Acquisitions, Investments and Licenses - Bio-Reference Purchase Price Allocation (Details) - USD ($) $ in Thousands	1 Months Ended
	Aug. 31, 2015	Sep. 30, 2016	Dec. 31, 2015
Intangible assets:
Goodwill		$ 700,526	$ 743,348
Bio-Reference
Purchase price:
Value of OPKO Common Stock issued to Bio-Reference shareholders	$ 947,889
Value of replacement stock options awards to holders of Bio-Reference stock options	2,259
Total purchase price	950,148
Current assets
Cash and cash equivalents	15,800
Accounts receivable	168,164
Inventory	19,674
Other current assets, principally deferred tax assets	100,052
Total current assets	303,690
Property, plant and equipment	112,457
Intangible assets:
Intangible assets	545,250
Goodwill	391,991	$ 392,000
Investments	5,326
Other assets	13,265
Total assets	1,371,979
Accounts payable and accrued expenses	(108,217)
Income taxes payable	(1,014)
Lines of credit and notes payable	(65,701)
Capital lease obligations	(18,293)
Deferred tax liability (non-current)	(228,606)
Total purchase price	950,148
Trade names | Bio-Reference
Intangible assets:
Intangible assets	47,100
Customer relationships | Bio-Reference
Intangible assets:
Intangible assets	389,800
Technology | Bio-Reference
Intangible assets:
Intangible assets	100,600
Other intangible assets | Bio-Reference
Intangible assets:
Intangible assets	$ 7,750