Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues:
Revenue from services	$ 329,739	$ 8,666	$ 11,658
Revenue from products	80,146	76,983	68,161
Revenue from transfer of intellectual property and other	81,853	5,476	16,711
Total revenues	491,738	91,125	96,530
Costs and expenses:
Costs of service revenue	193,305	9,372	10,419
Cost of product revenue	41,934	38,637	38,441
Selling, general and administrative	196,576	57,940	55,320
Research and development	99,488	83,571	53,902
In-process research and development	0	12,055	0
Contingent consideration	5,050	24,446	6,947
Amortization of intangible assets	27,977	10,919	11,133
Grant repayment	25,889	0	0
Total costs and expenses	590,219	236,940	176,162
Operating loss	(98,481)	(145,815)	(79,632)
Other income and (expense), net:
Interest income	255	771	376
Interest expense	(8,419)	(12,263)	(13,802)
Fair value changes of derivative instruments, net	(39,083)	(10,632)	(45,942)
Other income (expense), net	7,730	(3,088)	34,782
Other income and (expense), net	(39,517)	(25,212)	(24,586)
Loss before income taxes and investment losses	(137,998)	(171,027)	(104,218)
Income tax benefit (provision)	113,675	(24)	(1,672)
Loss before investment losses	(24,323)	(171,051)	(105,890)
Loss from investments in investees	(7,105)	(3,587)	(11,456)
Net loss	(31,428)	(174,638)	(117,346)
Less: Net loss attributable to noncontrolling interests	(1,400)	(2,972)	(2,939)
Net loss attributable to common shareholders before preferred stock dividend	(30,028)	(171,666)	(114,407)
Preferred stock dividend	0	0	(420)
Net loss attributable to common shareholders	$ (30,028)	$ (171,666)	$ (114,827)
Net loss per share (usd per share)	$ (0.06)	$ (0.41)	$ (0.32)
Weighted average number of common shares outstanding, basic and diluted	488,065,908	422,014,039	355,095,701