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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001144204-03-007379.txt : 20031117
<SEC-HEADER>0001144204-03-007379.hdr.sgml : 20031117
<ACCEPTANCE-DATETIME>20031117092143
ACCESSION NUMBER:		0001144204-03-007379
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031107
FILED AS OF DATE:		20031117

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MANHATTAN PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001001316
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				363898269
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		787 SEVENTH AVENUE
		STREET 2:		48TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
		BUSINESS PHONE:		2125544555

	MAIL ADDRESS:	
		STREET 1:		787 SEVENTH AVENUE
		STREET 2:		48TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ATLANTIC TECHNOLOGY VENTURES INC
		DATE OF NAME CHANGE:	20000330

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ATLANTIC PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19960703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ROSENWALD LINDSAY A MD
		CENTRAL INDEX KEY:			0000941841

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27282
		FILM NUMBER:		031006730

	BUSINESS ADDRESS:	
		STREET 1:		375 PARK AVE
		STREET 2:		SUITE 1501
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10152
		BUSINESS PHONE:		2128324366

	MAIL ADDRESS:	
		STREET 1:		375 PARK AVE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10152

	FORMER NAME:	
		FORMER CONFORMED NAME:	ROSENWALD LINDSAY MD
		DATE OF NAME CHANGE:	19950316
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>manh-rosen_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<!-- - EDGAR Ease Plus 1.0                                   07/25/03  TT    -->
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>3</documentType>
   <periodOfReport>2003-11-07</periodOfReport>
    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001001316</issuerCik>
        <issuerName>MANHATTAN PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>MHTT.OB</issuerTradingSymbol>
   </issuer>
   <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000941841</rptOwnerCik>
            <rptOwnerName>ROSENWALD LINDSAY A MD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O PARAMOUNT CAPITAL</rptOwnerStreet1>
            <rptOwnerStreet2>787 SEVENTH AVENUE, 48TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10019</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
         <isDirector>0</isDirector>
         <isOfficer>0</isOfficer>
         <isTenPercentOwner>1</isTenPercentOwner>
         <isOther>0</isOther>
      </reportingOwnerRelationship>
   </reportingOwner>
 <derivativeTable>
   <derivativeHolding>
      <securityTitle>
         <value>Series A Convertible Preferred Stock</value>
      </securityTitle>
      <conversionOrExercisePrice>
         <value>1.10</value>
      </conversionOrExercisePrice>
      <exerciseDate>
         <value>2003-11-07</value>
      </exerciseDate>
      <expirationDate>
            <footnoteId id="F1"/>
      </expirationDate>
      <underlyingSecurity>
         <underlyingSecurityTitle>
           <value>Common</value>
         </underlyingSecurityTitle>
         <underlyingSecurityShares>
           <value>221109</value>
            <footnoteId id="F2"/>
         </underlyingSecurityShares>
      </underlyingSecurity>
      <ownershipNature>
         <directOrIndirectOwnership>
           <value>D</value>
         </directOrIndirectOwnership>
      </ownershipNature>
   </derivativeHolding>
 </derivativeTable>
   <footnotes>
      <footnote id="F1"> The Series A Preferred Stock is immediately convertible into shares of common stock by Dr. Rosenwald and has no expiration date.</footnote>

      <footnote id="F2"> Dr. Rosenwald controls the right to vote and dispose of, and may therefore be deemed to beneficially own (i) 2,219,597 shares of common stock, (ii) warrants to purchase 74,047 shares of common stock and (iii) 221,109 shares of common stock issuable upon conversion of 24,322 shares of Series A Convertible Preferred Stock, owned directly by Dr. Rosenwald. Dr. Rosenwald disclaims beneficial ownership over 831,213 shares owned by three trusts for the benefit of Dr. Rosenwald, except to the extent of his pecuniary interest therein. Mr. Jay Lobell, who is the distribution and investment advisor to the trusts, has voting and dispositive control over such shares, and reports ownership on a separate Form 4.</footnote>
   </footnotes>
   <ownerSignature>
      <signatureName>Dr. Lindsay Rosenwald</signatureName>
      <signatureDate>2003-11-13</signatureDate>
   </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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