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Note 14 - Stockholders' Equity (Tables)
 12 Months Ended
Dec. 31, 2019
Notes Tables  
Common Shares Reserved for Future Issuance, Warrants [Table Text Block]
   
December 31,
    
 
 
 
Expiration
(in thousands, except price per share data)
  
2019
    
2018
    
Exercise Price
  
Date
                           
Investors - December 2019 financing
    
1,458
      
-
     $
12.09
  
12/06/24
Investors - AEROSURF
    
988
      
988
     $
-
  
02/14/24
Investors - December 2018 financing - long-term
    
1,296
      
1,296
     $
12.15
  
12/04/23
Investors - December 2018 financing - short-term
    
668
      
668
     $
11.04
  
06/24/20
Battelle - 2018 payables restructuring agreement (1)
    
25
      
25
     $
19.50
  
12/07/23
Panacea Venture Management Company Ltd.
    
63
      
63
     $
12.00
  
07/02/23
LPH II Investments Limited
    
45
      
45
     $
16.56
  
04/04/25
Investors - February 2017 financing
    
117
      
117
     $
82.20
  
02/15/24
Investors - July 2015 financing
    
80
      
80
     $
588.00
  
07/22/22
Battelle - 2014 collaboration agreement
    
1
      
1
     $
4,200.00
  
10/10/24
Total
    
4,741
      
3,283