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Fair Value Measurements - Level 3 Reconciliation (Details) (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2015
Contingent consideration  
Total losses (gains) for the period:  
Beginning Balance $ 71,567us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue
/ us-gaap_FairValueByLiabilityClassAxis
= opk_ContingentConsiderationMember
Included in results of operations 5,175us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings
/ us-gaap_FairValueByLiabilityClassAxis
= opk_ContingentConsiderationMember
Foreign currency impact (231)opk_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisForeignCurrencyImpact
/ us-gaap_FairValueByLiabilityClassAxis
= opk_ContingentConsiderationMember
Ending Balance 76,511us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue
/ us-gaap_FairValueByLiabilityClassAxis
= opk_ContingentConsiderationMember
Embedded conversion option  
Total losses (gains) for the period:  
Beginning Balance 65,947us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue
/ us-gaap_FairValueByLiabilityClassAxis
= us-gaap_EmbeddedDerivativeFinancialInstrumentsMember
Included in results of operations 53,730us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings
/ us-gaap_FairValueByLiabilityClassAxis
= us-gaap_EmbeddedDerivativeFinancialInstrumentsMember
Conversion (51,890)opk_DebtConversionEmbeddedDerivativeAmount
/ us-gaap_FairValueByLiabilityClassAxis
= us-gaap_EmbeddedDerivativeFinancialInstrumentsMember
Ending Balance $ 67,787us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue
/ us-gaap_FairValueByLiabilityClassAxis
= us-gaap_EmbeddedDerivativeFinancialInstrumentsMember