Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 174,973	$ 193,598
Accounts receivable, net	204,479	193,875
Inventory	40,575	39,681
Prepaid expenses and other current assets	33,505	26,904
Total current assets	453,532	454,058
Property, plant and equipment, net	133,948	131,798
Intangible assets, net	625,405	638,152
In-process research and development	793,626	792,275
Goodwill	746,961	743,348
Investments, net	35,212	34,716
Other assets	4,522	4,841
Total assets	2,793,206	2,799,188
Current liabilities:
Accounts payable	73,436	72,535
Accrued expenses	182,342	167,899
Current portion of lines of credit and notes payable	11,454	11,468
Total current liabilities	267,232	251,902
2033 Senior Notes and estimated fair value of embedded derivatives, net of discount	49,608	48,986
Deferred tax liabilities, net	202,680
Deferred tax liabilities, net		226,036
Other long-term liabilities, principally deferred revenue and line of credit	275,812	292,470
Total long-term liabilities	528,100	567,492
Total liabilities	795,332	819,394
Equity:
Common Stock - $0.01 par value, 750,000,000 shares authorized; 547,980,417 and 546,188,516 shares issued at March 31, 2016 and December 31, 2015, respectively	5,480	5,462
Treasury Stock - 586,760 and 1,120,367 shares at March 31, 2016 and December 31, 2015, respectively	(1,911)	(3,645)
Additional paid-in capital	2,728,264	2,705,385
Accumulated other comprehensive loss	(17,110)	(22,537)
Accumulated deficit	(716,849)	(704,871)
Total shareholders’ equity	1,997,874	1,979,794
Total liabilities and equity	$ 2,793,206	$ 2,799,188