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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenues:      
Net product revenues $ 135,375 $ 34,158 $ 25,111
Collaboration revenues 56,079 3,014 0
Total revenues 191,454 37,172 25,111
Operating expenses:      
Cost of goods sold 6,552 3,895 2,043
Research and development 95,967 96,351 189,101
Selling, general and administrative 116,145 57,305 50,829
Restructuring charges 914 1,042 7,596
Total operating expenses 219,578 158,593 249,569
Loss from operations (28,124) (121,421) (224,458)
Other income (expense), net:      
Interest income and other, net 4,863 412 4,341
Interest expense (33,060) (40,680) (41,362)
Loss on extinguishment of debt (13,901) 0 0
Total other expense, net (42,098) (40,268) (37,021)
Loss before income taxes (70,222) (161,689) (261,479)
Income tax provision (benefit) 0 55 (182)
Net (loss) income $ (70,222) $ (161,744) $ (261,297)
Net loss per share, basic and diluted (in dollars per share) $ (0.28) $ (0.77) $ (1.34)
Shares used in computing basic and diluted net loss per share 250,531 209,227 194,299