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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TVbvH+t982/inU7dq1FVdTGyu05riEPos2VZ/yueB6zSivlj8qGGlMyKgTxGVMeH
 T1zK30FXjuPbq3E2Pozlhg==

<SEC-DOCUMENT>0001383039-06-000002.txt : 20061211
<SEC-HEADER>0001383039-06-000002.hdr.sgml : 20061211
<ACCEPTANCE-DATETIME>20061211093237
ACCESSION NUMBER:		0001383039-06-000002
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20061211
FILED AS OF DATE:		20061211
DATE AS OF CHANGE:		20061211

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Bonelli Anthony
		CENTRAL INDEX KEY:			0001383039

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-13441
		FILM NUMBER:		061267250

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		973-214-4639

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 521
		CITY:			NEW VERNON
		STATE:			NJ
		ZIP:			07976

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HEMISPHERX BIOPHARMA INC
		CENTRAL INDEX KEY:			0000946644
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				520845822
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1617 JFK BLVD #660
		STREET 2:		ONE PENN CENTER
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19104
		BUSINESS PHONE:		2159880080

	MAIL ADDRESS:	
		STREET 1:		1617 JFK BLVD
		STREET 2:		ONE PENN CENTER
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19103
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-12-11</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000946644</issuerCik>
        <issuerName>HEMISPHERX BIOPHARMA INC</issuerName>
        <issuerTradingSymbol>HEB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001383039</rptOwnerCik>
            <rptOwnerName>Bonelli Anthony</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>P.O. BOX 521</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW VERNON</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>07976</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; COO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">2,500 shares of common stock was purchased on 12/1/2006 and the purchase was reported on a Form 4 that was filed on 12/8/2006.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Anthony Bonelli</signatureName>
        <signatureDate>2006-12-11</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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