Schedule of Stock Option Activity (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Share-based Payment Arrangement, Employee [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding, beginning of Period	1,049,695	127,747
Weighted Average Exercise Price Outstanding, beginning of Period	$ 5.38	$ 29.61
Number of Options, Granted	500,000	925,000
Weighted Average Exercise Price, Granted	$ 1.60	$ 2.28
Number of Options, Forfeited	(50,897)	(2,483)
Weighted Average Exercise Price, Forfeited		$ 19.50
Number of Options Outstanding, Ending of Period	1,498,798	1,049,695
Weighted Average Exercise Price Outstanding, End of Period	$ 4.22	$ 5.38
Number of Options Exercisable, End of Period	1,086,298
Weighted Average Remaining Contracted Term (years), Exercisable at End of Period	7 years 11 months 15 days
Weighted Average Exercise Price Exercisable, Ending of Period	$ 3.52
Weighted Average Remaining Contracted Term (years) Outstanding	9 years 3 months 10 days	6 years 4 months 28 days
Aggregate Intrinsic Value Outstanding, beginning of Period
Weighted Average Remaining Contracted Term (years) Granted	9 years 1 month 9 days	9 years 9 months 10 days
Aggregate Intrinsic Value, Granted
Aggregate Intrinsic Value, Forfeited
Number of Options, Expired		(569)
Weighted Average Exercise Price, Expired		$ 348.48
Aggregate Intrinsic Value, Expired
Weighted Average Remaining Contracted Term (years) Outstanding	9 years 1 month 9 days
Aggregate Intrinsic Value Outstanding, Ending of Period
Number of Options, Vested and Expected to Vest	1,498,798
Weighted Average Exercise Price, Vested and Expected to Vest	$ 4.22
Weighted Average Remaining Contracted Term (years), Vested and Expected to Vest	9 years 1 month 9 days
Aggregate Intrinsic Value, Vested and Expected to Vest
Aggregate Intrinsic Value, Exercisable at End of Period
Share-based Payment Arrangement, Nonemployee [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding, beginning of Period	166,533	66,675
Weighted Average Exercise Price Outstanding, beginning of Period	$ 11.03	$ 12.80
Number of Options, Granted	113,512	100,000
Weighted Average Exercise Price, Granted	$ 1.64	$ 2.77
Number of Options, Forfeited	(322)	(142)
Weighted Average Exercise Price, Forfeited	$ 965.93	$ 104.29
Number of Options, exercised
Weighted Average Exercise Price, Exercised
Number of Options Outstanding, Ending of Period	279,723	166,533
Weighted Average Exercise Price Outstanding, End of Period	$ 6.12	$ 11.03
Number of Options Exercisable, End of Period	181,892
Weighted Average Remaining Contracted Term (years), Exercisable at End of Period	7 years 6 months 10 days
Weighted Average Exercise Price Exercisable, Ending of Period	$ 7.11
Weighted Average Remaining Contracted Term (years) Outstanding	6 years 10 months 17 days	5 years 7 months 2 days
Aggregate Intrinsic Value Outstanding, beginning of Period
Aggregate Intrinsic Value, Granted
Weighted Average Remaining Contracted Term (years) Outstanding	7 years 11 months 4 days
Aggregate Intrinsic Value Outstanding, Ending of Period
Number of Options, Vested and Expected to Vest	279,723
Weighted Average Exercise Price, Vested and Expected to Vest	$ 6.12
Weighted Average Remaining Contracted Term (years), Vested and Expected to Vest	7 years 11 months 4 days
Aggregate Intrinsic Value, Vested and Expected to Vest
Aggregate Intrinsic Value, Exercisable at End of Period
Aggregate Intrinsic Value, exercised
Aggregate Intrinsic Value, Forfeited
Grants in period, weighted average grant date fair value	9 years 11 months 1 day
2009 Equity Incentive Plans [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding, beginning of Period	129,680	132,615
Weighted Average Exercise Price Outstanding, beginning of Period	$ 23.05	$ 31.65
Number of Options, Granted
Weighted Average Exercise Price, Granted
Option price, granted
Number of Options, Forfeited	(1,176)	(2,935)
Weighted Average Exercise Price, Forfeited	$ 289.62	$ 82.38
Number of Options, exercised
Option price, exercised
Weighted Average Exercise Price, Exercised
Number of Options Outstanding, Ending of Period	128,504	129,680
Weighted Average Exercise Price Outstanding, End of Period	$ 25.58	$ 23.05
Number of Options Exercisable, End of Period	126,393	98,138
Weighted Average Remaining Contracted Term (years), Exercisable at End of Period	5 years 10 months 24 days	5 years 7 months 6 days
2009 Equity Incentive Plans [Member] | Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Option price outstanding, beginning of year	$ 13.20	$ 13.20
Option price, forfeited	16.76	9.68
Option price outstanding, end of year	13.20	13.20
Option price exercisable, end of year	13.20	13.20
2009 Equity Incentive Plans [Member] | Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Option price outstanding, beginning of year	2,127.84	2,127.84
Option price, forfeited	1,056.00	380.16
Option price outstanding, end of year	2,127.84	2,127.84
Option price exercisable, end of year	$ 2,127.84	$ 2,127.84
2018 Equity Incentive Plans [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding, beginning of Period	1,086,549	61,806
Option price outstanding, beginning of year		$ 9.68
Weighted Average Exercise Price Outstanding, beginning of Period	$ 2.75	$ 9.68
Number of Options, Granted	613,512	1,025,000
Weighted Average Exercise Price, Granted	$ 1.67	$ 2.33
Number of Options, Forfeited	(50,044)	(257)
Weighted Average Exercise Price, Forfeited	$ 1.86	$ 2.75
Number of Options, exercised
Option price, exercised
Weighted Average Exercise Price, Exercised
Number of Options Outstanding, Ending of Period	1,650,017	1,086,549
Option price outstanding, end of year
Weighted Average Exercise Price Outstanding, End of Period	$ 2.35	$ 2.75
Number of Options Exercisable, End of Period	1,141,798	243,750
Weighted Average Remaining Contracted Term (years), Exercisable at End of Period	9 years 1 month 13 days	9 years 4 months 24 days
Weighted Average Exercise Price Exercisable, Ending of Period	$ 2.35	$ 2.75
Available for future grants	344,322	28,268
2018 Equity Incentive Plans [Member] | Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Option price outstanding, beginning of year	$ 1.85
Option price, granted	1.11	$ 1.85
Option price, forfeited	1.85	9.68
Option price outstanding, end of year	1.11	1.85
Option price exercisable, end of year	1.11	1.85
2018 Equity Incentive Plans [Member] | Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Option price outstanding, beginning of year	9.68
Option price, granted	1.71	3.07
Option price, forfeited	8.50	16.72
Option price outstanding, end of year	9.68	9.68
Option price exercisable, end of year	$ 9.68	$ 9.68