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Summary of Significant Accounting Policies (Details)
3 Months Ended 9 Months Ended
Sep. 30, 2022
USD ($)
Dec. 31, 2021
USD ($)
Sep. 30, 2022
USD ($)
Mar. 31, 2022
USD ($)
Sep. 30, 2021
USD ($)
Sep. 30, 2022
USD ($)
segment
Sep. 30, 2021
USD ($)
Jun. 30, 2022
USD ($)
Jan. 01, 2022
USD ($)
Jun. 30, 2021
USD ($)
Dec. 31, 2020
USD ($)
Summary of Significant Accounting Policies [Line Items]                      
Provision for inventory obsolescence     $ 3,000,000   $ 1,300,000 $ 4,000,000 $ 5,300,000        
Goodwill, in-process research and development and other intangible assets acquired $ 1,600,000,000 $ 1,400,000,000 1,600,000,000     1,600,000,000          
Goodwill 573,499,000 520,601,000 573,499,000     573,499,000     $ 710,408,000    
Net intangible assets other than goodwill 1,000,000,000 900,000,000 1,000,000,000     1,000,000,000          
Intangible assets, net 835,136,000 321,683,000 835,136,000     835,136,000          
In-process research and development 195,000,000 590,200,000 195,000,000     195,000,000          
Amortization expense     21,407,000   12,609,000 66,225,000 37,760,000        
Depreciation expense     5,000,000   6,400,000 16,000,000 21,800,000        
Allowance for credit losses 6,388,000 1,839,000 6,388,000     6,388,000          
Provision related to current period sales     57,900   29,300 241,500 636,100        
Equity-based compensation expense     3,400,000   3,800,000 $ 15,300,000 9,900,000        
Number of reportable segments | segment           2          
Foreign currency transaction losses     5,800,000   1,100,000 $ 7,600,000 5,600,000        
Equity 1,629,068,000 1,685,126,000 1,629,068,000   1,765,567,000 1,629,068,000 1,765,567,000 $ 1,718,799,000   $ 1,742,585,000 $ 1,671,551,000
Retained Earnings                      
Summary of Significant Accounting Policies [Line Items]                      
Equity (1,737,692,000) (1,511,976,000) (1,737,692,000)   (1,438,202,000) (1,737,692,000) (1,438,202,000) (1,651,601,000)   (1,466,941,000) (1,481,833,000)
Additional Paid-in Capital                      
Summary of Significant Accounting Policies [Line Items]                      
Equity $ 3,418,763,000 3,222,487,000 3,418,763,000   $ 3,218,583,000 $ 3,418,763,000 $ 3,218,583,000 $ 3,413,556,000   $ 3,214,351,000 $ 3,152,694,000
Cumulative Effect, Period of Adoption, Adjustment                      
Summary of Significant Accounting Policies [Line Items]                      
Equity   (21,642,000)             21,600,000    
Cumulative Effect, Period of Adoption, Adjustment | Retained Earnings                      
Summary of Significant Accounting Policies [Line Items]                      
Equity   17,458,000             17,500,000    
Cumulative Effect, Period of Adoption, Adjustment | Additional Paid-in Capital                      
Summary of Significant Accounting Policies [Line Items]                      
Equity   (39,100,000)             $ (39,100,000)    
In Process Research and Development                      
Summary of Significant Accounting Policies [Line Items]                      
Intangible assets, net       $ 590,200,000              
Intangible assets, estimated useful lives       12 years              
Detect Genomix                      
Summary of Significant Accounting Policies [Line Items]                      
Goodwill   $ 151,800,000                  
OPKO Biologics                      
Summary of Significant Accounting Policies [Line Items]                      
In-process research and development       $ 590,200,000              
Minimum                      
Summary of Significant Accounting Policies [Line Items]                      
Intangible assets, estimated useful lives           3 years          
Maximum                      
Summary of Significant Accounting Policies [Line Items]                      
Intangible assets, estimated useful lives           20 years          
Credit Concentration Risk | Accounts Receivable | Federal and State Governments                      
Summary of Significant Accounting Policies [Line Items]                      
Concentration percentage 14.00% 6.00%                  
Geographic Concentration Risk | Accounts Receivable | States, Cities and Other Municipalities                      
Summary of Significant Accounting Policies [Line Items]                      
Concentration percentage 2.70% 4.10%                  
Customer Concentration Risk | Accounts Receivable | Individual Patients                      
Summary of Significant Accounting Policies [Line Items]                      
Concentration percentage 2.80% 0.70%                  
Software                      
Summary of Significant Accounting Policies [Line Items]                      
Property, plant and equipment, estimated useful lives           3 years          
Machinery, Medical and Other Equipment | Minimum                      
Summary of Significant Accounting Policies [Line Items]                      
Property, plant and equipment, estimated useful lives           5 years          
Machinery, Medical and Other Equipment | Maximum                      
Summary of Significant Accounting Policies [Line Items]                      
Property, plant and equipment, estimated useful lives           8 years          
Furniture and Fixtures | Minimum                      
Summary of Significant Accounting Policies [Line Items]                      
Property, plant and equipment, estimated useful lives           5 years          
Furniture and Fixtures | Maximum                      
Summary of Significant Accounting Policies [Line Items]                      
Property, plant and equipment, estimated useful lives           12 years          
Buildings and Improvements | Minimum                      
Summary of Significant Accounting Policies [Line Items]                      
Property, plant and equipment, estimated useful lives           10 years          
Buildings and Improvements | Maximum                      
Summary of Significant Accounting Policies [Line Items]                      
Property, plant and equipment, estimated useful lives           40 years          
Automobiles and Aircraft | Minimum                      
Summary of Significant Accounting Policies [Line Items]                      
Property, plant and equipment, estimated useful lives           3 years          
Automobiles and Aircraft | Maximum                      
Summary of Significant Accounting Policies [Line Items]                      
Property, plant and equipment, estimated useful lives           5 years          
In Process Research and Development                      
Summary of Significant Accounting Policies [Line Items]                      
Net intangible assets other than goodwill $ 195,000,000 $ 590,200,000 $ 195,000,000     $ 195,000,000