Royalties, License and Employment Agreements (Details Narrative) - USD ($) $ / shares in Units, $ in Thousands		12 Months Ended
	Sep. 16, 2015	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012	Jun. 24, 2009
Stock compensation expense		$ 121	$ 223	$ 219
2009 Equity Incentive Plans [Member]
Number of option granted		7,819,534	7,673,262	6,708,978	4,688,978
Expiration period	3 years
Number of shares covered under plan	22,000,000					15,000,000
Maximum [Member] | 2009 Equity Incentive Plans [Member]
Share price (in dollars per share)		$ 4.03	$ 4.03	$ 4.03	$ 4.03
Minimum [Member] | 2009 Equity Incentive Plans [Member]
Share price (in dollars per share)		$ 0.21	$ 0.21	$ 0.21	$ 0.21
Mr.Thomas K. Equels [Member]
Number of option granted		300,000	300,000	300,000
Expiration period		10 years	10 years	10 years
Share price (in dollars per share)		$ 0.25	$ 0.36	$ 0.31
Vesting period		P1Y	P1Y	P1Y
Number of additional option granted				150,000
Additional option expiration period				10 years
Additional option share price (in dollars per share)				$ 0.25
Additional option vesting period				1 year
Dr. William A Carter [Member]
Number of option granted		500,000	500,000	500,000
Expiration period		10 years	10 years	10 years
Share price (in dollars per share)		$ 0.25	$ 0.36	$ 0.31
Vesting period		P1Y	P1Y	P1Y
Number of additional option granted			320,000	150,000
Additional option expiration period			10 years	10 years
Additional option share price (in dollars per share)			$ 2.60	$ 0.25
Additional option vesting period			1 year	1 year
Dr. William A Carter [Member] | 2009 Equity Incentive Plans [Member]
Number of shares covered under plan		3,000,000
Employment Contractual Agreements [Member] | Executive Officers [Member]
Annual base compensation		$ 2,259	$ 2,249	$ 2,788
Performance bonus		$ 0	386	0
Employment Contractual Agreements [Member] | Executive Officers [Member] | Maximum [Member]
Percent of performance bonus		25.00%
Employment Contractual Agreements [Member] | Executive Officers [Member] | Minimum [Member]
Percent of performance bonus		20.00%
Employment Contractual Agreements [Member] | Former CFO [Member]
Severance salary				238
Employment Contractual Agreements [Member] | Mr.Thomas K. Equels [Member]
Accrued bonus		$ 262	641	12
Employment Contractual Agreements [Member] | Dr. William A Carter [Member]
Accrued bonus		262	$ 1,282	$ 12
Annual professional fees payable monthly		$ 332