Note 5 - Composition of Certain Financial Statement Captions - Schedule of Goodwill (Details) $ in Thousands	3 Months Ended
Mar. 31, 2024 USD ($)
Goodwill, gross	$ 636,283
Goodwill, impairment	(38,023)
Goodwill, acquired (disposed of)	(65,294)
Goodwill, foreign exchange effect	(2,351)
Goodwill	530,615
Pharmaceutical [Member] \| CURNA [Member]
Goodwill, gross	4,827
Goodwill, impairment	(4,827)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	0
Pharmaceutical [Member] \| Rayaldee [Member]
Goodwill, gross	84,273
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	(1,816)
Goodwill	82,457
Pharmaceutical [Member] \| FineTech [Member]
Goodwill, gross	11,698
Goodwill, impairment	(11,698)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	0
Pharmaceutical [Member] \| ModeX Therapeutics, Inc [Member]
Goodwill, gross	80,260
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	80,260
Pharmaceutical [Member] \| OPKO Biologics [Member]
Goodwill, gross	139,784
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	(0)
Goodwill	139,784
Pharmaceutical [Member] \| OPKO Chile [Member]
Goodwill, gross	3,642
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	(374)
Goodwill	3,268
Pharmaceutical [Member] \| OPKO Health Europe [Member]
Goodwill, gross	7,276
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	(161)
Goodwill	7,115
Pharmaceutical [Member] \| OPKO Mexico [Member]
Goodwill, gross	100
Goodwill, impairment	(100)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	0
Pharmaceutical [Member] \| Transition Therapeutics [Member]
Goodwill, gross	3,421
Goodwill, impairment	(3,421)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	0
Diagnostics [Member] \| BioReference [Member]
Goodwill, gross	283,025
Goodwill, impairment	0
Goodwill, acquired (disposed of)	(65,294)
Goodwill, foreign exchange effect	0
Goodwill	217,731
Diagnostics [Member] \| OPKO Diagnostics [Member]
Goodwill, gross	17,977
Goodwill, impairment	(17,977)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	$ 0

Represents the amount of goodwill acquired (disposed of) during the period.

No definition available.

Name:	opk_GoodwillAcquiredDisposedOfDuringPeriod
Namespace Prefix:	opk_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Amount, after accumulated impairment loss, of asset representing future economic benefit arising from other asset acquired in business combination or from joint venture formation or both, that is not individually identified and separately recognized.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 55
-Paragraph 49
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482785/280-10-55-49

Reference 2: http://www.xbrl.org/2003/role/exampleRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 55
-Paragraph 24
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482548/350-20-55-24

Reference 3: http://www.xbrl.org/2003/role/exampleRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 55
-Paragraph 100
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482078/820-10-55-100

Reference 4: http://www.xbrl.org/2003/role/exampleRef
-Topic 852
-SubTopic 10
-Name Accounting Standards Codification
-Section 55
-Paragraph 10
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481372/852-10-55-10

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 210
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(15))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 45
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482598/350-20-45-1

Reference 7: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482573/350-20-50-1

Reference 8: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482573/350-20-50-1

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 942
-SubTopic 210
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-03(10)(1))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478546/942-210-S99-1

+ Details

Name:	us-gaap_Goodwill
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant

- Definition

Amount of foreign currency translation gain (loss) which increases (decreases) asset representing future economic benefit from other asset acquired in business combination or from joint venture formation or both, that is not individually identified and separately recognized.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (f)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482573/350-20-50-1

+ Details

Name:	us-gaap_GoodwillForeignCurrencyTranslationGainLoss
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

- Definition

Amount, before accumulated impairment loss, of asset representing future economic benefit arising from other asset acquired in business combination or from joint venture formation or both, that is not individually identified and separately recognized.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 55
-Paragraph 24
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482548/350-20-55-24

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482573/350-20-50-1

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 350
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482573/350-20-50-1

+ Details

Name:	us-gaap_GoodwillGross
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant

- Definition

Amount of accumulated impairment loss for asset representing future economic benefit arising from other asset acquired in business combination or from joint venture formation or both, that is not individually identified and separately recognized.

+ References

+ Details

Name:	us-gaap_GoodwillImpairedAccumulatedImpairmentLoss
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Details

Name:	us-gaap_StatementBusinessSegmentsAxis=opk_PharmaceuticalMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_CurnaMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_RayaldeeMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_FinetechMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_ModexTherapeuticsIncMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_OpkoBiologicsMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_OpkoChileMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_OpkoHealthEuropeMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_OpkoMexicoMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_TransitionTherapeuticsMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_StatementBusinessSegmentsAxis=opk_DiagnosticsMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_BioreferenceMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_SubsegmentsAxis=opk_OpkoDiagnosticsMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type: