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Segments (Details) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 12 Months Ended
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2013
Sep. 30, 2013
Jun. 30, 2013
Mar. 31, 2013
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Segment Reporting Information [Line Items]                      
Product revenues                 $ 76,983us-gaap_SalesRevenueGoodsNet $ 68,161us-gaap_SalesRevenueGoodsNet $ 45,295us-gaap_SalesRevenueGoodsNet
Revenue from services                 8,666us-gaap_SalesRevenueServicesNet 11,658us-gaap_SalesRevenueServicesNet 1,749us-gaap_SalesRevenueServicesNet
Revenue from transfer of intellectual property                 5,476opk_RevenueFromTransferOfIntellectualProperty 16,711opk_RevenueFromTransferOfIntellectualProperty 0opk_RevenueFromTransferOfIntellectualProperty
Operating (loss) income                 (145,815)us-gaap_OperatingIncomeLoss (79,632)us-gaap_OperatingIncomeLoss (37,269)us-gaap_OperatingIncomeLoss
Depreciation and amortization                 14,927us-gaap_DepreciationDepletionAndAmortization 15,216us-gaap_DepreciationDepletionAndAmortization 10,160us-gaap_DepreciationDepletionAndAmortization
Net loss from investment in investees                 (3,587)us-gaap_GainLossOnInvestments (11,456)us-gaap_GainLossOnInvestments (2,062)us-gaap_GainLossOnInvestments
Total revenues 25,533us-gaap_SalesRevenueNet 19,773us-gaap_SalesRevenueNet 23,545us-gaap_SalesRevenueNet 22,274us-gaap_SalesRevenueNet 20,692us-gaap_SalesRevenueNet 20,641us-gaap_SalesRevenueNet 23,821us-gaap_SalesRevenueNet 31,376us-gaap_SalesRevenueNet 91,125us-gaap_SalesRevenueNet 96,530us-gaap_SalesRevenueNet 47,044us-gaap_SalesRevenueNet
Assets 1,267,664us-gaap_Assets [1]       1,391,516us-gaap_Assets [1]       1,267,664us-gaap_Assets [1] 1,391,516us-gaap_Assets [1]  
Goodwill 224,292us-gaap_Goodwill [1]       226,373us-gaap_Goodwill [1]       224,292us-gaap_Goodwill [1] 226,373us-gaap_Goodwill [1] 80,450us-gaap_Goodwill
United States                      
Segment Reporting Information [Line Items]                      
Total revenues                 14,142us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_US
28,369us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_US
1,749us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_US
Chile                      
Segment Reporting Information [Line Items]                      
Total revenues                 29,154us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_CL
31,650us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_CL
26,514us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_CL
Spain                      
Segment Reporting Information [Line Items]                      
Total revenues                 21,323us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_ES
18,800us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_ES
6,124us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_ES
Israel                      
Segment Reporting Information [Line Items]                      
Total revenues                 20,638us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_IL
13,252us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_IL
7,655us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_IL
Mexico                      
Segment Reporting Information [Line Items]                      
Total revenues                 5,807us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_MX
4,459us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_MX
5,002us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_MX
Uruguay                      
Segment Reporting Information [Line Items]                      
Total revenues                 61us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_UY
0us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_UY
0us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_UY
Corporate, Non-Segment                      
Segment Reporting Information [Line Items]                      
Revenue from services                 240us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
825us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
1,354us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
Revenue from transfer of intellectual property                 0opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
0opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
0opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
Operating (loss) income                 (27,725)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
(24,473)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
(15,628)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
Depreciation and amortization                 97us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
149us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
179us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
Net loss from investment in investees                 0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
Assets 95,094us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
      209,539us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
      95,094us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
209,539us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
 
Goodwill 0us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
      0us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
      0us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
0us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
 
Segment Reconciling Items                      
Segment Reporting Information [Line Items]                      
Operating (loss) income                 (2,042)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_MaterialReconcilingItemsMember
(3,151)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_MaterialReconcilingItemsMember
(585)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_MaterialReconcilingItemsMember
Pharmaceutical | Operating Segments                      
Segment Reporting Information [Line Items]                      
Product revenues                 76,983us-gaap_SalesRevenueGoodsNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
68,161us-gaap_SalesRevenueGoodsNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
45,295us-gaap_SalesRevenueGoodsNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
Revenue from services                 0us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
0us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
0us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
Revenue from transfer of intellectual property                 5,285opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
15,160opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
0opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
Operating (loss) income                 (94,401)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
(29,809)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
(6,797)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
Depreciation and amortization                 7,936us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
8,234us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
6,367us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
Net loss from investment in investees                 (3,587)us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
(11,456)us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
(2,062)us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
Assets 1,064,498us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
      1,065,033us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
      1,064,498us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
1,065,033us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
 
Goodwill 173,327us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
      175,408us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
      173,327us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
175,408us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
 
Diagnostics | Operating Segments                      
Segment Reporting Information [Line Items]                      
Revenue from services                 8,426us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
10,833us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
395us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
Revenue from transfer of intellectual property                 191opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
1,551opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
0opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
Operating (loss) income                 (21,647)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
(22,199)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
(14,259)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
Depreciation and amortization                 6,894us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
6,833us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
3,614us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
Net loss from investment in investees                 0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
Assets 108,072us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
      116,944us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
      108,072us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
116,944us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
 
Goodwill $ 50,965us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
      $ 50,965us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
      $ 50,965us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
$ 50,965us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
 
[1] As of December 31, 2014 and December 31, 2013, total assets include $7.6 million and $6.7 million, respectively, and total liabilities include $12.1 million and $10.4 million, respectively, related to SciVac, previously known as SciGen (I.L.) Ltd, a consolidated variable interest entity. SciVac’s consolidated assets are owned by SciVac and SciVac’s consolidated liabilities have no recourse against us. Refer to Note 4.