Schedule of Stock Option Activity (Details) - USD ($)	3 Months Ended	12 Months Ended
Mar. 31, 2022	Dec. 31, 2021
Share-Based Payment Arrangement, Employee [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of Options Outstanding, Beginning of Period	1,498,798
Weighted Average Exercise Price Outstanding, beginning of Period	$ 4.22
Weighted Average Remaining Contracted Term (years) Outstanding	8 years 11 months 8 days	9 years 1 month 9 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Number of Options, Granted	150,000
Weighted Average Exercise Price, Granted	$ 0.70
Weighted Average Remaining Contracted Term (years) Granted	9 years 9 months
Aggregate Intrinsic Value, Granted
Number of Options, Forfeited
Weighted Average Exercise Price, Forfeited	$ 233.54
Aggregate Intrinsic Value, Forfeited
Number of Options, Expired	(739)
Weighted Average Exercise Price, Forfeited
Aggregate Intrinsic Value, Expired
Number of Options Outstanding, Ending of Period	1,648,059	1,498,798
Weighted Average Exercise Price Outstanding, End of Period	$ 3.80	$ 4.22
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number	1,648,059
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price	$ 3.80
Weighted Average Remaining Contracted Term (years), Vested and Expected to Vest	8 years 11 months 8 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number	1,216,894
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price	$ 3.15
Weighted Average Remaining Contracted Term (years), Exercisable at End of Period	6 years 29 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Share-Based Payment Arrangement, Nonemployee [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of Options Outstanding, Beginning of Period	279,723
Weighted Average Exercise Price Outstanding, beginning of Period	$ 6.12
Weighted Average Remaining Contracted Term (years) Outstanding	8 years 4 months 24 days	7 years 11 months 4 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Number of Options, Granted	150,000
Weighted Average Exercise Price, Granted	$ 0.70
Weighted Average Remaining Contracted Term (years) Granted	9 years 9 months
Aggregate Intrinsic Value, Granted
Aggregate Intrinsic Value, Forfeited
Aggregate Intrinsic Value, Expired
Number of Options Outstanding, Ending of Period	429,723	279,723
Weighted Average Exercise Price Outstanding, End of Period	$ 4.23	$ 6.12
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number	429,723
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price	$ 4.23
Weighted Average Remaining Contracted Term (years), Vested and Expected to Vest	8 years 4 months 24 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number	222,770
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price	$ 6.05
Weighted Average Remaining Contracted Term (years), Exercisable at End of Period	7 years 11 months 15 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value

Share based compensation arrangement by share based payment award options expired in period total intrinsic value.

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Net number of share options (or share units) granted during the period.

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Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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Number of options outstanding, including both vested and non-vested options.

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options of the plan that expired.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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