Summary of Significant Accounting Policies (Details) $ in Thousands	1 Months Ended	3 Months Ended		12 Months Ended
	Jan. 31, 2015 USD ($)	Mar. 31, 2018 USD ($) Segment	Mar. 31, 2017 USD ($)	Dec. 31, 2017 USD ($)	Jan. 01, 2018 USD ($)
Summary of Significant Accounting Policies [Line Items]
Provision for inventory obsolescence			$ 4,600
Goodwill, in-process research and development and other intangible assets acquired		$ 2,000,000		$ 2,000,000
Amortization expense		17,271	17,929
Depreciation expense		$ 7,500	7,800
Corporate income tax rate		21.00%
Allowance for doubtful accounts receivable		$ 1,527		1,446
Provision related to current period sales		100	900
Equity-based compensation expense		$ 5,900	9,700
Number of reportable segments | Segment		2
Reduction in revenue		$ (254,914)	(266,382)
Reduction in revenue from transfer of intellectual property and other		(15,748)	(15,606)	(15,606)
Accumulated deficit		$ 1,075,197		$ 1,036,959
Minimum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives		3 years
Maximum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives		20 years
Government Contracts Concentration Risk | Accounts Receivable
Summary of Significant Accounting Policies [Line Items]
Concentration percentage		15.10%		15.80%
Software
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives		3 years
Machinery, Medical and Other Equipment | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives		5 years
Machinery, Medical and Other Equipment | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives		8 years
Furniture and Fixtures | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives		5 years
Furniture and Fixtures | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives		12 years
Buildings and Improvements | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives		10 years
Buildings and Improvements | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives		40 years
Automobiles and Aircraft | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives		3 years
Automobiles and Aircraft | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives		5 years
Collaborative Arrangement, Product | Pfizer
Summary of Significant Accounting Policies [Line Items]
Non-refundable and non-creditable upfront payment	$ 295,000
Reduction in revenue from transfer of intellectual property and other		$ (14,700)	$ (14,100)
Self-Pay | Accounts Receivable
Summary of Significant Accounting Policies [Line Items]
Concentration percentage		2.70%		3.20%
Accumulated Deficit | Accounting Standards Update 2016-01
Summary of Significant Accounting Policies [Line Items]
Cumulative effect of new accounting update					$ 4,900
Difference between Revenue Guidance in Effect before and after Topic 606 | Accounting Standards Update 2014-09
Summary of Significant Accounting Policies [Line Items]
Reduction in revenue from transfer of intellectual property and other		$ 3,500
Effect of change | Accounting Standards Update 2014-09
Summary of Significant Accounting Policies [Line Items]
Reduction in revenue				$ 29,800
Reduction in revenue from transfer of intellectual property and other				2,973
Accumulated deficit				$ 29,800