<SEC-DOCUMENT>0000946644-15-000080-index.html : 20151215
<SEC-HEADER>0000946644-15-000080.hdr.sgml : 20151215
<ACCEPTANCE-DATETIME>20151215170017
ACCESSION NUMBER:		0000946644-15-000080
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20151215
DATE AS OF CHANGE:		20151215

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HEMISPHERX BIOPHARMA INC
		CENTRAL INDEX KEY:			0000946644
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				520845822
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-205228
		FILM NUMBER:		151289078

	BUSINESS ADDRESS:	
		STREET 1:		1617 JFK BLVD, SUITE #500
		STREET 2:		ONE PENN CENTER
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19103
		BUSINESS PHONE:		215-988-0080

	MAIL ADDRESS:	
		STREET 1:		1617 JFK BLVD, SUITE #500
		STREET 2:		ONE PENN CENTER
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19103
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>hebprosuppmaxim12-11x15.htm
<DESCRIPTION>HEBPROSUPPMAXIM12-11X15.HTM
<TEXT>
Document 1 - file: hebprosuppmaxim12-11x15.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>hemispherxprospectussimg1a04.jpg
<TEXT>
Document 2 - file: hemispherxprospectussimg1a04.jpg

</DOCUMENT>
</SEC-DOCUMENT>