Note 6 - Composition of Certain Financial Statement Captions - Schedule of Goodwill (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Goodwill, gross		$ 633,874	$ 710,408
Goodwill, impairment		(38,023)	(38,023)
Goodwill, acquired (disposed of)	$ (172)	(71,352)
Goodwill, foreign exchange effect	2,579	(5,182)
Goodwill	598,260	595,851
Pharmaceutical [Member] | CURNA [Member]
Goodwill, gross		4,827	4,827
Goodwill, impairment		(4,827)	(4,827)
Goodwill, acquired (disposed of)	0	0
Goodwill, foreign exchange effect	0	0
Goodwill	0	0
Pharmaceutical [Member] | Rayaldee [Member]
Goodwill, gross		81,786	86,554
Goodwill, impairment		0	0
Goodwill, acquired (disposed of)	0	0
Goodwill, foreign exchange effect	2,485	(4,768)
Goodwill	84,273	81,786
Pharmaceutical [Member] | FineTech [Member]
Goodwill, gross		11,698	11,698
Goodwill, impairment		(11,698)	(11,698)
Goodwill, acquired (disposed of)	0	0
Goodwill, foreign exchange effect	0	0
Goodwill	0	0
Pharmaceutical [Member] | ModeX Therapeutics, Inc [Member]
Goodwill, gross		80,432	0
Goodwill, impairment		0	0
Goodwill, acquired (disposed of)	(172)	80,432
Goodwill, foreign exchange effect	0	0
Goodwill	80,260	80,432
Pharmaceutical [Member] | OPKO Biologics [Member]
Goodwill, gross		139,784	139,784
Goodwill, impairment		0	0
Goodwill, acquired (disposed of)	0	0
Goodwill, foreign exchange effect	0	0
Goodwill	139,784	139,784
Pharmaceutical [Member] | OPKO Chile [Member]
Goodwill, gross		3,767	3,760
Goodwill, impairment		0	0
Goodwill, acquired (disposed of)	0	0
Goodwill, foreign exchange effect	(125)	7
Goodwill	3,642	3,767
Pharmaceutical [Member] | OPKO Health Europe [Member]
Goodwill, gross		7,057	7,478
Goodwill, impairment		0	0
Goodwill, acquired (disposed of)	0	0
Goodwill, foreign exchange effect	219	(421)
Goodwill	7,276	7,057
Pharmaceutical [Member] | OPKO Mexico [Member]
Goodwill, gross		100	100
Goodwill, impairment		(100)	(100)
Goodwill, acquired (disposed of)	0	0
Goodwill, foreign exchange effect	0	0
Goodwill	0	0
Pharmaceutical [Member] | Transition Therapeutics [Member]
Goodwill, gross		3,421	3,421
Goodwill, impairment		(3,421)	(3,421)
Goodwill, acquired (disposed of)	0	0
Goodwill, foreign exchange effect	0	0
Goodwill	0	0
Diagnostics [Member] | BioReference [Member]
Goodwill, gross		283,025	434,809
Goodwill, impairment		0	0
Goodwill, acquired (disposed of)	0	(151,784)
Goodwill, foreign exchange effect	0	0
Goodwill	283,025	283,025
Diagnostics [Member] | OPKO Diagnostics [Member]
Goodwill, gross		17,977	17,977
Goodwill, impairment		(17,977)	$ (17,977)
Goodwill, acquired (disposed of)	0	0
Goodwill, foreign exchange effect	0	0
Goodwill	$ 0	$ 0