 31, 2012	(26,720,871)		306,357	171,975,520		(309,204)	(198,693,544)
Ending Balance, shares at Dec. 31, 2012			30,635,720
Net gain on debt modification	682,670			682,670
Accretion of preferred stock	(20,942)			(20,942)
Gain on release and sale of contingent royalty liability	16,025,000			16,025,000
Net income (loss)	(941,529)						(941,529)
Net Unrealized gain (loss) on marketable securities	315,854					315,854
Ending Balance at Dec. 31, 2013	$ (10,659,818)		$ 306,357	$ 188,662,248		$ 6,650	$ (199,635,073)
Ending Balance, shares at Dec. 31, 2013			30,635,720