-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Tn3mZebcPWQfJlFFlj1fqOH994NJx6oYqgL3SyqBzhcmFrvoGC3nDX15Huw5tIpq
 sWkT3bL8Do630DHvhKfjSw==

<SEC-DOCUMENT>0000946644-09-000010.txt : 20090423
<SEC-HEADER>0000946644-09-000010.hdr.sgml : 20090423
<ACCEPTANCE-DATETIME>20090423140253
ACCESSION NUMBER:		0000946644-09-000010
CONFORMED SUBMISSION TYPE:	RW
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20090423
DATE AS OF CHANGE:		20090423

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HEMISPHERX BIOPHARMA INC
		CENTRAL INDEX KEY:			0000946644
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				520845822
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		RW
		SEC ACT:		
		SEC FILE NUMBER:	333-158518
		FILM NUMBER:		09766079

	BUSINESS ADDRESS:	
		STREET 1:		1617 JFK BLVD #660
		STREET 2:		ONE PENN CENTER
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19104
		BUSINESS PHONE:		2159880080

	MAIL ADDRESS:	
		STREET 1:		1617 JFK BLVD
		STREET 2:		ONE PENN CENTER
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19103
</SEC-HEADER>
<DOCUMENT>
<TYPE>RW
<SEQUENCE>1
<FILENAME>rwthdraw.txt
<TEXT>
                           HEMISPHERX BIOPHARMA, iNC.
                                One Penn Center
                               1617 JFK Boulevard
                             Philadelphia, PA 19103
                             Telephone 215-988-0080
                                Fax 215-988-0080

April 23,2009

Securtites and Exchange Commission
100 F Street, NE
Washington, D.C. 20549

                         Re: Hemispherx Biopharma, Inc.
                             Form S-1 4-9-2009
                             Sec filing No. 333-158518
                         ------------------------------
                                    FORM RW
                                   ---------
Dear Sir or Madam,

     We request that the above referenced Form S-1 be withdrawn.  We tagged this
filing as S-1 but it should have been tagged as POS AM. This withdrawal  request
is being made because we have to refile this document  under the correct tag POS
AM.

     If you have any questions or comments in regard to this withdrawal request,
please cantact me at the above address.


                                                       Very truly yours,

                                                       /s/ Charles T. Bernhardt
                                                       ------------------------
                                                       Charles T. Bernhardt,CFO
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----