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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934
(Amendment No. )*

COLEY PHARMACEUTICAL GROUP, INC.

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

19388P106

(CUSIP Number)

December 31, 2005

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     o Rule 13d-1(b)

     o Rule 13d-1(c)

     þ Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

CUSIP No. 19388P106  13G Page 2  of  8 

1	NAMES OF REPORTING PERSONS: Venrock Associates
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
	13-6300995
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
	(a)   þ1
	(b)   o
3	SEC USE ONLY:
4	CITIZENSHIP OR PLACE OF ORGANIZATION:
	New York, United States
		5	SOLE VOTING POWER:
NUMBER OF			0
SHARES		6	SHARED VOTING POWER:
BENEFICIALLY
OWNED BY			2,947,7962
EACH		7	SOLE DISPOSITIVE POWER:
REPORTING
PERSON			0
WITH:		8	SHARED DISPOSITIVE POWER:
			2,947,7962
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
	2,947,7962
10	CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
	o
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
	11.2%
12	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
	PN

1

Venrock Associates, Venrock Associates III, L.P. and Venrock Entrepreneurs Fund III, L.P. are members of a group for purposes of this Schedule 13G.

2

Consists of: (i) 453,967 shares of common stock and 76,637 shares of common stock issuable upon exercise of warrants exercisable within 60 days of December 31, 2005 owned by Venrock Associates, (ii) 2,017,630 shares of common stock and 340,608 shares of common stock issuable upon exercise of warrants exercisable within 60 days of December 31, 2005 owned by Venrock Associates III, L.P. and (iii) 50,439 shares of common stock and 8,515 shares of common stock issuable upon exercise of warrants exercisable within 60 days of December 31, 2005 owned by Venrock Entrepreneurs Fund III, L.P.

CUSIP No. 19388P106  13G  Page 3  of  8 

1	NAMES OF REPORTING PERSONS: Venrock Associates III, L.P.
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
	13-4120290
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
	(a)   þ1
	(b)   o
3	SEC USE ONLY:
4	CITIZENSHIP OR PLACE OF ORGANIZATION:
	New York, United States
		5	SOLE VOTING POWER:
NUMBER OF			0
SHARES		6	SHARED VOTING POWER:
BENEFICIALLY
OWNED BY			2,947,7962
EACH		7	SOLE DISPOSITIVE POWER:
REPORTING
PERSON			0
WITH:		8	SHARED DISPOSITIVE POWER:
			2,947,7962
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
	2,947,7962
10	CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
	o
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
	11.2%
12	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
	PN

1

Venrock Associates, Venrock Associates III, L.P. and Venrock Entrepreneurs Fund III, L.P. are members of a group for purposes of this Schedule 13G.

2

Consists of: (i) 453,967 shares of common stock and 76,637 shares of common stock issuable upon exercise of warrants exercisable within 60 days of December 31, 2005 owned by Venrock Associates, (ii) 2,017,630 shares of common stock and 340,608 shares of common stock issuable upon exercise of warrants exercisable within 60 days of December 31, 2005 owned by Venrock Associates III, L.P. and (iii) 50,439 shares of common stock and 8,515 shares of common stock issuable upon exercise of warrants exercisable within 60 days of December 31, 2005 owned by Venrock Entrepreneurs Fund III, L.P.

CUSIP No. 19388P106   13G Page 4  of  8 

1	NAMES OF REPORTING PERSONS: Venrock Entrepreneurs Fund III, L.P.
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):
	13-4161054
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):
	(a)   þ1
	(b)   o
3	SEC USE ONLY:
4	CITIZENSHIP OR PLACE OF ORGANIZATION:
	New York, United States
		5	SOLE VOTING POWER:
NUMBER OF			0
SHARES		6	SHARED VOTING POWER:
BENEFICIALLY
OWNED BY			2,947,7962
EACH		7	SOLE DISPOSITIVE POWER:
REPORTING
PERSON			0
WITH:		8	SHARED DISPOSITIVE POWER:
			2,947,7962
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
	2,947,7962
10	CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
	o
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
	11.2%
12	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
	PN

1

Venrock Associates, Venrock Associates III, L.P. and Venrock Entrepreneurs Fund III, L.P. are members of a group for purposes of this Schedule 13G.

2

Consists of: (i) 453,967 shares of common stock and 76,637 shares of common stock issuable upon exercise of warrants exercisable within 60 days of December 31, 2005 owned by Venrock Associates, (ii) 2,017,630 shares of common stock and 340,608 shares of common stock issuable upon exercise of warrants exercisable within 60 days of December 31, 2005 owned by Venrock Associates III, L.P. and (iii) 50,439 shares of common stock and 8,515 shares of common stock issuable upon exercise of warrants exercisable within 60 days of December 31, 2005 owned by Venrock Entrepreneurs Fund III, L.P.

CUSIP No. 19388P106 13G Page 5 of 8

     Introductory Note: This Statement on Schedule 13G is filed on behalf of Venrock Associates, a limited partnership organized under the laws of the State of New York (“Venrock”), Venrock Associates III, L.P., a limited partnership organized under the laws of the State of New York (“Venrock III”) and Venrock Entrepreneurs Fund III, L.P., a limited partnership organized under the laws of the State of New York (“Entrepreneurs Fund III” and collectively with Venrock and Venrock III, the “Venrock Entities”) in respect of shares of common stock of Coley Pharmaceutical Group, Inc.

Item 1(a)	Name of Issuer:
	Coley Pharmaceutical Group, Inc.
Item 1(b)	Address of Issuer’s Principal Executive Offices:
	93 Worcester Road, Suite 101
	Wellesley, MA 02481
Item 2(a)	Name of Person Filing:
	Venrock Associates
	Venrock Associates III, L.P.
	Venrock Entrepreneurs Fund III, L.P.
Item 2(b)	Address of Principal Business Office or, if none, Residence:

New York Office:	Menlo Park Office:	Cambridge Office:
30 Rockefeller Plaza	2494 Sand Hill Road	55 Cambridge Parkway
Suite 5508	Suite 200	Suite 100
New York, NY 10112	Menlo Park, CA 94025	Cambridge, MA 02142

Item 2(c) Citizenship:

          Each of Venrock, Venrock III and Entrepreneurs Fund III are limited partnerships organized in the State of New York.

Item 2(d)	Title of Class of Securities:
	Common Stock
Item 2(e)	CUSIP Number
	19388P106
Item 3	Not applicable.

CUSIP No. 19388P106 13G Page 6 of 8

Item 4	Ownership
	(a) and (b)

            Venrock beneficially owns 530,604 shares of common stock, or 2.0% or the outstanding shares of common stock. Venrock III owns 2,358,238 shares of common stock, or 9.0% or the outstanding shares of common stock. Entrepreneurs Fund III owns 58,954 shares of common stock, or 0.2% or the outstanding shares of common stock.

            (c)

             Each of the Venrock Entities has sole power to vote or to direct the vote of no shares of the common stock, sole power to dispose or to direct the disposition of no shares of the common stock, shared power to vote or to direct the vote of 2,947,796 shares of the common stock and shared power to dispose or to direct the disposition of 2,947,796 shares of the common stock.

Item 5	Ownership of Five Percent or Less of a Class: If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following o.
Item 6	Ownership of More than Five Percent on Behalf of Another Person:
	Not applicable.
Item 7	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company:
	Not applicable.
Item 8	Identification and Classification of Members of the Group:
	This Schedule is being filed pursuant to Rule 13d-1(d). The identities of each of the Venrock Entities are stated in Item 2(a).
Item 9	Notice of Dissolution of Group:
	Not applicable.

CUSIP No. 19388P106 13G Page 7 of 8

Item 10	Certification
	Not applicable.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this Statement is true, complete and correct.

Dated: February 14, 2006	VENROCK ASSOCIATES
	By: /s/ Anthony B. Evnin Name: Anthony B. Evnin Title: Managing General Partner
Dated: February 14, 2006	VENROCK ASSOCIATES III, L.P.
	By: /s/ Anthony B. Evnin Name: Anthony B. Evnin Title: Managing General Partner
Dated: February 14, 2006	VENROCK ENTREPRENEURS FUND III, L.P.
	By: /s/ Anthony B. Evnin Name: Anthony B. Evnin Title: Managing General Partner

CUSIP No. 19388P106 13G Page 8 of 8

Exhibit No. EXHIBIT INDEX

99.1 Agreement pursuant to 13d-1(k)(1) among Venrock Associates, Venrock Associates III, L.P. and Venrock Entrepreneurs Fund III, L.P.