Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the Registration Statement (No. 333-175839) on Form S-8 of Shire, plc of our report dated June 27, 2018, with respect to the statements of net assets available for benefits of Shire Holdings US AG 401(k) Savings Plan as of December 31, 2017 and 2016, the related statements of changes in net assets available for benefits for the years then ended, and the related supplemental schedule as of December 31, 2017, which report appears in the December 31, 2017 annual report on Form 11-K of Shire Holdings US AG 401(k) Savings Plan.

/s/ Fischer Cunnane & Associates Ltd       

Fischer Cunnane & Associates Ltd 

Certified Public Accountants

West Chester, Pennsylvania 

June 27, 2018