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Note 21 - Selected Quarterly Financial Data (Unaudited) (Tables)
 12 Months Ended
Dec. 31, 2018
Notes Tables  
Quarterly Financial Information [Table Text Block]
2018 Quarters Ended:
 
(in thousands, except per share data)
  
Mar. 31
    
June 30
    
Sept. 30
    
Dec. 31
    
Total Year
  
Revenues:
                                        
Grant revenue
   $
-
     $
695
     $
70
     $
-
     $
765
  
License revenue with affiliate
    
204
      
356
      
159
      
304
      
1,023
  
Total revenues
    
204
      
1,051
      
229
      
304
      
1,788
  
Expenses:
                                        
Research and development
    
3,118
      
2,879
      
2,197
      
2,368
      
10,562
  
Selling, general and administrative
    
1,926
      
1,208
      
1,500
      
2,787
      
7,421
  
Total expenses
    
5,044
      
4,087
      
3,697
      
5,155
      
17,983
  
Operating loss
    
(4,840
 )    
(3,036
 )    
(3,468
 )    
(4,851
 )    
(16,195
 )
Other income / (expense), net
    
328
      
(16
 )    
(459
 )    
(4,191
 )    
(4,338
 )
Net (loss) / income
   $
(4,512
 )   $
(3,052
 )   $
(3,927
 )   $
(9,042
 )   $
(20,533
 )
AEROSURF warrant dividend
    
-
      
-
      
-
      
(12,505
 )    
(12,505
 )
Deemed dividend on preferred stock
    
-
      
-
      
-
      
(1,718
 )    
(1,718
 )
Net (loss) / income attributable to common shareholders
   $
(4,512
 )   $
(3,052
 )   $
(3,927
 )   $
(23,265
 )   $
(34,756
 )
Net (loss) / income per common share - basic
   $
(1.40
 )   $
(0.81
 )   $
(1.04
 )   $
(3.24
 )   $
(7.74
 )
Net (loss) / income per common share - diluted
   $
(1.40
 )   $
(0.81
 )   $
(1.04
 )   $
(3.24
 )   $
(7.74
 )
Weighted average number of common shares outstanding - basic
    
3,227
      
3,751
      
3,769
      
7,191
      
4,493
  
Weighted average number of common shares outstanding - diluted
    
3,227
      
3,751
      
3,769
      
7,191
      
4,493
  
2017 Quarters Ended:
 
(in thousands, except per share data)
  
Mar. 31
    
June 30
    
Sept. 30
    
Dec. 31
    
Total Year
  
Revenues:
                                        
Grant revenue
   $
219
     $
1,147
     $
17
     $
-
     $
1,383
  
License revenue with affiliate
    
-
      
-
      
-
      
102
      
102
  
Total revenues
    
219
      
1,147
      
17
      
102
      
1,485
  
Expenses:
                                        
Research and development
    
6,413
      
5,483
      
3,062
      
2,418
      
17,376
  
Selling, general and administrative
    
1,922
      
1,804
      
1,749
      
1,182
      
6,657
  
Total expenses
    
8,335
      
7,287
      
4,811
      
3,600
      
24,033
  
Operating loss
    
(8,116
 )    
(6,140
 )    
(4,794
 )    
(3,498
 )    
(22,548
 )
Other income / (expense), net
    
(608
 )    
(612
 )    
(649
 )    
5,971
      
4,102
  
Net (loss) / income
   $
(8,724
 )   $
(6,752
 )   $
(5,443
 )   $
2,473
     $
(18,446
 )
Deemed dividend on preferred stock
    
(3,604
 )    
(532
 )    
(2,234
 )    
-
      
(6,370
 )
Net (loss) / income attributable to common shareholders
   $
(12,328
 )   $
(7,284
 )   $
(7,677
 )   $
2,473
     $
(24,816
 )
Net (loss) / income per common share - basic
   $
(27.40
 )   $
(14.37
 )   $
(10.53
 )   $
1.03
     $
(24.14
 )
Net (loss) / income per common share - diluted
   $
(27.40
 )   $
(14.37
 )   $
(10.53
 )   $
0.97
     $
(24.14
 )
Weighted average number of common shares outstanding - basic
    
450
      
507
      
729
      
2,405
      
1,028
  
Weighted average number of common shares outstanding - diluted
    
450
      
507
      
729
      
2,540
      
1,028