-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 GcnuzTRgc21e9o4s9dvfW9CcuefoVi/kOl4fG/oQx0jeZmdzhOGsldqwwJoXiMmQ
 8hLo2R/IXcMGcLQjm0vbsQ==

<SEC-DOCUMENT>0001181431-03-015234.txt : 20030724
<SEC-HEADER>0001181431-03-015234.hdr.sgml : 20030724
<ACCEPTANCE-DATETIME>20030724121123
ACCESSION NUMBER:		0001181431-03-015234
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030722
FILED AS OF DATE:		20030724

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			COLLETT MARC
		CENTRAL INDEX KEY:			0001208973

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21699
		FILM NUMBER:		03800178

	MAIL ADDRESS:	
		STREET 1:		VIROPHARMA INCORP
		STREET 2:		405 EAGLEVIEW BLVD
		CITY:			EXTON
		STATE:			PA
		ZIP:			19341

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VIROPHARMA INC
		CENTRAL INDEX KEY:			0000946840
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				232789550
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		405 EAGLEVIEW BLVD
		STREET 2:		PO BOX 5000
		CITY:			EXTON
		STATE:			PA
		ZIP:			19341
		BUSINESS PHONE:		6104587300

	MAIL ADDRESS:	
		STREET 1:		76 GREAT VALLEY PARKWAY
		CITY:			MALVERN
		STATE:			PA
		ZIP:			19355
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd13691.xml
<DESCRIPTION>COLLETT JULY 2003
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType>
<periodOfReport>2003-07-22</periodOfReport>
<notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000946840</issuerCik>
        <issuerName>VIROPHARMA INC</issuerName>
        <issuerTradingSymbol>VPHM</issuerTradingSymbol></issuer>
<reportingOwner>
<reportingOwnerId>
            <rptOwnerCik>0001208973</rptOwnerCik>
            <rptOwnerName>COLLETT MARC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
<isDirector>0</isDirector>
<isOfficer>1</isOfficer>
<isTenPercentOwner>0</isTenPercentOwner>
<isOther>0</isOther>
<officerTitle>VP, Drug Discovery</officerTitle>
<otherText></otherText></reportingOwnerRelationship></reportingOwner>
<derivativeSecurity>
<securityTitle>
<value>Employee Stock Option (right to buy)</value></securityTitle>
<conversionOrExercisePrice>
<value>2.09</value></conversionOrExercisePrice>
<transactionDate>
<value>2003-07-22</value></transactionDate>
<transactionCoding>
<transactionFormType>4</transactionFormType>
<transactionCode>A</transactionCode>
<equitySwapInvolved>0</equitySwapInvolved></transactionCoding>
<transactionAmounts>
<transactionShares>
<value>30000</value></transactionShares>
<transactionValue>
<value>2.09</value></transactionValue>
<transactionAcquiredDisposedCode>
<value>A</value></transactionAcquiredDisposedCode></transactionAmounts>
<exerciseDate>
<value>2004-07-22</value>
<footnoteId id="F1"/></exerciseDate>
<expirationDate>
<value>2013-07-22</value></expirationDate>
<underlyingSecurity>
<underlyingSecurityTitle>
<value>Common Stock</value></underlyingSecurityTitle>
<underlyingSecurityShares>
<value>30000</value></underlyingSecurityShares></underlyingSecurity>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>30000</value></sharesOwnedFollowingTransaction></postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>D</value></directOrIndirectOwnership>
<natureOfOwnership>
<value></value></natureOfOwnership></ownershipNature></derivativeSecurity>
<footnotes>
<footnote id="F1">The options vest in four equal annual installments beginning on the anniversary date from time of grant.</footnote></footnotes>
<ownerSignature>
<signatureName>Thomas F. Doyle</signatureName>
<signatureDate>2003-07-23</signatureDate></ownerSignature></ownershipDocument>


</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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