Exhibit 32.2

                           CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the amended Annual Report of Hemispherx Biopharma, Inc. (the
"Company") on Form 10-K for the fiscal year ended December 31, 2005 as filed
with the Securities and Exchange Commission on the date hereof (the "Report"),
I, Robert Peterson, Chief Financial Officer of the Company, certify, pursuant to
18 U.S.C. ss. 1350, as adopted pursuant to ss. 906 of the Sarbanes-Oxley Act of
2002, that:

            (1) The Report fully complies with the requirements of section 13(a)
or 15(d) of the Securities Exchange Act of 1934; and

            (2) The information contained in the Report fairly presents, in all
material respects, the financial condition and result of operations of the
Company.

                                                   /s/ Robert E. Peterson
                                                   -----------------------------
                                                   Robert Peterson
                                                   Chief Financial Officer
                                                   July 31, 2006



CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Hemispherx Biopharma, Inc.
Philadelphia, Pennsylvania

We hereby consent to the incorporation by reference in the Registration
Statements on Form S-8 (Nos. 333-57134 and 333-118903) of Hemispherx Biopharma,
Inc. and subsidiaries of our reports dated June 1, 2006, relating to the
consolidated financial statements and financial statement schedule, and the
effectiveness of Hemispherx Biopharma, Inc. and subsidiaries internal control
over financial reporting which appear in the Company's Annual Report on Form
10-K/A and 10-K/A-2.

/s/ BDO Seidman, LLP
------------------------------
BDO Seidman, LLP

Philadelphia, Pennsylvania
July 27, 2006