Research, Consulting and Supply Agreements (Details Narrative) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2018	Dec. 31, 2017
Payments for research and consulting	$ 1,398
Jubilant Hollister-Stier Laboratories LLC [Member]
Payments for research and consulting	1,078	$ 320
Nitto Avecia Pharma Services, Inc [Member]
Gain on litigation settlement	$ 474

Amount of gain (loss) recognized in settlement of litigation and insurance claims. Excludes claims within an insurance entity's normal claims settlement process.

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 450
-SubTopic 20
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=82911808&loc=d3e14326-108349

Name:	us-gaap_GainLossRelatedToLitigationSettlement
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration