<SEC-DOCUMENT>0001047469-16-015242-index.html : 20160902
<SEC-HEADER>0001047469-16-015242.hdr.sgml : 20160902
<ACCEPTANCE-DATETIME>20160902170712
ACCESSION NUMBER:		0001047469-16-015242
CONFORMED SUBMISSION TYPE:	S-3ASR
PUBLIC DOCUMENT COUNT:		14
FILED AS OF DATE:		20160902
DATE AS OF CHANGE:		20160902
EFFECTIVENESS DATE:		20160902

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Shire plc
		CENTRAL INDEX KEY:			0000936402
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-213502
		FILM NUMBER:		161869309

	BUSINESS ADDRESS:	
		STREET 1:		HAMPSHIRE INTL BUSINESS PARK
		STREET 2:		CHINEHAM BASINGSTOKE
		CITY:			HAMPSHIRE ENGLAND RG
		STATE:			X0
		ZIP:			RG24 8EP
		BUSINESS PHONE:		441256894000

	MAIL ADDRESS:	
		STREET 1:		HAMPSHIRE INTL BUSINESS PARK
		STREET 2:		CHINEHAM BASINGSTOKE
		CITY:			HAMPSHIRE ENGLAND RG
		STATE:			X0
		ZIP:			RG24 8EP

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Shire Ltd.
		DATE OF NAME CHANGE:	20080523

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Shire plc
		DATE OF NAME CHANGE:	20051125

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHIRE PHARMACEUTICALS GROUP PLC
		DATE OF NAME CHANGE:	19980302

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Shire Acquisitions Investments Ireland DAC
		CENTRAL INDEX KEY:			0001683108
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L2
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-213502-01
		FILM NUMBER:		161869310

	BUSINESS ADDRESS:	
		STREET 1:		5 RIVERWALK
		STREET 2:		CITYWEST BUSINESS CAMPUS
		CITY:			DUBLIN 24
		STATE:			L2
		ZIP:			00000
		BUSINESS PHONE:		353 1 429 7700

	MAIL ADDRESS:	
		STREET 1:		5 RIVERWALK
		STREET 2:		CITYWEST BUSINESS CAMPUS
		CITY:			DUBLIN 24
		STATE:			L2
		ZIP:			00000
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<TYPE>S-3ASR
<SEQUENCE>1
<FILENAME>a2229560zs-3asr.htm
<DESCRIPTION>S-3ASR
<TEXT>
Document 1 - file: a2229560zs-3asr.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.1
<SEQUENCE>2
<FILENAME>a2229560zex-4_1.htm
<DESCRIPTION>EX-4.1
<TEXT>
Document 2 - file: a2229560zex-4_1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>a2229560zex-5_1.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 3 - file: a2229560zex-5_1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.2
<SEQUENCE>4
<FILENAME>a2229560zex-5_2.htm
<DESCRIPTION>EX-5.2
<TEXT>
Document 4 - file: a2229560zex-5_2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.3
<SEQUENCE>5
<FILENAME>a2229560zex-5_3.htm
<DESCRIPTION>EX-5.3
<TEXT>
Document 5 - file: a2229560zex-5_3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-12.1
<SEQUENCE>6
<FILENAME>a2229560zex-12_1.htm
<DESCRIPTION>EX-12.1
<TEXT>
Document 6 - file: a2229560zex-12_1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>7
<FILENAME>a2229560zex-23_1.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 7 - file: a2229560zex-23_1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>8
<FILENAME>a2229560zex-23_2.htm
<DESCRIPTION>EX-23.2
<TEXT>
Document 8 - file: a2229560zex-23_2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.3
<SEQUENCE>9
<FILENAME>a2229560zex-23_3.htm
<DESCRIPTION>EX-23.3
<TEXT>
Document 9 - file: a2229560zex-23_3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.4
<SEQUENCE>10
<FILENAME>a2229560zex-23_4.htm
<DESCRIPTION>EX-23.4
<TEXT>
Document 10 - file: a2229560zex-23_4.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-25.1
<SEQUENCE>11
<FILENAME>a2229560zex-25_1.htm
<DESCRIPTION>EX-25.1
<TEXT>
Document 11 - file: a2229560zex-25_1.htm

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<TYPE>GRAPHIC
<SEQUENCE>12
<FILENAME>g175362ko03i001.gif
<DESCRIPTION>G175362KO03I001.GIF
<TEXT>
Document 12 - file: g175362ko03i001.gif

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<TYPE>GRAPHIC
<SEQUENCE>13
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<TEXT>
Document 13 - file: g175362ko05i001.gif

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Document 14 - file: g175362ko07i001.gif

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