Stockholders’ Equity (Details Narrative) - USD ($)				1 Months Ended	3 Months Ended			12 Months Ended
	Jul. 07, 2020	Sep. 27, 2019	Sep. 12, 2018	Dec. 31, 2020	Mar. 31, 2022	Dec. 31, 2021	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Mar. 16, 2018
Class of Stock [Line Items]
Preferred stock, shares authorized					5,000,000
Preferred stock stated value					$ 0.01
Warrant exercise price										$ 17.05
Warrants and rights outstanding term										5 years
Common stock, shares authorized					350,000,000	350,000,000		350,000,000
Common stock shares with specific limitations and restrictions on usage					8,000,000
Common stock shares issued, value							$ 12,887,000
Warrants issued										73,314
Warrant outstanding					15,000
Number of options granted					300,000		0
Common stock, shares outstanding					47,994,672	47,994,672		47,994,672
Director [Member]
Class of Stock [Line Items]
Option vested years			10 years
2018 Equity Incentive Plan [Member]
Class of Stock [Line Items]
Number of stock is reserved for potential issuance			7,000,000
2018 Equity Incentive Plan [Member] | Employees [Member]
Class of Stock [Line Items]
Number of options granted				675,000	300,000	613,512
Option exercise price per share					$ 0.70
Expiration period				10 years	10 years	10 years
Pre-funded Warrants [Member]
Class of Stock [Line Items]
Shares issued price per share		$ 0.899
Warrant [Member]
Class of Stock [Line Items]
Warrant exercise price		$ 0.99
Alliance Global Partners, LLC [Member]
Class of Stock [Line Items]
Number of shares issued upon transaction		1,740,550
Warrants issued		7,148,310
Proceeds from Issuance or Sale of Equity		$ 7,200,000
Alliance Global Partners, LLC [Member] | Warrants [Member]
Class of Stock [Line Items]
Number of warrant to purchase shares of common stock		8,888,860
Alliance Global Partners, LLC [Member] | Pre-funded Warrants [Member]
Class of Stock [Line Items]
Shares issued price per share		$ 0.90
Maxim Group LLC [Member] | Equity Distribution Agreement [Member]
Class of Stock [Line Items]
Proceeds from Issuance or Sale of Equity								$ 13,301,526	$ 53,936,615
Sale of stock, Number of shares issued								5,665,731	20,444,807
Shares sales fee percentage				3.50%		3.50%		3.50%	3.50%
Underwriting fee amount.								$ 465,533	$ 1,888,727
Minimum [Member] | 2018 Equity Incentive Plan [Member] | Employees [Member]
Class of Stock [Line Items]
Option exercise price per share				$ 1.85		$ 1.11
Maximum [Member] | 2018 Equity Incentive Plan [Member] | Employees [Member]
Class of Stock [Line Items]
Option exercise price per share				$ 1.96		1.71
Maximum [Member] | Alliance Global Partners, LLC [Member] | Representative Warrants [Member]
Class of Stock [Line Items]
Number of warrant to purchase shares of common stock		266,665
Directors, Officers and Employees [Member]
Class of Stock [Line Items]
Common stock shares issued, value	$ 500,000
Rights [Member]
Class of Stock [Line Items]
Warrant exercise price					$ 1,000
Proceeds from warrants					$ 4,700,000
Warrant [Member]
Class of Stock [Line Items]
Warrant exercise price					$ 8.80
Warrants and rights outstanding term					5 years
Series A Junior Participating Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, shares authorized					250,000
Series B Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, shares authorized					8,000
Preferred stock stated value					$ 1,000	$ 1,000		$ 1,000
Preferred Stock, No Par Value					$ 0
Preferred Stock, Shares Outstanding					715	715		715
Series B Convertible Preferred Stock [Member] | Rights [Member]
Class of Stock [Line Items]
Preferred stock face value					$ 1,000
Preferred Stock [Member]
Class of Stock [Line Items]
Number of shares to be issued on conversion					114	114		114
Common Stock [Member]
Class of Stock [Line Items]
Common stock shares issued, value								$ 205,000
Number of shares issued upon transaction					0			132,238
Common Stock [Member] | Minimum [Member]
Class of Stock [Line Items]
Shares issued price per share						$ 1.16		$ 1.16
Common Stock [Member] | Maximum [Member]
Class of Stock [Line Items]
Shares issued price per share						$ 2.35		$ 2.35