Acquisitions, Investments and Licenses - Available for Sale Investments, Sale of Investments and Warrants and Options Narrative (Details) shares in Thousands	Jun. 30, 2018 shares
Rxi Pharmaceuticals Corporation
Investment [Line Items]
Ownership percentage	1.00%
ChromaDex
Investment [Line Items]
Ownership percentage	0.00%
MabVax
Investment [Line Items]
Ownership percentage	2.00%
Eloxx Pharmaceuticals
Investment [Line Items]
Ownership percentage	4.00%
Xenetic Biosciences, Inc.
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	500
Neovasc
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	2,900
BioCardia, Inc.
Investment [Line Items]
Ownership percentage	5.00%
Number of shares into which warrants may be converted (in shares)	400
Investment options, vested (in shares)	100
Cocrystal
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	33
InCellDx, Inc
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	700
Rxi
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	22

Line items represent reporting concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Article 12
-Section 12
-Sentence Column A

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+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i)(2))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

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