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Organization and Summary of Significant Accounting Policies (Narrative) (Details)
$ in Thousands
3 Months Ended 12 Months Ended 24 Months Ended 36 Months Ended
Dec. 31, 2015
USD ($)
Sep. 30, 2015
USD ($)
Jun. 30, 2015
USD ($)
Mar. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Sep. 30, 2014
USD ($)
Jun. 30, 2014
USD ($)
Mar. 31, 2014
USD ($)
Dec. 31, 2013
Dec. 31, 2015
USD ($)
segment
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2015
USD ($)
Organization And Summary Of Significant Policies [Line Items]                            
Annual operating cycle                   364 days 371 days 364 days    
Fiscal period duration 98 days       91 days       91 days          
Number of operating segments | segment                   1        
Accrued collaboration liability $ 10,938       $ 732         $ 10,938 $ 732   $ 10,938 $ 10,938
Net (loss) income (43,641) $ (47,564) $ (43,362) $ (35,170) (57,953) $ (62,560) $ (73,410) $ (74,619)   (169,737) (268,542) $ (244,760)    
Retained earnings (accumulated deficit) (1,937,041)       (1,767,304)         (1,937,041) (1,767,304)   (1,937,041) (1,937,041)
Net product revenues                   34,158 25,111 15,017   74,300
Cash and investments 253,310       242,760         253,310 242,760   253,310 253,310
Cash available for operations 169,000                 169,000     169,000 169,000
Compensating balance investments 81,600                 81,600     81,600 81,600
Long-term restricted cash and investments $ 2,650       $ 4,684         $ 2,650 4,684   2,650 $ 2,650
Percent discount for prompt payment                   2.00%        
Discount expected to be earned (as a percent)                   100.00%        
Sobi [Member]                            
Organization And Summary Of Significant Policies [Line Items]                            
Reduction to net product revenues                   $ 100 $ 2,300   $ 2,400  
Amount of reduction relating to prior periods                       $ 700    
GlaxoSmithKline [Member]                            
Organization And Summary Of Significant Policies [Line Items]                            
Percent of royalty on net sale                   3.00%        
Minimum [Member]                            
Organization And Summary Of Significant Policies [Line Items]                            
Annual operating cycle                   364 days        
Maximum [Member]                            
Organization And Summary Of Significant Policies [Line Items]                            
Annual operating cycle                   371 days        
“Sell-In” Revenue Recognition Model [Member]                            
Organization And Summary Of Significant Policies [Line Items]                            
Net product revenues                   $ 2,600