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Operating Leases, Monthly Payments, Year Five

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Ownership percentage held by members.

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Payments for Filing Fees

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Private Placement Financing

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Tenant Improvements, Offset Against Operating Lease in Next Twelve Months

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Area of a real estate property.

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Exercise price per share or per unit of warrants or rights outstanding.

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-Publisher FASB

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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Face (par) amount of debt instrument at time of issuance.

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The percentage of ownership of common stock or equity participation in the investee accounted for under the equity method of accounting.

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Balance held at close of period in number of shares.

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The cash outflow to acquire debt and equity securities not classified as either held-to-maturity securities or trading securities which would be classified as available-for-sale securities and reported at fair value, with unrealized gains and losses excluded from earnings and reported in a separate component of shareholders' equity.

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The cash outflow associated with the purchase of or advances to an equity method investments, which are investments in joint ventures and entities in which the entity has an equity ownership interest normally of 20 to 50 percent and exercises significant influence.

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Expenses recognized resulting from transactions (excluding transactions that are eliminated in consolidated or combined financial statements) with related party.

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Amount of revenue, fees and commissions earned from transactions between (a) a parent company and its subsidiaries; (b) subsidiaries of a common parent; (c) an entity and trusts for the benefit of employees, for example, but not limited to, pension and profit-sharing trusts that are managed by or under the trusteeship of the entity's management; (d) an entity and its principal, owners, management, or members of their immediate families; and (e) affiliates.

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In accordance with the provisions of their lease agreement, this element represents allowable charges due a landlord from its tenant. In retail store and office building leases, for example, tenant reimbursements may cover items such as taxes, utilities, and common area expenses.

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Related Party Transactions - Textual (Details) (USD $)	12 Months Ended	3 Months Ended		12 Months Ended	1 Months Ended	0 Months Ended	12 Months Ended
Related Party Transactions - Textual (Details) (USD $)	Dec. 31, 2012	Mar. 31, 2015	Mar. 31, 2014	Dec. 31, 2014	Feb. 28, 2014	Jan. 16, 2014	Dec. 31, 2015	Jan. 31, 2013	Aug. 31, 2013	Jul. 28, 2014 sqft
Notes \| Notes Due February 1, 2033
Related Party Transaction [Line Items]
Debt face amount								$ 175,000,000.0
ARNO
Related Party Transaction [Line Items]
Warrants to purchase common shares				800,000
Ownership percentage		4.00%
Zebra
Related Party Transaction [Line Items]
Ownership percentage		27.00%
Sevion
Related Party Transaction [Line Items]
Warrants to purchase common shares				100,000
Ownership percentage		4.00%
Chromadex Corporation
Related Party Transaction [Line Items]
Ownership percentage		2.00%
Biozone Pharmaceuticals Inc
Related Party Transaction [Line Items]
Invested in common shares	1,700,000
Cocrystal
Related Party Transaction [Line Items]
Warrants to purchase common shares				1,000,000
Ownership percentage		8.00%
Neovasc
Related Party Transaction [Line Items]
Warrants to purchase common shares				1,000,000
Ownership percentage		5.00%
Dr Frost \| OPKO Biologics
Related Party Transaction [Line Items]
Beneficially owned held by members									5.00%
Dr. Hsiao and Mr. Rubin \| OPKO Biologics
Related Party Transaction [Line Items]
Beneficially owned held by members									5.00%
Frost Gamma Investments Trust and Hsu Gamma Investment, L.P. \| Notes \| Notes Due February 1, 2033
Related Party Transaction [Line Items]
Debt face amount								175,000,000
Teva \| FineTech
Related Party Transaction [Line Items]
Sale of API to TEVA		0	100,000
Frost Real Estate Holdings LLC
Related Party Transaction [Line Items]
Area of real estate property (in square feet)										22,000
Operating Leases, Monthly Payments, Year One										57,000
Operating Leases, Monthly Payments, Year Five										65,000
Tenant Improvements, Offset Against Operating Lease in Next Twelve Months										216,000
Real Estate Holdings LLC
Related Party Transaction [Line Items]
Credit for tenant improvements				113,000
FTC Filings \| Dr Frost
Related Party Transaction [Line Items]
Payments for Filing Fees					280,000
Equity Method Investee \| Biozone
Related Party Transaction [Line Items]
Invested in common shares						500,000
Private Placement Financing						2,750,000
Investment Owned, Balance, Shares						1,000,000
Warrants to purchase common shares						1,000,000
Warrants exercisable price (in USD per share)						$ 0.50
Warrants duration						10 years
Reimbursement Of Travel Expense \| Dr Frost
Related Party Transaction [Line Items]
Reimbursement paid to related party for travel		126,000	17,000
Scenario, Forecast [Member] \| Real Estate Holdings LLC
Related Party Transaction [Line Items]
Credit for tenant improvements							$ 103,000