Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2018

Schedule of Options and Equity Estimated Based on Weighted Average Assumptions

The fair values of the options and equity warrants granted were estimated based on the following weighted average assumptions:

	Year Ended December 31,
	2018		2017
Risk-free interest rate		2.6%-3.0%		1.72%-1.89%
Expected dividend yield		-		-
Expected life		5 years		1.25-5 years
Expected volatility		85.68%-86.89%		91.60%-144.15%
Weighted average grant date fair value for options and equity warrants issued		$0.23 per option for 5,864,505 options		$0.35per option/warrant for 1,340,517 options/equity warrants

Schedule of Warrants Outstanding and Exercisable

Information regarding warrants outstanding and exercisable into shares of common stock is summarized below:

	2017							2018
	Shares			Warrant Price		Weighted Average Exercise Price		Shares			Warrant Price		Weighted Average Exercise Price
Outstanding, beginning of year		2,830,516		$	1.08-$24.00	$	2.16		7,334,490		$	0.45-$10.68	$	0.63
Granted		17,512,308		$	0.45-$0.75	$	0.57		9,825,808		$	0.39	$	0.39
Forfeited		(10,508,334	)	$	0.60-$24.00	$	0.61		(25,000	)	$	6.00	$	6.00
Exercised		(2,500,000	)	$	0.50	$	0.50		(2,800,000	)	$	0.45	$	0.45
Outstanding, end of year		7,334,490		$	0.45-$10.68	$	0.63		14,335,298		$	0.39-$10.68	$	0.49
Exercisable		7,334,490		$	0.45-$10.68	$	0.63		14,335,298		$	0.39-$10.68	$	0.49
Weighted average remaining contractual life		2.7 years							2.3 years
Years exercisable		2017-2023							2019-2023

Employees [Member]

Schedule of Stock Option Activity

Stock option activity for employees

	Number of  Options			Weighted  Average  Exercise  Price		Weighted  Average  Remaining  Contracted  Term  (Years)		Aggregate  Intrinsic  Value
Outstanding December 31, 2016		836,256		$	16.82		4.47		—
Granted		584,794			0.50		—		—
Forfeited		(217,132	)		33.35		—		—
Outstanding December 31, 2017		1,203,918		$	5.91		6.89		—
Granted		4,164,585			0.32		—		—
Forfeited		(257,917	)		18.01		—		—
Outstanding December 31, 2018		5,110,586		$	0.75		9.01		—
Vested and expected to vest at December 31, 2018		5,110,586		$	0.75		9.01		—
Exercisable at December 31, 2018		1,804,927		$	1.04		8.09		—

Schedule of Unvested Stock Option Activity

Unvested stock option activity for employees:

	Number of  Options			Weighted  Average  Exercise  Price		Average  Remaining  Contracted  Term  (Years)		Aggregate  Intrinsic  Value
Unvested December 31, 2016		90,625		$	1.72		9.33		—
Granted		584,794			0.50		—		—
Vested		(309,271	)		0.88		—		—
Forfeited		—			—		—		—
Unvested December 31, 2017		366,148		$	0.48		9.62		—
Granted		4,164,585			0.32		—		—
Vested		(1,225,074	)		0.36		—		—
Forfeited		—			—		—		—
Unvested December 31, 2018		3,305,659		$	0.32		9.31		—

Non-Employees [Member]

Schedule of Stock Option Activity

Stock option activity for non-employees during the year:

	Number  of  Options			Weighted  Average  Exercise  Price		Weighted  Average  Remaining  Contracted  Term  (Years)		Aggregate  Intrinsic  Value
Outstanding December 31, 2016		271,500		$	10.41		4.66		—
Granted		605,772			0.42		—		—
Exercised		—			—		—		—
Forfeited		(42,396	)		19.41		—		—
Outstanding December 31, 2017		834,876		$	2.70		6.69		—
Granted		1,699,920			0.31		—		—
Exercised		—			—		—		—
Forfeited		(109,104	)		10.33		—		—
Outstanding December 31, 2018		2,425,692		$	0.68		8.55		—
Vested and expected to vest at December 31, 2018		2,425,692		$	0.68		8.55		—
Exercisable at December 31, 2018		874,164		$	1.52		7.78		—

Schedule of Unvested Stock Option Activity

Unvested stock option activity for non-employees:

	Number of  Options			Weighted  Average  Exercise  Price		Weighted  Average  Remaining  Contracted  Term  (Years)		Aggregate  Intrinsic  Value
Unvested December 31, 2016		26,389		$	1.65		8.61		—
Granted		606,772			0.42		—		—
Vested		(163,335	)		0.57		—		—
Forfeited		(4,861	)		7.58		—		—
Unvested December 31, 2016		464,965		$	0.36		7.84		—
Granted		1,699,920			0.31		—		—
Vested		(613,357	)		0.35		—		—
Forfeited		—			—		—		—
Unvested December 31, 2018		1,551,528		$	0.31		8.84		—

2009 Equity Incentive Plan [Member]

Schedule of Stock Option Activity

The plan expires June 24, 2019:

	2017							2018
	Shares			Option Price		Weighted Average Exercise Price		Shares			Option Price		Weighted Average Exercise Price
Outstanding, beginning of year		695,061			1.56-48.36		4.70		1,877,295			0.33-48.36		1.92
Granted		1,190,567			0.33-0.67		0.29		4,675,221			0.30-0.38		0.34
Forfeited		(8,333	)		1.56		1.56		(213,855	)		8.16-$48.36		28.26
Exercised		—			—		—		—			—		—
Outstanding, end of year		1,877,295			0.33-48.36		1.92		6,338,661			0.30-48.36		0.36
Exercisable, end of year		1,046,487			0.33-48.36		0.42		2,376,353			0.30-48.36
Weighted average remaining contractual life (years)		2-10 years							1-10 years
Available for future grants		4,139,454							159,322

2018 Equity Incentive Plans [Member]

Schedule of Stock Option Activity

Information regarding the options approved by the Board of Directors under the Equity Plan of 2018 is summarized below:

	2018
	Shares		Option Price		Weighted  Average  Exercise  Price
Outstanding, beginning of year		—		—		—
Granted		1,189,284		0.22		0.22
Forfeited		—		—		—
Exercised		—		—		—
Outstanding, end of year		1,189,284		0.22		0.22
Exercisable, end of year		294,404		0.22		0.22
Weighted average remaining contractual life (years)		10 years
Available for future grants		5,810,716