<SEC-DOCUMENT>0000950103-18-014346-index.html : 20181206
<SEC-HEADER>0000950103-18-014346.hdr.sgml : 20181206
<ACCEPTANCE-DATETIME>20181206070022
ACCESSION NUMBER:		0000950103-18-014346
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		5
CONFORMED PERIOD OF REPORT:	20181204
ITEM INFORMATION:		Submission of Matters to a Vote of Security Holders
ITEM INFORMATION:		Other Events
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20181206
DATE AS OF CHANGE:		20181206

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Shire plc
		CENTRAL INDEX KEY:			0000936402
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37896
		FILM NUMBER:		181218838

	BUSINESS ADDRESS:	
		STREET 1:		BLOCK 2, MIESIAN PLAZA
		STREET 2:		50-58 BAGGOT STREET LOWER
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 HW68
		BUSINESS PHONE:		353-1-609-6000

	MAIL ADDRESS:	
		STREET 1:		BLOCK 2, MIESIAN PLAZA
		STREET 2:		50-58 BAGGOT STREET LOWER
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 HW68

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Shire Ltd.
		DATE OF NAME CHANGE:	20080523

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Shire plc
		DATE OF NAME CHANGE:	20051125

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHIRE PHARMACEUTICALS GROUP PLC
		DATE OF NAME CHANGE:	19980302
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>dp99334_8k.htm
<DESCRIPTION>FORM 8-K
<TEXT>
Document 1 - file: dp99334_8k.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>dp99334_ex9901.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
Document 2 - file: dp99334_ex9901.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>3
<FILENAME>dp99334_ex9902.htm
<DESCRIPTION>EXHIBIT 99.2
<TEXT>
Document 3 - file: dp99334_ex9902.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>image_012.gif
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: image_012.gif

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>image_013.gif
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: image_013.gif

</DOCUMENT>
</SEC-DOCUMENT>