Exhibit 32.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of ViroPharma Incorporated (the
"Company") on Form 10-Q for the period ending June 30, 2003 as filed with the
Securities and Exchange Commission on the date hereof (the "Report"), each of
the undersigned officers of the Company, certify, pursuant to 18 U.S.C. (S)
1350, as adopted pursuant to (S) 906 of the Sarbanes-Oxley Act of 2002, that:

         (1)    The Report fully complies with the requirements of section 13(a)
or 15(d) of the Securities Exchange Act of 1934; and

         (2)    The information contained in the Report fairly presents, in all
material respects, the financial condition and results of operations of the
Company.

/s/ Michel de Rosen
-------------------------
Michel de Rosen
President, Chief Executive Officer and Chairman of the Board of Directors
August 14, 2003

/s/ Vincent J. Milano
-------------------------
Vincent J. Milano
Vice President, Chief Financial Officer and Treasurer
August 14, 2003