Stockholders’ Equity (Details Narrative) - USD ($)								1 Months Ended			3 Months Ended	12 Months Ended
	Jul. 07, 2020	Sep. 27, 2019	Jan. 28, 2019	Nov. 14, 2018	Oct. 17, 2018	Sep. 12, 2018	Jun. 24, 2009	Dec. 31, 2020	Aug. 31, 2020	Mar. 30, 2020	Dec. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Mar. 16, 2018
Class of Stock [Line Items]
Preferred stock, shares authorized											5,000,000	5,000,000
Preferred stock stated value											$ 0.01	$ 0.01
Warrant exercise price															$ 17.05
Preferred stock conversion price											$ 8.80	$ 8.80
Warrants and Rights Outstanding, Term															5 years
Common stock, shares authorized								350,000,000			350,000,000	350,000,000	350,000,000
Common stock shares with specific limitations and restrictions on usage											8,000,000	8,000,000
Common stock shares issued, value												$ 13,042,000	$ 61,248,000
Warrants issued								0			0	0	0		73,314
Number of warrant to purchase shares of common stock								9,826,661			568	568	9,826,661
Proceeds from Warrant Exercises										$ 264,000
Warrant modification.										$ 46,000
Warrant outstanding											15,000	15,000
Common stock, shares outstanding								42,154,371			47,994,672	47,994,672	42,154,371
Share based compensation expense												$ 1,568,000	$ 1,036,000
Unrecognized stock-based compensation cost								$ 1,599,000			$ 779,000	$ 779,000	$ 1,599,000
Share-based Payment Arrangement, Nonemployee [Member]
Class of Stock [Line Items]
Number of options granted												113,512	100,000
Option exercise price per share												$ 1.64	$ 2.77
Share based compensation expense												$ 1,568,000	$ 1,036,000
Employees [Member]
Class of Stock [Line Items]
Number of options granted				23
Option exercise price per share				$ 9.68
Officers [Member]
Class of Stock [Line Items]
Number of options granted			27,570
Option exercise price per share			$ 9.68
Options holding period			10 years
Employees [Member]
Class of Stock [Line Items]
Number of options granted												500,000	925,000
Option exercise price per share												$ 1.60	$ 2.28
Share-based payment award options vested in period fair value												$ 801,000	$ 2,110,250
Director [Member]
Class of Stock [Line Items]
Number of options granted					26,234
Option exercise price per share					$ 9.68
Option vested years					10 years	10 years
Number of common stock reserved for potential issuance						7,000,000
Non-Employee [Member]
Class of Stock [Line Items]
Number of options granted												109,154		1,000,000
Option exercise price per share												$ 1.66		$ 2.77
Share-based payment award options vested in period fair value												$ 181,161		$ 277,000
2018 Equity Incentive Plan [Member]
Class of Stock [Line Items]
Number of stock is reserved for potential issuance						7,000,000
Expiration period					10 years	10 years
Number of options granted					26,324
Option exercise price per share					$ 9.68
2018 Equity Incentive Plan [Member] | Employees [Member]
Class of Stock [Line Items]
Expiration period				10 years
Number of options granted				23
Option exercise price per share				$ 9.68
2018 Equity Incentive Plan [Member] | Officers [Member]
Class of Stock [Line Items]
Expiration period			10 years						10 years
Number of options granted			27,570						400,000
Option exercise price per share			$ 9.68
Option vested years			1 year						1 year
2018 Equity Incentive Plan [Member] | Employees [Member]
Class of Stock [Line Items]
Expiration period								10 years
Number of options granted								675,000			613,512
Option vested years								1 year			1 year
Pre-funded Warrants [Member]
Class of Stock [Line Items]
Shares issued price per share		$ 0.899
Stock Issued During Period, Shares, Other													1,870,000
Warrant [Member]
Class of Stock [Line Items]
Warrant exercise price		$ 0.99
Stock Issued During Period, Shares, Other													8,873,960
Number of options granted														16,907,471
Alliance Global Partners, LLC [Member]
Class of Stock [Line Items]
Number of shares issued upon transaction		1,740,550
Warrants issued		7,148,310
Proceeds from Issuance or Sale of Equity		$ 7,200,000
Alliance Global Partners, LLC [Member] | Warrants [Member]
Class of Stock [Line Items]
Number of warrant to purchase shares of common stock		8,888,860
Alliance Global Partners, LLC [Member] | Pre-funded Warrants [Member]
Class of Stock [Line Items]
Shares issued price per share		$ 0.90
Maxim Group LLC [Member] | Equity Distribution Agreement [Member]
Class of Stock [Line Items]
Proceeds from Issuance or Sale of Equity												$ 13,301,526	$ 53,936,615
Sale of Stock, Number of Shares Issued in Transaction												5,665,731	20,444,807
Shares sales fee percentage								3.50%			3.50%	3.50%	3.50%
Underwriting fee amount.												$ 465,533	$ 1,888,727
Minimum [Member] | 2018 Equity Incentive Plan [Member] | Officers [Member]
Class of Stock [Line Items]
Option exercise price per share									$ 2.77
Minimum [Member] | 2018 Equity Incentive Plan [Member] | Employees [Member]
Class of Stock [Line Items]
Option exercise price per share								$ 1.85			$ 1.11
Minimum [Member] | Warrant [Member]
Class of Stock [Line Items]
Option exercise price per share														$ 0.99
Maximum [Member] | 2018 Equity Incentive Plan [Member] | Officers [Member]
Class of Stock [Line Items]
Option exercise price per share									$ 3.07
Maximum [Member] | 2018 Equity Incentive Plan [Member] | Employees [Member]
Class of Stock [Line Items]
Option exercise price per share								1.96			1.71
Maximum [Member] | Warrant [Member]
Class of Stock [Line Items]
Option exercise price per share														$ 8.80
Maximum [Member] | Alliance Global Partners, LLC [Member] | Representative Warrants [Member]
Class of Stock [Line Items]
Number of warrant to purchase shares of common stock		266,665								266,665
Directors, Officers and Employees [Member]
Class of Stock [Line Items]
Common stock shares issued, value	$ 500,000
Rights [Member]
Class of Stock [Line Items]
Warrant exercise price											1,000	$ 1,000
Proceeds from warrants												$ 4,700,000
Warrant [Member]
Class of Stock [Line Items]
Warrant exercise price											$ 8.80	$ 8.80
Warrants and Rights Outstanding, Term											5 years	5 years
2009 Equity Incentive Plan [Member]
Class of Stock [Line Items]
Option vested years							10 years
Number of common stock reserved for potential issuance							22,000,000
Series A Junior Participating Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, shares authorized											250,000	250,000
Series B Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, shares authorized											8,000	8,000
Preferred stock stated value								$ 1,000			$ 1,000	$ 1,000	$ 1,000
Preferred Stock, No Par Value											$ 0	$ 0
Preferred Stock, Shares Outstanding								732			715	715	732
Series B Convertible Preferred Stock [Member] | Rights [Member]
Class of Stock [Line Items]
Preferred stock face value											$ 1,000	$ 1,000
Preferred Stock [Member]
Class of Stock [Line Items]
Number of shares to be issued on conversion											114	114
Common Stock [Member]
Class of Stock [Line Items]
Common stock shares issued, value	$ 25,000											$ 205,000	$ 50,000
Number of shares issued upon transaction	10,730											132,238	27,501
Shares issued price per share	$ 2.33
Common Stock [Member] | Minimum [Member]
Class of Stock [Line Items]
Shares issued price per share								$ 1.72			$ 1.16	$ 1.16	$ 1.72
Common Stock [Member] | Maximum [Member]
Class of Stock [Line Items]
Shares issued price per share								$ 2.03			$ 2.35	$ 2.35	$ 2.03