Stockholders’ Equity (Tables)

12 Months Ended

Dec. 31, 2021

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of Options and Equity Estimated Based on Weighted Average Assumptions

	Year Ended December 31,
	2021	2020
Risk-free interest rate	0.66% - 1.23%	0.3% - 0.46%
Expected dividend yield	—	—
Expected life	5 years	5 years
Expected volatility	108.08% - 108.46%	115.24% - 116.79%
Weighted average grant date fair value for options issued	$1.61 per option for 613,512 options	$2.28 per option for 1,025,000 options

Schedule of Warrants Outstanding and Exercisable

Information regarding warrants outstanding and exercisable into shares of common stock is summarized below:

	2021							2020
	Shares			Warrant Price		Weighted Average Exercise Price		Shares			Warrant Price		Weighted Average Exercise Price
Outstanding, beginning of year		375,100		$	0.99 – 469.92	$	116.38		10,201,761		$	0.99 – 469.92	$	1.54
Granted		—			—		—		—			—		—
Expired		(79,593	)		17.16 – 84.48		20.85		—			—		—
Exercised		(568	)		8.80		8.80		(9,826,661	)		0.90-8.80		0.97
Outstanding, end of year		294,939		$	0.99-469.92	$	15.19		375,100		$	0.99 – 469.92	$	116.38
Exercisable		294,939		$	0.99-469.92	$	15.19		375,100		$	0.99 – 469.92	$	116.38
Weighted average remaining contractual life		4.75 years							5.75 years
Years exercisable		2022-2025							2021-2024

Share-based Payment Arrangement, Employee [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of Stock Option Activity

Stock option activity for employees

	Number of Options			Weighted Average Exercise Price		Weighted Average Remaining Contracted Term (Years)		Aggregate Intrinsic Value
Outstanding December 31, 2019		127,747		$	29.61		6.41		—
Granted		925,000			2.28		9.78		—
Forfeited		(2,483	)		19.50		—		—
Expired		(569	)		348.48		—		—
Outstanding December 31, 2020		1,049,695		$	5.38		9.28		—
Granted		500,000			1.60		9.11		—
Forfeited		(50,897	)		—
Expired		—			—		—		—
Outstanding December 31, 2021		1,498,798		$	4.22		9.11		—
Vested and expected to vest at December 31, 2021		1,498,798		$	4.22		9.11		—
Exercisable at December 31, 2021		1,086,298		$	3.52		7.96		—

Schedule of Unvested Stock Option Activity

Unvested stock option activity for employees:

	Number of Options			Weighted Average Exercise Price		Average Remaining Contracted Term (Years)		Aggregate Intrinsic Value
Unvested December 31, 2019		30,100		$	23.79		7.48		—
Granted		925,000			2.28		9.78		—
Vested		(226,254	)		3.93		7.53		—
Forfeited		—			—		—		—
Unvested December 31, 2020		728,846		$	3.71		9.61		—
Granted		449,102			1.60		9.11		—
Vested		(765,448	)		2.24		8.36		—
Forfeited		—			—		—		—
Unvested December 31, 2021		412,500		$	4.15		5.85		—

Share-based Payment Arrangement, Nonemployee [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of Stock Option Activity

Stock option activity for non-employees during the year:

	Number of Options			Weighted Average Exercise Price		Weighted Average Remaining Contracted Term (Years)		Aggregate Intrinsic Value
Outstanding December 31, 2019		66,675		$	12.80		5.59		—
Granted		100,000			2.77		—		—
Exercised		—			—		—		—
Forfeited		(142	)		104.29		—		—
Outstanding December 31, 2020		166,533		$	11.03		6.88		—
Granted		113,512			1.64		9.92		—
Exercised		—			—		—		—
Forfeited		(322	)		965.93		—		—
Outstanding December 31, 2021		279,723		$	6.12		7.93		—
Vested and expected to vest at December 31, 2021		279,723		$	6.12		7.93		—
Exercisable at December 31, 2021		181,892		$	7.11		7.53		—

Schedule of Unvested Stock Option Activity

Unvested stock option activity for non-employees:

	Number of Options			Weighted Average Exercise Price		Weighted Average Remaining Contracted Term (Years)		Aggregate Intrinsic Value
Unvested December 31, 2019		25,566		$	12.80		5.59		—
Granted		100,000			2.77		9.58		—
Vested		(59,364	)		5.95		—		—
Forfeited		—			—		—		—
Unvested December 31, 2020		66,202		$	7.24		6.13		—
Granted		113,512			1.64		9.92		—
Vested		(81,883	)		3.48		—		—
Forfeited		—			—		—		—
Unvested December 31, 2021		97,831		$	3.89		7.82		—

2009 Equity Incentive Plan [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of Stock Option Activity

Information regarding the options approved by the Board of Directors under Equity Plan of 2009 is summarized below. The plan expired June 24, 2019:

	2021							2020
	Shares			Option Price		Weighted Average Exercise Price		Shares			Option Price		Weighted Average Exercise Price
Outstanding, beginning of year		129,680			13.20 – 2,127.84		23.05		132,615			13.20 -2,127.84		31.65
Granted		—					—		—			—		—
Forfeited		(1,176	)		16.76-1056.00		289.62		(2,935	)		9.68 – 380.16		82.38
Exercised		—			—		—		—			—
Outstanding, end of year		128,504			13.20-2,127.84		25.58		129,680			13.20 - 2,127.84		23.05
Exercisable, end of year		126,393			13.20-2,127.84				98,138			13.20 – 2,127.84
Weighted average remaining contractual life (years)		5.9 years							5.6 years

2018 Equity Incentive Plans [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Schedule of Stock Option Activity

Information regarding the options approved by the Board of Directors under the Equity Plan of 2018 is summarized below:

	2021							2020
	Shares			Option Price		Weighted Average Exercise Price		Shares			Option Price		Weighted Average Exercise Price
Outstanding, beginning of year		1,086,549			1.85 - 9.68		2.75		61,806			9.68		9.68
Granted		613,512			1.11 – 1.71		1.67		1,025,000			1.85 – 3.07		2.33
Forfeited		(50,044	)		1.85 – 8.50		1.86		(257	)		9.68 – 16.72		2.75
Exercised		—			—		—		—			—		—
Outstanding, end of year		1,650,017			1.11 – 9.68		2.35		1,086,549			1.85 – 9.68		2.75
Exercisable, end of year		1,141,798			1.11 – 9.68		2.35		243,750			1.85 – 9.68		2.75
Weighted average remaining contractual life (years)		9.12 years							9.4 years
Available for future grants		344,322							28,268