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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 NzUAnxL9FkUv0iaG/83o1ZDVZBssI93XzEwIPmGW2lpgypP8fV/0hY6qBo7FKRth
 NsmL365znDuerCNDqpFuMA==

<SEC-DOCUMENT>9999999995-09-001045.txt : 20090427
<SEC-HEADER>9999999995-09-001045.hdr.sgml : 20090427
<ACCEPTANCE-DATETIME>20090427001518
ACCESSION NUMBER:		9999999995-09-001045
CONFORMED SUBMISSION TYPE:	EFFECT
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20090424
DATE AS OF CHANGE:		20090427
EFFECTIVENESS DATE:		20090424

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HEMISPHERX BIOPHARMA INC
		CENTRAL INDEX KEY:			0000946644
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				520845822
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		EFFECT
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-152727
		FILM NUMBER:		09771011

	BUSINESS ADDRESS:	
		STREET 1:		1617 JFK BLVD #660
		STREET 2:		ONE PENN CENTER
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19104
		BUSINESS PHONE:		2159880080

	MAIL ADDRESS:	
		STREET 1:		1617 JFK BLVD
		STREET 2:		ONE PENN CENTER
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19103
</SEC-HEADER>
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<TYPE>EFFECT
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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    <schemaVersion>X0101</schemaVersion>

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    <act>33</act>

    <testOrLive>LIVE</testOrLive>

    <effectiveData>
        <finalEffectivenessDispDate>2009-04-24</finalEffectivenessDispDate>
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            <entityName>HEMISPHERX BIOPHARMA INC</entityName>
            <fileNumber>333-152727</fileNumber>
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