Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2012

Commitments and Contingencies

Schedule of future minimum contractual obligations and commercial commitments

(in thousands) Contractual Obligations	Total		2013		2014		2015		2016		2017		Thereafter
Operating leases	$	46,561	$	1,935	$	2,884	$	3,063	$	3,130	$	3,116	$	32,433
Collaboration agreements		2,644		1,322		1,322		—		—		—		—
Purchase obligations		477,767		97,487		108,377		112,630		78,036		81,237		—
Total	$	526,972	$	100,744	$	112,583	$	115,693	$	81,166	$	84,353	$	32,433