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Share-based Compensation (Details 2) (USD $) In Thousands, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Share-Based Compensation
Share-based compensation expense	$ 6,291	$ 5,457	$ 12,286	$ 10,360
Research and development
Share-Based Compensation
Share-based compensation expense	1,201	1,152	2,479	2,235
Selling, general and administrative
Share-Based Compensation
Share-based compensation expense	$ 5,090	$ 4,305	$ 9,807	$ 8,125

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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