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Cost Method Investment, Ownership Percentage

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Cost Method Investment, Shares Purchased in Period

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Equity Method Investment, Shares Purchased In Period

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Notes Conversion, Converted Receivable, Shares

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Operating Leases, Monthly Payments, Year One

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Operating Leases, Monthly Payments, Year Three

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Related Party Transaction, Future Contributions

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Subsidiary Or Equity Method Investee, Conversion Of Stock, Shares Converted

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Subsidiary Or Equity Method Investee, Conversion Of Stock, Shares Issued

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Area of a real estate property.

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- Definition

Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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Original amount of cost-method investments at the acquisition date.

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- Definition

Face (par) amount of debt instrument at time of issuance.

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The percentage of ownership of common stock or equity participation in the investee accounted for under the equity method of accounting.

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Balance held at close of period in number of shares.

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The cash outflow to acquire debt and equity securities not classified as either held-to-maturity securities or trading securities which would be classified as available-for-sale securities and reported at fair value, with unrealized gains and losses excluded from earnings and reported in a separate component of shareholders' equity.

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The cash outflow associated with the purchase of or advances to an equity method investments, which are investments in joint ventures and entities in which the entity has an equity ownership interest normally of 20 to 50 percent and exercises significant influence.

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Expenses recognized resulting from transactions (excluding transactions that are eliminated in consolidated or combined financial statements) with related party.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Percentage of the Variable Interest Entity's (VIE) voting interest owned by (or beneficial interest in) the reporting entity (directly or indirectly).

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Related Party Transactions (Details)	1 Months Ended									3 Months Ended		9 Months Ended
Related Party Transactions (Details)	Sep. 30, 2017 USD ($) shares	Aug. 31, 2017 shares	Jul. 31, 2017 USD ($) shares	Jun. 30, 2017 shares	May 31, 2017 USD ($) shares	Apr. 30, 2017 USD ($) shares	Dec. 31, 2016 USD ($) shares	Aug. 31, 2016 USD ($) shares	Jan. 31, 2016 USD ($) shares	Sep. 30, 2017 USD ($) shares	Sep. 30, 2016 USD ($)	Sep. 30, 2017 USD ($) shares	Sep. 30, 2016 USD ($)	Feb. 28, 2017 USD ($)	Jan. 01, 2017 USD ($) ft²	Nov. 30, 2016 USD ($)	Oct. 31, 2016 shares
Zebra
Related Party Transaction [Line Items]
Stock ownership percentage												29.00%
Equity method investment, ownership percentage	29.00%									29.00%		29.00%
Sevion
Related Party Transaction [Line Items]
Equity method investment, ownership percentage	31.00%									31.00%		31.00%
Additional investment in equity method investment \| $			$ 1,500,000
Equity method investment, additional investment in period (in shares)			10,000,000
Number of shares into which warrants may be converted (in shares)	300,000									300,000		300,000
Neovasc
Related Party Transaction [Line Items]
Equity method investment, ownership percentage	4.00%									4.00%		4.00%
Number of shares into which warrants may be converted (in shares)	1,000,000									1,000,000		1,000,000
ChromaDex Corporation
Related Party Transaction [Line Items]
Available-for-sale investment, ownership percentage	1.00%									1.00%		1.00%
MabVax
Related Party Transaction [Line Items]
Available-for-sale investment, ownership percentage	4.00%									4.00%		4.00%
Available-for-sale investment, additional investment in period \| $			$ 100,000		$ 500,000			$ 1,000,000
Number of shares into which warrants may be converted (in shares)	200,000									200,000		200,000
COCP
Related Party Transaction [Line Items]
Equity method investment, ownership percentage	9.00%									9.00%		9.00%
Additional investment in equity method investment \| $						$ 1,000,000		2,000,000
Number of shares into which warrants may be converted (in shares)	1,000,000									1,000,000		1,000,000
Eloxx Pharmaceuticals
Related Party Transaction [Line Items]
Ownership percentage, cost method												3.00%
Cost method investment \| $	$ 1,500,000									$ 1,500,000		$ 1,500,000
ARNO
Related Party Transaction [Line Items]
Available-for-sale investment, ownership percentage	5.00%									5.00%		5.00%
Available-for-sale investment, additional investment in period \| $								$ 300,000	$ 300,000
InCellDx, Inc
Related Party Transaction [Line Items]
Equity method investment, ownership percentage	28.00%									28.00%		28.00%
Number of shares into which warrants may be converted (in shares)	700,000									700,000		700,000
BioCardia, Inc.
Related Party Transaction [Line Items]
Equity method investment, ownership percentage	5.00%									5.00%		5.00%
Available-for-sale investment, ownership percentage	5.00%									5.00%		5.00%
Number of shares into which warrants may be converted (in shares)	5,000,000									5,000,000		5,000,000
NIMS
Related Party Transaction [Line Items]
Available-for-sale investment, ownership percentage	1.00%									1.00%		1.00%
Frost Real Estate Holdings LLC
Related Party Transaction [Line Items]
Area of real estate property (in square feet) \| ft²															29,500
Lease payments per month in first year \| $															$ 81,000
Lease payments per month in third year \| $															$ 86,000
Dr Frost
Related Party Transaction [Line Items]
Available-for-sale investment, additional investment in period \| $							$ 2,500,000
Sevion
Related Party Transaction [Line Items]
Debt face amount \| $														$ 300,000.0		$ 200,000.0
Shares received in conversion of notes receivable (in shares)		4,100,000
Reimbursement Of Travel Expense \| Dr Frost
Related Party Transaction [Line Items]
Reimbursement paid to related party for travel \| $										$ 168,000	$ 154,000	$ 309,000	$ 274,000
Common Stock \| MabVax
Related Party Transaction [Line Items]
Available-for-sale investment, additional investment in period (in shares)								207,900
Number of shares into which warrants may be converted (in shares)								415,800
Common Stock \| COCP
Related Party Transaction [Line Items]
Equity method investment, additional investment in period (in shares)						4,166,667		4,878,050
Common Stock \| ARNO
Related Party Transaction [Line Items]
Available-for-sale investment, additional investment in period (in shares)								714,285	714,285
Number of shares into which warrants may be converted (in shares)								357,142
Common Stock \| BioCardia, Inc.
Related Party Transaction [Line Items]
Investment owned (in shares)																	5,027,726
Common Stock \| Dr Frost
Related Party Transaction [Line Items]
Investment owned (in shares)							19,230,769
Common Stock \| Sevion
Related Party Transaction [Line Items]
Shares received upon conversion (in shares)	1,250,006
Series G Preferred Stock \| MabVax
Related Party Transaction [Line Items]
Available-for-sale investment, additional investment in period (in shares)			152,143		285,714
Series I Preferred Stock \| MabVax
Related Party Transaction [Line Items]
Available-for-sale investment, additional investment in period (in shares)					322,820
Preferred C Stock \| Eloxx Pharmaceuticals
Related Party Transaction [Line Items]
Cost method investment, shares purchased during period (in shares)				99,915
Preferred C Stock \| Sevion
Related Party Transaction [Line Items]
Shares converted (in shares)	66,667
Museum of Science, Inc \| Dr Frost and Mr Pfenniger
Related Party Transaction [Line Items]
Related party future contribution \| $																$ 1,000,000