Exhibit 32.1

CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350

AS ADOPTED PURSUANT TO SECTION 906 OF THE

SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of Discovery Laboratories, Inc. (the “Company”), for the period ended September 30, 2004, as filed with the Securities and Exchange Commission (the “Commission”) on the date hereof (the “Report”), each of the undersigned, in his capacity as an officer of the Company, certifies, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

1.   the Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

2.   the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

A signed original of this written statement required by Section 906 of the Sarbanes-Oxley Act of 2002 has been provided to the Company and will be retained by the Company and furnished to the Commission or its staff upon request.

Date: November 9, 2004

Name: /s/ Robert J. Capetola

Name: Robert J. Capetola, Ph.D.

Title: President, and Chief Executive Officer

Name: /s/ John G. Cooper

Name: John G. Cooper

Title: Executive VicePresident, and Chief Financial Officer