POWER OF ATTORNEY

            Know all by these presents, that the undersigned hereby constitutes and appoints
each of J. Peter Wolf and Vincent J. Milano, signing individually, the undersigned's true and
lawful attorney-in-fact to:
(1)	execute for and on behalf of the undersigned, in the undersigned's
capacity as an Director of ViroPharma Incorporated (the "Company"),
Forms 3, 4, and 5 with respect to the undersigned's holdings of and
transactions in securities issued by the Company in accordance with Section
16(a) of the Securities Exchange Act of 1934, as amended, and the rules
thereunder;
(2)	do and perform any and all acts for and on behalf of the undersigned
which may be necessary or desirable to complete and execute any such
Form 3, 4, or 5 with respect to the undersigned's holdings of and
transactions in securities issued by the Company, complete and execute any
amendment or amendments thereto, and timely file such form with the
United States Securities and Exchange Commission and any stock exchange
or similar authority; and
(3)	take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney-in-fact, may be of benefit
to, in the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney-in-fact on behalf
of the undersigned pursuant to this Power of Attorney shall be in such form
and shall contain such terms and conditions as such attorney-in-fact may
approve in such attorney-in-fact's discretion.
            The undersigned hereby grants to each such attorney-in-fact full power and
authority to do and perform any and every act and thing whatsoever requisite, necessary or
proper to be done in the exercise of any of the rights and powers herein granted, as fully to all
intents and purposes as the undersigned might or could do if personally present, with full power
of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or
such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of
this power of attorney and the rights and powers herein granted.  The undersigned acknowledges
that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned,
are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to
comply with Section 16 of the Securities Exchange Act of 1934, as amended.



            This Power of Attorney shall remain in full force and effect until the undersigned
is no longer required to file Forms 3, 4 and 5 with respect to the undersigned's holdings of and
transactions in securities issued by the Company, unless earlier revoked by the undersigned in a
signed writing delivered to the foregoing attorneys-in-fact.
            IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of this 18th day of February, 2008.

            				_/s/ John Leone_____________________
            				Signature


John Leone
Print Name

PHLEGAL: #1299168 v1 (R%G001!.DOC)



PHLEGAL: #1299168 v1 (R%G001!.DOC)