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Consolidated Statements of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Revenues:      
Contract $ 20,736 $ 41,309 $ 61,271
License 26,714 245,549 96,363
Collaboration reimbursement 0 2,778 27,411
Total revenues 47,450 289,636 185,045
Operating expenses:      
Research and development 128,878 156,836 210,678
General and administrative 31,837 33,129 33,020
Restructuring charge 9,171 10,136 32,744
Total operating expenses 169,886 200,101 276,442
(Loss) income from operations (122,436) 89,535 (91,397)
Other income (expense), net:      
Interest income and other, net 1,986 1,462 138
Interest expense (27,088) (16,259) (9,340)
Gain on sale of businesses 0 2,254 8,197
Total other income (expense), net (25,102) (12,543) (1,005)
(Loss) income before income taxes (147,538) 76,992 (92,402)
Income tax provision (benefit) 107 1,295 (72)
Net (loss) income $ (147,645) $ 75,697 $ (92,330)
Net (loss) income per share, basic (in dollars per share) $ (0.92) $ 0.60 $ (0.85)
Net (loss) income per share, diluted (in dollars per share) $ (0.92) $ 0.58 $ (0.85)
Shares used in computing basic (loss) income per share amounts 160,138 126,018 108,522
Shares used in computing diluted (loss) income per share amounts 160,138 130,479 108,522