UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 12b-25                  SEC FILE NUMBER
                                                                1-13441
                           NOTIFICATION OF LATE FILING          ---------------
                                                                 CUSIP NUMBER
                                                                42366C103
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(Check  One):|_|Form  10-K |_|Form 20-F |_|Form 11-K |X| Form 10-Q |_|Form N-SAR
|_|Form N-CSR

          For Period Ended:   June 30, 2004
                           -------------------
          (   ) Transition Report on Form 10-K
          (   ) Transition Report on Form 20-F
          (   ) Transition Report on Form 11-K
          (   ) Transition Report on Form 10-Q
          (   ) Transition Report on Form N-SAR
          For the Transition Period Ended:_____________________________________

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 Read Instructions (on back page) Before Preparing Form. Please Print or Type.

      NOTHING    IN THIS FORM SHALL BE  CONSTRUED  TO IMPLY THAT THE  COMMISSION
                 HAS VERIFIED ANY INFORMATION CONTAINED HEREIN.
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     If     the  notification  relates to a portion of the filing checked above,
            identify the Item(s) to which the notification relates:

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PART I -- REGISTRANT INFORMATION

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Full Name of Registrant

Hemispherx Biopharma, Inc.
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Former Name if Applicable


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Address of Principal Executive Offices (Street and Number)
1617 JFK Blvd. #660
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City, State and Zip Code

Philadelphia, PA 19103
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PART II - RULES 12b-25(b) AND (c)

If the subject report could not be filed without  unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed (Check box if appropriate)

       (a)  The reasons  described in reasonable detail in Part III of this form
            could not be eliminated without unreasonable effort or expense;
 |X|   (b)  The  subject  quarterly  report on Form 10-Q will be filed on or
            before the fifth calendar day following the prescribed due date; and
       (c)  The  accountant's  statement  or  other  exhibit  required  by  Rule
            12(b)-25(c) has been attached if applicable.

PART III -- NARRATIVE

State  below in  reasonable  detail the  reasons  why the Form 10-Q,  or portion
thereof,  could not be filed within the  prescribed  time period.  (Attach Extra
Sheets If Needed)

The registrant was unable to file its form 10-Q for the period ended
June 30, 2004 without unreasonable expense and effort due to its inability
to finish the form 10-Q within a sufficient time for management to review
the financial statements and complete the management discussion and analysis.
This quarterly report will be filed on or before the third calendar day
following the prescribed due date.

PART IV --OTHER INFORMATION

(1)  Name  and  telephone  number  of  person  to  contact  in  regard  to  this
     notification:


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        Name                                      Area Code    Telephone Number

(2)  Have all other periodic  reports  required under Section 13 or 15(d) of the
     Securities Exchange Act of 1934 or Section 30 of the Investment Company Act
     of 1940 during the preceding 12 months or for such shorter  period that the
     registrant  was required to file such reports been filed?  If answer is no,
     identify report(s). _ _
                                                   |x| Yes    |_| No

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(3)  Is it anticipated that any significant change in results of operations from
     the corresponding  period for the last fiscal year will be reflected by the
     earnings  statements  to be  included  in the  subject  report  or  portion
     thereof? _ _
                                                   |_| Yes    |X| No


     If so, attach an explanation of the anticipated  change,  both  narratively
     and quantitatively, and, if appropriate, state the reasons why a reasonable
     estimate of the results cannot be made.
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                  Hemispherx Biopharma, Inc.
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                  (Name of Registrant as Specified in Charter)

has caused this  notification  to be signed on their  behalf by the  undersigned
hereunto duly authorized.


Date     August 9, 2004                  By  /s/ William A. Carter
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                                         William A. Carter, CEO

Instruction: The form may be signed by an executive officer of the registrant or
by any other duly  authorized  representative.  The name and title of the person
signing  the form  shall  be typed or  printed  beneath  the  signature.  If the
statement is signed on behalf of the registrant by an authorized  representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with the form.

- -----------------------------------ATTENTION------------------------------------
    INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE FEDERAL CRIMINAL
                        VIOLATIONS (SEE 18 U.S.C. 1001).
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