10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the Quarterly Period ended March 31, 2015

Commission File Number: 0-29630

SHIRE PLC

(Exact name of registrant as specified in its charter)

Jersey (Channel Islands) (State or other jurisdiction of incorporation or organization)	98-0601486 (I.R.S. Employer Identification No.)
5 Riverwalk, Citywest Business Campus, Dublin 24, Republic of Ireland  (Address of principal executive offices and zip code)	+353 1 429 7700 (Registrant’s telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months, and (2) has been subject to such filing requirements for the past 90 days.

Yes [X] No [  ]

Indicate by check mark whether the Registrant has submitted electronically and posted on its corporate website, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (232,405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).

Yes  [X]  No [ ]

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer.

Large accelerated filer [X] Accelerated filer [  ] Non-accelerated filer [  ] Smaller reporting company [  ]

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

Yes [  ] No [X]

As at April 24, 2015 the number of outstanding ordinary shares of the Registrant was 600,292,756.

1

THE “SAFE HARBOR” STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995

Statements included herein that are not historical facts are forward-looking statements. Such forward-looking statements involve a number of risks and uncertainties and are subject to change at any time. In the event such risks or uncertainties materialize, Shire’s results could be materially adversely affected. The risks and uncertainties include, but are not limited to, that:

· Shire’s products may not be a commercial success;

· product sales from ADDERALL XR and INTUNIV are subject to generic competition;

· the failure to obtain and maintain reimbursement, or an adequate level of reimbursement, by third-party payers in a timely manner for Shire’s products may affect future revenues, financial condition and results of operations;

· Shire conducts its own manufacturing operations for certain of its products and is reliant on third party contract manufacturers to manufacture other products and to provide goods and services. Some of Shire’s products or ingredients are only available from a single approved source for manufacture. Any disruption to the supply chain for any of Shire’s products may result in Shire being unable to continue marketing or developing a product or may result in Shire being unable to do so on a commercially viable basis for some period of time;

· the manufacture of Shire’s products is subject to extensive oversight by various regulatory agencies. Regulatory approvals or interventions associated with changes to manufacturing sites, ingredients or manufacturing processes could lead to significant delays, an increase in operating costs, lost product sales, an interruption of research activities or the delay of new product launches;

· Shire has a portfolio of products in various stages of research and development. The successful development of these products is highly uncertain and requires significant expenditures and time, and there is no guarantee that these products will receive regulatory approval;

· the actions of certain customers could affect Shire’s ability to sell or market products profitably. Fluctuations in buying or distribution patterns by such customers can adversely affect Shire’s revenues, financial condition or results of operations;

· investigations or enforcement action by regulatory authorities or law enforcement agencies relating to Shire’s activities in the highly regulated markets in which it operates may result in significant legal costs and the payment of substantial compensation or fines;

· adverse outcomes in legal matters and other disputes, including Shire’s ability to enforce and defend patents and other intellectual property rights required for its business, could have a material adverse effect on Shire’s revenues, financial condition or results of operations;

· Shire faces intense competition for highly qualified personnel from other companies and organizations. Shire is undergoing a corporate reorganization and was the subject of an unsuccessful acquisition proposal and the consequent uncertainty could adversely affect Shire’s ability to attract and/or retain the highly skilled personnel needed for Shire to meet its strategic objectives;

· failure to achieve Shire’s strategic objectives with respect to the acquisition of NPS Pharmaceuticals Inc. (“NPS Pharma”) may adversely affect Shire’s financial condition and results of operations; and

other risks and uncertainties detailed from time to time in Shire’s filings with the Securities and Exchange Commission, including those risks outlined in “Item 1A: Risk Factors” in Shire’s Annual Report on Form 10-K for the year ended December 31, 2014.

2

The following are trademarks either owned or licensed by Shire plc or its subsidiaries, which are the subject of trademark registrations in certain territories, or which are owned by third parties as indicated and referred to in this Form 10-Q:

ADDERALL XR® (mixed salts of a single entity amphetamine)

AGRYLIN® (anagrelide hydrochloride)

BUCCOLAM® (midazolam hydrochloride oromucosal solution)

CALCICHEW® (trademark of Takeda Nycomed AS

CARBATROL® (carbamazepine extended-release capsules)

CEREZYME® (trademark of Genzyme)

CINRYZE® (C1 esterase inhibitor [human])

DAYTRANA® (trademark of Noven Pharmaceutical Inc. (“Noven”))

DERMAGRAFT® (trademark of Organogenesis Inc. (“Organogenesis”))

ELAPRASE® (idursulfase)

ELVANSE® (lisdexamfetamine dimesylate)

ELVANSE ADULT® (lisdexamfetamine dimesylate)

ELVANSE VUXEN® (lisdexamfetamine dimesylate)

ESTRACE® (trademark of Trimel Pharmaceuticals Inc.)

EQUASYM® (methylphenidate hydrochloride)

EQUASYM XL® (methylphenidate hydrochloride)

FIRAZYR® (icatibant)

FOSRENOL® (lanthanum carbonate)

GATTEX® (teduglutide [rDNA origin])

INTUNIV® (guanfacine extended release)

LIALDA® (trademark of Nogra International Limited)

MEZAVANT® (trademark of Giuliani International Limited)

MIMPARA® (cinacalcet HCl)

NATPAR® (parathyroid hormone)

NATPARA® (parathyroid hormone (rDNA))

PENTASA® (trademark of Ferring B.V. Corp (“Ferring”))

PLENADREN® (hydrocortisone, modified release tablet)

PREMIPLEX®(IGF-I/IGFBP-3)

REGPARA® (cinacalcet HCl)

REPLAGAL® (agalsidase alfa)

RESOLOR® (prucalopride)

REVESTIVE® (teduglutide)

SENSIPAR® (cinacalcet HCl)

TYVENSE® (lisdexamfetamine dimesylate)

VASCUGEL® (allogeneic aortic endothelial cells cultured in a porcine gelatin matrix [Gelfoam®] with cytokines, implanted)

VANCOCIN® (trademark of ANI Pharmaceuticals Inc.)

VENVANSE® (lisdexamfetamine dimesylate)

VPRIV® (velaglucerase alfa)

VYVANSE® (lisdexamfetamine dimesylate)

XAGRID® (anagrelide hydrochloride)

ZEFFIX® (trademark of GSK)

3TC® (trademark of GSK)

3

SHIRE PLC

Form 10-Q for the three months to March 31, 2015

Table of contents

		Page
PART I          FINANCIAL INFORMATION		5
ITEM 1.  FINANCIAL STATEMENTS
	Unaudited Consolidated Balance Sheets at March 31, 2015 and December 31, 2014	5
	Unaudited Consolidated Statements of Income for the three months to March 31, 2015 and March 31, 2014	7
	Unaudited Consolidated Statements of Comprehensive Income for the three months to March 31, 2015 and March 31, 2014	9
	Unaudited Consolidated Statement of Changes in Equity for the three months to March 31, 2015	10
	Unaudited Consolidated Statements of Cash Flows for the three months to March 31, 2015 and March 31, 2014	11
	Notes to the Unaudited Consolidated Financial Statements	13
ITEM 2.  MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS		39
ITEM 3.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK		53
ITEM 4.  CONTROLS AND PROCEDURES		53
PART II  OTHER INFORMATION		53
ITEM 1.  LEGAL PROCEEDINGS		53
ITEM 1A.  RISK FACTORS		53
ITEM 2.  UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS		53
ITEM 3.  DEFAULTS UPON SENIOR SECURITIES		53
ITEM 4.  MINE SAFETY DISCLOSURES		53
ITEM 5.  OTHER INFORMATION		54
ITEM 6.  EXHIBITS		54

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PART I: FINANCIAL INFORMATION

ITEM1: FINANCIAL STATEMENTS

SHIRE PLC

UNAUDITED CONSOLIDATED BALANCE SHEETS

		March 31,		December 31,
		2015		2014
	Notes		$’M		$’M
ASSETS
Current assets:
Cash and cash equivalents			74.3		2,982.4
Restricted cash			68.9		54.6
Accounts receivable, net	5		1,116.3		1,035.1
Inventories	6		588.7		544.8
Deferred tax asset			461.8		344.7
Prepaid expenses and other current assets	8		216.6		221.5
Total current assets			2,526.6		5,183.1
Non-current assets:
Investments			45.7		43.7
Property, plant and equipment, net (“PP&E”)			821.9		837.5
Goodwill	9		4,178.7		2,474.9
Other intangible assets, net	10		9,980.0		4,934.4
Deferred tax asset			102.7		112.1
Other non-current assets			22.7		46.4
Total assets			17,678.3		13,632.1
LIABILITIES AND EQUITY
Current liabilities:
Accounts payable and accrued expenses	11		1,991.6		1,909.4
Short-term borrowings	13		2,570.2		850.0
Other current liabilities	12		303.2		262.5
Total current liabilities			4,865.0		3,021.9
Non-current liabilities:
Long-term borrowings	13		78.7		-
Deferred tax liability			2,909.9		1,210.6
Other non-current liabilities	14		844.0		736.7
Total liabilities			8,697.6		4,969.2
Commitments and contingencies	15		-		-

5

SHIRE PLC

UNAUDITED CONSOLIDATED BALANCE SHEETS (continued)

		March 31,			December 31,
		2015			2014
	Notes		$’M			$’M
Equity:
Common stock of 5p par value; 1,000 million shares authorized; and 600.2 million shares issued and outstanding (2014: 1,000 million shares authorized; and 599.1 million shares issued and outstanding)			58.9			58.7
Additional paid-in capital			4,373.2			4,338.0
Treasury stock: 10.0 million shares (2014: 10.6 million shares)			(330.1	)		(345.9	)
Accumulated other comprehensive loss	16		(160.3	)		(31.5	)
Retained earnings			5,039.0			4,643.6
Total equity			8,980.7			8,662.9
Total liabilities and equity			17,678.3			13,632.1

The accompanying notes are an integral part of these unaudited consolidated financial statements.

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SHIRE PLC

UNAUDITED CONSOLIDATED STATEMENTS OF INCOME

		3 months to			3 months to
		March 31,			March 31,
		2015			2014
	Notes		$’M			$’M
Revenues:
Product sales			1,423.2			1,308.1
Royalties			62.8			32.3
Other revenues			2.4			6.4
Total revenues			1,488.4			1,346.8
Costs and expenses:
Cost of product sales			227.8			229.5
Research and development(1)			193.7			360.5
Selling, general and administrative(1)			506.6			430.3
Gain on sale of product rights			(5.2	)		(36.4	)
Reorganization costs	3		15.2			49.4
Integration and acquisition costs	4		75.7			6.6
Total operating expenses			1,013.8			1,039.9
Operating income from continuing operations			474.6			306.9
Interest income			2.0			0.5
Interest expense			(9.6	)		(7.8	)
Other income, net			4.3			4.7
Total other expense, net			(3.3	)		(2.6	)
Income from continuing operations before income taxes and equity in losses of equity method investees			471.3			304.3
Income taxes			(57.4	)		(50.6	)
Equity in losses of equity method investees, net of taxes			(1.0	)		(0.6	)
Income from continuing operations, net of taxes			412.9			253.1
Loss from discontinued operations, net of  taxes1	7		(2.5	)		(22.7	)
Net income			410.4			230.4

(1) Research and development (“R&D”) includes intangible asset impairment charges of $nil for the three months to March 31, 2015 (2014: $166.0 million). Selling, general and administrative (“SG&A”) costs include amortization of intangible assets relating to intellectual property rights acquired of $88.3 million for the three months to March 31, 2015 (2014: $57.8 million).

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SHIRE PLC

UNAUDITED CONSOLIDATED STATEMENTS OF INCOME (continued)

		3 months to		3 months to
		March 31,		March 31,
	Notes	2015		2014
Earnings per ordinary share - basic
Earnings from continuing operations			70.1c		43.3c
Loss from discontinued operations	1		(0.4c)		(3.9c)
Earnings per ordinary share - basic			69.7c		39.4c
Earnings per ordinary share - diluted
Earnings from continuing operations			69.7c		43.0c
Loss from discontinued operations	1		(0.4c)		(3.9c)
Earnings per ordinary share - diluted			69.3c		39.1c
Weighted average number of shares (millions):
Basic	19		589.1		584.3
Diluted	19		592.7		588.8

The accompanying notes are an integral part of these unaudited consolidated financial statements.

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SHIRE PLC

 UNAUDITED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME

	3 months to			3 months to
	March 31,			March 31,
	2015			2014
	$’M			$’M
Net income		410.4			230.4
Other comprehensive income:
Foreign currency translation adjustments		(129.5	)		(1.7	)
Unrealized holding gain on available-for-sale securities (net of taxes of $nil and $2.5 million)		0.7			4.3
Comprehensive income		281.6			233.0

The components of accumulated other comprehensive income as at March 31, 2015 and December 31, 2014 are as follows:

	March 31,			December 31,
	2015			2014
		$’M			$’M
Foreign currency translation adjustments		(155.2	)		(25.7	)
Unrealized holding loss on available-for-sale securities, net of taxes		(5.1	)		(5.8	)
Accumulated other comprehensive loss		(160.3	)		(31.5	)

The accompanying notes are an integral part of these unaudited consolidated financial statements.

9

SHIRE PLC

UNAUDITED CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

(In millions of US dollars except share data)

	Shire plc shareholders’ equity
	Common stock Number of shares M’s		Common stock $’M		Additional paid-in capital $’M		Treasury stock $’M			Accumulated other comprehensive loss $’M			Retained earnings $’M			Total equity $’M
As at January 1, 2015		599.1		58.7		4,338.0		(345.9	)		(31.5	)		4,643.6			8,662.9
Net income		-		-		-		-			-			410.4			410.4
Other comprehensive loss, net of tax		-		-		-		-			(128.8	)		-			(128.8	)
Options exercised		1.1		0.2		-		-			-			-			0.2
Share-based compensation		-		-		15.3		-			-			-			15.3
Tax benefit associated with exercise of stock options		-		-		19.9		-			-			-			19.9
Shares released by employee benefit trust to satisfy exercise of stock options		-		-		-		15.8			-			(15.0	)		0.8
As at March 31, 2015		600.2		58.9		4,373.2		(330.1	)		(160.3	)		5,039.0			8,980.7

The accompanying notes are an integral part of these unaudited consolidated financial statements.

10

SHIRE PLC

UNAUDITED CONSOLIDATED STATEMENTS OF CASH FLOWS

3 months to March 31,	2015			2014
		$’M			$’M
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income		410.4			230.4
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization		120.6			94.6
Share-based compensation		15.3			26.2
Change in fair value of contingent consideration		2.4			(59.2	)
Unwind of inventory fair value step-ups		11.2			38.8
Impairment of IPR&D intangible assets		-			166.0
Impairment of PP&E1		-			12.1
Gain on sale of product rights		(5.2	)		(36.4	)
Other, net		1.1			(0.3	)
Movement in deferred taxes		16.6			18.5
Equity in losses of equity method investees		1.0			0.6
Changes in operating assets and liabilities:
Increase in accounts receivable		(85.1	)		(77.3	)
(Decrease)/increase in sales deduction accruals		(24.6	)		70.8
Increase in inventory		(22.0	)		(18.6	)
Decrease/(increase) in prepayments and other assets		42.4			(74.6	)
Increase/(decrease) in accounts and notes payable and other liabilities		77.5			(145.5	)
Net cash provided by operating activities (A)		561.6			246.1
CASH FLOWS FROM INVESTING ACTIVITIES:
Movements in restricted cash		(14.5	)		(10.1	)
Purchases of subsidiary undertakings and businesses, net of cash acquired		(5,199.7	)		(3,764.4	)
Purchases of non-current investments and PP&E		(22.3	)		(15.6	)
Proceeds from short-term investments		54.5			46.8
Proceeds received on sale of product rights		3.9			48.0
Proceeds from disposal of non-current investments and PP&E		0.9			8.0
Other, net		-			(2.9	)
Net cash used in investing activities (B)		(5,177.2	)		(3,690.2	)

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SHIRE PLC

UNAUDITED CONSOLIDATED STATEMENTS OF CASH FLOWS (continued)

3 months to March 31,	2015			2014
		$’M			$’M
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from revolving line of credit, long-term and short-term borrowings		2,230.0			2,170.0
Repayment of revolving line of credit		(535.2	)		(650.2	)
Repayment of debt acquired with ViroPharma Inc. (“ViroPharma”)		-			(533.9	)
Proceeds from ViroPharma call options		-			346.7
Excess tax benefit associated with exercise of stock options		19.9			20.5
Contingent consideration payments		(2.4	)		(7.8	)
Other, net		(3.2	)		0.2
Net cash provided by financing activities(C)		1,709.1			1,345.5
Effect of foreign exchange rate changes on cash and cash equivalents (D)		(1.6	)		(1.7	)
Net decrease in cash and cash equivalents(A+B+C+D)		(2,908.1	)		(2,100.3	)
Cash and cash equivalents at beginning of period		2,982.4			2,239.4
Cash and cash equivalents at end of period		74.3			139.1

Supplemental information associated with continuing
operations:
3 months to March 31,	2015			2014
		$’M			$’M
Interest paid		(5.0	)		(2.6	)
Income taxes repaid/(paid), net		48.8			(82.6	)

The accompanying notes are an integral part of these unaudited consolidated financial statements.

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SHIRE PLC

NOTES TO THE UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS

1.    Summary of Significant Accounting Policies

(a)    Basis of preparation

These interim financial statements of Shire plc and its subsidiaries (collectively “Shire” or the “Company”) and other financial information included in this Form 10-Q, are unaudited. They have been prepared in accordance with generally accepted accounting principles in the United States of America (“US GAAP”) and US Securities and Exchange Commission (“SEC”) regulations for interim reporting.

The balance sheet as at December 31, 2014 was derived from audited financial statements but does not include all disclosures required by US GAAP.

These interim financial statements should be read in conjunction with the consolidated financial statements and accompanying notes included in the Company’s Annual Report on Form 10-K for the year to December 31, 2014.

Certain information and footnote disclosures normally included in financial statements prepared in accordance with US GAAP have been condensed or omitted from these interim financial statements. However, these interim financial statements include all adjustments, which are, in the opinion of management, necessary to fairly state the results of the interim period and the Company believes that the disclosures are adequate to make the information presented not misleading. Interim results are not necessarily indicative of results to be expected for the full year.

(b)    Use of estimates in interim financial statements

The preparation of interim financial statements, in conformity with US GAAP and SEC regulations, requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the consolidated financial statements and reported amounts of revenues and expenses during the reporting period. Estimates and assumptions are primarily made in relation to the valuation of intangible assets, sales deductions, income taxes (including provisions for uncertain tax positions and the realization of deferred tax assets), provisions for litigation and legal proceedings, contingent consideration receivable from product divestments and contingent consideration payable in respect of business combinations and asset purchases. If actual results differ from the Company’s estimates, or to the extent these estimates are adjusted in future periods, the Company’s results of operations could either benefit from, or be adversely affected by, any such change in estimate.

(c)    New accounting pronouncements

Adopted during the period

Reporting Discontinued Operations and Disclosures of Disposals of Components of an Entity

In April 2014 the Financial Accounting Standard Board (“FASB”) issued guidance on the reporting of discontinued operations and disclosures of disposals of components of an entity. The amendments in this update revise the definition of discontinued operations by limiting discontinued operations reporting to disposals of components of an entity that represent strategic shifts that have (or will have) a major effect on an entity’s operations and financial results. The guidance requires expanded disclosures for discontinued operations which provide users of financial statements with more information about the assets, liabilities, revenues, and expenses of discontinued operations. The guidance also requires an entity to disclose the pre-tax profit or loss of an individually significant component of an entity that does not qualify for discontinued operations reporting.

Shire adopted this guidance in the period, which will be effective for discontinued operations occurring after January 1, 2015. The adoption of this guidance did not impact the Company’s consolidated financial position, results of operations or cash flows.

To be adopted in future periods

Revenue from Contracts with Customers

In May 2014 the FASB and the International Accounting Standards Board (together the “Accounting Standards Boards”) issued a new accounting standard that is intended to clarify and converge the financial reporting requirements for revenue

13

from contracts with customers. The core principle of the standard is that an “entity recognizes revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services”. To achieve that core principle the Accounting Standard Boards developed a five-step model (as presented below) and related application guidance, which will replace most existing revenue recognition guidance in US GAAP.

Five-step model:

Step 1: Identify the contract(s) with a customer.

Step 2: Identify the performance obligations in the contract.

Step 3: Determine the transaction price.

Step 4: Allocate the transaction price to the performance obligations in the contract.

Step 5: Recognize revenue when (or as) the entity satisfies a performance obligation.

The Accounting Standards Boards also issued new qualitative and quantitative disclosure requirements as part of the new accounting standard which aims to enable financial statement users to understand the nature, amount, timing, and uncertainty of revenue and cash flows arising from contracts with customers.

In April 2015 the FASB proposed to defer the effective date of the guidance by one year. Based on this proposal, public entities would need to apply the new guidance for annual reporting periods beginning after December 15, 2017, and interim periods therein. The Company is currently evaluating the impact of adopting this guidance.

Elimination of Certain Financial Reporting Requirements, Including an Amendment to Variable Interest Entities (“VIEs”) Guidance in Topic 810, Consolidation

In June 2014 the FASB issued guidance on the reporting requirements for development stage entities. The amendments in this update simplify the existing guidance by removing all incremental financial reporting requirements for development stage entities. The amendments also eliminate an exception provided with respect to development stage entities in Topic 810, Consolidation, for determining whether an entity is a VIE on the basis of the amount of equity that is at risk. The elimination of the exception may change the consolidation analysis, consolidation decision, and disclosure requirements for a reporting entity that has an interest in an entity in the development stage. The guidance to eliminate the exception to the sufficiency-of-equity-at-risk criterion for development stage entities should be applied retrospectively for annual reporting periods beginning after December 15, 2015, and interim periods therein. Early application of both of these amendments is permitted for any annual reporting period or interim period for which the entity’s financial statements have not yet been issued. The Company is currently evaluating the impact of adopting this guidance.

Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern

In August 2014 the FASB issued guidance about management’s responsibility to evaluate whether there is substantial doubt about an entity’s ability to continue as a going concern and to provide related footnote disclosures. An entity’s management should evaluate whether there are conditions or events, considered in the aggregate, that raise substantial doubt about the entity’s ability to continue as a going concern within one year after the date that the financial statements are issued (or within one year after the date that the financial statements are available to be issued when applicable). Management’s evaluation should be based on relevant conditions and events that are known and reasonably knowable at the date that the financial statements are issued (or available to be issued). Substantial doubt about an entity’s ability to continue as a going concern exists when relevant conditions and events, considered in the aggregate, indicate that it is probable that the entity will be unable to meet its obligations as they become due within one year after the date that the financial statements are issued (or available to be issued). The term probable is used consistently with its use in Topic 450, Contingencies. The amendments in this update are effective for the annual period ending after December 15, 2016, and for annual periods and interim periods thereafter. Early application is permitted. The Company does not expect the adoption of this guidance to have a material effect on its consolidated financial position, results of operations and cash flows.

Amendments to the Consolidation Analysis

In February 2015 the FASB issued guidance to respond to stakeholders’ concerns about the current accounting for consolidation of certain legal entities. Financial statement users asserted that in certain situations in which consolidation is ultimately required, deconsolidated financial statements are necessary to better analyze the reporting entity’s economic and operational results. Previously, the FASB issued an indefinite deferral for certain entities to partially address those concerns. However, the amendments in this guidance rescind that deferral and address those concerns by making changes to the consolidation guidance.

14

Under the amendments, all reporting entities are within the scope of Subtopic 810-10, Consolidation, including limited partnerships and similar legal entities, unless a scope exception applies. The presumption that a general partner controls a limited partnership has been eliminated. In addition, fees paid to decision makers that meet certain conditions no longer cause decision makers to consolidate a VIE in certain instances. The amendments place more emphasis in the consolidation evaluation on variable interests other than fee arrangements such as principal investment risk (for example, debt or equity interests), guarantees of the value of the assets or liabilities of the VIE, written put options on the assets of the VIE, or similar obligations, including some liquidity commitments or agreements (explicit or implicit). Additionally, the amendments reduce the extent to which related party arrangements cause an entity to be considered a primary beneficiary.

The amendments are effective for public business entities for fiscal years, and for interim periods therein, beginning after December 15, 2015. Early adoption is permitted, including adoption in an interim period. The Company does not expect the adoption of this guidance to have a material effect on its consolidated financial position, results of operations and cash flows.

Simplifying the Presentation of Debt Issuance Costs

In April 2015 the FASB issued guidance to simplify the presentation of debt issuance costs. The guidance requires that debt issuance costs related to a recognized debt liability be presented in the balance sheet as a direct deduction from the carrying amount of that debt liability, consistent with debt discounts. The recognition and measurement guidance for debt issuance costs are not affected by the amendments in this update. The amendments in this update are effective for financial statements issued for fiscal years beginning after December 15, 2015, and interim periods therein.

Early adoption of the amendments in this update is permitted for financial statements that have not been previously issued. An entity should apply the new guidance on a retrospective basis, wherein the balance sheet of each individual period presented should be adjusted to reflect the period-specific effects of applying the new guidance. Upon transition, an entity is required to comply with the applicable disclosures for a change in an accounting principle. The Company does not expect the adoption of this guidance to have a material effect on its consolidated financial position, results of operations and cash flows.

2.    Business combinations

Acquisition of NPS Pharmaceuticals Inc. (“NPS Pharma”)

On February 21, 2015 Shire completed its acquisition of 100% of the outstanding share capital of NPS Pharma. The acquisition-date fair value of cash consideration paid on closing was $5,218 million.

The acquisition of NPS Pharma added GATTEX/REVESTIVE, approved in the US and EU for the treatment of adults with short bowel syndrome (“SBS”), a rare and potentially fatal gastrointestinal disorder and NATPARA/NATPAR approved in the US for the treatment of hypoparathyroidism (“HPT”), a rare endocrine disease, to Shire’s portfolio of currently marketed products.

The acquisition of NPS Pharma has been accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from NPS Pharma have been recorded at their preliminary fair values at the date of acquisition, being February 21, 2015. The Company’s consolidated financial statements include the results of NPS Pharma from February 21, 2015.

The amount of NPS Pharma’s post-acquisition revenues and pre-tax losses included in the Company’s consolidated statement of income for the three months to March 31, 2015 were $26.2 million and $51.2 million respectively. The pre-tax loss includes charges on the unwind of inventory fair value adjustments of $9.9 million, intangible asset amortization of $30.1 million and integration costs of $17.4 million.

15

The Company’s preliminary allocation of the purchase price to the assets acquired and liabilities assumed is outlined below:

	Preliminary
	Fair value
		$’M
ASSETS
Current assets:
Cash and cash equivalents		41.6
Short-term investments		67.0
Accounts receivable		31.7
Inventories		51.1
Deferred tax assets		151.5
Other current assets		10.1
Total current assets		353.0
Non-current assets:
PPE		4.2
Goodwill		1,691.6
Other intangible assets
- currently marketed products		4,670.0
- royalty rights (categorized as "Other amortized intangible assets")		353.0
Total assets		7,071.8
LIABILITIES
Current liabilities:
Accounts payable and other current liabilities		72.5
Short-term debt		27.4
Non-current liabilities:
Long-term debt, less current portion		78.9
Deferred tax liabilities		1,671.0
Other non-current liabilities		4.2
Total liabilities		1,854.0
Fair value of identifiable assets acquired and liabilities assumed		5,217.8
Consideration
Cash consideration paid		5,217.8

The purchase price allocation is preliminary pending final determination of the fair values of certain assets and liabilities. In particular the fair values of inventories, intangible assets, assumed non-recourse debt obligations and current and deferred taxes are preliminary pending receipt of the final valuations for those items. The final determination of these fair values will be completed as soon as possible but no later than one year from the acquisition date.

(a) Other intangible assets – currently marketed products

Other intangible assets totaling $4,670.0 million relate to intellectual property rights acquired for NPS Pharma’s currently marketed products, primarily attributed to NATPARA/NATPAR, and GATTEX/REVESTIVE. The fair value of the currently marketed products is preliminary and has been estimated using an income approach, based on the present value of incremental after tax cash flows attributable to each separately identifiable intangible asset.

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The estimated useful lives of the NATPARA/NATPAR and GATTEX/REVESTIVE intangible assets are 24 years, with amortization being recorded on a straight-line basis.

(b) Other intangible assets – Royalty rights

Other intangibles totaling $353.0 million relate to the royalty rights arising from the collaboration agreements with Amgen, Janssen and Kyowa Hakko Kirin. Amgen markets cinacalcet HCl as Sensipar in the US and as Mimpara in the EU; Janssen Pharmaceuticals markets tapentadol as Nucynta in the US; and Kyowa Hakko Kirin markets cinacalcet HCI as Regpara in Japan, Hong Kong, Malaysia, Macau, Singapore, and Taiwan. NPS Pharma is entitled to royalties from the relevant net sales of these products.

The fair value of these royalty rights is preliminary and has been estimated using an income approach, based on the present value of incremental after tax cash flows attributable to each royalty right.

The estimated useful lives of these royalty rights range from 4 to 5 years (weighted average 4 years), with amortization being recorded on a straight-line basis.

 (c) Goodwill

Goodwill arising of $1,691.6 million, which is not deductible for tax purposes, includes the expected synergies that will result from combining the operations of NPS Pharma with the operations of Shire; particularly those synergies expected to be realized due to Shire’s structure; intangible assets that do not qualify for separate recognition at the time of the acquisition; and the value of the assembled workforce.

In the three months to March 31, 2015 the Company expensed costs of $69.9 million relating to the acquisition and post-acquisition integration of NPS Pharma, which have been recorded within Integration and acquisition costs in the Company’s consolidated statement of income.

Supplemental disclosure of pro forma information

The following unaudited pro forma financial information presents the combined results of the operations of Shire and NPS Pharma as if the acquisition of NPS Pharma had occurred as at January 1, 2014. The unaudited pro forma financial information is not necessarily indicative of what the consolidated results of operations actually would have been had the acquisition been completed at the date indicated. In addition, the unaudited pro forma financial information does not purport to project the future results of operations of the combined Company.

	3 months to			3 months to
	March 31,			March 31,
	2015			2014
		$’M			$’M
Revenues		1,518.3			1,390.8
Net income from continuing operations		358.8			85.8
Per share amounts:
Net income from continuing operations per share - basic		60.9	c		14.7	c
Net income from continuing operations per share - diluted		60.5	c		14.6	c

The unaudited pro forma financial information above reflects the following pro forma adjustments:

(i) an adjustment to decrease net income by $106.8 million for the period to March 31, 2014 to reflect acquisition costs incurred by Shire and NPS Pharma, and increase net income by $106.8 million for the period to March 31, 2015,  to eliminate acquisition costs incurred;

(ii) an adjustment to decrease net income by $6.1 million for the period to March 31 2014, to reflect charges on the unwind of inventory fair value adjustments as acquisition date inventory is sold, and a corresponding increase in net income for the period to March 31, 2015;

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(iii) an adjustment of $5.6 million in the period to March 31, 2014 to reflect additional interest expense associated with the drawdown of debt to partially finance the acquisition of NPS Pharma and the amortization of related deferred debt issuance costs;

(iv) an adjustment to increase amortization expense by approximately $21.1 million in the period to March 31, 2015 and $42.3 million in the period March 31, 2014 related to amortization of the fair value of identifiable intangible assets acquired and the elimination of NPS Pharma’s historical intangible asset amortization expense; and

(v) the tax effect of the above adjustments, where applicable.

Acquisition of Meritage Pharma Inc. (“Meritage”)

Prior to the acquisition of ViroPharma by Shire (see below), ViroPharma had entered into an exclusive development and option agreement with Meritage, a privately owned US company focusing on developing oral budesonide suspension (“OBS”) as a treatment for eosinophilic esophagitis. Under the terms of this agreement Meritage controlled and conducted all related research up to achievement of pre-defined development success criteria at which point ViroPharma had the option to acquire Meritage.

On February 18, 2015, following the exercise of the purchase option, Shire acquired all the outstanding equity of Meritage. The acquisition date fair value of the consideration totaled $166.9 million, comprising cash consideration paid on closing of $74.8 million and the fair value of contingent consideration payable of $92.1 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $175.0 million dependent upon achievement of certain clinical development and regulatory milestones.

With the Meritage acquisition, Shire has acquired the global rights to Meritage’s Phase 3-ready compound, OBS, for the treatment of adolescents and adults with eosinophilic esophagitis.

The acquisition of Meritage has been accounted for as a business combination using the acquisition method. The assets and liabilities assumed from Meritage have been recorded at their preliminary fair values at the date of acquisition, being February 18, 2015. The Company’s consolidated financial statements and results of operations include the results of Meritage from February 18, 2015.

The purchase price allocation is preliminary pending the determination of the fair values of certain assets and liabilities. The purchase price has been allocated on a preliminary basis to the OBS IPR&D intangible asset ($175 million), net current assets assumed ($5.5 million), net non-current liabilities assumed (including deferred tax liabilities) ($54.7 million) and goodwill ($41.1 million). Goodwill arising of $41.1 million is not deductible for tax purposes.

Unaudited pro forma financial information to present the combined results of operations of Shire and Meritage are not provided as the impact of this acquisition is not material to the Company’s results of operations for any period presented.

Acquisition of ViroPharma Incorporated

On January 24, 2014, Shire completed its acquisition of 100% of the outstanding share capital of ViroPharma. The acquisition-date fair value of cash consideration paid on closing was $3,997 million.

The acquisition of ViroPharma added CINRYZE to Shire’s portfolio of currently marketed products. CINRYZE is a leading brand for the prophylactic treatment of Hereditary Angioedema (“HAE”) in adolescents and adults.

The acquisition of ViroPharma has been accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from ViroPharma have been recorded at their fair values at the date of acquisition, being January 24, 2014. The Company’s consolidated financial statements include the results of ViroPharma from January 24, 2014.

The purchase price allocation was finalized in the fourth quarter of 2014. The Company’s allocation of the purchase price to the fair value of assets acquired and liabilities assumed is outlined below:

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	Acquisition date fair value
		$’M
Identifiable assets acquired and liabilities assumed
ASSETS
Current assets:
Cash and cash equivalents		232.6
Short-term investments		57.8
Accounts receivable		52.2
Inventories		203.6
Deferred tax assets		100.7
Purchased call option		346.7
Other current assets		50.9
Total current assets		1,044.5
Non-current assets:
PPE		24.7
Goodwill		1,655.5
Other intangible assets
- Currently marketed products		2,320.0
- In-Process Research and Development (“IPR&D”)		315.0
Other non-current assets		10.4
Total assets		5,370.1
LIABILITIES
Current liabilities:
Accounts payable and other current liabilities		122.7
Convertible bond		551.4
Non-current liabilities:
Deferred tax liabilities		603.5
Other non-current liabilities		95.5
Total liabilities		1,373.1
Fair value of identifiable assets acquired and liabilities assumed		3,997.0
Consideration
Cash consideration paid		3,997.0

(a) Other intangible assets – currently marketed products

Other intangible assets totaled $2,320.0 million at the date of acquisition, relating to intellectual property rights acquired for ViroPharma’s then currently marketed products, primarily attributed to CINRYZE, for the routine prophylaxis against HAE attacks in adolescent and adult patients. Shire also obtained intellectual property rights to three other commercialized products, PLENADREN, an orphan drug for the treatment of adrenal insufficiency in adults, BUCCOLAM, an oromucosal solution for the treatment of prolonged, acute, and convulsive seizures in infants, toddlers, children and adolescents and VANCOCIN, an oral capsule formulation for the treatment of C. difficile-associated diarrhea (“CDAD”), which was divested by Shire in the third quarter of 2014. The fair value of currently marketed products has been estimated using an income approach, based on the present value of incremental after tax cash flows attributable to each separately identifiable intangible asset.

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The estimated useful lives of the CINRYZE, PLENADREN and BUCCOLAM intangible assets range from 10 to 23 years (weighted average 22 years), with amortization being recorded on a straight-line basis.

(b) Other intangible assets – IPR&D

The IPR&D asset of $315.0 million relates to maribavir (now SHP620), an investigational antiviral product for cytomegalovirus. The fair value of this IPR&D asset was estimated based on an income approach, using the present value of incremental after tax cash flows expected to be generated by this development project after the deduction of contributory asset charges for other assets employed in this project. The estimated cash flows have been probability adjusted to take into account the stage of completion and the remaining risks and uncertainties surrounding the future development and commercialization.

The major risks and uncertainties associated with the timely completion of the acquired IPR&D project include  the ability to confirm the efficacy of the technology based on the data from clinical trials, and obtaining the relevant regulatory approvals as well as other risks as described in the Company’s Annual Report on Form 10-K. The valuation of IPR&D has been based on information available at the time of the acquisition (and information obtained during the measurement period) and on expectations and assumptions that (i) have been deemed reasonable by the Company’s management and (ii) are based on information, expectations and assumptions that would be available to a market participant. However, no assurance can be given that the assumptions and events associated with such assets will occur as projected. For these reasons, the actual cash flows may vary from forecast future cash flows.

The estimated probability adjusted after tax cash flows used in fair valuing other intangible assets have been discounted at rates ranging from 9.5% to 10.0%.

(c) Goodwill

Goodwill arising of $1,655.5 million, which is not deductible for tax purposes, includes the expected operational synergies that will result from combining the commercial operations of ViroPharma with those of Shire (valued at approximately $400 million); other synergies expected to be realized due to Shire’s structure; intangible assets that do not qualify for separate recognition at the time of the acquisition; and the value of the assembled workforce.

In the three months to March 31, 2015 the Company expensed costs of $3.3 million (2014: $65.8 million) relating to the acquisition and post-acquisition integration of ViroPharma, which have been recorded within Integration and acquisition costs in the Company’s consolidated statement of income.

3.    Reorganization costs

One Shire business reorganization

On May 2, 2013, the Company initiated the reorganization of its business to integrate the three divisions into a simplified One Shire organization in order to drive future growth and innovation.

In 2014 certain aspects of the One Shire program were temporarily put on hold due to AbbVie’s offer for Shire, which was terminated in October 2014. Subsequent to the termination of AbbVie’s offer, Shire announced on November 10, 2014 its plans to relocate over 500 positions to Lexington Massachusetts from its Chesterbrook, Pennsylvania, site and establish Lexington as the Company’s US operational headquarters in continuation of the One Shire efficiency program. This relocation will streamline business globally through two principal locations, Massachusetts and Switzerland, with support from regional and country-based offices around the world.

In the three months to March 31, 2015 the Company incurred reorganization costs totaling $15.2 million, relating to employee involuntary termination benefits and other reorganization costs. Reorganization costs of $260.7 million have been incurred since May 2013. The One Shire reorganization is expected to be substantially completed by the first quarter of 2016. Currently, the Company estimates that further costs in respect of the One Shire reorganization of approximately $115 million will be expensed as incurred during 2015 and 2016.

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The liability for reorganization costs arising from the One Shire business reorganization at March 31, 2015 is as follows:

	Opening liability		Amount					Closing liability at
	at January 1,		charged to re-					March 31,
	2015		organization		Paid/Utilized			2015
	$’M		$’M		$’M			$’M
Involuntary termination benefits		38.0		9.4		(5.1	)		42.3
Other reorganization costs		-		5.8		(5.0	)		0.8
		38.0		15.2		(10.1	)		43.1

At March 31, 2015 the closing reorganization cost liability was recorded within accounts payable and accrued expenses.

4.    Integration and acquisition costs

For the three months to March 31, 2015 Shire recorded integration and acquisition costs of $75.7 million primarily related to the acquisition and integration of NPS Pharma.

In the three months to March 31, 2014 integration and acquisition costs of $6.6 million primarily related to the acquisition and integration of ViroPharma ($65.8 million), offset by a net credit related to the change in fair values of contingent consideration liabilities ($59.2 million). The net credit arose principally due to the re-measurement of contingent consideration payable on the acquisition of FerroKin Biosciences, Inc. following the decision to place the ongoing Phase 2 clinical trial for SHP602 on hold.

5.    Accounts receivable, net

Accounts receivable at March 31, 2015 of $1,116.3 million (December 31, 2014: $1,035.1 million), are stated net of a provision for discounts and doubtful accounts of $46.7 million (December 31, 2014: $48.5 million).

Provision for discounts and doubtful accounts:

	2015			2014
		$’M			$’M
As at January 1,		48.5			47.9
Provision charged to operations		80.8			80.7
Provision utilization		(82.6	)		(81.2	)
As at March 31,		46.7			47.4

At March 31, 2015 accounts receivable included $57.2 million (December 31, 2014: $59.0 million) related to royalty income.

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6.    Inventories

Inventories are stated at the lower of cost or market. Inventories comprise:

	March 31,		December 31,
	2015		2014
		$’M		$’M
Finished goods		137.8		136.0
Work-in-progress		307.4		305.3
Raw materials		143.5		103.5
		588.7		544.8

7.    Results of discontinued operations

Following the divestment of the Company’s DERMAGRAFT business in January 2014, the operating results associated with the DERMAGRAFT business have been classified as discontinued operations in the consolidated statements of income for all periods presented. In the three months to March 31, 2015 the Company recorded a loss of $2.5 million, primarily relating to costs associated with the divestment. The components of discontinued operations which relate to the DERMAGRAFT business are as follows:

	3 months to			3 months to
	March 31,			March 31,
	2015			2014
Revenues:		$’M			$’M
Product revenues		-			1.9
Loss from discontinued operations before income taxes		(3.9	)		(35.8	)
Income taxes		1.4			13.1
Loss from discontinued operations, net of taxes		(2.5	)		(22.7	)

8.    Prepaid expenses and other current assets

	March 31,		December 31,
	2015		2014
		$’M		$’M
Prepaid expenses		72.9		36.9
Income tax receivable		68.8		121.5
Value added taxes receivable		15.0		13.8
Other current assets		59.9		49.3
		216.6		221.5

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9.    Goodwill

	March 31,		December 31,
	2015		2014
		$’M		$’M
Goodwill arising on businesses acquired		4,178.7		2,474.9

In the three months to March 31, 2015 the Company completed the acquisitions of NPS Pharma and Meritage, which resulted in aggregate goodwill with a preliminary value of $1,732.7 million (see Note 2 for details).

	2015			2014
		$’M			$’M
As at January 1,		2,474.9			624.6
Acquisitions		1,732.7			1,536.6
Foreign currency translation		(28.9	)		-
As at March 31,		4,178.7			2,161.2

10.    Other intangible assets, net

	March 31,			December 31,
	2015			2014
		$’M			$’M
Amortized intangible assets
Intellectual property rights acquired for currently marketed products		9,404.0			4,816.9
Other intangible assets		375.0			30.0
		9,779.0			4,846.9
Unamortized intangible assets
Intellectual property rights acquired for IPR&D		1,724.5			1,550.0
		11,503.5			6,396.9
Less: Accumulated amortization		(1,523.5	)		(1,462.5	)
		9,980.0			4,934.4

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The change in the net book value of other intangible assets for the three months to March 31, 2015 and 2014 is shown in the table below:

	Other intangible assets
	3 months to March 31, 2015			3 months to March 31, 2014
		$’M			$’M
As at January 1,		4,934.4			2,312.6
Acquisitions		5,198			2,854.0
Amortization charged		(88.3	)		(57.8	)
Impairment charges		-			(166.0	)
Foreign currency translation		(64.1	)		0.6
As at March 31,		9,980.0			4,943.4

In the three months to March 31, 2015 the Company acquired intangible assets totaling $5,198 million, relating to the fair value of intangible assets for currently marketed products and royalty right assets acquired with NPS Pharma of $5,023 million and IPR&D assets of $175 million acquired with Meritage (see Note 2 for further details).

The Company reviews its intangible assets for impairment whenever events or circumstances suggest that their carrying value may not be recoverable. Based on estimates and circumstances at March 31, 2015 the Company determined that its intangible assets remained recoverable.

On April 9, 2015 the Company announced that the 13-week Phase 2 IMAGO trial of its investigational compound SHP625 did not meet the primary or secondary endpoints in the study of 20 pediatric patients with Alagille syndrome (“ALGS”). As a result, it is possible that changes in estimates or circumstances in the second quarter of 2015 could result in an impairment loss being recorded in respect of the SHP625 IPR&D intangible asset, with a charge to R&D. The Company cannot currently estimate the amount of the impairment loss, if any. It is also possible that the fair value of the related contingent consideration payable from the Lumena acquisition (through which Shire acquired SHP625) will be reduced, with a credit to Integration and acquisition costs.

In the three months to March 31, 2014 the Company identified indicators of impairment in respect of its SHP602 (iron chelating agent for the treatment of iron overload secondary to chronic transfusion) IPR&D asset. The Company therefore reviewed the recoverability of its SHP602 IPR&D asset and recorded an impairment charge of $166.0 million within R&D expenses in the consolidated statement of income to record the SHP602 IPR&D asset to its revised fair value.

Management estimates that the annual amortization charge in respect of intangible assets held at March 31, 2015 will be approximately $481 million for each of the five years to March 31, 2020. Estimated amortization expense can be affected by various factors including future acquisitions, disposals of product rights, regulatory approval and subsequent amortization of acquired IPR&D projects, foreign exchange movements and the technological advancement and regulatory approval of competitor products.

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11.    Accounts payable and accrued expenses

	March 31,		December 31,
	2015		2014
		$’M		$’M
Trade accounts payable and accrued purchases		384.1		247.7
Accrued rebates – Medicaid		555.9		563.9
Accrued rebates – Managed care		306.8		318.2
Sales return reserve		134.8		131.7
Accrued bonuses		72.6		150.7
Accrued employee compensation and benefits payable		174.0		109.1
R&D accruals		55.9		88.3
Other accrued expenses		307.5		299.8
		1,991.6		1,909.4

12.    Other current liabilities

	March 31,		December 31,
	2015		2014
		$’M		$’M
Income taxes payable		25.8		16.2
Value added taxes		18.0		16.6
Contingent consideration payable		166.2		194.5
Other current liabilities		93.2		35.2
		303.2		262.5

13.    Borrowings

	March 31,		December 31,
	2015		2014
		$’M		$’M
Short term borrowings:
Borrowings under the 2015 Facility Agreement		850.0		-
Borrowings under the 2013 Facilities Agreement		850.0		850.0
Borrowings under the RCF		845.0		-
Secured non-recourse debts		25.2		-
		2,570.2		850.0
Long term borrowings:
Secured non-recourse debts		78.7		-
		2,648.9		850.0

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Term Loan Agreements

2015 Facility Agreement

On January 11, 2015, Shire entered into an $850 million Facility Agreement with, among others, CitiGroup Global Markets Limited (acting as mandated lead arranger and bookrunner) (the “2015 Facility Agreement”).  At March 31, 2015 the 2015 Facility Agreement was comprised of an $850 million term loan facility, which matures on January 10, 2016, and was fully utilized. The maturity date may be extended twice, at Shire’s option by six months on each occasion.

The 2015 Facility Agreement has been used to partially finance the purchase price payable in respect of Shire’s acquisition of NPS Pharma (including certain related costs). See the Company’s 2014 Annual Report on Form 10-K for details of the 2015 Facility Agreement. 

2013 Facilities Agreement

On November 11, 2013, Shire entered into a $2,600 million facilities agreement with, among others, Morgan Stanley Bank International Limited (acting as mandated lead arranger and bookrunner) (the “2013 Facilities Agreement”).  The 2013 Facilities Agreement comprised two credit facilities: (i) a $1,750 million term loan facility and (ii) a $850 million term loan facility.  

On December 13, 2013 and at various points during the year to December 31, 2014, the Company cancelled part of the $2,600 million term loan facility. At March 31, 2015 the 2013 Facilities Agreement was comprised of an $850 million term loan facility which matures on November 11, 2015 and was fully utilized.

The $850 million remaining borrowing from the 2013 Facilities Agreement was used to partially finance the purchase price payable in respect of Shire’s acquisition of ViroPharma (including certain related costs) during the year ended December 31, 2014. See the Company’s 2014 Annual Report on Form 10-K for details of the 2013 Facilities Agreement.

Revolving Credit Facility (“RCF”)

On December 12, 2014, Shire entered into a $2,100 million RCF with a number of financial institutions. See the Company’s 2014 Annual Report on Form 10-K for details. At March 31, 2015 the Company has utilized $845 million of the RCF to partially finance the purchase price payable in respect of Shire’s acquisition of NPS Pharma (including certain related costs).

The RCF, which terminates on December 12, 2019, may be applied towards financing the general corporate purposes of Shire. The RCF incorporates a $250 million US dollar and euro swingline facility operating as a sub-limit thereof.

Secured Non-recourse Debts

Prior to the acquisition by Shire, NPS Pharma had:

· partially monetized rights to receive future royalty payments from Amgen’s sales of SENSIPAR and MIMPARA through the issuance of $145 million of non-recourse debt that is both serviced and secured by SENSIPAR and MIMPARA royalty revenue;

· sold to DRI Capital Inc. (“DRI”) certain rights to receive up to $96 million of future royalty payments arising from Kyowa Hakko Kirin’s sales of REGPARA and granted DRI a security interest in the license agreement with Kyowa Hakko Kirin, certain patents  and other intellectual property related to REGPARA which DRI would be entitled to enforce in the event of default by NPS Pharma; and

· partially monetized PTH-184 (now marketed as NATPARA) through an agreement with an affiliate of DRI pursuant to which NPS Pharma, its licensees and its predecessors in interest, are obligated to pay up to $125 million royalties on sales of PTH-184. Additionally, NPS Pharma granted DRI a security interest in certain patents and other intellectual property related to PTH 1-84 which DRI would be entitled to enforce in the event of default by NPS Pharma.

Following the acquisition of NPS Pharma the Company has assumed these secured non-recourse debt obligations.

The acquisition-date fair value of these debt obligations is preliminary pending the receipt of final valuations for these liabilities. The preliminary acquisition-date fair value of these non-recourse debt obligations totals $106.3 million. As at March 31, 2015 $25.2 million has been included within Short-term borrowings, and $78.7 million has been included within Long-term borrowings in respect of these obligations.

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14.    Other non-current liabilities

	March 31,		December 31,
	2015		2014
		$’M		$’M
Income taxes payable		180.7		199.2
Deferred revenue		6.7		7.2
Deferred rent		6.2		6.6
Contingent consideration payable		557.8		435.4
Other non-current liabilities		92.6		88.3
		844.0		736.7

15.    Commitments and contingencies

(a)    Leases

Future minimum lease payments under operating leases at March 31, 2015 are presented below:

	Operating
	leases
		$’M
2015		30.6
2016		26.4
2017		30.2
2018		25.4
2019		19.4
2020		19.3
Thereafter		125.2
		276.5

The Company leases land, facilities, motor vehicles and certain equipment under operating leases expiring through 2032. Lease and rental expense amounted to $14.2 million and $13.2 million for the three months to March 31, 2015 and 2014 respectively, which is predominately included in SG&A expenses in the Company’s consolidated income statement.

(b)    Letters of credit and guarantees

At March 31, 2015 the Company had irrevocable standby letters of credit and guarantees with various banks and insurance companiestotaling $46 million (being the contractual amounts), providing security for the Company’s performance of various obligations. These obligations are primarily in respect of the recoverability of insurance claims, lease obligations and supply commitments.

(c)    Collaborative and other licensing arrangements

Details of significant updates in collaborative and other licensing arrangements are included below:

Out-licensing arrangements

Shire has entered into various collaborative and out-licensing arrangements under which the Company has out-licensed certain product or intellectual property rights for consideration such as up-front payments, development milestones, sales milestones and/or royalty payments. In some of these arrangements Shire and the licensee are both actively involved in the development and commercialization of the licensed product and have exposure to risks and rewards dependent on its commercial success. Under the terms of these collaborative and out-licensing arrangements, the Company may receive development milestone payments up to an aggregate amount of $39 million and sales milestones up to an aggregate

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amount of $46 million. The receipt of these substantive milestones is uncertain and contingent on the achievement of certain development milestones or the achievement of a specified level of annual net sales by the licensee. In the three months to March 31, 2015 Shire received cash in respect of up-front and milestone payments totaling $12.6 million (2014: $1.0 million). In the three months to March 31, 2015 Shire recognized milestone income of $0.5 million (2014: $1.5 million) in other revenues and $9.2 million (2014: $12.5 million) in product sales for shipment of product to the relevant licensee.

(d)    Commitments

(i)    Clinical testing

At March 31, 2015 the Company had committed to pay approximately $402 million (December 31, 2014: $382 million) to contract vendors for administering and executing clinical trials. The timing of these payments is dependent upon actual services performed by the organizations as determined by patient enrollment levels and related activities.

(ii)    Contract manufacturing

At March 31, 2015 the Company had committed to pay approximately $397 million (December 31, 2014: $384 million) in respect of contract manufacturing. The Company expects to pay $154 million of these commitments in 2015.

(iii)    Other purchasing commitments

At March 31, 2015 the Company had committed to pay approximately $320 million (December 31, 2014: $265 million) for future purchases of goods and services, predominantly relating to active pharmaceutical ingredients sourcing. The Company expects to pay $306 million of these commitments in 2015.

(iv)    Investment commitments

At March 31, 2015 the Company had outstanding commitments to subscribe for interests in companies and partnerships for amounts totaling $58 million (December 31, 2014: $67 million) which may all be payable in 2015, depending on the timing of capital calls. The investment commitments include additional funding to certain VIEs of which Shire is not the primary beneficiary.

(v)    Capital commitments

At March 31, 2015 the Company had committed to spend $9 million (December 31, 2014: $3 million) on capital projects.

(e)    Legal and other proceedings

The Company expenses legal costs as they are incurred.

The Company recognizes loss contingency provisions for probable losses when management is able to reasonably estimate the loss. When the estimated loss lies within a range, the Company records a loss contingency provision based on its best estimate of the probable loss. If no particular amount within that range is a better estimate than any other amount, the minimum amount is recorded.  Estimates of losses may be developed substantially before the ultimate loss is known, and are therefore refined each accounting period as additional information becomes known. In instances where the Company is unable to develop a reasonable estimate of loss, no loss contingency provision is recorded at that time. As information becomes known a loss contingency provision is recorded when a reasonable estimate can be made. The estimates are reviewed quarterly and the estimates are changed when expectations are revised. An outcome that deviates from the Company’s estimate may result in an additional expense or release in a future accounting period. At March 31, 2015, provisions for litigation losses, insurance claims and other disputes totaled $26.0 million (December 31, 2014: $16.9 million).

The Company’s principal pending legal and other proceedings are disclosed below. The outcomes of these proceedings are not always predictable and can be affected by various factors. For those legal and other proceedings for which it is considered at least reasonably possible that a loss has been incurred, the Company discloses the possible loss or range of possible loss in excess of the recorded loss contingency provision, if any, where such excess is both material and estimable.

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VYVANSE

In May and June 2011, Shire was notified that six separate Abbreviated New Drug Applications ("ANDAs") were submitted under the Hatch-Waxman Act seeking permission to market generic versions of all approved strengths of VYVANSE. The notices were from Sandoz, Inc. ("Sandoz"); Amneal Pharmaceuticals LLC ("Amneal"); Watson Laboratories, Inc; Roxane Laboratories, Inc. ("Roxane"); Mylan Pharmaceuticals, Inc.; and Actavis Elizabeth LLC and Actavis Inc. (collectively, "Actavis").  Since filing suit against these ANDA filers, along with API suppliers Johnson Matthey Inc. and Johnson Matthey Pharmaceuticals Materials (collectively “Johnson Matthey”), Shire has been engaged in a consolidated patent infringement litigation in the US District Court for the District of New Jersey against the aforementioned parties (except Watson Laboratories, Inc., who withdrew their ANDA).

On June 23, 2014, the US District Court for the District of New Jersey granted Shire’s summary judgment motion holding that 18 claims of the patents-in-suit were both infringed and valid.  The ruling prevents all of the ANDA filers (Sandoz, Roxane, Amneal, Actavis and Mylan) from launching generic versions of VYVANSE until the earlier of either a successful appeal to the US Court of Appeals for the Federal Circuit (“CAFC”), or the expiration of these patents in 2023.  To appeal successfully, the ANDA-defendants must overturn the court’s rulings for each of these 18 patent claims. All of the defendants have appealed the court’s summary judgment ruling to the CAFC.  Oral argument has been scheduled to occur on May 6, 2015.

LIALDA

In May 2010, Shire was notified that Zydus Pharmaceuticals USA, Inc. (“Zydus”) had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the District of Delaware against Zydus and Cadila Healthcare Limited, doing business as Zydus Cadila. A Markman hearing took place on January 29, 2015. The previously scheduled trial date has been vacated; at present, there is no trial date.

In February 2012, Shire was notified that Osmotica Pharmaceutical Corporation ("Osmotica") had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Northern District of Georgia against Osmotica. A Markman hearing took place on August 22, 2013 and a Markman ruling was issued on September 25, 2014. The Court issued an Order on February 27, 2015 in which all dates in the scheduling order have been stayed.

In March 2012, Shire was notified that Watson Laboratories Inc.-Florida had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Southern District of Florida against Watson Laboratories Inc.-Florida and Watson Pharmaceuticals, Inc. Watson Pharma, Inc. and Watson Laboratories, Inc. were subsequently added as defendants.  A trial took place in April, 2013 and on May 9, 2013 the trial court issued a decision finding that the proposed generic product infringes the patent-in-suit and that the patent is not invalid.  Watson appealed the trial court’s ruling to the CAFC and a hearing took place on December 2, 2013.  The ruling of the CAFC was issued on March 28, 2014 overruling the trial court on the interpretation of two claim terms and remanding the case for further proceedings.  Shire petitioned the Supreme Court for a writ of certiori, which was granted on January 26, 2015.  The Supreme Court also vacated the CAFC decision and remanded the case to the CAFC for further consideration in light of the Supreme Court’s recent decision in Teva v Sandoz.    The remanded case has been briefed to the CAFC.  No dates have been set for oral argument.

In April 2012, Shire was notified that Mylan Pharmaceuticals, Inc. had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Middle District of Florida against Mylan. A Markman hearing took place on December 22, 2014. A trial is scheduled during the court’s trial term beginning on September 1, 2015.

In March 2015, Shire was notified that Amneal Pharmaceuticals LLC had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the District of New Jersey against Amneal Pharmaceuticals LLC, Amneal Pharmaceuticals of New York, LLC and Amneal Pharmaceuticals Co. India Pvt. Ltd.  No trial date has been set.

Investigation related to DERMAGRAFT

The Department of Justice, including the US Attorney’s Office for the Middle District of Florida, Tampa Division and the US Attorney’s Office for Washington, DC, is conducting civil and criminal investigations into the sales and marketing practices of Advanced BioHealing Inc. (“ABH”) relating to DERMAGRAFT.

Following the disposal of the DERMAGRAFT business in January 2014, Shire has retained certain legacy liabilities including any liability that may arise from this investigation. Shire is cooperating fully with these investigations. Shire is not in a position at this time to predict the scope, duration or outcome of these investigations.

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Civil Investigative Demand relating to VANCOCIN

On April 6, 2012, ViroPharma received a notification that the United States Federal Trade Commission (“FTC”) is conducting an investigation into whether ViroPharma had engaged in unfair methods of competition with respect to VANCOCIN. On August 3, 2012, and September 8, 2014, ViroPharma and Shire respectively received Civil Investigative Demands from the FTC requesting additional information related to this matter. Shire intends to continue to cooperate fully with the FTC investigation. At this time, Shire is unable to predict the outcome or duration of this investigation.

Lawsuit related to supply of ELAPRASE to certain patients in Brazil

On September 24, 2014 Shire’s Brazilian affiliate, Shire Farmaceutica Brasil Ltda, was served with a lawsuit brought by the State of Sao Paulo and in which the Brazilian Public Attorney’s office has intervened alleging that Shire is obligated to provide certain medical care including ELAPRASE for an indefinite period at no cost to patients who participated in ELAPRASE clinical trials in Brazil, and seeking recoupment to the Brazilian government for amounts paid for these patients to date, and moral damages associated with these claims.  Shire intends to defend itself against these allegations but is not able to predict the outcome or duration of this case.

16.    Accumulated Other Comprehensiveloss

The changes in accumulated other comprehensive loss, net of their related tax effects, in the year to March 31, 2015 and 2014 are included below:

	Foreign currency translation adjustment			Unrealized holding loss on available-for- sale securities			Accumulated other comprehensive loss
		$M			$M			$M
As at January 1, 2015		(25.7	)		(5.8	)		(31.5	)
Net current period other comprehensive (loss)/income		(129.5	)		0.7			(128.8	)
As at March 31, 2015		(155.2	)		(5.1	)		(160.3	)

As at March 31, 2014	Foreign currency translation adjustment			Unrealized holding gain/(loss) on available-for-sale securities			Accumulated other comprehensive income
		$M			$M			$M
As at January 1, 2014		110.4			(0.2	)		110.2
Current period change:
Other comprehensive income before reclassification		(1.7	)		7.5			5.8
Gain transferred to the income statement (within Other income, net) on disposal of available-for-sale securities		-			(3.2	)		(3.2	)
Net current period other comprehensive income		(1.7	)		4.3			2.6
As at March 31, 2014		108.7			4.1			112.8

17.    Financial instruments

Treasury policies and organization

The Company’s principal treasury operations are coordinated by its corporate treasury function. All treasury operations are conducted within a framework of policies and procedures approved annually by the Board. As a matter of policy, the Company does not undertake speculative transactions that would increase its currency or interest rate exposure.

Interest rate risk

The Company is principally exposed to interest rate risk on borrowings under its $2,100 million RCF, its $850 million 2013 Facilities Agreement and its $850 million 2015 Facility Agreement, on which interest is set at floating rates, to the extent any of these facilities are utilized. At March 31, 2015 the Company had fully utilized the 2013 Facilities Agreement, fully utilized the 2015 Facility Agreement and utilized $845 million of the RCF. Shire’s exposure under its 2013 Facilities Agreement, 2015 Facility Agreement and RCF is to US dollar interest rates.

The Company has evaluated the interest rate risk on the RCF, the 2013 Facilities Agreement and the 2015 Facility Agreement and considers the risks associated with floating interest rates on borrowings under its facilities as appropriate. A hypothetical one percentage point increase or decrease in the interest rates applicable to drawings under the 2013 Facilities Agreement, 2015 Facility Agreement and RCF at March 31, 2015 would increase interest expense by approximately $25 million per annum and would decrease the interest expense by approximately $5 million per annum.

The Company is also exposed to interest rate risk on its restricted cash, cash and cash equivalents and on foreign exchange contracts on which interest is set at floating rates. This exposure is primarily limited to US dollar, Pounds sterling and Euro interest rates. As the Company maintains all of its cash, liquid investments and foreign exchange contracts on a short term basis for liquidity purposes, this risk is not actively managed. In the three months to March 31, 2015 the average

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interest rate received on cash and liquid investments was less than 1% per annum. The largest proportion of these cash and liquid investments was in US dollar money market and liquidity funds.

No derivative instruments were entered into during the three months to March 31, 2015 to manage interest rate exposure. The Company continues to review its interest rate risk and the policies in place to manage the risk.

Credit risk

Financial instruments that potentially expose Shire to concentrations of credit risk consist primarily of short-term cash investments, derivative contracts and trade accounts receivable (from product sales and from third parties from which the Company receives royalties). Cash is invested in short-term money market instruments, including money market and liquidity funds and bank term deposits. The money market and liquidity funds in which Shire invests are all triple A rated by both Standard and Poor’s and by Moody’s credit rating agencies.

The Company is exposed to the credit risk of the counterparties with which it enters into derivative instruments. The Company limits this exposure through a system of internal credit limits which vary according to ratings assigned to the counterparties by the major rating agencies. The internal credit limits are approved by the Board and exposure against these limits is monitored by the corporate treasury function. The counterparties to these derivatives contracts are major international financial institutions.

The Company’s revenues from product sales in the US are mainly governed by agreements with major pharmaceutical wholesalers and relationships with other pharmaceutical distributors and retail pharmacy chains. For the year to December 31, 2014 there were three customers in the US that accounted for 47% of the Company’s product sales. However, such customers typically have significant cash resources and as such the risk from concentration of credit is considered acceptable. The Company has taken positive steps to manage any credit risk associated with these transactions and operates clearly defined credit evaluation procedures. However, an inability of one or more of these wholesalers to honor their debts to the Company could have an adverse effect on the Company’s financial condition and results of operations.

A substantial portion of the Company’s accounts receivable in countries outside of the United States is derived from product sales to government-owned or government-supported healthcare providers. The Company’s recovery of these accounts receivable is therefore dependent upon the financial stability and creditworthiness of the relevant governments.  In recent years global and national economic conditions have negatively affected the growth, creditworthiness and general economic condition of certain markets in which the Company operates.  As a result, in some countries outside of the US, specifically, Argentina, Greece, Italy, Portugal and Spain (collectively the “Relevant Countries”)  the Company is experiencing delays in the remittance of receivables due from government-owned or government-supported healthcare providers. The Company continued to receive remittances in relation to government-owned or government-supported healthcare providers in all the Relevant Countries in the three months to March 31, 2015, including receipts of $17.1 million and $17.4 million in respect of Spanish and Italian receivables, respectively.

To date the Company has not incurred significant losses on accounts receivable in the Relevant Countries, and continues to consider that such accounts receivable are recoverable. The Company will continue to evaluate all its accounts receivable for potential collection risks and has made provision for amounts where collection is considered to be doubtful. If the financial condition of the Relevant Countries or other Eurozone countries suffer significant deterioration, such that their ability to make payments becomes uncertain, or if one or more Eurozone member countries withdraws from the Euro, additional allowances for doubtful accounts may be required, and losses may be incurred, in future periods. Any such loss could have an adverse effect on the Company’s financial condition and results of operations.

Foreign exchange risk

The Company trades in numerous countries and as a consequence has transactional and translational foreign exchange exposures.

Transactional exposure arises where transactions occur in currencies different to the functional currency of the relevant subsidiary. The main trading currencies of the Company are the US dollar, Pounds Sterling, Swiss Franc, Canadian dollar and the Euro. It is the Company’s policy that these exposures are minimized to the extent practicable by denominating transactions in the subsidiary’s functional currency.

Where significant exposures remain, the Company uses foreign exchange contracts (being spot, forward and swap contracts) to manage the exposure for balance sheet assets and liabilities that are denominated in currencies different to the functional currency of the relevant subsidiary. These assets and liabilities relate predominantly to inter-company financing. The foreign exchange contracts have not been designated as hedging instruments. Cash flows from derivative instruments are presented within net cash provided by operating activities in the consolidated cash flow statement, unless the derivative instruments are economically hedging specific investing or financing activities.

Translational foreign exchange exposure arises on the translation into US dollars of the financial statements of non-US dollar functional subsidiaries.

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At March 31, 2015 the Company had 40 swap and forward foreign exchange contracts outstanding to manage currency risk.  The swap and forward contracts mature within 90 days. The Company did not have credit risk related contingent features or collateral linked to the derivatives.  The Company has master netting agreements with a number of  counterparties to these foreign exchange contracts and on the occurrence of specified events, the Company has the ability to terminate contracts and settle them with a net payment by one party to the other. The Company has elected to present derivative assets and derivative liabilities on a gross basis in the consolidated balance sheet. As at March 31, 2015 the potential effect of rights of set-off associated with the foreign exchange contracts would be an offset to both assets and liabilities of $1.5 million, resulting in net derivative assets and derivative liabilities of $9.4 million and $4.0 million, respectively. Further details are included below:

		Fair value		Fair value
		March 31,		December 31,
		2015		2014
			$’M		$’M
Assets	Prepaid expenses and other current assets		10.9		12.6
Liabilities	Other current liabilities		5.5		7.8

Net gains (both realized and unrealized) arising on foreign exchange contracts have been classified in the consolidated statements of income as follows:

	Location of net gains recognized in income	Amount of net gains recognized in income
In the three months to		March 31,		March 31,
		2015		2014
			$’M		$’M
Foreign exchange contracts	Other income, net		16.3		1.8

These net foreign exchange gains are offset within Other income, net by net foreign exchange (losses)/gains arising on the balance sheet items that these contracts were put in place to manage.

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18.    Fair value measurement

Assets and liabilities that are measured at fair value on a recurring basis

As at March 31, 2015 and December 31, 2014 the following financial assets and liabilities are measured at fair value on a recurring basis using quoted prices in active markets for identical assets (Level 1); significant other observable inputs (Level 2); and significant unobservable inputs (Level 3).

	Carrying value and Fair value
	Total		Level 1		Level 2		Level 3
At March 31, 2015	$’M		$’M		$’M		$’M
Financial assets:
Available-for-sale securities(1)		26.4		26.4		-		-
Contingent consideration receivable (2)		15.0		-		-		15.0
Foreign exchange contracts		10.9		-		10.9		-
Financial liabilities:
Foreign exchange contracts		5.5		-		5.5		-
Contingent consideration payable(3)		724.0		-		-		724.0
	Total		Level 1		Level 2		Level 3
At December 31, 2014	$’M		$’M		$’M		$’M
Financial assets:
Available-for-sale securities(1)		13.1		13.1		-		-
Contingent consideration receivable (2)		15.9		-		-		15.9
Foreign exchange contracts		12.6		-		12.6		-
Financial liabilities:
Foreign exchange contracts		7.8		-		7.8		-
Contingent consideration payable(3)		629.9		-		-		629.9

(1)  Available-for-sale securities are included within Investments and Prepaid expenses and other current assets in the consolidated balance sheet.

(2) Contingent consideration receivable is included within Prepaid expenses and other current assets and Other non-current assets in the consolidated balance sheet.

(3) Contingent consideration payable is included within Other current liabilities and Other non-current liabilities in the consolidated balance sheet.

Certain estimates and judgments were required to develop the fair value amounts. The fair value amounts shown above are not necessarily indicative of the amounts that the Company would realize upon disposition, nor do they indicate the Company’s intent or ability to dispose of the financial instrument.

The following methods and assumptions were used to estimate the fair value of each material class of financial instrument:

· Available-for-sale securities – the fair values of available-for-sale securities are estimated based on quoted market prices for those investments.

· Contingent consideration receivable – the fair value of the contingent consideration receivable has been estimated using the income approach (using a probability weighted discounted cash flow method).

· Foreign exchange contracts – the fair values of the swap and forward foreign exchange contracts have been determined using an income approach based on current market expectations about the future cash flows.

· Contingent consideration payable – the fair value of the contingent consideration payable has been estimated using the income approach (using a probability weighted discounted cash flow method).

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Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs (Level 3)

The change in the fair value of the Company’s contingent consideration receivable and payables, which are measured at fair value on a recurring basis using significant unobservable inputs (Level 3), are as follows:

Contingent consideration receivable

	2015			2014
	$’M			$’M
Balance at January 1,		15.9			36.1
Initial recognition of contingent consideration receivable		-			33.6
Gain/(loss) recognized in the income statement (within Gain on sale of product rights) due to change in fair value during the period		5.2			(7.1	)
Reclassification of amounts to Other receivables within Other current assets		(5.9	)		(4.0	)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)		0.2			0.8
Balance at March 31,		15.0			59.4
Contingent consideration payable
		2015			2014
	$’M			$’M
Balance at January 1,		629.9			405.9
Initial recognition of contingent consideration payable		92.1			10.0
Change in fair value during the period with the corresponding adjustment recognized as a loss in the income statement (within Integration and acquisition costs)		2.4			(59.2	)
Reclassification of amounts to Other current liabilities		(2.1	)		(2.4	)
Change in fair value during the period with corresponding adjustment to the associated intangible asset		(0.7	)		(4.0	)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)		2.4			-
Balance at March 31,		724.0			350.3

Of the $724.0 million of contingent consideration payable as at March 31, 2015 $166.2 million is recorded within other current liabilities and $557.8 million is recorded within other non-current liabilities in the Company’s balance sheet

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Quantitative Information about Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs (Level 3)

Quantitative information about the Company’s recurring Level 3 fair value measurements is included below:

Financial assets:	Fair Value at the Measurement Date
At March 31, 2015	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$’M
Contingent consideration receivable ("CCR")	15.0	Income approach (probability weighted discounted cash flow)	• Probability weightings applied to different sales scenarios • Future forecast consideration receivable based on contractual terms with purchaser • Assumed market participant discount rate	• 10 to 70% • $25 million to $33 million • 8.3% to 11.5%
Financial liabilities:	Fair Value at the Measurement Date
At March 31, 2015	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$’M
Contingent consideration payable	724.0	Income approach (probability weighted discounted cash flow)	• Cumulative probability of  milestones being achieved • Assumed market participant discount rate • Periods in which milestones are expected to be achieved • Forecast quarterly royalties payable on net sales of relevant products	• 4 to 95% • 0.6 to 11.8% • 2015 to 2030 • $0.2 to $7.6 million

The Company re-measures the CCR (relating to contingent consideration due to the Company following divestment of certain of the Company’s products) at fair value at each balance sheet date, with the fair value measurement based on forecast cash flows, over a number of scenarios which vary depending on the expected performance outcome of the products following divestment. The forecast cash flows under each of these differing outcomes have been included in probability weighted estimates used by the Company in determining the fair value of the CCR.

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Contingent consideration payable represents future milestones the Company may be required to pay in conjunction with various business combinations and future royalties payable as a result of certain business combinations and licenses. The amount ultimately payable by Shire in relation to business combinations is dependent upon the achievement of specified future milestones, such as the achievement of certain future development, regulatory and sales milestones. The Company assesses the probability, and estimated timing, of these milestones being achieved and re-measures the related contingent consideration to fair value each balance sheet date. The amount of contingent consideration which may ultimately be payable by Shire in relation to future royalties is dependent upon future net sales of the relevant products over the life of the royalty term. The Company assesses the present value of forecast future net sales of the relevant products and re-measures the related contingent consideration to fair value each balance sheet date.

The fair value of the Company’s contingent consideration receivable and payable could significantly increase or decrease due to changes in certain assumptions which underpin the fair value measurements. Each set of assumptions and milestones is specific to the individual contingent consideration receivable or payable. The assumptions include, among other things, the probability and expected timing of certain milestones being achieved, the forecast future net sales of the relevant products and related future royalties payable, the probability weightings applied to different sales scenarios of the Company’s divested products and forecast future royalties receivable under scenarios developed by the Company, and the discount rates used to determine the present value of contingent future cash flows. The Company regularly reviews these assumptions, and makes adjustments to the fair value measurements as required by facts and circumstances.

The carrying amounts of other financial assets and liabilities materially approximate to their fair value either because of the short-term maturity of these amounts or because there have been no significant changes since the asset or liability was last re-measured to fair value on a non-recurring basis.

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19.    Earnings per share

The following table reconciles net income and the weighted average ordinary shares outstanding for basic and diluted earnings per share for the periods presented:

	3 months to			3 months to
	March 31,			March 31,
	2015			2014
		$’M			$’M
Income from continuing operations, net of taxes		412.9			253.1
Loss from discontinued operations1		(2.5	)		(22.7	)
Numerator for basic and diluted earnings per share		410.4			230.4
Weighted average number of shares:
	Millions			Millions
Basic 1		589.1			584.3
Effect of dilutive shares:
Share-based awards to employees 2		3.6			4.5
Diluted		592.7			588.8

1. Excludes shares purchased by the EBT and presented by Shire as treasury stock.

2. Calculated using the treasury stock method.

The share equivalents not included in the calculation of the diluted weighted average number of shares are shown below:

	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	No. of shares	No. of shares
	Millions	Millions
Share-based awards to employees1	1.4	0.8

1. Certain stock options have been excluded from the calculation of diluted EPS because (a) their exercise prices exceeded Shire plc’s average share price during the calculation period or (b) the required performance conditions were not satisfied as at the balance sheet date.

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20.    Segmental reporting

Shire comprises a single operating and reportable segment engaged in the research, development, licensing, manufacturing, marketing, distribution and sale of innovative specialist medicines to meet significant unmet patient needs.

This segment is supported by several key functions: a Pipeline group, consisting of R&D and Corporate Development, which prioritizes its activities towards late-stage development programs across a variety of therapeutic areas, while focusing its pre-clinical development activities primarily in Rare Diseases; a Technical Operations group responsible for the Company’s global supply chain; and an In-line marketed products group which focuses on commercialized products. The In-Line marketed products group has commercial units that focus exclusively on the commercial execution of its marketed products including in the areas of Rare Diseases, Neuroscience, and Gastrointestinal (“GI”) and Internal Medicine, and to support the development of our pipeline candidates, in Ophthalmics. This ensures that the Company provides innovative treatments, and services the needs of its customers and patients, as efficiently as possible. The business is also supported by a simplified, centralized corporate function group. None of these functional groups meets all of the criteria to be an operating segment.

This single operating and reportable segment is consistent with the financial information regularly reviewed by the Executive Committee (which is Shire’s chief operating decision maker) for the purposes of evaluating performance, allocating resources, and planning and forecasting future periods.

In the periods set out below, revenues by major product were as follows:

3 months to	March 31,		March 31,
	2015		2014
		$’M		$’M
VYVANSE		416.8		351.2
LIALDA/MEZAVANT		148.5		128.9
CINRYZE		148.1		85.6
ELAPRASE		125.0		128.6
REPLAGAL		97.5		114.3
ADDERALL XR		95.7		85.1
FIRAZYR		92.5		74.9
VPRIV		86.4		86.9
PENTASA		78.7		72.3
FOSRENOL		44.1		41.4
XAGRID		25.3		27.1
INTUNIV		17.4		82.3
GATTEX/REVESTIVE		14.9		-
Other product sales		32.3		29.5
Total product sales		1,423.2		1,308.1

21.    Related parties

Shire considers that ArmaGen, Inc. (“ArmaGen”) is a related party by virtue of a combination of Shire’s equity stake in ArmaGen and the worldwide licensing and collaboration agreement between the two parties to develop and commercialize AGT-182. In the three months to March 31, 2015 Shire paid $2.5 million in cash to ArmaGen in exchange for an additional equity stake in ArmaGen, following which Shire holds approximately 21% of ArmaGen’s issued equity. In addition, Shire recorded a credit to R&D costs of $0.4 million in the first quarter of 2015, reflecting the Company’s share of expenditure under the licensing and collaboration arrangement. No amounts were due to or from ArmaGen as at March 31, 2015.

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ITEM 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

The following discussion should be read in conjunction with Shire’s unaudited consolidated financial statements and related notes appearing elsewhere in this report.

Significant events in the three months to March 31, 2015 and recent developments

Products

The Company has made good progress with its product portfolio in the quarter, launching VYVANSE in an important new indication, approval of NATPARA was achieved and the Company extended the range of doses available for VYVANSE.

VYVANSE– for the treatment of Binge Eating Disorder (“BED”) in adults

· On January 30, 2015 Shire launched VYVANSE for the treatment of adults with moderate to severe BED.

NATPARA – for the treatment of hypoparathyroidism (“HPT”)

· On January 23, 2015 it was announced that the U.S. Food and Drug Administration (“FDA”) had approved NATPARA as an adjunct to calcium and vitamin D to control hypocalcemia in patients with HPT. HPT is a rare endocrine disorder characterized by insufficient levels of parathyroid hormone, or PTH. NATPARA is a bioengineered replica of human PTH. NATPARA was launched in the US on April 1, 2015.

VYVANSE – for the treatment of Attention Deficit Hyperactivity Disorder (“ADHD”)

· On March 23, 2015 Shire announced VYVANSE was available in a 10mg strength capsule. This new titration dose, which was approved by the FDA on October 30, 2014, is the seventh VYVANSE dosage strength available in addition to the 20mg, 30mg, 40mg, 50mg, 60mg, and 70mg capsule strengths. On April 7, 2015 Health Canada approved the 10mg dose strength for incremental titration adjustments.

Pipeline

The Company has progressed the pipeline, the most significant developments of which are gaining Priority Review for lifitegrast and gaining agreement with the FDA on the regulatory path for SHP465.  Shire now has its broadest and deepest pipeline in its history.

SHP606 (lifitegrast) – for the treatment of the signs and symptoms of Dry Eye Disease (“DED”)

· On April 9, 2015 Shire announced that the FDA had accepted the New Drug Application (“NDA”) for lifitegrast and had granted the NDA Priority Review designation. The FDA has set an action date of October 25, 2015, based on the Prescription Drug User Fee Act V.

SHP609 – for the treatment of Hunter syndrome with CNS symptoms

· On January 26, 2015 Shire announced that the FDA has granted Fast Track designation for SHP609 for the treatment of neurocognitive decline associated with Hunter syndrome (mucopolysaccharidosis II).

SHP465 – for the treatment of adults with ADHD

· On April 7, 2015 Shire announced that it had reached an agreement with the FDA on a clear regulatory path for SHP465 (triple-bead mixed amphetamine salts), an investigational oral stimulant medication being evaluated as a potential treatment for ADHD in adults.

SHP611 – for the treatment of the late infantile form of Metachromatic Leukodystrophy (“MLD”)

· SHP611 is in development as recombinant human arylsulfatase A (rASA) delivered intrathecally every other week for the treatment of the late infantile form of MLD. This product has been granted orphan drug designation in the US and the EU. The Company initiated a 24 patient Phase 1/2 clinical trial in August 2012. The primary endpoint of this trial is to determine the safety of ascending doses (10mg, 30mg, and 100 mg) of rASA over 40 weeks.

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Secondary and exploratory endpoints focused on efficacy and include decline in motor function as defined by change in baseline Gross Motor Function Measure (GMFM-88). Based upon interim data for the first 18 patients, SHP611 was safe and well tolerated at all doses. In addition, while not statistically significant and despite a decline in GMFM-88 score across all doses, the 100mg dose caused a slower decline over the 40 week study period compared to the other two treatment groups, most notably for those patients with GMFM-88 > 40-50 at baseline. Analysis of other exploratory efficacy measures were also encouraging. Shire will continue to analyze these interim results and determine an optimal path forward in this development program.

SHP625 – for the treatment of cholestatic liver disease

· On April 9, 2015 Shire announced that the small 13-week Phase 2 IMAGO trial of its investigational compound SHP625 did not meet the primary or secondary endpoints in the study of 20 pediatric patients with Alagille syndrome. Given the topline results from the IMAGO study of SHP625 in pediatric patients with Alagille syndrome, the Company plans to analyze the totality of data to better understand the results the Company has seen. Data for this and other indications will be important to fully understand the safety and efficacy of SHP625 in patients with cholestatic liver disease.

OTHER DEVELOPMENTS

NPS Pharmaceuticals Inc. (“NPS Pharma”) acquisition

· On February 21, 2015 Shire completed the acquisition of NPS Pharma. Shire plans to accelerate the growth of NPS Pharma’s innovative portfolio through its market expertise in gastrointestinal (“GI”) disorders, core capabilities in rare disease patient management and global footprint. The integration is progressing according to plan.

Meritage Pharma Inc. (“Meritage”) acquisition

· On February 24, 2015 Shire announced that it had acquired Meritage Pharma, Inc., a privately-held company, for an upfront payment of $75 million and additional contingent payments based on the achievement of development and regulatory milestones. With the acquisition, Shire has acquired the global rights to Meritage’s Phase 3-ready compound, Oral Budesonide Suspension (“OBS”) (SHP621), for the treatment of adolescents and adults with eosinophilic esophagitis (“EoE”), a rare, chronic inflammatory GI disease. This acquisition further enhances Shire’s late-stage pipeline and leverages the Company’s rare disease and GI commercial infrastructure and expertise.

BOARD AND COMMITTEE CHANGES

On April 30, 2015 the Company announced that Jeff Poulton had been appointed Chief Financial Officer (“CFO”) and member of the Executive Committee. Jeff will additionally join the Shire Board of Directors. Both appointments are effective from April 30, 2015.

Jeff has served as Interim CFO since December 2014, while overseeing Investor Relations. An experienced pharmaceuticals and biotechnology executive, Jeff has extensive experience across financial, commercial and strategic leadership roles. He joined Shire in 2003.

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Products in registration as of March 31, 2015

INTUNIV for the treatment of ADHD in the EU

In March 2014 the Company announced the acceptance of submission of a Marketing Authorization Application (“MAA”) by the EMA for once-daily, non-stimulant guanfacine extended release for the treatment of ADHD in children/adolescents aged 6-17 years.

SHP606 (lifitegrast) for the treatment of DED

On April 9, 2015 Shire announced that the FDA had accepted the NDA for lifitegrast and had granted a Priority Review designation. The FDA is expected to provide a decision on October 25, 2015, based on the Prescription Drug User Fee Act V action date. In parallel to the NDA submission, Shire is conducting a Phase 3 safety and efficacy study (OPUS-3) in support of a potential US label and labels in international markets. OPUS-3 is a multicenter, randomized, double-masked, placebo-controlled, parallel arm study with a 14 day open-label placebo screening run-in period followed by a 12 week randomized, masked treatment period with a primary efficacy endpoint in subjective patient reported symptoms of dry eye disease, eye dryness score.

On April 30, 2014 Shire announced top-line results from the prospective, randomized, double-masked, placebo-controlled SONATA trial which indicated no ocular or drug-related serious adverse events. The safety data indicated in the SONATA trial was entirely consistent with that observed in the Phase 2, OPUS-1 and OPUS-2 studies for lifitegrast. Additional data and analyses will be submitted for presentation at upcoming medical meetings.

NATPAR for the treatment of HPT

NATPAR (NATPARA in the US) is currently under review in Europe as an adjunct to calcium and vitamin D to control hypocalcemia in patients with HPT.

Products in clinical development as of March 31, 2015

Phase 3 and Phase 3-ready

SHP465 for the treatment of ADHD in adults

Shire’s NDA for SHP465 was previously submitted in 2006 to support the use of SHP465 as a longer-acting, once-daily treatment for ADHD in adults. With the growing adult ADHD population there is now a larger patient population and Shire expects a greater commercial need for this type of product than in 2006. SHP465 (mixed salts of a single entity amphetamine) capsules provide an extended-release of amphetamines to provide coverage of ADHD symptoms for adults throughout the day.  On April 7, 2015 Shire announced that it had reached an agreement with the FDA on a clear regulatory path for SHP465, an investigational oral stimulant medication being evaluated as a potential treatment for ADHD in adults.

SHP621 OBS, for the treatment of adolescents and adults with EoE

With the Meritage acquisition, Shire has acquired the global rights to Meritage’s Phase 3-ready compound, OBS, for the treatment of adolescents and adults with EoE, a rare, chronic inflammatory GI disease. EoE is a chronic disease that is increasingly being diagnosed in children and adults, with an estimated prevalence in the U.S. of ~181,000. It is characterized by inflammation and accumulation of a specific type of immune cell, called an eosinophil, in the esophagus. EoE patients may have persistent or relapsing symptoms related to esophageal dysfunction, which include dysphagia (difficulty swallowing) and food impaction.

OBS is a proprietary viscous oral formulation of budesonide that is designed to coat the esophagus where the drug can act locally. Budesonide is a corticosteroid and has an established safety profile in those diseases. Budesonide is the active pharmaceutical ingredient in several products approved by the FDA, including products for the treatment of asthma, allergic rhinitis, ulcerative colitis and Crohn’s disease. Budesonide is a corticosteroid and has an established safety profile in those diseases. The FDA has granted orphan drug designation to OBS for the treatment of patients with EoE.

FIRAZYR for the treatment of ACE inhibitor-induced Angioedema (“ACE-I AE”)

A Phase 3 clinical trial to assess the efficacy of FIRAZYR for the treatment of ACE-I AE was initiated in the fourth quarter of 2013 and is ongoing.

FIRAZYR for the treatment of Hereditary Angioedema (“HAE”) in Japan

Shire plans to initiate a Phase 3 trial to evaluate the efficacy and safety of FIRAZYR for the treatment of HAE in Japanese patients in 2015.

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SHP555 (prucalopride; marketed as RESOLOR in the EU) for the treatment of chronic constipation in the US

On January 10, 2012 Shire announced that it had acquired the rights to develop and market prucalopride in the US in an agreement with Janssen Pharmaceutica N.V. Discussions have been conducted with the FDA and an NDA submission pathway has been agreed. Planning is underway to confirm Phase 3 program activities and timelines. 

INTUNIV for the treatment of ADHD in Japan

Under a collaboration agreement, Shionogi and Shire will co-develop and sell treatments for ADHD in Japan, including INTUNIV. A Phase 3 clinical program to evaluate the efficacy and safety of INTUNIV in Japanese patients aged 6 to 17 was initiated in the second quarter of 2013 and is ongoing.

SHP616 (CINRYZE) for routine prophylaxis against HAE attacks in adolescent and adult patients in Japan

CINRYZE is indicated in the US for prophylaxis and in the EU for both prophylaxis and acute treatment of angioedema attacks in adolescent and adult patients with HAE. Based on feedback from the Pharmaceutical and Medical Devices Agency (“PMDA”), a Clinical Trial Notification (“CTN”) was resubmitted and approved on October 2, 2014.

Phase 2

LDX1 for the treatment of ADHD in Japan

Under a collaboration agreement, Shionogi and Shire will co-develop and sell ADHD products in Japan, including LDX. A Phase 2 clinical program to evaluate the efficacy and safety of LDX in Japanese patients aged 6 to 17 was initiated in the second quarter of 2013 and is ongoing.

SHP602 iron chelating agent for the treatment of iron overload secondary to chronic transfusion

A Phase 2 trial in pediatric and adult patients with transfusion iron overload is currently on clinical hold as Shire evaluates nonclinical toxicology findings. The potential relevance of these findings to humans, if any, is unknown.  This product has received orphan drug designation in both the US and EU for the treatment of chronic iron overload requiring chelation therapy.

SHP607 for the prevention of Retinopathy of Prematurity (“ROP”)

SHP607 is in development as a protein replacement therapy for the preventative treatment of ROP, a rare eye disorder associated with premature birth. In December 2014 Shire received notification that SHP607 was granted Fast Track designation by the FDA.  In addition, this product has been granted orphan drug designation in both the US and EU. A Phase 2 clinical trial is currently ongoing.

SHP609 for the treatment of Hunter syndrome with CNS symptoms

SHP609 is in development as an enzyme replacement therapy (“ERT”) delivered intrathecally for Hunter syndrome patients with cognitive impairment. In January 2015 the FDA granted SHP609 Fast Track designation.  In addition, this product has been granted orphan designation in the US. The Company initiated a pivotal Phase 2/3 clinical trial in the fourth quarter of 2013 which is ongoing.

SHP610 for Sanfilippo A syndrome (Mucopolysaccharidosis IIIA)

SHP610 is in development as an ERT delivered intrathecally for the treatment of Sanfilippo A syndrome, a Lysosomal Storage Disorder. The Company initiated a Phase 1/2 clinical trial in August 2010 which has now completed. Shire initiated a Phase 2b clinical trial for SHP610, which is designed to establish clinical proof of concept. The product has been granted orphan drug designation in the US and in the EU.

SHP620 (maribavir) for the treatment of cytomegalovirus (“CMV”) infection in transplant patients

SHP620 was acquired as part of the acquisition of ViroPharma. Shire has completed two Phase 2 studies in transplant recipients. The first trial was in first-line treatment of asymptomatic CMV viremia in transplant recipients and the results of this study showed that maribavir, at all doses, was at least as effective as valganciclovir in the reduction of circulating CMV to below the limits of assay detection (undetectable plasma CMV). The second study recently completed was for the treatment of resistant/refractory CMV infection/disease in transplant recipients. The purpose of this study was to determine whether maribavir is efficacious and safe in patients with disease which is resistant or refractory to the standard of care CMV therapy (e.g., valganciclovir, foscarnet). This study also showed that maribavir, at all doses, was effective at lowering CMV to below the limits of assay detection. Approximately two-thirds of patients across the maribavir treatment groups achieved an undetectable plasma CMV DNA (viral load) within 6 weeks. This product has been granted orphan drug designation in both the US and EU.

1. Currently marketed as VYVANSE in the US and ELVANSE in certain countries in the EU for the treatment of ADHD

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SHP625 for the treatment of cholestatic liver disease

SHP625 was acquired as part of the recent acquisition of Lumena. Shire is currently conducting Phase 2 studies in the following indications:  Alagille Syndrome (“ALGS”), Progressive Familial Intrahepatic Cholestasis, Primary Biliary Cirrhosis, and Primary Sclerosing Cholangitis. This product has been granted orphan drug designation both in the US and EU.

On April 9, 2015 Shire announced that the 13-week Phase 2 IMAGO trial of SHP625 did not meet the primary or secondary endpoints in the study of 20 pediatric patients with ALGS. Mean serum bile acid levels and pruritus at the end of the study were lower in both SHP625 and placebo treated groups as compared to baseline. However, in a post-hoc analysis, a positive correlation between percent changes from baseline in serum bile acid levels and pruritis was observed in the SHP625 treated group.

SHP616 (CINRYZE) for the treatment of Acute Antibody Mediated Rejection (“AMR”)

A Phase 2 study for the treatment of AMR with SHP616 was completed in 18 patients. Shire has received FDA and EMA feedback and Shire plans to initiate a Phase 2/3 study in 2015.

Phase 1

SHP611 for the treatment of MLD

SHP611 is in development as recombinant human arylsulfatase A (rASA) delivered intrathecally every other week for the treatment of the late infantile form of MLD. This product has been granted orphan drug designation in the US and the EU. The Company initiated a 24 patient Phase 1/2 clinical trial in August 2012.  The primary endpoint of this trial is to determine the safety of ascending doses (10mg, 30mg, and 100 mg) of rASA over 40 weeks.  The secondary endpoint focuses on decline in motor function as defined by change in baseline Gross Motor Function Measure (GMFM-88).   Exploratory endpoints include change from baseline in cerebrospinal fluid sulfatide levels and change from baseline in the total MLD severity score based on brain MRI.   The trial is currently ongoing, but top line interim results were available in late April.  Based upon interim data for the first 18 patients, SHP611 was safe and well tolerated at all doses.  In addition, while not statistically significant and despite a decline in GMFM-88 score across all doses, the 100mg dose caused a slower decline over the 40 week study period compared to the other two treatment groups, most notably for those patients with GMFM-88 > 40-50 at baseline. A decrease in MLD MRI score was observed at week 40 versus baseline for the 100 mg dose group (suggestive of stabilization or improvement), whereas there was a decline in MRI status in the 10 mg and 30 mg groups.  While there were also no significant mean changes from baseline in CSF sulfatide levels between groups, sustained reductions of CSF sulfatide levels to values below the upper limit of normal in individual patients were observed in the 100mg dose group as compared to the other two groups. Shire will continue to analyze these interim results and determine an optimal path forward in this development program.

SHP616 (CINRYZE) life cycle management and new uses

Shire is pursuing a subcutaneous formulation of CINRYZE for routine prophylaxis against HAE attacks in adolescent and adult patients.  In addition, Shire is further considering opportunities to pursue additional therapeutic indications that may involve the C1 Inhibitor.  In addition to AMR, these new uses include Neuromyelitis Optica (“NMO”) and Paroxysmal Nocturnal Hemoglobinuria (“PNH”).   In NMO, a Phase 1b investigator sponsored trial study was completed in 10 patients for acute therapy, and Shire plans to solicit FDA feedback in the second quarter of 2015 on advancing to Phase 3.  In PNH, an ex-vivo proof of concept study in 6 patients has been completed, and Shire plans to advance to Investigational New Drug (“IND”) filing in 2015 based on the results of an additional pre-clinical study.  

SHP622 for the treatment of Friedreich’s Ataxia (“FA”)

SHP622 is in development for the treatment of Friedreich’s Ataxia and was acquired as part of the acquisition of ViroPharma.  This product is a naturally occurring small molecular weight drug compound that prevents oxidative stress OX1 (indole-3-propionic acid) by a combination of hydroxyl radical scavenging activity and metal chelation. Phase 1 studies in healthy adults were completed in 2010. The drug was found to be generally well tolerated, and the pharmacokinetics revealed that the drug was rapidly absorbed and distributed in the body after oral administration. A Phase 1b trial of SHP622 in adults with FA is ongoing.

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SHP626 for the treatment of nonalcoholic steatohepatitis (“NASH”)

SHP626 was acquired as part of the acquisition of Lumena and is in development for the treatment of NASH, a common and often “silent” liver disease characterized by fat deposits in the liver and inflammation which can progress to significant fibrosis.  A US IND was approved by the FDA in the fourth quarter of 2014, and a Phase 1b multiple dose trial is ongoing.

SHP627 for the treatment of focal segmental glomerulosclerosis (“FSGS”)

On July 4, 2014 Shire completed its acquisition of Fibrotech, an Australian biopharmaceutical company developing a new class of orally available drugs with a novel mechanism of action which has the potential to address both the inflammatory and fibrotic components of disease processes. SHP627 has completed a Phase 1a study in healthy volunteers and is currently in a Phase 1b study in patients with diabetic nephropathy. The first Phase 2 study is expected to be initiated in FSGS patients in 2016.

Other development projects

A number of additional early development projects, focused on Rare Diseases, are underway in various stages of pre-clinical development.

Following the acquisition of NPS Pharma on February 21, 2015, Shire acquired NPS Pharma’s pipeline portfolio. Shire is currently assessing NPS Pharma’s pipeline portfolio.

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Results of operations for the three months to March 31, 2015 and 2014

Financial highlights for the three months to March 31, 2015 are as follows:

· Product sales in the first quarter of 2015 were up 9% to $1,423 million (2014: $1,308 million) even after the effect of significantly lower INTUNIV sales (down 79% to $17 million) following the introduction of generic competition in December 2014. On a Constant Exchange Rate (“CER”) basis, which is a Non GAAP measure, product sales were up 13%.

Excluding INTUNIV, product sales were up 15%. This growth was primarily driven by VYVANSE (up 19% to $417 million), CINRYZE(1) (up 73% on a reported basis to $148 million), LIALDA/MEZAVANT (up 15% to $148 million) and FIRAZYR (up 23% to $92 million).

As expected, product sales growth in the first quarter of 2015 was held back 4 percentage points by foreign exchange headwinds from the strengthening US dollar, primarily affecting sales of ELAPRASE, REPLAGAL and VPRIV.

· Total revenues were up 11% to $1,488 million (2014: $1,347 million), as the first quarter of 2015 benefited from higher royalties and other revenues, principally INTUNIV royalties and the inclusion of SENSIPAR royalties acquired with NPS Pharma.

· Operating income was up 55% to $475 million (2014: $307 million). Operating income in the first quarter of 2015 included $76 million of integration and acquisition costs (2014: $6.6 million); $15 million of reorganization costs (2014: $49 million); and $88 million of amortization expense (2014: $224 million of combined amortization and intangible asset impairments). Excluding these items operating income was up 11% to $654 million (2014: $587 million) as combined R&D and SG&A costs increased at a lower rate than total revenues.

· Diluted earnings per ordinary share increased 77% to $0.69 (2014: $0.39) primarily due to higher operating income and a lower effective tax rate in the first quarter of 2015.

Results of operations for the three months to March 31, 2015 and 2014

Total revenues

The following table provides an analysis of the Company’s total revenues by source:

	3 months to		3 months to
	March 31,		March 31,
	2015		2014		change
	$’M		$’M		%
Product sales		1,423.2		1,308.1		+9
Royalties		62.8		32.3		+94
Other revenues		2.4		6.4		-63
Total		1,488.4		1,346.8		+11

(1) CINRYZE sales recorded in the first quarter of 2014 are from January 24, 2014, following the acquisition of ViroPharma by Shire. Including sales prior to January 24, 2014 which were recorded by ViroPharma, CINRYZE sales grew by 28%.

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Product sales

The following table provides an analysis of the Company’s key product sales:

	3 months to		3 months to
	March 31,		March 31,		Product sales		Non-GAAP CER		US prescription			Exit market
	2015		2014		growth		growth4		growth1			share1
Net product sales:	$’M		$’M		%		%		%			%
VYVANSE		416.8		351.2		+19		+20		+6			17
LIALDA/MEZAVANT		148.5		128.9		+15		+17		+12			34
CINRYZE		148.1		85.6		+73		+74		n/a	2		n/a	2
ELAPRASE		125.0		128.6		-3		+7		n/a	2		n/a	2
REPLAGAL		97.5		114.3		-15		-3		n/a	3		n/a	3
ADDERALL XR		95.7		85.1		+12		+14		+15			5
FIRAZYR		92.5		74.9		+23		+26		n/a	2		n/a	2
VPRIV		86.4		86.9		-1		+6		n/a	2		n/a	2
PENTASA		78.7		72.3		+9		+9		-7			13
FOSRENOL		44.1		41.4		+7		+14		-11			3
XAGRID		25.3		27.1		-7		+15		n/a	2		n/a	2
INTUNIV		17.4		82.3		-79		-78		-64			1
GATTEX/REVESTIVE		14.9		-		n/a		n/a		n/a	2		n/a	2
Other product sales		32.3		29.5		+9		+13		n/a			n/a
Total product sales		1,423.2		1,308.1		+9

(1) Data provided by IMS Health National Prescription Audit (“IMS NPA”) relates solely to US-based prescriptions. Exit market share represents the average monthly US market share in the month ended March 31, 2015.

(2) IMS NPA Data not available.

(3) Not sold in the US in the first quarter of 2015.

(4) The Company’s management analyzes product sales and revenue growth for certain products sold in markets outside of the US on a constant exchange rate (“CER”) basis, so that product sales and revenue growth can be considered excluding movements in foreign exchange rates. Product sales and revenue growth on a CER basis is a Non GAAP financial measure (“Non GAAP CER”), computed by comparing 2015 product sales and revenues restated using 2014 average foreign exchange rates to 2014 actual product sales and revenues. Average exchange rates for the three months to March 31, 2015 were $1.54:£1.00 and $1.15:€1.00 (2014: $1.66:£1.00 and $1.37:€1.00).

VYVANSE – ADHD and BED

VYVANSE product sales grew strongly (up 19%) in the first quarter of 2015 compared to the first quarter of 2014 due to the benefit of a price1 increase taken since the first quarter of 2014 and higher prescription demand. To a lesser extent product sales growth in the first quarter of 2015 benefited from lower destocking in the first quarter of 2015 compared to

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the first quarter of 2014, and growth in ex-US product sales. VYVANSE was launched in mid-February for moderate to severe BED in adults and the Company is pleased with the overall increase in VYVANSE prescriptions since the product became available for that indication

Litigation proceedings regarding VYVANSE are ongoing. Further information about this litigation can be found in PART I: ITEM 1 of this Form 10-Q.

LIALDA/MEZAVANT – Ulcerative Colitis

Product sales for LIALDA/MEZAVANT in the first quarter of 2015 were up 15%, primarily driven by higher prescription demand due to higher market share and to a slightly lesser extent the benefit of a price1 increase taken since the first quarter of 2014. The growth was partially offset by higher sales deductions as a percentage of product sales.

Litigation proceedings regarding LIALDA are ongoing. Further information about this litigation can be found in PART I: ITEM 1 of this Form 10-Q.

CINRYZE – for the prophylactic treatment of HAE

Shire acquired CINRYZE through its acquisition of ViroPharma in the first quarter of 2014. CINRYZE sales were $148.1 million in the first quarter of 2015, growing 73% (28% on a pro-forma basis) on the first quarter of 2014(2), primarily driven by more patients on therapy and a price1 increase taken since the first quarter of 2014.

ELAPRASE – Hunter syndrome

ELAPRASE product sales in the first quarter of 2015 were down 3% (up 7% on a Non GAAP CER basis) compared to the first quarter of 2014. Continued growth in the number of patients on therapy and a price1 increase taken since the first quarter of 2014 were more than offset by the negative impact of foreign exchange movements, as expected.

REPLAGAL – Fabry disease

REPLAGAL sales were down 15% (down 3% on a Non GAAP CER basis) compared to the first quarter of 2014, driven primarily by the negative impact of foreign exchange, as expected.

ADDERALL XR – ADHD

ADDERALL XR product sales increased (up 12%) in the first quarter of 2015, primarily due to an increase in prescription demand.

FIRAZYR – for the treatment of acute HAE attacks

FIRAZYR product sales were up 23% (up 26% on a Non GAAP CER basis), primarily due to growth in patients on therapy, higher unit sales and a price1 increase taken in January 2015.

VPRIV – Gaucher disease

VPRIV product sales in the first quarter of 2015 were down 1% (up 6% on a Non GAAP CER basis), reflecting the negative impact of foreign exchange, as expected, partially offset by higher unit sales as the Company has seen an increase in the number of patients on therapy.

PENTASA – Ulcerative Colitis

PENTASA product sales increased in the first quarter of 2015 (up 9%) driven by price1 increases taken since the first quarter of 2014 and higher stocking, partially offset by higher sales deductions as a percentage of product sales and decrease in prescription demand.

INTUNIV – ADHD

INTUNIV product sales were down 79% in the first quarter of 2015 reflecting the impact of generic competition from December 2014, which resulted in lower prescription demand, significantly higher sales deductions as a percentage of product sales and a higher level of destocking.

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GATTEX/REVESTIVE – Short Bowel Syndrome (“SBS”)

Shire acquired GATTEX/REVESTIVE through its acquisition of NPS Pharma on February 21, 2015, and recorded sales of $14.9 million (up 44% on a pro-forma basis(3))for the period subsequent to acquisition. The inclusion of GATTEX/REVESTIVE contributed 1 percentage point to Shire’s total product sales growth in the quarter.

1The actual net effect of price increases on current period net sales compared to the comparative period is difficult to quantify due to the various managed care rebates, Medicaid discounts, other discount programs in which the Company participates and fee for service agreements with wholesalers customers.

2 Sales prior to January 24, 2014 were recorded by ViroPharma, prior to the acquisition by Shire.

3 Sales prior to February 21, 2015 were recorded by NPS, prior to the acquisition by Shire.

Royalties

The following table provides an analysis of Shire’s royalty income:

	3 months to		3 months to
	March 31,		March 31,
	2015		2014		Change
	$’M		$’M		%
INTUNIV		21.7		-		n/a
SENSIPAR/MIMPARA		10.4		-		n/a
ADDERALL XR		8.5		9.0		-6
FOSRENOL		8.4		12.8		-34
3TC and ZEFFIX		7.5		7.5		-
Other		6.3		3.0		+110
Total royalties		62.8		32.3		+94

Royalty income increased by 94% in the first quarter of 2015 due to the inclusion of royalties receivable from Actavis on its generic sales of INTUNIV, and inclusion for the first time of royalty income receivable from Amgen’s sales of SENSIPAR/MIMPARA, following the acquisition of NPS Pharma by Shire.

Cost of product sales

Cost of product sales decreased to $227.8 million for the three months to March 31, 2015 (16% of product sales), from $229.5 million in the corresponding period in 2014 (18% of product sales). Cost of product sales as a percentage of product sales decreased by 2% in the first quarter of 2015, due to lower charges on the unwind of the fair value adjustment on acquired inventories.

For the three months to March 31, 2015 cost of product sales included depreciation of $11.7 million (2014: $10.2 million).

R&D

R&D expenditure decreased by 46% to $193.7 million for the three months to March 31, 2015 (14% of product sales), compared to $360.5 million in the corresponding period in 2014 (28% of product sales), as the first quarter of 2014 included an impairment charge of $166.0 million related to the SHP602 IPR&D intangible asset. Excluding this impairment charge, R&D expenditure in the three months to March 31, 2015 slightly decreased by $0.8 million, as increased investment behind programs acquired through business development activities since the first quarter of 2014, and increased spend on Shire’s existing pipeline programs, was more than offset by the effect of the completion of several large Phase 3 programs since the first quarter of 2014 including new uses for LDX.

R&D in the three months to March 31, 2015 included depreciation of $2.8 million (2014: $5.8 million).

SG&A

SG&A expenditure increased by 18% to $506.6 million (36% of product sales) from $430.3 million (33% of product sales), due to increased SG&A spend in relation to the launch of VYVANSE for the treatment of moderate to severe BED in

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adults, the inclusion of SG&A costs related to NPS Pharma, higher intangible asset amortization and costs incurred in respect of employee retention awards following AbbVie’s terminated offer for Shire.

For the three months to March 31, 2015 SG&A included depreciation of $17.8 million (2014: $20.8 million) and amortization of $88.3 million (2014: $57.8 million).

Gain on sale of product rights

For the three months to March 31, 2015 Shire recorded a net gain on sale of non-core product rights of $5.2 million (2014: $36.4 million). The gain in the first quarter of 2014 reflected a gain of $43.5 million on the sale of certain CALCICHEW trademarks to Takeda partially offset by the re-measurement of the contingent consideration receivable relating to the divestment of DAYTRANA.

Reorganization costs

For the three months to March 31, 2015 Shire recorded reorganization costs of $15.2 million (2014:  $49.4 million). Costs in the first quarter of 2015 primarily related to the relocation of roles from Chesterbrook to Lexington as part of the ongoing One Shire reorganization. In 2014 these costs related to the implementation of the new One Shire operating structure.

Integration and acquisition costs

For the three months to March 31, 2015 Shire recorded integration and acquisition costs of $75.7 million primarily related to the acquisition and integration of NPS Pharma.

In the first quarter of 2014 Shire recorded integration and acquisition costs of $6.6 million. This net charge included costs of $65.8 million related to the acquisition and integration of ViroPharma, partially offset by a net credit of $59.2 million relating to the change in fair values of contingent consideration liabilities.

Interest expense

For the three months to March 31, 2015 Shire incurred interest expense of $9.6 million (2014: $7.8 million). Interest expense in the first quarter of 2015 primarily related to interest and the amortization of financing fees incurred on borrowings to fund the NPS Pharma acquisition. Interest expense in the first quarter of 2014 principally related to interest and amortization of issue costs incurred on borrowings to fund the ViroPharma acquisition.

Taxation

The effective rate of tax in the first quarter of 2015 was 12% (2014: 17%).       

The effective rate of tax in the first quarter of 2015 is lower than the same period in 2014 primarily due to changes in profit mix and the adverse impact in the first quarter of 2014 of the re-measurement of deferred tax as a result of the ViroPharma acquisition.

Discontinued operations

The loss from discontinued operations for the three months to March 31, 2015 was $2.5 million net of tax (2014: $22.7 million) relating to costs associated with the divestment of the DERMAGRAFT business in 2014.

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Financial condition at March 31, 2015 and December 31, 2014

Cash & cash equivalents

Cash and cash equivalents decreased by $2,908.1 million to $74.3 million at March 31, 2015 (December 31, 2014: $2,982.4 million), primarily due to the use of existing cash and cash equivalents to fund the acquisition of NPS Pharma and Meritage.

Accounts receivable, net

Accounts receivable, net increased by $81.2 million to $1,116.3 million at March 31, 2015 (December 31, 2014: $1,035.1 million), primarily due to the increase in revenue. Days sales outstanding increased to 47 days (December 31, 2014: 43 days).

Goodwill

Goodwill increased by $1,703.8 million to $4,178.7 million at March 31, 2015 (December 31, 2014: $2,474.9 million), principally due to the acquisitions of NPS Pharma and Meritage.

Other intangible assets, net

Other intangible assets increased by $5,045.6 million to $9,980.0 million at March 31, 2015 (December 31, 2014: $4,934.4 million), principally due to the intangible assets acquired with NPS Pharma and Meritage, offset by intangible asset amortization.

Short term borrowing

Short term borrowings increased by $1,720.2 million to $2,570.2 million at March 31, 2015 (December 31, 2014: $850.0 million), reflecting the utilization of short term debt facilities to partially fund the acquisition of NPS Pharma and the recognition of secured non-recourse debt liabilities assumed as part of the NPS Pharma acquisition.

Non-current deferred tax liabilities

Non-current deferred tax liabilities increased by $1,699.3 million to $2,909.9 million at March 31 2015 (December 31, 2014: $1,210.6 million) primarily due to deferred tax liabilities arising on intangible assets partially offset by deferred tax assets arising on tax attributes both acquired with NPS Pharma and Meritage.

Other non-current liabilities

Other non-current liabilities increased by $107.3 million to $844.0 million at March 31, 2015 (December 31, 2014: $736.7 million) principally due to the recognition of contingent consideration payable in respect of the Meritage acquisition.

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Liquidity and capital resources

General

The Company’s funding requirements depend on a number of factors, including the timing and extent of its development programs; corporate, business and product acquisitions; the level of resources required for the expansion of certain manufacturing and marketing capabilities as the product base expands; increases in accounts receivable and inventory which may arise with any increase in product sales; competitive and technological developments; the timing and cost of obtaining required regulatory approvals for new products; the timing and quantum of milestone payments on business combinations, in-licenses and collaborative projects; the timing and quantum of tax and dividend payments; the timing and quantum of purchases by the Employee Benefit Trust of Shire shares in the market to satisfy awards granted under Shire’s employee share plans; and the amount of cash generated from sales of Shire’s products and royalty receipts.

An important part of Shire’s business strategy is to protect its products and technologies through the use of patents, proprietary technologies and trademarks, to the extent available. The Company intends to defend its intellectual property and as a result may need cash for funding the cost of litigation.

The Company finances its activities through cash generated from operating activities; credit facilities; private and public offerings of equity and debt securities; and the proceeds of asset or investment disposals.

Shire’s balance sheet includes $74.3 million of cash and cash equivalents at March 31, 2015.

Shire has a revolving credit facility of $2,100 million which matures in 2019, $845 million of which was utilized as March 31, 2015 to partially finance the purchase price paid in respect of Shire’s acquisition of NPS Pharma (including certain related costs).

In connection with its acquisition of NPS Pharma, on January 11, 2015 the Company also entered into a $850 million term loan facility agreement, which matures on January 10, 2016, with, among others, Citi Global Markets Limited (acting as mandated lead arranger and bookrunner) (the “2015 Facility Agreement”). At March 31, 2015 the 2015 Facility Agreement was fully utilized and recorded within short term borrowings. The Company also assumed non-recourse secured debt obligations of $106 million as part of the NPS Pharma acquisition. See Note 13 in Part 1 of this Form 10-Q for details.

In connection with its acquisition of ViroPharma, on November 11, 2013 the Company also entered into a $2,600 million term loan facilities agreement with, among others, Morgan Stanley Bank International Limited (acting as lead arranger and agent) (the “2013 Facilities Agreement”). Amounts drawn under the 2013 Facilities Agreement were subsequently reduced to $850 million. At March 31, 2015 the 2013 Facilities Agreement comprises an $850 million term loan facility which matures on November 11, 2015, and was fully utilized and recorded within short term borrowings.

Financing

Shire anticipates that its operating cash flow together with available cash, cash equivalents and the RCF will be sufficient to meet its anticipated future operating expenses, capital expenditures, tax and interest payments, lease obligations, repayment of the term loans and milestone payments as they become due over the next twelve months.

If the Company decides to acquire other businesses, it expects to fund these acquisitions from cash resources, the RCF, term loan facilities and through new borrowings or the issuance of new equity if necessary.

Sources and uses of cash

The following table provides an analysis of the Company’s gross and net (debt)/cash position (excluding restricted cash), as at March 31, 2015 and December 31, 2014:

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	March 31,			December 31,
	2015			2014
		$’M			$’M
Cash and cash equivalents1		74.3			2,982.4
Long term borrowings		(78.7	)		-
Short term borrowings		(2,570.2	)		(850.0	)
Other debt		(13.0	)		(13.7	)
Total debt		(2,661.9	)		(863.7	)
Net (debt)/cash2		(2,587.6	)		2,118.7

(1) Substantially all of the Company’s cash and cash equivalents are held by foreign subsidiaries (i.e, those subsidiaries incorporated outside of Jersey, Channel Islands, the jurisdiction of incorporation of Shire plc, Shire’s holding company). The amount of cash and cash equivalents held by foreign subsidiaries has not had, and is not expected to have, a material impact on the Company’s liquidity and capital resources.

(2) Net(debt)/ cash is a Non-GAAP measure.  The Company believes that Net (debt)/cash is a useful measure as it indicates the level of borrowings after taking account the cash and cash equivalents that could be utilized to pay down the outstanding borrowings.

Cash flow activity

Net cash provided by operating activities for the three months to March 31, 2015 increased by $315.5 million or 128% to $561.6 million (2014: $246.1 million), primarily due to higher cash receipts from gross product sales, from the timing of rebate payments and the benefit of a net cash tax repayment in the first quarter of 2015 (from the recovery of an over-payment of tax and favorable timing of cash tax payments).

Net cash used in investing activities was $5,177.2 million in the three months to March 31, 2015, principally relating to the cash paid for the acquisition of NPS Pharma of $5,125 million (less cash acquired with NPS Pharma of $42 million) and for the acquisition of Meritage of $75 million.

Net cash used in investing activities was $3,690.2 million in the three months to March 31, 2014, principally relating to the cash paid for the acquisition of ViroPharma of $3,997 million, net of cash acquired with ViroPharma of $233 million.

Net cash provided by financing activities was $1,709.1 million for the three months to March 31, 2015, principally due to the drawings, net of subsequent repayments, made under Shire’s RCF and 2015 Facility Agreement to partially fund the NPS Pharma acquisition.

Net cash provided by financing activities was $1,345.5 million for the three months to March 31, 2014, principally due to the drawings net of subsequent repayments made under the RCF and 2013 Facilities Agreement used to partially fund the ViroPharma acquisition. In addition the Company paid cash of $533.9 million to settle the convertible debt assumed with ViroPharma, and received cash of $346.7 million upon settlement of a purchased call option acquired with ViroPharma.

Obligations and commitments

Other than the borrowings incurred to finance, or assumed following, the acquisition of NPS, as outlined above, during the three months to March 31, 2015 there have been no material changes to the Company’s contractual obligations previously disclosed in PART II: ITEM 7 of the Company’s Annual Report on Form 10-K for the year ended December 31, 2014.

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ITEM 3.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Note 17 to the unaudited consolidated financial statements included in PART I: ITEM 1 of this Form 10-Q and PART II: ITEM 7A of the Company’s Annual Report on Form 10-K for the year ended December 31, 2014 contains a discussion of the Company’s exposure to market and other risks.

ITEM 4.  CONTROLS AND PROCEDURES

The Company maintains disclosure controls and procedures that are designed to ensure that information required to be disclosed in reports that the Company files under the Securities Exchange Act of 1934, as amended, is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the SEC.

As at March 31, 2015 the Company, under the supervision and with the participation of the Company’s management, including the Chief Executive Officer and the Chief Financial Officer, performed an evaluation of the effectiveness of the Company’s disclosure controls and procedures, including those with respect to the Income Access Share (“IAS”) Trust. The Company’s management necessarily applied its judgment in assessing the costs and benefits of such controls and procedures, which by their nature can provide only reasonable assurance regarding management’s control objectives. Based on this evaluation, the Company’s Chief Executive Officer and Chief Financial Officer concluded that the Company’s disclosure controls and procedures, including those with respect to the IAS Trust, are effective at the reasonable level of assurance to ensure that information required to be disclosed in reports that the Company files under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the SEC.

In February 2015 the company acquired NPS Phama which represents a change in the Company's internal control over financial reporting. Management is continuing to integrate the NPS Pharma internal controls over financial reporting with those of the Company. Excluding the NPS Pharma acquisition, there has been no change in the Company’s internal control over financial reporting that occurred during the period covered by this quarterly report that has materially affected, or is reasonably likely to materially affect, the Company’s internal control over financial reporting.

PART II.  OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS

The information required by this Item is incorporated herein by reference to Note 15 to the unaudited consolidated financial statements included in PART I: ITEM 1 of this Form 10-Q.

ITEM 1A.  RISK FACTORS

There have been no material changes from the risk factors set forth in the Company’s Annual Report on Form 10-K for the year ended December 31, 2014.

ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

None.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

None.

ITEM 4. MINE SAFETY DISCLOSURES

Not applicable.

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ITEM 5. OTHER INFORMATION

None.

ITEM 6. EXHIBITS

EXHIBITS

2.01 Agreement and Plan of Merger by and among Shire Pharmaceuticals Group plc, Transkaryotic Therapies, Inc. and Sparta Acquisition Corporation, dated as of April 21, 2005.(1)

2.02 Agreement of Merger dated as of February 20, 2007 among Shire plc, Shuttle Corporation and New River Pharmaceuticals, Inc.(2)

2.03 Business Combination Agreement dated as of July 3, 2008 between Maia Elfte Vermögensverwaltungs GmbH and Jerini AG. (3)

2.04 Heads of Agreement by and among Shire plc and Movetis NV relating to a friendly tender offer, dated August 3, 2010. (4)

2.05 Agreement and Plan of Merger, dated as of May 17, 2011, by and among Shire Pharmaceuticals Inc., ABH Merger Sub Inc., Advanced Biohealing, Inc., and solely for the limited purposes set forth therein, Canaan VII L.P. and Shire plc. (5)

2.06 Agreement and Plan of Merger, dated as of March 14, 2012, by and among Shire Pharmaceuticals LLC, Pelegrina Corporation, FerroKin BioSciences, Inc. and Shareholder Representative Services LLC, solely for the limited purposes set forth therein. (6)

2.07 Agreement and Plan of Merger dated as of November 11, 2013 among Shire Pharmaceutical Holdings Ireland Limited, Venus Newco, Inc., ViroPharma Incorporated and Shire plc. (7)

2.08 Asset Purchase Agreement dated as of January 16, 2014 among Shire US Holdings, Inc., Shire Regenerative Medicine, Inc. and Organogenesis Inc. (8)

2.09 Cooperation Agreement dated July 18, 2014 between AbbVie Inc.and Shire plc. (9)

2.10 Termination Agreement dated October 20, 2014 between AbbVie Inc.and Shire plc. (10)

2.11 Agreement and Plan of Merger dated as of January 11, 2015 among Shire Pharmaceuticals Holdings Ireland Limited, Knight NewCo 2, Inc., NPS Pharmaceuticals Inc., and Shire plc. (11)

3.01 Form of Memorandum of Association of Shire plc as adopted by a special resolution passed on April 10, 2008 and amended by a special resolution passed on September 24, 2008. (12)

3.02 Form of Article of Association of Shire plc as amended by a special resolution passed on April 26, 2011 and adopted by a special resolution passed on April 26, 2011. (13)

4.01 Form of Assignment and Novation Agreement between Shire Limited, Shire plc, JPMorgan Chase Bank, N.A. dated April 16, 2008 relating to the Deposit Agreement among Shire plc, JPMorgan Chase Bank, N.A. as depositary and all holders from time to time of ADRs issued thereunder dated November 21, 2005.(14)

4.02 Form of Deposit Agreement among Shire plc, JPMorgan Chase Bank, N.A. as depositary and all holders from time to time of ADRs issued thereunder dated November 21, 2005. (15)

4.03 Form of Ordinary Share Certificate of Shire Limited. (16)

4.04 Form of American Depositary Receipt Certificate of Shire Limited. (17)

4.05 Trust Deed for the New Shire Income Access Trust, dated August 29, 2008. (18)

4.06 Form of Amended and Restated Deposit Agreement among Shire plc, Citibank, N.A. as successor depositary, and all holders from time to time of ADRs thereunder dated May 23, 2011. (19)

10.01 Tender and Support Agreement dated as of February 20, 2007 among Shire plc, Mr. Randal J. Kirk and the other parties named therein. (20)

10.02 Multicurrency Term and Revolving Facilities Agreement as of February 20, 2007 by and among Shire plc, ABN AMRO Bank N.V., Barclays Capital, Citigroup Global Markets Limited, The Royal Bank of Scotland plc, and Barclays Bank plc. (21)

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10.03 Accession and Amendment Deed dated April 15, 2008 between Shire Limited, Shire plc, certain subsidiaries of Shire plc and Barclays Bank PLC as Facility Agent relating to a US $1,200,000,000 facility agreement dated February 20, 2007 (as amended by a syndication and amendment agreement dated July 19, 2007). (22)

10.04 Subscription Agreement dated May 2, 2007 relating to the 2.75% Convertible Bonds due 2014 between Shire plc and ABN AMRO Bank N.V. and NM Rothschild & Sons Limited (trading together as ABN AMRO Rothschild, an unincorporated equity capital markets joint venture) and Barclays Bank PLC and Citigroup Global Markets Limited and Goldman Sachs International and Morgan Stanley & Co. International plc and others. (23)

10.05 Amending Subscription Agreement dated May 8, 2007 relating to the 2.75% Convertible Bonds due 2014 between Shire plc and ABN AMRO Bank N.V. and NM Rothschild & Sons Limited (trading together as ABN AMRO Rothschild, an unincorporated equity capital markets joint venture) and Barclays Bank PLC and Citigroup Global Markets Limited and Goldman Sachs International and Morgan Stanley & Co. International plc and others. (24)

10.06 Trust Deed dated May 9, 2007 relating to the 2.75% Convertible Bonds due 2014 between Shire plc and BNY Corporate Trustee Services Limited. (25)

10.07 Supplemental Trust Deed dated April 15, 2008 between Shire Limited, Shire plc and BNY Corporate Trustee Services Limited relating to a trust deed dated May 9, 2007 relating to US $1,100,000,000 2.75% Convertible Bonds due 2014. (26)

10.08 Accession and Amendment Agreement dated April 15, 2008 between Shire Limited, Shire plc, BNY Corporate Trustee Services Limited and The Bank of New York relating to a paying and conversion agency agreement dated May 9, 2007 relating to US $1,100,000,000 2.75% Convertible Bonds due 2014. (27)

10.09* Revised and Restated Master License Agreement dated November 20, 1995 among Shire BioChem Inc (f/k/a BioChem Pharma Inc.), Glaxo Group Limited, Glaxo Wellcome Inc. (formerly Glaxo Canada Inc.), Glaxo Wellcome Inc. (formerly Glaxo Inc.), Tanaud Holdings (Barbados) Limited, Tanaud International B.V. and Tanaud LLC. (28)

10.10* Settlement Agreement, dated August 14, 2006 by and between Shire Laboratories Inc. and Barr. (29)

10.11* Product Development and License Agreement, dated August 14, 2006 by and between Shire LLC and Duramed Pharmaceuticals, Inc. (30)

10.12* Product Acquisition and License Agreement, dated August 14, 2006 by and among Shire LLC, Shire plc and Duramed Pharmaceuticals, Inc. (31)

10.13 Novation Agreement dated November 21, 2005 relating to the Employment Agreement of Angus Russell dated March 10, 2004. (32)

10.14 Novation Agreement dated April 11, 2008 relating to the Employment Agreement of Angus Russell dated March 10, 2004, as previously novated on November 21, 2005. (33)

10.15 Form of Amended and Restated Employment Agreement between Shire plc and Mr Matthew Emmens, dated March 12, 2004. (34)

10.16 Amendment Agreement dated November 21, 2005 relating to the Amended and Restated Employment Agreement of Matthew Emmens dated March 12, 2004. (35)

10.17 Ratification and Guaranty dated November 21, 2005 relating to the Amended and Restated Employment Agreement of Matthew Emmens dated March 12, 2004. (36)

10.18 Amendment Agreement dated May 20, 2008 relating to the Amended and Restated Employment Agreement of Matthew Emmens dated March 12, 2004, as amended on November 21, 2005. (37)

10.19 Ratification and Guaranty dated May 20, 2008 relating to the Amended and Restated Employment Agreement of Matthew Emmens dated March 12, 2004. (38)

10.20 Form of Indemnity Agreement for Directors of Shire Limited. (39)

10.21 Service Agreement between Shire Limited and Mr Graham Hetherington, dated July 2, 2008. (40)

10.22 Form of Settlement Agreement and Mutual Release in re: Transkaryotic Therapies, Inc., by and between Shire Human Genetic Therapies, Inc., Shire plc and the parties set forth therein. (41)

10.23 Amended Agreement dated February 24, 2009 relating to the Product Development and License Agreement dated August 14, 2006. (42)

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10.24 Amendment to the Shire Portfolio Share Plan as approved by the Annual General meeting held on April 27, 2010. (43)

10.25 Multicurrency revolving and swingline facilities agreement as at November 23, 2010 by and among Shire plc & with a number of financial institutions, for which Abbey National Treasury Services Plc (trading as Santander Global Banking and Markets), Bank of America Securities Limited, Barclays Capital, Citigroup Global Markets Limited, Lloyds TSB Bank plc and The Royal Bank of Scotland plc acted as mandated lead arrangers and bookrunners and Credit Suisse AG, London Branch, Deutsche Bank AG, London Branch, Goldman Sachs International, Morgan Stanley Bank, N.A. and Sumitomo Mitsui Banking Corporation, Brussels Branch acted as arrangers. (44)

10.26 Service Agreement between Shire Pharmaceutical, LLC and Mr. Flemming Ornskov, dated October 24, 2012. (45)

10.27 Facilities Agreement dated November 11, 2013 among Shire plc, Morgan Stanley Bank International Limited, as mandated lead arranger, bookrunner and agent, and the other parties thereto. (46)

10.28 Letter agreement dated December 13, 2013 among Shire plc, Morgan Stanley Bank International Limited, as agent, and the other parties thereto. (47)

10.29 Letter agreement dated February 18, 2014 between Shire plc and Barclays Bank plc, as agent. (48)

10.30 Letter agreement dated April 8, 2014 between Shire plc and Barclays Bank plc, as agent. (49)

10.31 US $ 2,100,000,000 Multicurrency Revolving and Swingline Facilities Agreement dated 12 December 2014. (50)

10.32 Facilities Agreement dated January 11, 2015 among Shire Plc, Citigroup Global Markets Limited, as mandated lead arranger and bookrunner, and the other parties thereto. (51)

31.1 Certification of Flemming Ornskov pursuant to Rule 13a - 14 under The Exchange Act.

31.2 Certification of Jeffrey Poulton pursuant to Rule 13a - 14 under The Exchange Act.

32.1 Certification of Flemming Ornskov and Jeffrey Poulton pursuant to Section 906 of the Sarbanes - Oxley Act of 2002.

101.INS XBRL Instance Document

101.SCH XBRL Taxonomy Extension Schema Document

101.CAL XBRL Taxonomy Extension Calculation Linkbase Document

101.DEF XBRL Taxonomy Definition Linkbase Document

101.LAB XBRL Taxonomy Extension Label Linkbase Document

101.PRE XBRL Taxonomy Extension Presentation Linkbase Document

* Certain portions of this exhibit have been omitted intentionally, subject to a confidential treatment request. A complete version of this agreement has been filed separately with the Securities and Exchange Commission.

(1) Incorporated by reference to Exhibit 99.02 to Shire’s Form 8-K filed on April 25, 2005.

(2) Incorporated by reference to Exhibit 2.1 to Shire’s Form 8-K filed on February 23, 2007.

(3) Incorporated by reference to Exhibit 2.1 to Shire’s Form 8-K filed on July 10, 2008.

(4) Incorporated by reference to Exhibit 2.04 to Shire’s Form 10-Q filed on November 5, 2010.

(5) Incorporated by reference to Exhibit 2.1 to Shire’s Form 8-K filed on June 30, 2011.

(6) Incorporated by reference to Exhibit 2.06 to Shire’s Form 10-Q filed on May 23, 2012.

(7)  Incorporated by reference to Exhibit 2.1 to Shire’s Form 8-K filed on November 12, 2013.

(8)  Incorporated by reference to Exhibit 2.1 to Shire’s Form 8-K filed on January 22, 2014.

(9)  Incorporated by reference to Exhibit 2.2 to Shire’s Form 8-K filed on July 24, 2014.

(10)  Incorporated by reference to Exhibit 2.1 to Shire’s Form 8-K filed on October 22, 2014.

(11)  Incorporated by reference to Exhibit 2.1 to Shire’s Form 8-K filed on January 12, 2015.

(12)  Incorporated by reference to Exhibit 99.02 to Shire’s Form 8-K filed on October 1, 2008.

(13) Incorporated by reference to Exhibit 3.1 to Shire’s Form 8-K filed on May 1, 2014.

56

(14) Incorporated by reference to Exhibit 4.01 to Shire’s Form 8-K filed on May 23, 2008.

(15) Incorporated by reference to Exhibit 4.02 to Shire’s Form 8-K filed on May 23, 2008.

(16) Incorporated by reference to Exhibit 4.03 to Shire’s Form 8-K filed on May 23, 2008.

(17) Incorporated by reference to Exhibit 4.04 to Shire’s Form 8-K filed on May 23, 2008.

(18) Incorporated by reference to Exhibit 4.05 to Shire’s Form 10-K filed on February 27, 2009.

(19) Incorporated by reference to Exhibit (a) to Shire’s Form F-6 filed on April 27, 2011.

(20) Incorporated by reference to Exhibit 99.1 to Shire’s Form 8-K filed on February 23, 2007.

(21) Incorporated by reference to Exhibit 10.2 to Shire’s Form 10-Q filed on May 1, 2007.

(22) Incorporated by reference to Exhibit 10.01 to Shire’s Form 8-K filed on May 23, 2008.

(23) Incorporated by reference to Exhibit 10.1 to Shire’s Form 10-Q filed on August 2, 2007.

(24) Incorporated by reference to Exhibit 10.2 to Shire’s Form 10-Q filed on August 2, 2007.

(25) Incorporated by reference to Exhibit 10.3 to Shire’s Form 10-Q filed on August 2, 2007.

(26) Incorporated by reference to Exhibit 10.02 to Shire’s Form 8-K filed on May 23, 2008.

(27) Incorporated by reference to Exhibit 10.03 to Shire’s Form 8-K filed on May 23, 2008.

(28) Incorporated by reference to Exhibit 10.09 to Shire’s Form 10-K/A filed on May 30, 2008.

(29) Incorporated by reference to Exhibit 10.1 to Shire’s Form 10-Q filed on November 7, 2006.

(30) Incorporated by reference to Exhibit 10.2 to Shire’s Form 10-Q filed on November 7, 2006.

(31) Incorporated by reference to Exhibit 10.3 to Shire’s Form 10-Q filed on November 7, 2006.

(32) Incorporated by reference to Exhibit 10.03 to Shire’s Form 8-K filed on November 25, 2005.

(33) Incorporated by reference to Exhibit 10.06 to Shire’s Form 8-K filed on May 23, 2008.

(34) Incorporated by reference to Exhibit 10.13 to Shire’s Form 10-K filed on March 12, 2004.

(35) Incorporated by reference to Exhibit 10.01 to Shire’s Form 8-K filed on November 25, 2005.

(36) Incorporated by reference to Exhibit 10.02 to Shire’s Form 8-K filed on November 25, 2005.

(37) Incorporated by reference to Exhibit 10.04 to Shire’s Form 8-K filed on May 23, 2008.

(38) Incorporated by reference to Exhibit 10.05 to Shire’s Form 8-K filed on May 23, 2008.

(39) Incorporated by reference to Exhibit 10.07 to Shire’s Form 8-K filed on May 23, 2008.

(40) Incorporated by reference to Exhibit 10.23 to Shire’s Form 10-Q filed on November 10, 2008.

(41) Incorporated by reference to Exhibit 10.24 to Shire’s Form 10-Q filed on November 10, 2008.

(42) Incorporated by reference to Exhibit 10.25 to Shire’s Form 10-Q filed on May 7, 2009.

(43) Incorporated by reference to Exhibit 10.27 to Shire’s Form 10-Q filed on May 6, 2010.

(44) Incorporated by reference to Exhibit 10.28 to Shire’s Form 10-K filed on February 23, 2011.

(45) Incorporated by reference to Exhibit 10.29 to Shire’s Form 10-K filed on February 25, 2013.

(46) Incorporated by reference to Exhibit 10.1 to Shire’s Form 8-K filed on November 12, 2013.

(47) Incorporated by reference to Exhibit 10.1 to Shire’s Form 8-K filed on December 16, 2013.

(48) Incorporated by reference to Exhibit 10.1 to Shire’s Form 8-K filed on February 21, 2014.

(49) Incorporated by reference to Exhibit 10.1 to Shire’s Form 8-K filed on April 11, 2014.

(50) Incorporated by reference to Exhibit 10.1 to Shire’s Form 8-K filed on December 17, 2014.

(51) Incorporated by reference to Exhibit 10.1 to Shire’s Form 8-K filed on January 12, 2015.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 (the “Exchange Act”) the Company has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

Date: May 5, 2015	/s/ Flemming Ornskov Flemming Ornskov Chief Executive Officer
Date: May 5, 2015	/s/ Jeffrey Poulton Jeffrey Poulton Chief Financial Officer

58

EX-31.1

EXHIBIT 31.1

CERTIFICATION OF FLEMMING ORNSKOV PURSUANT TO

RULE 13A-14 UNDER THE

SECURITIES EXCHANGE ACT OF 1934

FORM 10-Q FOR THE QUARTER ENDED

MARCH 31, 2015 OF

SHIRE PLC

I, Flemming Ornskov, certify that:

1.           I have reviewed this quarterly report on Form 10-Q of Shire plc;

2. Based on my knowledge, this quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this quarterly report;

3. Based on my knowledge, the financial statements, and other financial information included in this quarterly report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this quarterly report;

4. The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d - 15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d - 15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this quarterly report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this quarterly report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation;

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

Date: May 5, 2015

/s/ Flemming Ornskov

Flemming Ornskov

Chief Executive Officer

EX-31.2

EXHIBIT 31.2

CERTIFICATION OF JEFFREY POULTON PURSUANT TO

RULE 13A-14 UNDER THE

SECURITIES EXCHANGE ACT OF 1934

FORM 10-Q FOR THE QUARTER ENDED

MARCH 31, 2015 OF

SHIRE PLC

I, Jeffrey Poulton, certify that:

1.  I have reviewed this quarterly report on Form 10-Q of Shire plc;

2. Based on my knowledge, this quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this quarterly report;

3. Based on my knowledge, the financial statements, and other financial information included in this quarterly report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this quarterly report;

4. The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d - 15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d - 15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this quarterly report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this quarterly report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation;

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

Date: May 5, 2015

/s/ Jeffrey Poulton

Jeffrey Poulton

Chief Financial Officer

EX-32.1

EXHIBIT 32.1

The certification set forth below is being submitted in connection with the Quarterly Report on Form 10-Q of Shire plc for the quarter ended March 31, 2015 (the “Report”) for the purpose of complying with Rule 13a-14(b) or Rule 15d-14(b) of the Securities Exchange Act of 1934 (the “Exchange Act”) and Section 1350 of Chapter 63 of Title 18 of the United States Code.

Flemming Ornskov, the Chief Executive Officer and Jeffrey Poulton, the Chief Financial Officer of Shire plc, each certifies that, to the best of his knowledge:

1. the Report fully complies with the requirements of Section 13(a) or 15(d) of the Exchange Act; and

2. the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Shire plc.

Date: May 5, 2015

/s/ Flemming Ornskov

Flemming Ornskov

Chief Executive Officer

/s/ Jeffrey Poulton

Jeffrey Poulton

Chief Financial Officer

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Other Intangible Assets, Net (Tables)

3 Months Ended

Mar. 31, 2015

Intangible Assets, Net (Excluding Goodwill) [Abstract]

Schedule of Other Intangible Assets

		March 31,	December 31,
		2015	2014
		$’M	$’M
		________________	________________
Amortized intangible assets
	Intellectual property rights acquired for currently marketed products	9,404.0	4,816.9
	Other intangible assets	375.0	30.0
		________________	________________
		9,779.0	4,846.9
Unamortized intangible assets
	Intellectual property rights acquired for IPR&D	1,724.5	1,550.0
		________________	________________
		11,503.5	6,396.9
Less: Accumulated amortization		(1,523.5)	(1,462.5)
		________________	________________
		9,980.0	4,934.4
		________________	________________

Intangible Assets (Excluding Goodwill) Roll Forward

	Other intangible assets
	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	$’M	$’M
	________________	________________
As at January 1,	4,934.4	2,312.6
Acquisitions	5,198.0	2,854.0
Amortization charged	(88.3)	(57.8)
Impairment charges	-	(166.0)
Foreign currency translation	(64.1)	0.6
	________________	________________
As at March 31,	9,980.0	4,943.4
	________________	________________

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Accounts Receivable, Net (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014	Dec. 31, 2014
Provision for discounts and doubtful accounts
As at January 1,	$ 48.5	$ 47.9
Provision charged to operations	80.8	80.7
Provision utilization	(82.6)	(81.2)
As at March 31,	46.7	47.4
Accounts receivable, net	1,116.3		1,035.1
Accounts receivable related to royalty income	$ 57.2		$ 59.0

XML

Earnings Per Share (Tables)

3 Months Ended

Mar. 31, 2015

Earnings Per Share [Abstract]

Schedule of Calculation of Numerator and Denominator in Earnings Per Share

	2015	2014
	$’M	$’M
	_________________	_________________
Income from continuing operations, net of taxes	412.9	253.1
Loss from discontinued operations1	(2.5)	(22.7)
	_________________	_________________
Numerator for basic and diluted earnings per share	410.4	230.4
	_________________	_________________

Schedule of Weighted Average Number of Shares

Weighted average number of shares:
	Millions	Millions
	_________________	_________________
Basic 1	589.1	584.3
Effect of dilutive shares:
Share-based awards to employees 2	3.6	4.5
	_________________	_________________
Diluted	592.7	588.8
	_________________	_________________

Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share

	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	No. of shares	No. of shares
	Millions	Millions
	_________________	_________________
Share-based awards to employees1	1.4	0.8
	_________________	_________________

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Financial Instruments (Foreign Exchange Risk and Its Classification on Balance Sheet) (Details) (Foreign Exchange Contract, USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015 contract	Dec. 31, 2014
Derivatives, Fair Value
Net derivative fair value assets	$ 9.4
Net derivative fair value liabilities	4.0
Potential effect of rights of set off associated with the foreign exchange contracts	1.5
Number of swap and forward foreign exchange contracts outstanding	40
Swaps and forward contracts maturity	90 days
Prepaid expenses and other current assets
Derivatives, Fair Value
Assets	10.9	12.6
Other current liabilities
Derivatives, Fair Value
Liabilities	$ 5.5	$ 7.8

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Inventories (Details) (USD $) In Millions, unless otherwise specified	Mar. 31, 2015	Dec. 31, 2014
Schedule of Inventory
Finished goods	$ 137.8	$ 136.0
Work-in-progress	307.4	305.3
Raw materials	143.5	103.5
Total inventories	$ 588.7	$ 544.8

XML

Financial Instruments (Tables)

3 Months Ended

Mar. 31, 2015

Derivative Instrument Detail [Abstract]

Schedule of Foreign Exchange Contracts, Statement of Financial Position

		Fair value	Fair value
		March 31,	December 31,
		2015	2014
		$’M	$’M
		_____________	_____________
Assets	Prepaid expenses and other current assets	10.9	12.6
Liabilities	Other current liabilities	5.5	7.8
		_____________	_____________

Schedule of Foreign Exchange Contracts, Gain (Loss) in Other Income (Expense)

	Location of net gains recognized in income	Amount of net gains recognized in income
	__________________________________	____________
In the three months to		March 31,	March 31,
		2015	2014
		$’M	$’M
		_____________	_____________
Foreign exchange contracts	Other income, net	16.3	1.8
		_____________	_____________

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Reorganization costs (Table)

3 Months Ended

Mar. 31, 2015

Restructuring and Related Activities [Abstract]

Schedule of Reorganization costs

	Opening liability	Amount		Closing liability at
	at January 1,	charged to re-		March 31,
	2015	organization	Paid/Utilized	2015
	$'M	$'M	$'M	$'M
	___________	____________	___________	___________
Involuntary termination benefits	38.0	9.4	(5.1)	42.3
Other reorganization costs	-	5.8	(5.0)	0.8
	___________	___________	___________	___________
	38.0	15.2	(10.1)	43.1
	___________	___________	___________	___________

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Fair Value Measurement (Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs) (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014	Dec. 31, 2014
Change in the Fair Value of Contigent Consideration Receivable
Balance at beginning of period	$ 15.9	$ 36.1
Initial recognition of contingent consideration receivable	0	33.6
Gain/(loss) recognized in the income statement (within Gain on sale of product rights) due to change in fair value during the period	5.2	(7.1)
Reclassification of amounts to Other receivables within Other current assets	(5.9)	(4.0)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)	(0.2)	0.8
Balance at end of period	15.0	59.4
Change in the Fair Value of Contigent Consideration Payable
Balance at beginning of period	629.9	405.9
Initial recognition of contingent consideration payable	92.1	10.0
Change in fair value during the period with the corresponding adjustment recognized as a loss in the income statement (within Integration and acquisition costs)	2.4	(59.2)
Reclassification of amounts to Other current liabilities	(2.1)	(2.4)
Change in fair value during the period with corresponding adjustment to the associated intangible asset	(0.7)	(4.0)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)	2.4	0
Balance at end of period	724.0	350.3
Contingent consideration payable, current (within other current liabilities)	166.2		194.5
Contingent consideration payable, non-current (within other non-current liabilities)	$ 557.8		$ 435.4

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Prepaid Expenses and Other Current Assets (Details) (USD $) In Millions, unless otherwise specified	Mar. 31, 2015	Dec. 31, 2014
Prepaid Expense and Other Assets, Current [Abstract]
Prepaid expenses	$ 72.9	$ 36.9
Income tax receivable	68.8	121.5
Value added taxes receivable	15.0	13.8
Other current assets	59.9	49.3
Prepaid expenses and other current assets, total	$ 216.6	$ 221.5

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Segmental Reporting (Revenue by Product) (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Revenue from External Customer [Line Items]
Product sales	$ 1,423.2	$ 1,308.1
VYVANSE
Revenue from External Customer [Line Items]
Product sales	416.8	351.2
ADDERALL XR
Revenue from External Customer [Line Items]
Product sales	95.7	85.1
INTUNIV
Revenue from External Customer [Line Items]
Product sales	17.4	82.3
LIALDA and MEZAVANT
Revenue from External Customer [Line Items]
Product sales	148.5	128.9
PENTASA
Revenue from External Customer [Line Items]
Product sales	78.7	72.3
FOSRENOL
Revenue from External Customer [Line Items]
Product sales	44.1	41.4
XAGRID
Revenue from External Customer [Line Items]
Product sales	25.3	27.1
Other Products
Revenue from External Customer [Line Items]
Product sales	32.3	29.5
REPLAGAL
Revenue from External Customer [Line Items]
Product sales	97.5	114.3
ELAPRASE
Revenue from External Customer [Line Items]
Product sales	125.0	128.6
VPRIV
Revenue from External Customer [Line Items]
Product sales	86.4	86.9
FIRAZYR
Revenue from External Customer [Line Items]
Product sales	92.5	74.9
CINRYZE
Revenue from External Customer [Line Items]
Product sales	148.1	85.6
GATTEX/REVESTIVE
Revenue from External Customer [Line Items]
Product sales	$ 14.9	$ 0

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Related parties (Details) (ArmaGen, USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015
ArmaGen
Related Party Transaction [Line Items]
Amount paid for an equity stake and the license to develop and commercialize AGT-182	$ 2.5
Share of R&D credit recorded within R&D expense	$ 0.4
Percentage of equity stake	21.00%

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Financial Instruments (Foreign Exchange Risk and Its Effect on Income Statement) (Details) (Foreign Exchange Contract, Other income, net, USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Foreign Exchange Contract | Other income, net
Derivative Instruments, Gain (Loss) [Line Items]
Amount of net income (loss) recognized in income	$ 16.3	$ 1.8

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Accumulated Other Comprehensive Income

3 Months Ended

Mar. 31, 2015

Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract]

Accumulated Other Comprehensive Income (Loss)

16.Accumulated Other Comprehensiveloss

The changes in accumulated other comprehensive loss, net of their related tax effects, in the three months to March 31, 2015and 2014are included below:

As at March 31, 2015		Foreign currency translation adjustment	Unrealized holding loss on available-for-sale securities	Accumulated other comprehensive loss
		$M	$M	$M
As at January 1, 2015		(25.7)	(5.8)	(31.5)
Net current period other comprehensive (loss)/income		(129.5)	0.7	(128.8)
As at March 31, 2015		(155.2)	(5.1)	(160.3)
As at March 31, 2014		Foreign currency translation adjustment	Unrealized holding gain/(loss) on available-for-sale securities	Accumulated other comprehensive income
		$M	$M	$M
As at January 1, 2014		110.4	(0.2)	110.2
Current period change:
	Other comprehensive income before reclassification	(1.7)	7.5	5.8
	Gain transferred to the income statement (within Other income, net) on disposal of available-for-sale securities	0	(3.2)	(3.2)
Net current period other comprehensive income		(1.7)	4.3	2.6
As at March 31, 2014		108.7	4.1	112.8

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Business Combinations (ViroPharrma,NPS Pharma, Meritage) (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended		0 Months Ended
	Mar. 31, 2015	Mar. 31, 2014	Feb. 21, 2015	Dec. 31, 2014	Feb. 18, 2015	Dec. 31, 2013
Non-current assets:
Goodwill	$ 4,178.7	$ 2,161.2		$ 2,474.9		$ 624.6
Pro Forma Information
Post acquisition unwind of inventory fair value adjustment included in consolidated statement of income	11.2	38.8
Integration and acquisition costs	75.7	6.6
NPS Pharma
Business Acquisition [Line Items]
Percentage of voting interests acquired	100.00%
Cash consideration paid			5,217.8
Acquisition-date fair value of consideration			5,217.8
Current assets:
Cash and cash equivalents			41.6
Short term investments			67.0
Accounts receivable			31.7
Inventories			51.1
Deferred tax assets			151.5
Other current assets			10.1
Total current assets			353.0
Non-current assets:
Property, plant and equipment			4.2
Goodwill			1,691.6
Total assets			7,071.8
Current liabilities:
Accounts payable and other current liabilities			72.5
Short-term debt			27.4
Non-current liabilities:
Long term debt, less current portion			78.9
Deferred tax liabilities			1,671.0
Other non-current liabilities			4.2
Total liabilities			1,854.0
Fair value of identified assets acquired and liabilities assumed			5,217.8
Pro Forma Information
Post acquisition revenues included in consolidated statement of income	26.2
Post acquisition pre-tax losses included in consolidated statement of income	51.2
Post acquisition amortization of intangible assets included in consolidated statement of income	30.1
Post acquisition unwind of inventory fair value adjustment included in consolidated statement of income	9.9
Post acquisition integration costs included in consolidated statement of income	17.4
Integration and acquisition costs	69.9	0
NPS Pharma | Currently Marketed Products
Non-current assets:
Other intangible assets, net			4,670.0
NPS Pharma | Currently Marketed Products | GATTEX/REVESTIVE
Pro Forma Information
Estimated useful life of intangible assets			24 years
NPS Pharma | Currently Marketed Products | NATPARA/NATPAR
Pro Forma Information
Estimated useful life of intangible assets			24 years
NPS Pharma | Royalty rights
Non-current assets:
Other intangible assets, net			353.0
Pro Forma Information
Weighted average amortization period of acquired amortizable intangible assets			4 years
NPS Pharma | Royalty rights | Minimum
Pro Forma Information
Estimated useful life of intangible assets			4 years
NPS Pharma | Royalty rights | Maximum
Pro Forma Information
Estimated useful life of intangible assets			5 years
Viropharma
Business Acquisition [Line Items]
Percentage of voting interests acquired				100.00%
Cash consideration paid				3,997.0
Acquisition-date fair value of consideration				3,997.0
Expected operational synergies that will result from combining the commercial operations of Viropharma with those of Shire				400.0
Current assets:
Cash and cash equivalents				232.6
Short term investments				57.8
Accounts receivable				52.2
Inventories				203.6
Deferred tax assets				100.7
Purchased call option				346.7
Other current assets				50.9
Total current assets				1,044.5
Non-current assets:
Property, plant and equipment				24.7
Goodwill				1,655.5
Other non-current assets				10.4
Total assets				5,370.1
Current liabilities:
Accounts payable and other current liabilities				122.7
Short-term debt				551.4
Non-current liabilities:
Deferred tax liabilities				603.5
Other non-current liabilities				95.5
Total liabilities				1,373.1
Fair value of identified assets acquired and liabilities assumed				3,997.0
Pro Forma Information
Discount rate used in determining fair value of acquired in process research and development, low rate				9.50%
Discount rate used in determining fair value of acquired in process research and development, high rate				10.00%
Integration and acquisition costs	3.3	65.8
Viropharma | Currently Marketed Products
Non-current assets:
Other intangible assets, net				2,320.0
Pro Forma Information
Weighted average amortization period of acquired amortizable intangible assets				22 years
Viropharma | Currently Marketed Products | Minimum
Pro Forma Information
Estimated useful life of intangible assets				10 years
Viropharma | Currently Marketed Products | Maximum
Pro Forma Information
Estimated useful life of intangible assets				23 years
Viropharma | IPR&D
Non-current assets:
Other intangible assets, net				315.0
Meritage
Business Acquisition [Line Items]
Cash consideration paid					74.8
Acquisition-date fair value of consideration					166.9
Maximum amount of contingent cash consideration					175.0
Fair value of contingent consideration payable					92.1
Current assets:
Total current assets					5.5
Non-current assets:
Goodwill					41.1
Non-current liabilities:
Total liabilities					54.7
Fair value of identified assets acquired and liabilities assumed					166.9
Meritage | IPR&D | OBS
Non-current assets:
Other intangible assets, net					$ 175.0

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Borrowings (Tables)

3 Months Ended

Mar. 31, 2015

Debt Disclosure [Abstract]

Schedule of Borrowings

	March 31,	December 31,
	2015	2014
	$’M	$’M
	_____________	_____________
Short term borrowings:
Borrowings under the 2015 Facilities Agreement	850.0	-
Borrowings under the 2013 Facilities Agreement	850.0	850.0
Borrowings under the RCF	845.0	-
Secured non-recourse debts	25.2	-
	_____________	_____________
	2,570.2	850.0
Long term borrowings:
Secured non-recourse debts	78.7	-
	_____________	_____________
	2,648.9	850.0
	_____________	_____________

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Earnings Per Share (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015		Mar. 31, 2014
Schedule of Calculation of Numerator and Denominator in Earnings Per Share
Income from continuing operations, net of taxes	$ 412.9		$ 253.1
Loss from discontinued operations, net of taxes	(2.5)		(22.7)
Net income	$ 410.4		$ 230.4
Schedule of Weighted Average Number of Shares
Basic (in shares)	589.1	[1]	584.3	[1]
Effect of dilutive shares:
Share based awards to employees (in shares)	3.6	[2]	4.5	[2]
Diluted (in shares)	592.7		588.8
Share Awards
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	1.4	[3]	0.8	[3]

[1] Excludes shares purchased by the EBT and presented by Shire as treasury stock

[2] . Calculated using the treasury stock method

[3] Certain stock options have been excluded from the calculation of diluted EPS because (a) their exercise prices exceeded Shire plc’s average share price during the calculation period or (b) the required performance conditions were not satisfied as at the balance sheet date.

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Prepaid Expenses and Other Current Assets (Tables)

3 Months Ended

Mar. 31, 2015

Prepaid Expense and Other Assets, Current [Abstract]

Prepaid Expense and Other Assets, Current

	March 31,	December 31,
	2015	2014
	$’M	$’M
	______________	____________
Prepaid expenses	72.9	36.9
Income tax receivable	68.8	121.5
Value added taxes receivable	15.0	13.8
Other current assets	59.9	49.3
	______________	______________
	216.6	221.5
	______________	______________

XML

Reorganization Costs (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015 number	Mar. 31, 2014
Restructuring and Related Cost [Line Items]
Reorganization costs	$ 15.2	$ 49.4
Reorganization cost incurred to date	260.7
Reorganizations costs, expected costs	115.0
Restructuring Reserve [Roll Forward]
Reorganization Reserve Opening liability	38.0
Amounts charged to re-organization	15.2	49.4
Reorganization liability, Paid and Utilized	(10.1)
Reorganization Reserve Closing liability	43.1
Number of divisions	3
Involuntary termination benefits
Restructuring and Related Cost [Line Items]
Reorganization costs	9.4
Restructuring Reserve [Roll Forward]
Reorganization Reserve Opening liability	38.0
Amounts charged to re-organization	9.4
Reorganization liability, Paid and Utilized	(5.1)
Reorganization Reserve Closing liability	42.3
Other reorganization costs
Restructuring and Related Cost [Line Items]
Reorganization costs	5.8
Restructuring Reserve [Roll Forward]
Reorganization Reserve Opening liability	0
Amounts charged to re-organization	5.8
Reorganization liability, Paid and Utilized	(5.0)
Reorganization Reserve Closing liability	$ 0.8

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Commitments and Contingencies (Commitments and Loss Contingency) (Details) (USD $) In Millions, unless otherwise specified	Mar. 31, 2015	Dec. 31, 2014
Legal Matters [Line Items]
Provisions for litigation loss, insurance claims and other disputes	$ 26.0	$ 16.9
Clinical Testing
Commitment [Line Items]
Commitment amount	402.0	382.0
Contract Manufacturing
Commitment [Line Items]
Commitment amount	397.0	384.0
Commitments expected to be paid in next year	154.0
Other Purchasing Commitment
Commitment [Line Items]
Commitment amount	320.0	265.0
Commitments expected to be paid in next year	306.0
Investment Commitment
Commitment [Line Items]
Commitment amount	58.0	67.0
Capital Commitment
Commitment [Line Items]
Commitment amount	$ 9.0	$ 3.0

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Accounts Payable and Accrued Expenses (Details) (USD $) In Millions, unless otherwise specified	Mar. 31, 2015	Dec. 31, 2014
Accounts Payable and Accrued Liabilities, Current [Line Items]
Trade accounts payable and accrued purchases	$ 384.1	$ 247.7
Accrued rebates - Medicaid	555.9	563.9
Accrued rebates - Managed care	306.8	318.2
Sales return reserve	134.8	131.7
Accrued bonuses	72.6	150.7
Accrued employee compensation and benefits payable	174.0	109.1
R&D accruals	55.9	88.3
Other accrued expenses	307.5	299.8
Accounts payable and accrued expenses, total	$ 1,991.6	$ 1,909.4

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Fair Value Measurement (Tables)

3 Months Ended

Mar. 31, 2015

Fair Value Disclosures [Abstract]

Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis

		Carrying value and Fair value
		Total	Level 1	Level 2	Level 3
At March 31, 2015		$'M	$'M	$'M	$'M
		____________	___________	___________	___________
Financial assets:
Available-for-sale securities(1)		26.4	26.4	-	-
Contingent consideration receivable (2)		15.0	-	-	15.0
Foreign exchange contracts		10.9	-	10.9	-
Financial liabilities:
Foreign exchange contracts		5.5	-	5.5	-
Contingent consideration payable(3)		724.0	-	-	724.0
		____________	___________	___________	___________
		Total	Level 1	Level 2	Level 3
At December 31, 2014		$'M	$'M	$'M	$'M
		____________	___________	___________	___________
Financial assets:
Available-for-sale securities(1)		13.1	13.1	-	-
Contingent consideration receivable (2)		15.9	-	-	15.9
Foreign exchange contracts		12.6	-	12.6	-
Financial liabilities:
Foreign exchange contracts		7.8	-	7.8	-
Contingent consideration payable(3)	1	629.9	-	-	629.9
		____________	___________	___________	___________

• Available-for-sale securities are included within Investments and Prepaid expenses and other current assetsin the consolidated

balance sheet.

(2)Contingent consideration receivable is included within Prepaid expenses and other current assets and Other non-current assets in the consolidated balance sheet.

(3)Contingent consideration payableis included within Other current liabilities and Other non-current liabilities in the consolidated balance sheet.

Assets Measured at Fair Value on a Recurring Basis Using Significant Unobervable Inputs (Level 3)

Contingent consideration receivable
	2015	2014
	$'M	$'M
	____________	____________
Balance at January 1,	15.9	36.1
Initial recognition of contingent consideration receivable	-	33.6
Gain/(loss) recognized in the income statement (within Gain on sale of product rights) due to change in fair value during the period	5.2	(7.1)
Reclassification of amounts to Other receivables within Other current assets	(5.9)	(4.0)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)	(0.2)	0.8
Balance at March 31,	15.0	59.4

Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobervable Inputs (Level 3)

Contingent consideration payable
	2015	2014
	$'M	$'M
	____________	____________
Balance at January 1,	629.9	405.9
Initial recognition of contingent consideration payable	92.1	10.0
Change in fair value during the period with the corresponding adjustment recognized as a loss in the income statement (within Integration and acquisition costs)	2.4	(59.2)
Reclassification of amounts to Other current liabilities	(2.1)	(2.4)
Change in fair value during the period with corresponding adjustment to the associated intangible asset	(0.7)	(4.0)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)	2.4	-
Balance at March 31,	724.0	350.3

Fair Value Inputs, Assets Quantitative Information Table

Financial assets:	Fair Value at the Measurement Date
At March 31, 2015	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
	____________	___________	___________	___________
Contingent consideration receivable ("CCR")	15.0	Income approach (probability weighted discounted cash flow)	• Probability weightings applied to different sales scenarios • Future forecast consideration receivable based on contractual terms with purchaser • Assumed market participant discount rate	• 10 to 70% • $25 million to $33 million • 8.3% to 11.5%
	____________	____________	____________	____________

Fair Value Inputs, Liabilities Quantitative Information Table

Financial liabilities:	Fair Value at the Measurement Date
At March 31, 2015	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
	____________	___________	___________	___________
Contingent consideration payable	724.0	Income approach (probability weighted discounted cash flow)	• Cumulative probability of milestones being achieved • Assumed market participant discount rate • Periods in which milestones are expected to be achieved • Forecast quarterly royalties payable on net sales of relevant products	• 4 to 95% • 0.6 to 11.8% • 2015 to 2030 • $0.2 to $7.6 million
	____________	____________	____________	____________

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Consolidated Statements of Cash Flows (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income	$ 410.4	$ 230.4
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	120.6	94.6
Share-based compensation	15.3	26.2
Change in fair value of contingent consideration	2.4	(59.2)
Unwind of inventory fair value step-ups	11.2	38.8
Impairment of IPR&D intangible assets	0	166.0
Impairment of PP&E	0	12.1
Gain on sale of product rights	(5.2)	(36.4)
Other, net	1.1	(0.3)
Movement in deferred taxes	16.6	18.5
Equity in earnings of equity method investees	1.0	0.6
Changes in operating assets and liabilities:
Increase in accounts receivable	(85.1)	(77.3)
(Decrease)/increase in sales deduction accruals	(24.6)	70.8
Increase in inventory	(22.0)	(18.6)
Decrease/(increase) in prepayments and other assets	42.4	(74.6)
Increase/(decrease) in accounts and notes payable and other liabilities	77.5	(145.5)
Net cash provided by operating activities	561.6	246.1
CASH FLOWS FROM INVESTING ACTIVITIES:
Movements in restricted cash	(14.5)	(10.1)
Purchases of subsidiary undertakings and businesses, net of cash acquired	(5,199.7)	(3,764.4)
Purchases of non-current investments and PP&E	(22.3)	(15.6)
Proceeds from short-term investments	54.5	46.8
Proceeds received on sale of product rights	3.9	48.0
Proceeds from disposal of non-current investments and PP&E	0.9	8.0
Other, net	0	(2.9)
Net cash used in investing activities	(5,177.2)	(3,690.2)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from revolving line of credit, long-term and short-term borrowings	2,230.0	2,170.0
Repayment of revolving line of credit	(535.2)	(650.2)
Repayment of debt acquired ViroPharma Inc. ("ViroPharma")	0	(533.9)
Proceeds from ViroPharma call options	0	346.7
Excess tax benefit associated with exercise of stock options	19.9	20.5
Contingent consideration payments	(2.4)	(7.8)
Other, net	(3.2)	0.2
Net cash provided by/(used in) financing activities	1,709.1	1,345.5
Effect of foreign exchange rate changes on cash and cash equivalents	(1.6)	(1.7)
Net decrease in cash and cash equivalents	(2,908.1)	(2,100.3)
Cash and cash equivalents at beginning of period	2,982.4	2,239.4
Cash and cash equivalents at end of period	74.3	139.1
Supplemental information associated with continuing operations:
Interest paid	(5.0)	(2.6)
Income taxes repaid/(paid)	$ 48.8	$ (82.6)

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Other Current Liabilities (Details) (USD $) In Millions, unless otherwise specified	Mar. 31, 2015	Dec. 31, 2014
Other Liabilities, Current [Abstract]
Income taxes payable	$ 25.8	$ 16.2
Value added taxes	18.0	16.6
Contingent consideration payable	166.2	194.5
Other current liabilities	93.2	35.2
Other current liabilities, total	$ 303.2	$ 262.5

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Other Non-current Liabilities (Tables)

3 Months Ended

Mar. 31, 2015

Other Liabilities, Noncurrent [Abstract]

Schedule of Other Noncurrent Liabilities

	March 31,	December 31,
	2015	2014
	$’M	$’M
	____________	____________
Income taxes payable	180.7	199.2
Deferred revenue	6.7	7.2
Deferred rent	6.2	6.6
Contingent consideration payable	557.8	435.4
Other non-current liabilities	92.6	88.3
	____________	____________
	844.0	736.7
	____________	____________

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Segmental Reporting

3 Months Ended

Mar. 31, 2015

Segment Reporting [Abstract]

Segment Reporting Disclosure

20.       Segmental reporting

Shire comprises a single operating and reportable segment engaged in the research, development, licensing, manufacturing, marketing, distribution and sale of innovative specialist medicines to meet significant unmet patient needs.

This segment is supported by several key functions: a Pipeline group, consisting of R&D and Corporate Development, which prioritizes its activities towards late-stage development programs across a variety of therapeutic areas, while focusing its pre-clinical development activities primarily in Rare Diseases; a Technical Operations group responsible for the Company's global supply chain; and an In-line marketed products group which focuses on commercialized products. The In-Line marketed products group has commercial units that focus exclusively on the commercial execution of its marketed products including in the areas of Rare Diseases, Neuroscience, and Gastrointestinal (“GI”) and Internal Medicine, and to support the development of our pipeline candidates, in Ophthalmics. This ensures that the Company provides innovative treatments, and services the needs of its customers and patients, as efficiently as possible. The business is also supported by a simplified, centralized corporate function group. None of these functional groups meets all of the criteria to be an operating segment.

This single operating and reportable segment is consistent with the financial information regularly reviewed by the Executive Committee (which is Shire's chief operating decision maker) for the purposes of evaluating performance, allocating resources, and planning and forecasting future periods.

In the periods set out below, revenues by major product were as follows:

3 months to	March 31,	March 31,
	2015	2014
	$’M	$’M
	___________	___________
VYVANSE	416.8	351.2
LIALDA/MEZAVANT	148.5	128.9
CINRYZE	148.1	85.6
ELAPRASE	125.0	128.6
REPLAGAL	97.5	114.3
ADDERALL XR	95.7	85.1
FIRAZYR	92.5	74.9
VPRIV	86.4	86.9
PENTASA	78.7	72.3
FOSRENOL	44.1	41.4
XAGRID	25.3	27.1
INTUNIV	17.4	82.3
GATTEX/REVESTIVE	14.9	-
Other product sales	32.3	29.5
	____________	____________
Total product sales	1,423.2	1,308.1
	____________	____________

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Earnings Per Share

3 Months Ended

Mar. 31, 2015

Earnings Per Share [Abstract]

Earnings Per Share Disclosure

19.Earnings per share

The following table reconciles net income and the weighted average ordinary shares outstanding for basic and diluted earnings per share for the periods presented:

	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	$’M	$’M
	_________________	_________________
Income from continuing operations, net of taxes	412.9	253.1
Loss from discontinued operations1	(2.5)	(22.7)
	_________________	_________________
Numerator for basic and diluted earnings per share	410.4	230.4
	_________________	_________________
Weighted average number of shares:
	Millions	Millions
	_________________	_________________
Basic 1	589.1	584.3
Effect of dilutive shares:
Share-based awards to employees 2	3.6	4.5
	_________________	_________________
Diluted	592.7	588.8
	_________________	_________________

1. Excludes shares purchased by the EBT and presented by Shire as treasury stock.

2. Calculated using the treasury stock method.

The share equivalents not included in the calculation of the diluted weighted average number of shares are shown below:

	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	No. of shares	No. of shares
	Millions	Millions
	_________________	_________________
Share-based awards to employees1	1.4	0.8
	_________________	_________________

• Certain stock options have been excluded from the calculation of diluted EPS because (a) their exercise prices exceeded Shire plc's average share price during the calculation period or (b) the required performance conditions were not satisfied as at the balance sheet date.

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Results of discontinued operations (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Loss from discontinued operations, net of taxes	$ (2.5)	$ (22.7)
DERMAGRAFT
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Product Revenues	0	1.9
Loss from discontinuing operations before income taxes	(3.9)	(35.8)
Income taxes	1.4	13.1
Loss from discontinued operations, net of taxes	$ (2.5)	$ (22.7)

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Commitments and Contingencies (Tables)

3 Months Ended

Mar. 31, 2015

Commitments and Contingencies Disclosure [Abstract]

Future Minimum Lease Payments under Operating Leases

		Operating
		leases
		$’M
		_____________
2015	1	30.6
2016	1	26.4
2017	1	30.2
2018	1	25.4
2019	1	19.4
2020		19.3
Thereafter	1	125.2
	111	_____________
		276.5
		_____________

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Related Parties

3 Months Ended

Mar. 31, 2015

Related Party Transactions [Abstract]

Related Party Disclosure

21.       Related parties

Shire considers that ArmaGen, Inc. (“ArmaGen”) is a related party by virtue of a combination of Shire's equity stake in ArmaGen and the worldwide licensing and collaboration agreement between the two parties to develop and commercialize AGT-182. In the three months to March 31, 2015 Shire paid $2.5 million in cash to ArmaGen in exchange for an additional equity stake in ArmaGen, following which Shire holds approximately 21% of ArmaGen's issued equity. In addition, Shire recorded a credit to R&D costs of $0.4 million in the first quarter of 2015, reflecting the Company's share of expenditure under the licensing and collaboration arrangement. No amounts were due to or from ArmaGen as at March 31, 2015.

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Summary of Significant Accounting Policies (Policies)

3 Months Ended

Mar. 31, 2015

Basis of preparation

(a)       Basis of preparation

These interim financial statements of Shire plc and its subsidiaries (collectively “Shire” or the “Company”) and other financial information included in this Form 10-Q, are unaudited. They have been prepared in accordance with generally accepted accounting principles in the United States of America (“US GAAP”) and US Securities and Exchange Commission (“SEC”) regulations for interim reporting.

The balance sheet as at December 31, 2014 was derived from audited financial statements but does not include all disclosures required by US GAAP.

These interim financial statements should be read in conjunction with the consolidated financial statements and accompanying notes included in the Company's Annual Report on Form 10-K for the year to December 31, 2014.

Certain information and footnote disclosures normally included in financial statements prepared in accordance with US GAAP have been condensed or omitted from these interim financial statements. However, these interim financial statements include all adjustments, which are, in the opinion of management, necessary to fairly state the results of the interim period and the Company believes that the disclosures are adequate to make the information presented not misleading. Interim results are not necessarily indicative of results to be expected for the full year.

Use of estimates in consolidated financial statements

(b)       Use of estimates in interim financial statements

The preparation of interim financial statements, in conformity with US GAAP and SEC regulations, requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the consolidated financial statements and reported amounts of revenues and expenses during the reporting period. Estimates and assumptions are primarily made in relation to the valuation of intangible assets, sales deductions, income taxes (including provisions for uncertain tax positions and the realization of deferred tax assets), provisions for litigation and legal proceedings, contingent consideration receivable from product divestmentsandcontingent consideration payable in respect of business combinations and asset purchases. If actual results differ from the Company's estimates, or to the extent these estimates are adjusted in future periods, the Company's results of operations could either benefit from, or be adversely affected by, any such change in estimate.

New accounting pronouncements

(c)       New accounting pronouncements

Adopted during the period

Reporting Discontinued Operations and Disclosures of Disposals of Components of an Entity

In April 2014 the Financial Accounting Standard Board (“FASB”) issued guidance on the reporting of discontinued operations and disclosures of disposals of components of an entity. The amendments in this update revise the definition of discontinued operations by limiting discontinued operations reporting to disposals of components of an entity that represent strategic shifts that have (or will have) a major effect on an entity's operations and financial results. The guidance requires expanded disclosures for discontinued operations which provide users of financial statements with more information about the assets, liabilities, revenues, and expenses of discontinued operations. The guidance also requires an entity to disclose the pre-tax profit or loss of an individually significant component of an entity that does not qualify for discontinued operations reporting.

Shire adopted this guidance in the period, which will be effective for discontinued operations occurring after January 1, 2015. The adoption of this guidance did not impact the Company's consolidated financial position, results of operations or cash flows.

To be adopted in future periods

Revenue from Contracts with Customers

In May 2014 the FASB and the International Accounting Standards Board (together the “Accounting Standards Boards”) issued a new accounting standard that is intended to clarify and converge the financial reporting requirements for revenue from contracts with customers. The core principle of the standard is that an “entity recognizes revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services”. To achieve that core principle the Accounting Standard Boards developed a five-step model (as presented below) and related application guidance, which will replace most existing revenue recognition guidance in US GAAP.

Five-step model:

Step 1: Identify the contract(s) with a customer.

Step 2: Identify the performance obligations in the contract.

Step 3: Determine the transaction price.

Step 4: Allocate the transaction price to the performance obligations in the contract.

Step 5: Recognize revenue when (or as) the entity satisfies a performance obligation.

The Accounting Standards Boards also issued new qualitative and quantitative disclosure requirements as part of the new accounting standard which aims to enable financial statement users to understand the nature, amount, timing, and uncertainty of revenue and cash flows arising from contracts with customers.

In April 2015 the FASB proposed to defer the effective date of the guidance by one year. Based on this proposal, public entities would need to apply the new guidance for annual reporting periods beginning after December 15, 2017, and interim periods therein. The Company is currently evaluating the impact of adopting this guidance.

Elimination of Certain Financial Reporting Requirements, Including an Amendment to Variable Interest Entities (“VIEs”) Guidance in Topic 810, Consolidation

In June 2014 the FASB issued guidance on the reporting requirements for development stage entities. The amendments in this update simplify the existing guidance by removing all incremental financial reporting requirements for development stage entities. The amendments also eliminate an exception provided with respect to development stage entities in Topic 810, Consolidation, for determining whether an entity is a VIE on the basis of the amount of equity that is at risk. The elimination of the exception may change the consolidation analysis, consolidation decision, and disclosure requirements for a reporting entity that has an interest in an entity in the development stage. The guidance to eliminate the exception to the sufficiency-of-equity-at-risk criterion for development stage entities should be applied retrospectively for annual reporting periods beginning after December 15, 2015, and interim periods therein. Early application of both of these amendments is permitted for any annual reporting period or interim period for which the entity's financial statements have not yet been issued. The Company is currently evaluating the impact of adopting this guidance.

Disclosure of Uncertainties about an Entity's Ability to Continue as a Going Concern

In August 2014 the FASB issued guidance aboutmanagement's responsibilitytoevaluatewhetherthereissubstantialdoubtaboutanentity's ability tocontinueasagoingconcernandtoproviderelatedfootnotedisclosures. An entity's management should evaluate whether there are conditions or events, considered in the aggregate, that raise substantial doubt about the entity's ability to continue as a going concern within one year after the date that the financial statements are issued (or within one year after the date that the financial statements are available to be issued when applicable). Management's evaluation should be based on relevant conditions and events that are known and reasonably knowable at the date that the financial statements are issued (or available to be issued). Substantial doubt about an entity's ability to continue as a going concern exists when relevant conditions and events, considered in the aggregate, indicate that it is probable that the entity will be unable to meet its obligations as they become due within one year after the date that the financial statements are issued (or available to be issued). The term probable is used consistently with its use in Topic 450, Contingencies. The amendments in this update are effective for the annual period ending after December 15, 2016, and for annual periods and interim periods thereafter. Early application is permitted. The Company does not expect the adoption of this guidance to have a material effect on its consolidated financial position, results of operations and cash flows.

Amendments to the Consolidation Analysis

In February 2015 the FASB issued guidanceto respond to stakeholders' concerns about the current accounting for consolidation of certain legal entities. Financial statement users asserted that in certain situations in which consolidation is ultimately required, deconsolidated financial statements are necessary to better analyze the reporting entity's economic and operational results. Previously, the FASB issued an indefinite deferral for certain entities to partially address those concerns. However, the amendments in this guidance rescind that deferral and address those concerns by making changes to the consolidation guidance.

Under the amendments, all reporting entities are within the scope of Subtopic 810-10, Consolidation, including limited partnerships and similar legal entities, unless a scope exception applies. The presumption that a general partner controls a limited partnership has been eliminated. In addition, fees paid to decision makers that meet certain conditions no longer cause decision makers to consolidate a VIE in certain instances. The amendments place more emphasis in the consolidation evaluation on variable interests other than fee arrangements such as principal investment risk (for example, debt or equity interests), guarantees of the value of the assets or liabilities of the VIE, written put options on the assets of the VIE, or similar obligations, including some liquidity commitments or agreements (explicit or implicit). Additionally, the amendments reduce the extent to which related party arrangements cause an entity to be considered a primary beneficiary.

The amendments are effective for public business entities for fiscal years, and for interim periods therein, beginning after December 15, 2015. Early adoption is permitted, including adoption in an interim period. The Company does not expect the adoption of this guidance to have a material effect on its consolidated financial position, results of operations and cash flows.

Simplifying the Presentation of Debt Issuance Costs

In April 2015 the FASB issued guidancetosimplify the presentation of debt issuance costs. The guidance requires that debt issuance costs related to a recognized debt liability be presentedin the balance sheet as a directdeduction from the carrying amount of that debtliability, consistent with debt discounts. The recognition andmeasurementguidance for debt issuance costs are not affected by the amendments in this update. The amendments in this update are effective forfinancial statements issued for fiscal years beginning after December 15, 2015,and interim periods therein.

Early adoption of the amendments in this update is permitted for financial statements that have not been previously issued. An entity should apply the new guidance on a retrospective basis, wherein the balance sheet of each individual period presented should be adjusted to reflect the period-specific effects of applying the new guidance. Upon transition, an entity is required to comply with the applicable disclosures for a change in an accounting principle. The Company does not expect the adoption of this guidance to have a material effect on its consolidated financial position, results of operations and cash flows.

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Consolidated Statements of Changes in Equity (USD $) In Millions	Total	Common stock	Additional paid-in capital	Treasury stock	Accumulated other comprehensive (loss)/income	Retained earnings
As at Dec. 31, 2014	$ 8,662.9	$ 58.7	$ 4,338.0	$ (345.9)	$ (31.5)	$ 4,643.6
Shares as at Dec. 31, 2014	599.1	599.1
Net income	410.4					410.4
Other comprehensive loss, net of tax	(128.8)				(128.8)
Options exercised	0.2	0.2
Option exercised (in shares)		1.1
Share-based compensation	15.3		15.3
Tax benefit associated with exercise of stock options (in US dollar)	19.9		19.9
Shares released by Employee Benefit Trust ("EBT") to satisfy exercise of stock options	0.8			15.8		(15.0)
As at Mar. 31, 2015	$ 8,980.7	$ 58.9	$ 4,373.2	$ (330.1)	$ (160.3)	$ 5,039.0
Shares as at Mar. 31, 2015	600.2	600.2

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Business Combinations (Tables)

3 Months Ended

Mar. 31, 2015

NPS Pharma

Business Acquisition [Line Items]

Schedule of Purchase Price Allocation

	Preliminary
	Fair value
	$’M
ASSETS
Current assets:
Cash and cash equivalents	41.6
Short-term investments	67.0
Accounts receivable	31.7
Inventories	51.1
Deferred tax assets	151.5
Other current assets	10.1
	_______________
Total current assets	353.0
Non-current assets:
PPE	4.2
Goodwill	1,691.6
Other intangible assets
- currently marketed products	4,670.0
- royalty rights (categorized as "Other amortized intangible assets" )	353.0
	_______________
Total assets	7,071.8
	_______________
LIABILITIES
Current liabilities:
Accounts payable and other current liabilities	72.5
Short-term debt	27.4
Non-current liabilities:
Long-term debt, less current portion	78.9
Deferred tax liabilities	1,671.0
Other non-current liabilities	4.2
	_______________
Total liabilities	1,854.0
	_______________
Fair value of identifiable assets acquired and liabilities assumed	5,217.8
Consideration	_______________
Cash consideration paid	5,217.8
	_______________

Business Acquisition, Pro Forma Information

	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	$’M	$’M
	_______________	_______________
Revenues	1,518.3	1,390.8
Net income from continuing operations	358.8	85.8
	_______________	_______________
Per share amounts:
Net income from continuing operations per share - basic	60.9c	14.7c
Net income from continuing operations per share - diluted	60.5c	14.6c
	_______________	_______________

Viropharma

Business Acquisition [Line Items]

Schedule of Purchase Price Allocation

	Acquisition date fair value
	$’M
Identifiable assets acquired and liabilities assumed
ASSETS
Current assets:
Cash and cash equivalents	232.6
Short-term investments	57.8
Accounts receivable	52.2
Inventories	203.6
Deferred tax assets	100.7
Purchased call option	346.7
Other current assets	50.9
	_______________
Total current assets	1,044.5
Non-current assets:
PPE	24.7
Goodwill	1,655.5
Other intangible assets
- Currently marketed products	2,320.0
- In-Process Research and Development (“IPR&D”)	315.0
Other non-current assets	10.4
	_______________
Total assets	5,370.1
	_______________
LIABILITIES
Current liabilities:
Accounts payable and other current liabilities	122.7
Convertible bond	551.4
Non-current liabilities:
Deferred tax liabilities	603.5
Other non-current liabilities	95.5
	_______________
Total liabilities	1,373.1
	_______________
Fair value of identifiable assets acquired and liabilities assumed	3,997.0
	_______________
Consideration
Cash consideration paid	3,997.0
	_______________

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Accounts Payable and Accrued Expenses (Tables)

3 Months Ended

Mar. 31, 2015

Accounts Payable and Accrued Liabilities, Current [Abstract]

Schedule of Accounts Payable and Accrued Expenses

	March 31,	December 31,
	2015	2014
	$’M	$’M
	________________	________________
Trade accounts payable and accrued purchases	384.1	247.7
Accrued rebates – Medicaid	555.9	563.9
Accrued rebates – Managed care	306.8	318.2
Sales return reserve	134.8	131.7
Accrued bonuses	72.6	150.7
Accrued employee compensation and benefits payable	174.0	109.1
R&D accruals	55.9	88.3
Other accrued expenses	307.5	299.8
	________________	________________
	1,991.6	1,909.4
	________________	________________

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Integration and acquisition costs (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Business Acquisition [Line Items]
Integration and acquisition costs	$ 75.7	$ 6.6
Acquisition and Integration Costs, Gross Amount
Business Acquisition [Line Items]
Integration and acquisition costs		65.8
Change in fair value of contingent consideration		$ (59.2)

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Fair Value Measurement (Assets and Liabilities That are Measured and Not Measured at Fair Value on a Recurring Basis) (Details) (Recurring Basis, USD $) In Millions, unless otherwise specified	Mar. 31, 2015		Dec. 31, 2014
Estimated fair value
Financial assets:
Available-for-sale securities	$ 26.4	[1]	$ 13.1	[1]
Contingent consideration receivable	15.0	[2]	15.9	[2]
Foreign exchange contracts, asset	10.9		12.6
Financial liabilities:
Foreign exchange contracts, liability	5.5		7.8
Contingent consideration payable	724.0	[3]	629.9	[3]
Level 1
Financial assets:
Available-for-sale securities	26.4	[1]	13.1	[1]
Contingent consideration receivable	0	[2]	0	[2]
Foreign exchange contracts, asset	0		0
Financial liabilities:
Foreign exchange contracts, liability	0		0
Contingent consideration payable	0	[3]	0	[3]
Level 2
Financial assets:
Available-for-sale securities	0	[1]	0	[1]
Contingent consideration receivable	0	[2]	0	[2]
Foreign exchange contracts, asset	10.9		12.6
Financial liabilities:
Foreign exchange contracts, liability	5.5		7.8
Contingent consideration payable	0	[3]	0	[3]
Level 3
Financial assets:
Available-for-sale securities	0	[1]	0	[1]
Contingent consideration receivable	15.0	[2]	15.9	[2]
Foreign exchange contracts, asset	0		0
Financial liabilities:
Foreign exchange contracts, liability	0		0
Contingent consideration payable	$ 724.0	[3]	$ 629.9	[3]

[1] Available-for-sale securities are included within Investments and Prepaid expenses and other current assets in the consolidated balance sheet.

[2] Contingent consideration receivable is included within Prepaid expenses and other current assets and Other non-current assets in the consolidated balance sheet.

[3] Contingent consideration payable is included within Other current liabilities and Other non-current liabilities in the consolidated balance sheet.

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Consolidated Balance Sheets (USD $) In Millions, unless otherwise specified	Mar. 31, 2015	Dec. 31, 2014
Current assets:
Cash and cash equivalents	$ 74.3	$ 2,982.4
Restricted cash	68.9	54.6
Accounts receivable, net	1,116.3	1,035.1
Inventories	588.7	544.8
Deferred tax asset	461.8	344.7
Prepaid expenses and other current assets	216.6	221.5
Total current assets	2,526.6	5,183.1
Non-current assets:
Investments	45.7	43.7
Property, plant and equipment, net ("PP&E")	821.9	837.5
Goodwill	4,178.7	2,474.9
Other intangible assets, net	9,980.0	4,934.4
Deferred tax asset	102.7	112.1
Other non-current assets	22.7	46.4
Total assets	17,678.3	13,632.1
Current liabilities:
Accounts payable and accrued expenses	1,991.6	1,909.4
Short-term borrowings	2,570.2	850.0
Other current liabilities	303.2	262.5
Total current liabilities	4,865.0	3,021.9
Non-current liabilities
Long-term borrowings	78.7	0
Deferred tax liability	2,909.9	1,210.6
Other non-current liabilities	844.0	736.7
Total liabilities	8,697.6	4,969.2
Commitments and contingencies
Equity:
Common stock of 5p par value; 1,000 million shares authorized; and 600.2 million shares issued and outstanding (2014: 1,000 million shares authorized; and 599.1 million shares issued and outstanding)	58.9	58.7
Additional paid-in capital	4,373.2	4,338.0
Treasury stock: 10.0 million shares (2014: 10.6 million shares)	(330.1)	(345.9)
Accumulated other comprehensive loss	(160.3)	(31.5)
Retained earnings	5,039.0	4,643.6
Total equity	8,980.7	8,662.9
Total liabilities and equity	$ 17,678.3	$ 13,632.1

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Accumulated Other Comprehensive Income (Tables)

3 Months Ended

Mar. 31, 2015

Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract]

Changes in Accumulated Other Comprehensive Income, Net of Tax

As at March 31, 2015		Foreign currency translation adjustment	Unrealized holding loss on available-for-sale securities	Accumulated other comprehensive loss
		$M	$M	$M
As at January 1, 2015		(25.7)	(5.8)	(31.5)
Net current period other comprehensive (loss)/income		(129.5)	0.7	(128.8)
As at March 31, 2015		(155.2)	(5.1)	(160.3)
As at March 31, 2014		Foreign currency translation adjustment	Unrealized holding gain/(loss) on available-for-sale securities	Accumulated other comprehensive income
		$M	$M	$M
As at January 1, 2014		110.4	(0.2)	110.2
Current period change:
	Other comprehensive income before reclassification	(1.7)	7.5	5.8
	Gain transferred to the income statement (within Other income, net) on disposal of available-for-sale securities	0	(3.2)	(3.2)
Net current period other comprehensive income		(1.7)	4.3	2.6
As at March 31, 2014		108.7	4.1	112.8

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Consolidated Statements of Comprehensive Income (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Statement of Income and Comprehensive Income [Abstract]
Net income	$ 410.4	$ 230.4
Other comprehensive income:
Foreign currency translation adjustments	(129.5)	(1.7)
Unrealized holding gain on available-for-sale securities (net of taxes of $nil and $2.5 million)	0.7	4.3
Comprehensive income	281.6	233.0
Components of accumulated other comprehensive income
Foreign currency translation adjustments	(155.2)	(25.7)
Unrealized holding loss on available-for-sale securities, net of taxes	(5.1)	(5.8)
Accumulated other comprehensive loss	$ (160.3)	$ (31.5)

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Other Intangible Assets, Net (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014	Dec. 31, 2014	Dec. 31, 2013
Intangible Assets (Excluding Goodwill) [Line Items]
Amortized intangible assets	$ 9,779.0		$ 4,846.9
Other intangible assets, gross	11,503.5		6,396.9
Less: Accumulated amortization	(1,523.5)		(1,462.5)
Other intangible assets, net	9,980.0	4,943.4	4,934.4	2,312.6
Other Disclosures
Acquisitions	5,198.0	2,854.0
Estimates of Annual Amortization
2015	481
2016	481
2017	481
2018	481
2019	481
NPS Pharma and Meritage, Combined
Other Disclosures
Acquisitions	5,198.0
Currently Marketed Products
Intangible Assets (Excluding Goodwill) [Line Items]
Amortized intangible assets	9,404.0		4,816.9
Royalty rights
Intangible Assets (Excluding Goodwill) [Line Items]
Amortized intangible assets	375.0		30.0
IPR&D
Intangible Assets (Excluding Goodwill) [Line Items]
Unamortized intangible assets	1,724.5		1,550.0
IPR&D | Meritage
Other Disclosures
Acquisitions	175.0
Currently marketed products and royalty rights | NPS Pharma
Other Disclosures
Acquisitions	$ 5,023.0

XML

Inventories (Tables)

3 Months Ended

Mar. 31, 2015

Inventory Disclosure [Abstract]

Schedule of Inventory

	March 31,	December 31,
	2015	2014
	$’M	$’M
	____________	____________
Finished goods	137.8	136.0
Work-in-progress	307.4	305.3
Raw materials	143.5	103.5
	____________	____________
	588.7	544.8
	____________	____________

XML

Commitments and Contingencies (Leases, and LC and Guarantees ) (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Future Minimum Lease Payments under Operating Leases
2015	$ 30.6
2016	26.4
2017	30.2
2018	25.4
2019	19.4
2020	19.3
Thereafter	125.2
Future minimum lease payments, total	276.5
Operating Leases, Rent Expense
Lease and rental expense	14.2	13.2
Letters of credit and guarantees
Irrevocable standby letters of credit and guarantees	$ 46.0

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Borrowings

3 Months Ended

Mar. 31, 2015

Debt Disclosure [Abstract]

Borrowings Disclosure

13.Borrowings

	March 31,	December 31,
	2015	2014
	$’M	$’M
	_____________	_____________
Short term borrowings:
Borrowings under the 2015 Facilities Agreement	850.0	-
Borrowings under the 2013 Facilities Agreement	850.0	850.0
Borrowings under the RCF	845.0	-
Secured non-recourse debts	25.2	-
	_____________	_____________
	2,570.2	850.0
Long term borrowings:
Secured non-recourse debts	78.7	-
	_____________	_____________
	2,648.9	850.0
	_____________	_____________

Term Loan Agreements

2015 Facility Agreement

On January 11, 2015, Shire entered into an $850 million Facility Agreement with, among others, CitiGroupGlobal Markets Limited (acting as mandated lead arranger and bookrunner) (the “2015 Facility Agreement”).  At March 31, 2015 the 2015 Facility Agreementwas comprisedof an $850 million term loan facility, which matures on January 10, 2016,and was fully utilized. The maturity date may be extended twice, at Shire's option by six months on each occasion.

The 2015 Facility Agreementhas been used to partially finance the purchase price payable in respect of Shire's acquisition of NPS Pharma (including certain related costs). See the Company's 2014 Annual Report on Form 10-K for details of the 2015 Facility Agreement.

2013 Facilities Agreement

On November 11, 2013, Shire entered into a $2,600million facilities agreement with, among others, Morgan Stanley Bank International Limited (acting as mandated lead arranger andbookrunner) (the “2013 Facilities Agreement”).  The 2013 Facilities Agreement comprised two credit facilities: (i) a $1,750million term loan facility and (ii) a $850million term loan facility.  

On December 13, 2013 and at various points during the year to December 31, 2014, the Company cancelled part of the $2,600 million term loan facility. At March 31, 2015 the 2013 Facilities Agreement was comprised of an $850 million term loan facility which matures on November 11, 2015 and was fully utilized.

The $850 millionremaining borrowing from the 2013 Facilities Agreementwas used to partially finance the purchase price payable in respect of Shire's acquisition of ViroPharma (including certain related costs)during the year ended December 31, 2014.See the Company's 2014 Annual Report on Form 10-K for details of the 2013 Facilities Agreement.

Revolving Credit Facility (“RCF”)

On December 12, 2014, Shire entered into a $2,100 million RCF with a number of financial institutions.See the Company's 2014 Annual Report on Form 10-K for details. At March 31, 2015 the Company has utilized $845 million of the RCF to partially finance the purchase price payable in respect of Shire's acquisition of NPS Pharma (including certain related costs).

The RCF, which terminates on December 12, 2019, may be applied towards financing the general corporate purposes of Shire. The RCF incorporates a $250 million US dollar and euro swingline facility operating as a sub-limit thereof.

Secured Non-recourse Debts

Prior to the acquisition by Shire, NPS Pharma had:

• partially monetized rights to receive future royalty payments from Amgen's sales of SENSIPAR and MIMPARA through the issuance of $145 million of non-recourse debt that is both serviced and secured by SENSIPAR and MIMPARA royalty revenue;
• sold to DRI Capital Inc. (“DRI”) certain rights to receive up to $96 million of future royalty payments arising from Kyowa Hakko Kirin's sales of REGPARA and granted DRI a security interest in the license agreement with Kyowa Hakko Kirin, certain patents and other intellectual property related to REGPARAwhich DRI would be entitled to enforce in the event of default by NPS Pharma; and
• partially monetized PTH-184 (now marketed as NATPARA) through an agreement with an affiliate of DRI pursuant to which NPS Pharma, its licensees and its predecessors in interest, are obligated to pay up to $125 million royalties on sales of PTH-184. Additionally, NPS Pharma granted DRI a security interest in certain patents and other intellectual property related to PTH 1-84 which DRI would be entitled to enforce in the event of default by NPS Pharma.

Following the acquisition of NPS Pharma the Company has assumed these secured non-recourse debt obligations.

The acquisition-date fair value of these debt obligations is preliminary pending the receipt of final valuations for these liabilities. The preliminary acquisition-date fair value of these non-recourse debt obligations totals $106.3 million. As at March 31, 2015 $25.2 million has been included within Short-term borrowings, and $78.7 million has been included within Long-term borrowings in respect of these obligations.

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Results of discontinued operations (Table)

3 Months Ended

Mar. 31, 2015

DiscontinuedOperationIncomeLossFromDiscontinuedOperationDisclosuresAbstract

Schedule of discontinued operations

	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	$’M	$’M
Revenues:	_______________	_______________
Product revenues	-	1.9
	_______________	_______________
Loss from discontinued operations before income taxes	(3.9)	(35.8)
Income taxes	1.4	13.1
	_______________	_______________
Loss from discontinued operations, net of taxes	(2.5)	(22.7)
	_______________	_______________

XML

Commitments and Contingencies

3 Months Ended

Mar. 31, 2015

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies Disclosure

15.       Commitments and contingencies

(a)       Leases

Future minimum lease payments under operating leases at March 31, 2015are presented below:

		Operating
		leases
		$’M
		_____________
2015	1	30.6
2016	1	26.4
2017	1	30.2
2018	1	25.4
2019	1	19.4
2020		19.3
Thereafter	1	125.2
	111	_____________
		276.5
		_____________

The Company leases land, facilities, motor vehicles and certain equipment under operating leases expiring through 2032. Lease and rental expense amounted to $14.2million and$13.2 million for the three monthsto March 31, 2015 and2014respectively, which is predominately included in SG&Aexpenses in the Company's consolidated income statement.

(b)       Letters of credit and guarantees

At March 31, 2015 the Company had irrevocable standby letters of credit and guarantees with various banks and insurance companiestotaling $46million (being the contractual amounts), providing security for the Company's performance of various obligations. These obligations are primarily in respect of the recoverability of insurance claims, lease obligations and supply commitments.

(c)       Collaborative and other licensing arrangements

Details of significant updates in collaborative and other licensing arrangements are included below:

Out-licensing arrangements

Shire has entered into various collaborative and out-licensing arrangements under which the Company has out-licensed certain product or intellectual property rights for consideration such as up-front payments, development milestones, sales milestones and/or royalty payments. In some of these arrangements Shire and the licensee are both actively involved in the development and commercialization of the licensed product and have exposure to risks and rewards dependent on its commercial success. Under the terms of these collaborative and out-licensing arrangements, the Company may receive development milestone payments up to an aggregate amount of $39 million and sales milestones up to an aggregate amount of $46 million. The receipt of these substantive milestones is uncertain and contingent on the achievement of certain development milestones or the achievement of a specified level of annual net sales by the licensee. In the three monthsto March 31, 2015 Shire received cash in respect of up-front and milestone payments totaling $12.6 million (2014: $1.0 million). In the three monthsto March 31, 2015 Shire recognized milestone income of $0.5 million (2014: $1.5 million) in other revenues and $9.2 million (2014: $12.5 million) in product sales for shipment of product to the relevant licensee.

(d)       Commitments

(i)       Clinical testing

At March 31, 2015 the Company had committed to pay approximately $ 402 million (December 31, 2014: $ 382 million) to contract vendors for administering and executing clinical trials. The timing of these payments is dependent upon actual services performed by the organizations as determined by patient enrollment levels and related activities.

(ii)       Contract manufacturing

At March 31, 2015 the Company had committed to pay approximately $ 397 million (December 31, 2014: $ 384 million) in respect of contract manufacturing. The Company expects to pay $ 154 million of these commitments in 2015.

(iii)       Other purchasing commitments

At March 31, 2015 the Company had committed to pay approximately $ 320 million (December 31, 2014: $ 265 million) for future purchases of goods and services, predominantly relating to active pharmaceutical ingredients sourcing. The Company expects to pay $ 306 million of these commitments in 2015.

(iv)       Investment commitments

At March 31, 2015 the Company had outstanding commitments to subscribe for interests in companies and partnerships for amounts totaling $ 58 million (December 31, 2014: $ 67 million) which may all be payable in 2015, depending on the timing of capital calls. The investment commitments include additional funding to certain VIEs of which Shire is not the primary beneficiary.

(v)       Capital commitments

At March 31, 2015 the Company had committed to spend $ 9 million (December 31, 2014: $ 3 million) on capital projects.

(e)Legal and other proceedings

The Company expenses legal costs as they are incurred.

The Company recognizes loss contingency provisions for probable losses when management is able to reasonably estimate the loss. When the estimated loss lies within a range, the Company records a loss contingency provision based on its best estimate of the probable loss. If no particular amount within that range is a better estimate than any other amount, the minimum amount is recorded.  Estimates of losses may be developed substantially before the ultimate loss is known, and are therefore refined each accounting period as additional information becomes known. In instances where the Company is unable to develop a reasonable estimate of loss, no loss contingency provision is recorded at that time. As information becomes known a loss contingency provision is recorded when a reasonable estimate can be made. The estimates are reviewed quarterly and the estimates are changed when expectations are revised. An outcome that deviates from the Company's estimate may result in an additional expense or release in a future accounting period. At March 31, 2015, provisions for litigation losses, insurance claims and other disputes totaled $26.0million (December 31, 2014: $16.9million).

The Company's principal pending legal and other proceedings are disclosed below. The outcomes of these proceedings are not always predictable and can be affected by various factors. For those legal and other proceedings for which it is considered at least reasonably possible that a loss has been incurred, the Company discloses the possible loss or range of possible loss in excess of the recorded loss contingency provision, if any, where such excess is both material and estimable.

VYVANSE

In May and June 2011, Shire was notified that six separate Abbreviated New Drug Applications ("ANDAs") were submitted under the Hatch-Waxman Act seeking permission to market generic versions of all approved strengths of VYVANSE. The notices were from Sandoz, Inc. ("Sandoz"); Amneal Pharmaceuticals LLC ("Amneal"); Watson Laboratories, Inc; Roxane Laboratories, Inc. ("Roxane"); Mylan Pharmaceuticals, Inc.; and Actavis Elizabeth LLC and Actavis Inc. (collectively, "Actavis"). Since filing suit against these ANDA filers, along with API suppliers Johnson Matthey Inc. and Johnson Matthey Pharmaceuticals Materials (collectively “Johnson Matthey”), Shire has been engaged in a consolidated patent infringement litigation in the US District Court for the District of New Jerseyagainst the aforementioned parties (except Watson Laboratories, Inc., who withdrew their ANDA).

On June 23, 2014, the US District Court for the District of New Jersey granted Shire's summary judgment motion holding that 18 claims of the patents-in-suit were both infringed and valid. The ruling prevents all of the ANDA filers (Sandoz, Roxane, Amneal, Actavis and Mylan) from launching generic versions of VYVANSE until the earlier of either a successful appeal to the US Court of Appeals for the Federal Circuit (“CAFC”), or the expiration of these patents in 2023. To appeal successfully, the ANDA-defendants must overturn the court's rulings for each of these 18 patent claims. All of the defendants have appealed the court's summary judgment ruling to the CAFC. Oral argument has been scheduled to occur on May 6, 2015.

LIALDA

In May 2010, Shire was notified that Zydus Pharmaceuticals USA, Inc. (“Zydus”) had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the District of Delaware against Zydus and Cadila Healthcare Limited, doing business as Zydus Cadila. A Markman hearing took place on January 29, 2015. The previously scheduled trial date has been vacated; at present, there is no trial date.

In February 2012, Shire was notified that Osmotica Pharmaceutical Corporation ("Osmotica") had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Northern District of Georgia against Osmotica. A Markman hearing took place on August 22, 2013 and a Markman ruling was issued on September 25, 2014. The Court issued an Order on February 27, 2015 in which all dates in the scheduling order have been stayed.

In March 2012, Shire was notified that Watson Laboratories Inc.-Florida had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Southern District of Florida against Watson Laboratories Inc.-Florida and Watson Pharmaceuticals, Inc. Watson Pharma, Inc. and Watson Laboratories, Inc. were subsequently added as defendants. A trial took place in April, 2013 and on May 9, 2013 the trial court issued a decision finding that the proposed generic product infringes the patent-in-suit and that the patent is not invalid. Watson appealed the trial court's ruling to the CAFC and a hearing took place on December 2, 2013. The ruling of the CAFC was issued on March 28, 2014 overruling the trial court on the interpretation of two claim terms and remanding the case for further proceedings. Shire petitioned the Supreme Court for a writ of certiori, which was granted on January 26, 2015. The Supreme Court also vacated the CAFC decision and remanded the case to the CAFC for further consideration in light of the Supreme Court's recent decision in Teva v Sandoz. The remanded case has been briefed to the CAFC. No dates have been set for oral argument.

In April 2012, Shire was notified that Mylan Pharmaceuticals, Inc. had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Middle District of Florida against Mylan. A Markman hearing took place on December 22, 2014. A trial is scheduled during the court's trial term beginning on September 1, 2015.

In March 2015, Shire was notified that Amneal Pharmaceuticals LLC had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the District of New Jersey against Amneal Pharmaceuticals LLC, Amneal Pharmaceuticals of New York, LLC and Amneal Pharmaceuticals Co. India Pvt. Ltd. No trial date has been set.

Investigation related to DERMAGRAFT

The Department of Justice, including the US Attorney's Office for the Middle District of Florida, Tampa Division and the US Attorney's Office for Washington, DC, is conducting civil and criminal investigations into the sales and marketing practices of Advanced BioHealing Inc. (“ABH”) relating to DERMAGRAFT.

Following the disposal of the DERMAGRAFT business in January 2014, Shire has retained certain legacy liabilities including any liability that may arise from this investigation. Shire is cooperating fully with these investigations. Shire is not in a position at this time to predict the scope, duration or outcome of these investigations.

Civil Investigative Demand relating to VANCOCIN

On April 6, 2012, ViroPharma received a notification that the United States Federal Trade Commission (“FTC”) is conducting an investigation into whether ViroPharma had engaged in unfair methods of competition with respect to VANCOCIN. On August 3, 2012, and September 8, 2014, ViroPharma and Shire respectively received Civil Investigative Demands from the FTC requesting additional information related to this matter. Shire intends to continue to cooperate fully with the FTC investigation. At this time, Shire is unable to predict the outcome or duration of this investigation.

Lawsuit related to supply of ELAPRASE to certain patients in Brazil

On September 24, 2014 Shire's Brazilian affiliate, Shire Farmaceutica Brasil Ltda, was served with a lawsuit brought by the State of Sao Paulo and in which the Brazilian Public Attorney's office has intervened alleging that Shire is obligated to provide certain medical care including ELAPRASE for an indefinite period at no cost to patients who participated in ELAPRASE clinical trials in Brazil, and seeking recoupment to the Brazilian government for amounts paid for these patients to date, and moral damages associated with these claims.  Shire intends to defend itself against these allegations but is not able to predict the outcome or duration of this case.

XML

Accumulated Other Comprehensive Income (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Accumulated Other Comprehensive Income (Loss) [Line Items]
As at January 1,	$ (31.5)
Net current period other comprehensive (loss)/income	(128.8)
As at March 31,	(160.3)	(31.5)
Foreign currency translation adjustment
Accumulated Other Comprehensive Income (Loss) [Line Items]
As at January 1,	(25.7)	110.4
Other Comprehensive (loss)/income before reclassification		(1.7)
Gain transferred to the income statement (within Other income),net) on disposal of available-for-sale-securities		0
Net current period other comprehensive (loss)/income	(129.5)	(1.7)
As at March 31,	(155.2)	108.7
Unrealized holding gain/(loss) on available-for-sale securities
Accumulated Other Comprehensive Income (Loss) [Line Items]
As at January 1,	(5.8)	(0.2)
Other Comprehensive (loss)/income before reclassification		7.5
Gain transferred to the income statement (within Other income),net) on disposal of available-for-sale-securities		(3.2)
Net current period other comprehensive (loss)/income	0.7	4.3
As at March 31,	(5.1)	4.1
Accumulated other comprehensive (loss)/income
Accumulated Other Comprehensive Income (Loss) [Line Items]
As at January 1,	(31.5)	110.2
Other Comprehensive (loss)/income before reclassification		5.8
Gain transferred to the income statement (within Other income),net) on disposal of available-for-sale-securities		(3.2)
Net current period other comprehensive (loss)/income	(128.8)	2.6
As at March 31,	$ (160.3)	$ 112.8

XML

Consolidated Statements of Comprehensive Income (Parenthetical) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Statement of Income and Comprehensive Income [Abstract]
Unrealized holding gain on available-for-sale securities, tax	$ 0	$ 2.5

XML

Consolidated Balance Sheets (Parenthetical) (GBP £) In Millions, except Per Share data, unless otherwise specified	Mar. 31, 2015	Dec. 31, 2014
Statement of Financial Position [Abstract]
Common Stock, Par Value (in GBP per share)	£ 0.05	£ 0.05
Common Stock, Shares Authorized	1,000.0	1,000.0
Common Stock, Shares, Issued	600.2	599.1
Common Stock, Shares, Outstanding	600.2	599.1
Treasury Stock, Shares	10.0	10.6

XML

Prepaid Expenses and Other Current Assets

3 Months Ended

Mar. 31, 2015

Prepaid Expense and Other Assets, Current [Abstract]

Prepaid Expense and Other Assets, Current

8.       Prepaid expenses and other current assets

	March 31,	December 31,
	2015	2014
	$’M	$’M
	______________	____________
Prepaid expenses	72.9	36.9
Income tax receivable	68.8	121.5
Value added taxes receivable	15.0	13.8
Other current assets	59.9	49.3
	______________	______________
	216.6	221.5
	______________	______________

XML

Document and Entity Information (USD $) In Billions, except Share data in Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Apr. 24, 2015	Jun. 30, 2014
Document and Entity Information [Abstract]
Document Type	10-Q
Document Period End Date	Mar. 31, 2015
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Central Index Key	0000936402
Entity Current Reporting Status	Yes
Entity Filer Category	Large Accelerated Filer
Trading Symbol	SHP, SHPG
Entity Registrant Name	Shire plc
Entity Voluntary Filers	No
Entity Well-known Seasoned Issuer	Yes
Entity Common Stock, Shares Outstanding		600.3
Document Fiscal Year Focus	2015
Document Fiscal Period Focus	Q1
Entity Public Float			$ 45.9

XML

Goodwill

3 Months Ended

Mar. 31, 2015

Goodwill and Intangible Assets Disclosure [Abstract]

Goodwill Disclosure

9.Goodwill

	March 31,	December 31,
	2015	2014
	$’M	$’M
	____________	____________
Goodwill arising on businesses acquired	4,178.7	2,474.9
	____________	____________

In the three months to March 31, 2015 the Company completed the acquisitions of NPS Pharma and Meritage, which resulted in aggregate goodwill with a preliminary value of $1,732.7 million (see Note 2 for details).

	2015	2014
	$’M	$’M
	____________	____________
As at January 1,	2,474.9	624.6
Acquisitions	1,732.7	1,536.6
Foreign currency translation	(28.9)	-
	____________	____________
As at March 31,	4,178.7	2,161.2
	____________	____________

XML

Consolidated Statements of Income (USD $) In Millions, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2015		Mar. 31, 2014
Revenues:
Product sales	$ 1,423.2		$ 1,308.1
Royalties	62.8		32.3
Other revenues	2.4		6.4
Total revenues	1,488.4		1,346.8
Costs and expenses:
Cost of product sales	227.8		229.5
Research and development	193.7	[1]	360.5	[1]
Selling, general and administrative	506.6	[1]	430.3	[1]
Gain on sale of product rights	(5.2)		(36.4)
Reorganization costs	15.2		49.4
Integration and acquisition costs	75.7		6.6
Total operating expenses	1,013.8		1,039.9
Operating income from continuing operations	474.6		306.9
Interest income	2.0		0.5
Interest expense	(9.6)		(7.8)
Other income, net	4.3		4.7
Total other expense, net	(3.3)		(2.6)
Income from continuing operations before income taxes and equity in losses of equity method investees	471.3		304.3
Income taxes	(57.4)		(50.6)
Equity in losses of equity method investees, net of taxes	(1.0)		(0.6)
Income from continuing operations, net of taxes	412.9		253.1
Loss from discontinued operations, net of taxes	(2.5)		(22.7)
Net income	$ 410.4		$ 230.4
Earnings from continuing operations (in USD per share)	$ 0.701		$ 0.433
Loss from discontinued operations (in USD per share)	$ (0.004)		$ (0.039)
Earnings per ordinary share - basic (in USD per share)	$ 0.697		$ 0.394
Earnings from continuing operations (in USD per share)	$ 0.697		$ 0.430
Loss from discontinued operations (in USD per share)	$ (0.004)		$ (0.039)
Earnings per ordinary share - diluted (in USD per share)	$ 0.693		$ 0.391
Weighted average number of shares:
Basic (in shares)	589.1	[2]	584.3	[2]
Diluted (in shares)	592.7		588.8

[1] Research and development (“R&D”) includes intangible asset impairment charges of $nil for the three months to March 31, 2015 (2014: $166.0 million). Selling, general and administrative (“SG&A”) costs include amortization of intangible assets relating to intellectual property rights acquired of $88.3 million for the three months to March 31, 2015 (2014: $57.8 million).

[2] Excludes shares purchased by the EBT and presented by Shire as treasury stock

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Reorganization Costs

3 Months Ended

Mar. 31, 2015

Restructuring and Related Activities [Abstract]

Reorganization Costs Disclosure

3.Reorganization costs

One Shire business reorganization

On May 2, 2013, the Company initiated the reorganization of its business to integrate the three divisions into a simplified One Shire organization in order to drive future growth and innovation.

In 2014 certain aspects of the One Shire program were temporarily put on hold due to AbbVie's offer for Shire, which was terminated in October 2014. Subsequent to the termination of AbbVie's offer, Shire announced on November 10, 2014 its plans to relocate over 500 positions to Lexington Massachusetts from its Chesterbrook, Pennsylvania, site and establish Lexington as the Company's US operational headquarters in continuation of the One Shire efficiency program. This relocation will streamline business globally through two principal locations, Massachusetts and Switzerland, with support from regional and country-based offices around the world.

In the three months to March 31, 2015 the Company incurred reorganization costs totaling $15.2 million, relating to employee involuntary termination benefits and other reorganization costs. Reorganization costs of $260.7 million have been incurred since May 2013. The One Shire reorganization is expected to be substantially completed by the first quarter of 2016. Currently, the Company estimates that further costs in respect of the One Shire reorganization of approximately $115 million will be expensed as incurred during 2015 and 2016.

The liability for reorganization costs arising from the One Shire business reorganization at March 31, 2015 is as follows:

	Opening liability	Amount		Closing liability at
	at January 1,	charged to re-		March 31,
	2015	organization	Paid/Utilized	2015
	$'M	$'M	$'M	$'M
	___________	____________	___________	___________
Involuntary termination benefits	38.0	9.4	(5.1)	42.3
Other reorganization costs	-	5.8	(5.0)	0.8
	___________	___________	___________	___________
	38.0	15.2	(10.1)	43.1
	___________	___________	___________	___________

At March 31, 2015the closing reorganization cost liability was recorded within accounts payable and accrued expenses.

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Business Combinations

3 Months Ended

Mar. 31, 2015

Business Combinations [Abstract]

Business Combination Disclosure

2.       Business combinations

Acquisition of NPS Pharmaceuticals Inc.(“NPS Pharma”)

On February 21, 2015Shirecompleted its acquisition of 100% of the outstanding share capital of NPS Pharma. The acquisition-date fair value of cash consideration paid on closing was $5,218 million.

The acquisition of NPS Pharma added GATTEX/REVESTIVE, approved in the US and EU for the treatment of adults with short bowel syndrome (“SBS”), a rare and potentially fatal gastrointestinal disorder and NATPARA/NATPAR approved in the US for the treatment of hypoparathyroidism (“HPT”), a rare endocrine disease, to Shire's portfolio of currently marketed products.

The acquisition of NPS Pharmahas been accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from NPS Pharmahave been recorded at their preliminary fair values at the date of acquisition, being February 21, 2015. The Company's consolidated financial statements include the results of NPS Pharma from February 21, 2015.

The amount of NPS Pharma's post-acquisition revenues and pre-tax losses included in the Company's consolidated statement of income for the three months to March 31, 2015 were $26.2million and $51.2million respectively. The pre-tax loss includes charges on the unwind of inventory fair value adjustments of $9.9 million, intangible asset amortization of $30.1 million and integration costs of $17.4 million.

The Company's preliminary allocation of the purchase price to the assets acquired and liabilities assumed is outlined below:

	Preliminary
	Fair value
	$’M
ASSETS
Current assets:
Cash and cash equivalents	41.6
Short-term investments	67.0
Accounts receivable	31.7
Inventories	51.1
Deferred tax assets	151.5
Other current assets	10.1
	_______________
Total current assets	353.0
Non-current assets:
PPE	4.2
Goodwill	1,691.6
Other intangible assets
- currently marketed products	4,670.0
- royalty rights (categorized as "Other amortized intangible assets" )	353.0
	_______________
Total assets	7,071.8
	_______________
LIABILITIES
Current liabilities:
Accounts payable and other current liabilities	72.5
Short-term debt	27.4
Non-current liabilities:
Long-term debt, less current portion	78.9
Deferred tax liabilities	1,671.0
Other non-current liabilities	4.2
	_______________
Total liabilities	1,854.0
	_______________
Fair value of identifiable assets acquired and liabilities assumed	5,217.8
Consideration	_______________
Cash consideration paid	5,217.8
	_______________

The purchase price allocation is preliminary pending final determination of the fair values of certain assets and liabilities. In particular the fair values of inventories, intangible assets, assumed non-recourse debt obligations and current and deferred taxes are preliminary pending receipt of the final valuations for those items. The final determination of these fair values will be completed as soon as possible but no later than one year from the acquisition date.

(a) Other intangible assets – currently marketed products

Other intangible assets totaling $4,670.0 million relate to intellectual property rights acquired for NPS Pharma's currently marketed products, primarily attributed to NATPARA/NATPAR, and GATTEX/REVESTIVE. The fair value of the currently marketed products is preliminary and has been estimated using an income approach, based on the present value of incremental after tax cash flows attributable to each separately identifiable intangible asset.

The estimated useful lives of the NATPARA/NATPAR and GATTEX/REVESTIVE intangible assets are 24 years, with amortization being recorded on a straight-line basis.

(b) Other intangible assets – Royalty rights

Other intangibles totaling $353.0 million relate to the royalty rights arising from the collaboration agreements with Amgen, Janssen and Kyowa Hakko Kirin. Amgen markets cinacalcetHCl as Sensipar in the US and as Mimpara in the EU; Janssen Pharmaceuticals markets tapentadol as Nucynta in theUS; and Kyowa Hakko Kirin markets cinacalcet HCI as Regpara in Japan, Hong Kong, Malaysia, Macau, Singapore, and Taiwan. NPS Pharma is entitled to royalties from the relevant net sales of these products.

The fair value of these royalty rights is preliminary and has been estimated using an income approach, based on the present value of incremental after tax cash flows attributable to each royalty right.

The estimated useful lives of these royalty rights range from 4 to 5 years (weighted average 4 years), with amortization being recorded on a straight-line basis.

(c) Goodwill

Goodwill arising of $1,691.6million, which is not deductible for tax purposes, includes the expected synergies that will result from combining the operations of NPS Pharma with the operations of Shire; particularly those synergies expected to be realized due to Shire's structure; intangible assets that do not qualify for separate recognition at the time of the acquisition; and the value of the assembled workforce.

In the three months to March 31, 2015 the Company expensed costs of $69.9million relating to the acquisition and post-acquisition integration of NPS Pharma, which have been recorded within Integration and acquisition costs in the Company's consolidated statement of income.

Supplemental disclosure of pro forma information

The following unaudited pro forma financial information presents the combined results of the operations of Shire and NPS Pharma as if the acquisition of NPS Pharma had occurred as at January 1, 2014. The unaudited pro forma financial information is not necessarily indicative of what the consolidated results of operations actually would have been had the acquisition been completed at the date indicated. In addition, the unaudited pro forma financial information does not purport to project the future results of operations of the combined Company.

	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	$’M	$’M
	_______________	_______________
Revenues	1,518.3	1,390.8
Net income from continuing operations	358.8	85.8
	_______________	_______________
Per share amounts:
Net income from continuing operations per share - basic	60.9c	14.7c
Net income from continuing operations per share - diluted	60.5c	14.6c
	_______________	_______________

The unaudited pro forma financial information above reflects the following pro forma adjustments:

• an adjustment to decrease net income by $106.8 million for the period to March 31, 2014 to reflect acquisition costs incurred by Shire and NPS Pharma, and increase net income by $106.8 million for the period to March 31, 2015, to eliminate acquisition costs incurred;
• an adjustment to decrease net income by $6.1 million for the period to March 31 2014, to reflect charges on the unwind of inventory fair value adjustments as acquisition date inventory is sold, and a corresponding increase in net income for the period to March 31, 2015;
• an adjustment of $5.6 million in the period to March 31, 2014 to reflect additional interest expense associated with the drawdown of debt to partially finance the acquisition of NPS Pharma and the amortization of related deferred debt issuance costs;
• an adjustment to increase amortization expense by approximately $21.1 million in the period to March 31, 2015 and $42.3 million in the period March 31, 2014 related to amortization of the fair value of identifiable intangible assets acquired and the elimination of NPS Pharma's historical intangible asset amortization expense; and
• the tax effect of the above adjustments, where applicable.

Acquisition of Meritage Pharma Inc. (“Meritage”)

Prior to the acquisition of ViroPharmaby Shire (see below), ViroPharma had entered into an exclusive development and option agreement with Meritage, a privately owned US company focusing on developing oral budesonide suspension (“OBS”) as a treatment for eosinophilic esophagitis. Under the terms of this agreement Meritage controlled and conducted all related research up to achievement of pre-defined development success criteria at which point ViroPharma had the option to acquire Meritage.

On February 18, 2015, following the exercise of the purchase option, Shire acquired all the outstanding equity of Meritage. The acquisition date fair value of the consideration totaled $166.9 million, comprising cash consideration paid on closing of $74.8 million and the fair value of contingent consideration payable of $92.1 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $175.0 million dependent upon achievement of certain clinical development and regulatory milestones.

With the Meritageacquisition, Shire has acquired the global rights to Meritage's Phase 3-ready compound, OBS, for the treatment of adolescents and adults with eosinophilic esophagitis.

The acquisition of Meritage has been accounted for as a business combination using the acquisition method. The assets and liabilities assumed from Meritage have been recorded at their preliminary fair values at the date of acquisition, being February 18, 2015. The Company's consolidated financial statements and results of operations include the results of Meritage from February 18, 2015.

The purchase price allocation is preliminary pending the determination of the fair values of certain assets and liabilities. The purchase price has been allocated on a preliminary basis to the OBS IPR&D intangible asset ($175 million), net current assets assumed ($5.5 million), net non-current liabilities assumed (including deferred tax liabilities) ($54.7 million) and goodwill ($41.1 million). Goodwill arising of $41.1 million is not deductible for tax purposes.

Unaudited pro forma financial information to present the combined results of operations of Shire and Meritage are not provided as the impact of this acquisition is not material to the Company's results of operations for any period presented.

Acquisition of ViroPharma Incorporated

On January 24, 2014, Shire completed its acquisition of 100% of the outstanding share capital of ViroPharma. The acquisition-date fair value of cash consideration paid on closing was $3,997 million.

The acquisition of ViroPharma added CINRYZE to Shire's portfolio of currently marketed products. CINRYZE is a leading brand for the prophylactic treatment of Hereditary Angioedema (“HAE”) in adolescents and adults.

The acquisition of ViroPharma has been accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from ViroPharma have been recorded at their fair values at the date of acquisition, being January 24, 2014. The Company's consolidated financial statements include the results of ViroPharma from January 24, 2014.

The purchase price allocation was finalized in the fourth quarter of 2014. The Company's allocation of the purchase price to the fair value of assets acquired and liabilities assumed is outlined below:

	Acquisition date fair value
	$’M
Identifiable assets acquired and liabilities assumed
ASSETS
Current assets:
Cash and cash equivalents	232.6
Short-term investments	57.8
Accounts receivable	52.2
Inventories	203.6
Deferred tax assets	100.7
Purchased call option	346.7
Other current assets	50.9
	_______________
Total current assets	1,044.5
Non-current assets:
PPE	24.7
Goodwill	1,655.5
Other intangible assets
- Currently marketed products	2,320.0
- In-Process Research and Development (“IPR&D”)	315.0
Other non-current assets	10.4
	_______________
Total assets	5,370.1
	_______________
LIABILITIES
Current liabilities:
Accounts payable and other current liabilities	122.7
Convertible bond	551.4
Non-current liabilities:
Deferred tax liabilities	603.5
Other non-current liabilities	95.5
	_______________
Total liabilities	1,373.1
	_______________
Fair value of identifiable assets acquired and liabilities assumed	3,997.0
	_______________
Consideration
Cash consideration paid	3,997.0
	_______________

(a) Other intangible assets – currently marketed products

Other intangible assets totaled $2,320.0 million at the date of acquisition, relating to intellectual property rights acquired for ViroPharma'sthen currently marketed products, primarily attributed to CINRYZE, for the routine prophylaxis against HAE attacks in adolescent and adult patients. Shire also obtained intellectual property rights to three other commercialized products, PLENADREN, an orphan drug for the treatment of adrenal insufficiency in adults, BUCCOLAM, an oromucosal solution for the treatment of prolonged, acute, and convulsive seizures in infants, toddlers, children and adolescents and VANCOCIN, an oral capsule formulation for the treatment of C. difficile-associated diarrhea (“CDAD”), which was divested by Shire in the third quarter of 2014. The fair value of currently marketed products has been estimated using an income approach, based on the present value of incremental after tax cash flows attributable to each separately identifiable intangible asset.

The estimated useful lives of the CINRYZE, PLENADREN and BUCCOLAM intangible assets range from 10to 23 years (weighted average 22 years), with amortization being recorded on a straight-line basis.

(b) Other intangible assets – IPR&D

The IPR&D asset of $315.0 millionrelates to maribavir (now SHP620), an investigational antiviral product for cytomegalovirus. The fair value of this IPR&D assetwas estimated based on an income approach, using the present value of incremental after tax cash flows expected to be generated by this development project after the deduction of contributory asset charges for other assets employed in this project. The estimated cash flows have been probability adjusted to take into account the stage of completion and the remaining risks and uncertainties surrounding the future development and commercialization.

The major risks and uncertainties associated with the timely completion of the acquired IPR&D project include the ability to confirm the efficacy of the technology based on the data from clinical trials, and obtaining the relevant regulatory approvals as well as other risks as described in the Company's Annual Report on Form 10-K. The valuation of IPR&D has been based on information available at the time of the acquisition (and information obtained during the measurement period) and on expectations and assumptions that (i) have been deemed reasonable by the Company's management and (ii) are based on information, expectations and assumptions that would be available to a market participant. However, no assurance can be given that the assumptions and events associated with such assets will occur as projected. For these reasons, the actual cash flows may vary from forecast future cash flows.

The estimated probability adjusted after tax cash flows used in fair valuing other intangible assets have been discounted at rates ranging from 9.5% to 10.0%.

(c) Goodwill

Goodwill arising of $1,655.5 million, which is not deductible for tax purposes, includes the expected operational synergies that will result from combining the commercial operations of ViroPharma with those of Shire (valued at approximately $400million); other synergies expected to be realized due to Shire's structure; intangible assets that do not qualify for separate recognition at the time of the acquisition; and the value of the assembled workforce.

In the three months to March 31, 2015 the Company expensed costs of $3.3 million (2014: $65.8 million) relating to the acquisition and post-acquisition integration of ViroPharma, which have been recorded within Integration and acquisition costs in the Company's consolidated statement of income.

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Other Non-current Liabilities

3 Months Ended

Mar. 31, 2015

Other Liabilities, Noncurrent [Abstract]

Other non-current Liabilities Disclosure

14.       Other non-current liabilities

	March 31,	December 31,
	2015	2014
	$’M	$’M
	____________	____________
Income taxes payable	180.7	199.2
Deferred revenue	6.7	7.2
Deferred rent	6.2	6.6
Contingent consideration payable	557.8	435.4
Other non-current liabilities	92.6	88.3
	____________	____________
	844.0	736.7
	____________	____________

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Other Intangible Assets, Net

3 Months Ended

Mar. 31, 2015

Intangible Assets, Net (Excluding Goodwill) [Abstract]

Other Intangible Assets Disclosure

10.       Other intangible assets, net

		March 31,	December 31,
		2015	2014
		$’M	$’M
		________________	________________
Amortized intangible assets
	Intellectual property rights acquired for currently marketed products	9,404.0	4,816.9
	Other intangible assets	375.0	30.0
		________________	________________
		9,779.0	4,846.9
Unamortized intangible assets
	Intellectual property rights acquired for IPR&D	1,724.5	1,550.0
		________________	________________
		11,503.5	6,396.9
Less: Accumulated amortization		(1,523.5)	(1,462.5)
		________________	________________
		9,980.0	4,934.4
		________________	________________

The change in the net book value of other intangible assets for the three monthsto March 31, 2015 and 2014is shown in the table below:

	Other intangible assets
	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	$’M	$’M
	________________	________________
As at January 1,	4,934.4	2,312.6
Acquisitions	5,198.0	2,854.0
Amortization charged	(88.3)	(57.8)
Impairment charges	-	(166.0)
Foreign currency translation	(64.1)	0.6
	________________	________________
As at March 31,	9,980.0	4,943.4
	________________	________________

In the three months to March 31, 2015 the Company acquired intangible assets totaling $5,198 million, relating to the fair value of intangible assets for currently marketed products and royalty right assets acquired with NPS Pharma of $5,023 million and IPR&D assets of $175 million acquired with Meritage (see Note 2 for further details).

The Company reviews its intangible assets for impairment whenever events or circumstances suggest that their carrying value may not be recoverable. Based on estimates and circumstances at March 31, 2015 the Company determined that its intangible assets remained recoverable.

On April 9, 2015 the Company announced that the 13-week Phase 2 IMAGO trial of its investigational compound SHP625 did not meet the primary or secondary endpoints in the study of 20 pediatric patients with Alagille syndrome (“ALGS”). As a result, it is possible that changes in estimates or circumstances in the second quarter of 2015 could result in an impairment loss being recorded in respect of the SHP625 IPR&D intangible asset, with a charge to R&D. The Company cannot currently estimate the amount of the impairment loss, if any. It is also possible that the fair value of the related contingent consideration payable from the Lumena acquisition (through which Shire acquired SHP625) will be reduced, with a credit to Integration and acquisition costs.

In the three months to March 31, 2014 the Company identified indicators of impairment in respect of its SHP602 (iron chelating agent for the treatment of iron overload secondary to chronic transfusion) IPR&D asset.The Company therefore reviewed the recoverability of its SHP602 IPR&D asset and recorded an impairment charge of $166.0 million within R&D expenses in the consolidated statement of income to record the SHP602 IPR&D asset to its revised fair value.

Management estimates that the annual amortization charge in respect of intangible assets held at March 31, 2015will be approximately $481 million for each of the five years to March 31, 2020.Estimated amortization expense can be affected by various factors including future acquisitions, disposals of product rights, regulatory approval and subsequent amortization of acquired IPR&D projects, foreign exchange movements and the technological advancement and regulatory approval of competitor products.

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Inventories

3 Months Ended

Mar. 31, 2015

Inventory Disclosure [Abstract]

Inventory Disclosure

6.       Inventories

Inventories are stated at the lower of cost or market. Inventories comprise:

	March 31,	December 31,
	2015	2014
	$’M	$’M
	____________	____________
Finished goods	137.8	136.0
Work-in-progress	307.4	305.3
Raw materials	143.5	103.5
	____________	____________
	588.7	544.8
	____________	____________

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Other Intangible Assets, Net (Roll Forward) (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Other Intangible Assets Roll Forward
As at January 1,	$ 4,934.4	$ 2,312.6
Acquisitions	5,198.0	2,854.0
Amortization charged	(88.3)	(57.8)
Impairment charges	0	(166.0)
Foreign currency translation	(64.1)	0.6
As at March 31,	$ 9,980.0	$ 4,943.4

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Integration and acquisition costs

3 Months Ended

Mar. 31, 2015

IntegrationAndAcquisitionCosts[Abstract]

Integration and acquisition costs

4.       Integration and acquisition costs

For the three months to March 31, 2015 Shire recorded integration and acquisition costs of $75.7 million primarily related to the acquisition and integration of NPS Pharma.

In the three months to March 31, 2014 integration and acquisition costs of $6.6 million primarily related to the acquisition and integration of ViroPharma ($65.8 million), offset by a net credit related to the change in fair values of contingent consideration liabilities ($59.2 million). The net credit arose principally due to the re-measurement of contingent consideration payable on the acquisition of FerroKin Biosciences, Inc. following the decision to place the ongoing Phase 2 clinical trial for SHP602 on hold.

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Accounts Receivable, Net

3 Months Ended

Mar. 31, 2015

Receivables [Abstract]

Accounts Receivable Disclosure

5.Accounts receivable, net

Accounts receivable at March 31, 2015 of $1,116.3 million(December 31, 2014: $1,035.1 million), are stated net of a provision for discounts and doubtful accounts of $46.7 million (December 31, 2014: $48.5million).

Provision for discounts and doubtful accounts:

	2015	2014
	$’M	$’M
	_____________	_____________
As at January 1,	48.5	47.9
Provision charged to operations	80.8	80.7
Provision utilization	(82.6)	(81.2)
	_____________	_____________
As at March 31,	46.7	47.4
	_____________	_____________

At March 31, 2015 accounts receivable included $57.2million (December 31, 2014: $59.0million) related to royalty income.

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Results of discontinued operations

3 Months Ended

Mar. 31, 2015

DiscontinuedOperationsAndDisposalGroupsAbstract

Results of discontinued operations Disclosure

7.Resultsof discontinued operations

Following the divestment of the Company's DERMAGRAFT business in January 2014, the operating results associated with the DERMAGRAFT business have been classified as discontinued operations in the consolidated statements of income for all periods presented. In the three months to March 31, 2015 the Company recorded a loss of $2.5 million, primarily relating to costs associated with the divestment. The components of discontinued operations which relate to the DERMAGRAFT business are as follows:

	3 months to	3 months to
	March 31,	March 31,
	2015	2014
	$’M	$’M
Revenues:	_______________	_______________
Product revenues	-	1.9
	_______________	_______________
Loss from discontinued operations before income taxes	(3.9)	(35.8)
Income taxes	1.4	13.1
	_______________	_______________
Loss from discontinued operations, net of taxes	(2.5)	(22.7)
	_______________	_______________

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Other Non-current Liabilities (Details) (USD $) In Millions, unless otherwise specified	Mar. 31, 2015	Dec. 31, 2014
Other Liabilities, Noncurrent [Abstract]
Income taxes payable	$ 180.7	$ 199.2
Deferred revenue	6.7	7.2
Deferred rent	6.2	6.6
Contingent consideration payable	557.8	435.4
Other non-current liabilities	92.6	88.3
Other noncurrent liabilities, total	$ 844.0	$ 736.7

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Commitments and Contingencies (Collaborative Arrangements) (Details) (Out-licensing Arrangement, USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Out-licensing arrangements
Milestone payments received	$ 12.6	$ 1.0
Other Revenues
Out-licensing arrangements
Milestone revenues recognized	0.5	1.5
Product Sales
Out-licensing arrangements
Milestone revenues recognized	9.2	12.5
Development Milestone
Out-licensing arrangements
Maximum milestone payment receivable	39.0
Sales Milestone
Out-licensing arrangements
Maximum milestone payment receivable	$ 46.0

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Borrowings (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015 contract	Dec. 31, 2014
Line of Credit Facility [Line Items]
Long-term borrowings	$ 78.7	$ 0
Short-term borrowings	2,570.2	850.0
Borrowing, Long-term and Short-term ,Combined Amount	2,648.9	850.0
2013 Facilities Agreement
Line of Credit Facility [Line Items]
Facility agreement initiation date	Nov. 11, 2013
Facilitiy agreement total amount	2,600
Term loan facility	850
Number of term loan facilities	2
Short-term borrowings	850.0	850.0
2015 Facility Agreement
Line of Credit Facility [Line Items]
Facility agreement initiation date	Jan. 11, 2015
Facilitiy agreement total amount	850
Facility agreement expiration date	Jan. 10, 2016
Short-term borrowings	850.0	0
Secured Non-recourse Debts
Line of Credit Facility [Line Items]
Long-term borrowings	78.7	0
Short-term borrowings	25.2	0
Secured Non-recourse Debts | NPS Pharma
Line of Credit Facility [Line Items]
Non-recourse debt obligations, acquisition date fair value	106.3
Sensipar and Mimpara Debt, Amgen
Line of Credit Facility [Line Items]
Debt Instrument, Face Amount	145
Regpara Debt, DRI
Line of Credit Facility [Line Items]
Debt instrument, maximum obligation	96
PTH-184 Debt, DRI
Line of Credit Facility [Line Items]
Debt instrument, maximum obligation	125
Term loan facility one | 2013 Facilities Agreement
Line of Credit Facility [Line Items]
Term loan facility	1,750
Term loan facility one | 2015 Facility Agreement
Line of Credit Facility [Line Items]
Term loan facility	850
Term loan facilitly two | 2013 Facilities Agreement
Line of Credit Facility [Line Items]
Facility agreement expiration date	Nov. 11, 2015
Term loan facility	850
Revolving Credit Facility
Line of Credit Facility [Line Items]
Facility agreement initiation date	Dec. 12, 2014
Facilitiy agreement total amount	2,100
Facility agreement expiration date	Dec. 12, 2019
Swingline Facility	250
Short-term borrowings	$ 845.0	$ 0

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Accounts Receivable, Net (Tables)

3 Months Ended

Mar. 31, 2015

Receivables [Abstract]

Provision for discounts and doubtful accounts

	2015	2014
	$’M	$’M
	_____________	_____________
As at January 1,	48.5	47.9
Provision charged to operations	80.8	80.7
Provision utilization	(82.6)	(81.2)
	_____________	_____________
As at March 31,	46.7	47.4
	_____________	_____________

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Business Combinations (Pro Forma Information) (Details) (NPS Pharma, USD $) In Millions, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
NPS Pharma
Pro Forma Information
Revenues	$ 1,518.3	$ 1,390.8
Net income from continuing operations	358.8	85.8
Net income from continuing operations per share - basic	$ 0.609	$ 0.147
Net income from continuing operations per share - diluted	$ 0.605	$ 0.146
Pro Forma Data Adjustments
An adjustment to increase amortization of intangible assets	(21.1)	(42.3)
Increase/(decrease) to net income to reflect acquisition related costs	106.8	(106.8)
Decrease to net income to reflect the additional interest expense		(5.6)
Increase/(decrease) to net income to reflect the fair value adjustment to acquisition date inventory.	$ 6.1	$ (6.1)

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Other Current Liabilities

3 Months Ended

Mar. 31, 2015

Other Liabilities, Current [Abstract]

Other Current Liabilities

12.       Other current liabilities

	March 31,	December 31,
	2015	2014
	$’M	$’M
	_____________	_____________
Income taxes payable	25.8	16.2
Value added taxes	18.0	16.6
Contingent consideration payable	166.2	194.5
Other current liabilities	93.2	35.2
	_____________	_____________
	303.2	262.5
	_____________	_____________

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Financial Instruments

3 Months Ended

Mar. 31, 2015

Derivative Instrument Detail [Abstract]

Financial Instruments Disclosure

17.Financial instruments

Treasury policies and organization

The Company's principal treasury operations are coordinated by its corporate treasury function. All treasury operations are conducted within a framework of policies and procedures approved annually by the Board. As a matter of policy, the Company does not undertake speculative transactions that would increase its currency or interest rate exposure.

Interest rate risk

The Company is principally exposed to interest rate risk on borrowings under its $2,100 million RCF, its $850 million 2013 Facilities Agreement and its $850 million 2015 Facility Agreement, on which interest is set at floating rates, to the extent any of these facilities are utilized. At March 31, 2015 the Company had fully utilized the 2013 Facilities Agreement, fully utilized the 2015 Facility Agreement and utilized $845 million of the RCF. Shire's exposure under its 2013 Facilities Agreement, 2015 Facility Agreementand RCF is to US dollar interest rates.

The Company has evaluated the interest rate risk on the RCF, the 2013 Facilities Agreement and the 2015 Facility Agreement and considers the risks associated with floating interest rates on borrowings under its facilities as appropriate.A hypothetical one percentage point increase or decrease in the interest rates applicable to drawings under the 2013 Facilities Agreement,2015 Facility Agreement and RCF at March 31, 2015 would increase interest expense by approximately$25 million per annum and would decrease the interest expense by approximately $5 million per annum.

The Company is also exposed to interest rate risk on its restricted cash, cash and cash equivalents and on foreign exchange contracts on which interest is set at floating rates. This exposure is primarily limited to US dollar, Pounds sterling and Euro interest rates. As the Company maintains all of its cash, liquid investments and foreign exchange contracts on a short term basis for liquidity purposes, this risk is not actively managed. In the three months to March 31, 2015 the average interest rate received on cash and liquid investments was less than 1% per annum. The largest proportion of these cash and liquid investments was in US dollar money market and liquidity funds.

No derivative instruments were entered into during the three months to March 31, 2015 to manage interest rate exposure. The Company continues to review its interest rate risk and the policies in place to manage the risk.

Credit risk

Financial instruments that potentially expose Shire to concentrations of credit risk consist primarily of short-term cash investments, derivative contracts and trade accounts receivable (from product sales and from third parties from which the Company receives royalties). Cash is invested in short-term money market instruments, including money market and liquidity funds and bank term deposits. The money market and liquidity funds in which Shire invests are all triple A rated by both Standard and Poor's and by Moody's credit rating agencies.

The Company is exposed to the credit risk of the counterparties with which it enters into derivative instruments. The Company limits this exposure through a system of internal credit limits which vary according to ratings assigned to the counterparties by the major rating agencies. The internal credit limits are approved by the Board and exposure against these limits is monitored by the corporate treasury function. The counterparties to these derivatives contracts are major international financial institutions.

The Company's revenues from product sales in the US are mainly governed by agreements with major pharmaceutical wholesalers and relationships with other pharmaceutical distributors and retail pharmacy chains. For the year to December 31, 2014 there were three customers in the US that accounted for 47%of the Company's product sales. However, such customers typically have significant cash resources and as such the risk from concentration of credit is considered acceptable. The Company has taken positive steps to manage any credit risk associated with these transactions and operates clearly defined credit evaluation procedures. However, an inability of one or more of these wholesalers to honor their debts to the Company could have an adverse effect on the Company's financial condition and results of operations.

A substantial portion of the Company's accounts receivable in countries outside of the United States is derived from product sales to government-owned or government-supported healthcare providers. The Company's recovery of these accounts receivable is therefore dependent upon the financial stability and creditworthiness of the relevant governments. In recent years global and national economic conditions have negatively affected the growth, creditworthiness and general economic condition of certain markets in which the Company operates. As a result, in some countries outside of the US, specifically,Argentina, Greece, Italy, Portugal and Spain (collectively the “Relevant Countries”) the Company is experiencing delays in the remittance of receivables due from government-owned or government-supported healthcare providers. The Company continued to receive remittances in relation to government-owned or government-supported healthcare providers in all the Relevant Countries in the three months March 31, 2015, including receiptsof$17.1million and $17.4million in respect of Spanish and Italian receivables, respectively.

To date the Company has not incurred significant losses on accounts receivable in the Relevant Countries, and continues to consider that such accounts receivable are recoverable. The Company will continue to evaluate all its accounts receivable for potential collection risks and has made provision for amounts where collection is considered to be doubtful. If the financial condition of the Relevant Countries or other Eurozone countries suffer significant deterioration, such that their ability to make payments becomes uncertain, or if one or more Eurozone member countries withdraws from the Euro, additional allowances for doubtful accounts may be required, and losses may be incurred, in future periods. Any such loss could have an adverse effect on the Company's financial condition and results of operations.

Foreign exchange risk

The Company trades in numerous countries and as a consequence has transactional and translational foreign exchange exposures.

Transactional exposure arises where transactions occur in currencies different to the functional currency of the relevant subsidiary. The main trading currencies of the Company are the US dollar, Pounds Sterling, Swiss Franc, Canadian dollar and the Euro. It is the Company's policy that these exposures are minimized to the extent practicable by denominating transactions in the subsidiary's functional currency.

Where significant exposures remain, the Company uses foreign exchange contracts (being spot, forward and swap contracts) to manage the exposure for balance sheet assets and liabilities that are denominated in currencies different to the functional currency of the relevant subsidiary. These assets and liabilities relate predominantly to inter-company financing. The foreign exchange contracts have not been designated as hedging instruments. Cash flows from derivative instruments are presented within net cash provided by operating activities in the consolidated cash flow statement, unless the derivative instruments are economically hedging specific investing or financing activities.

Translational foreign exchange exposure arises on the translation into US dollars of the financial statements of non-US dollar functional subsidiaries.

At March 31, 2015 the Company had 40swap and forward foreign exchange contracts outstanding to manage currency risk. The swap and forward contracts mature within 90 days. The Company did not have credit risk related contingent features or collateral linked to the derivatives. The Company has master netting agreements with a number of counterparties to these foreign exchange contracts and on the occurrence of specified events, the Company has the ability to terminate contracts and settle them with a net payment by one party to the other. The Company has elected to present derivative assets and derivative liabilities on a gross basis in the consolidated balance sheet. As at March 31, 2015 the potential effect of rights of set-off associated with the foreign exchange contracts would be an offset to both assets and liabilities of $1.5million, resulting in net derivative assets and derivative liabilities of $9.4million and $4.0million, respectively. Further details are included below:

		Fair value	Fair value
		March 31,	December 31,
		2015	2014
		$’M	$’M
		_____________	_____________
Assets	Prepaid expenses and other current assets	10.9	12.6
Liabilities	Other current liabilities	5.5	7.8
		_____________	_____________

Net gains(both realized and unrealized) arising on foreign exchange contracts have been classified in the consolidated statements of income as follows:

	Location of net gains recognized in income	Amount of net gains recognized in income
	__________________________________	____________
In the three months to		March 31,	March 31,
		2015	2014
		$’M	$’M
		_____________	_____________
Foreign exchange contracts	Other income, net	16.3	1.8
		_____________	_____________

These net foreign exchange gains are offset within Other income, net by net foreign exchange (losses)/gains arising on the balance sheet items that these contracts were put in place to manage.

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Segmental Reporting (Tables)

3 Months Ended

Mar. 31, 2015

Segment Reporting [Abstract]

Schedule of Segment Revenue from Major Products

3 months to	March 31,	March 31,
	2015	2014
	$’M	$’M
	___________	___________
VYVANSE	416.8	351.2
LIALDA/MEZAVANT	148.5	128.9
CINRYZE	148.1	85.6
ELAPRASE	125.0	128.6
REPLAGAL	97.5	114.3
ADDERALL XR	95.7	85.1
FIRAZYR	92.5	74.9
VPRIV	86.4	86.9
PENTASA	78.7	72.3
FOSRENOL	44.1	41.4
XAGRID	25.3	27.1
INTUNIV	17.4	82.3
GATTEX/REVESTIVE	14.9	-
Other product sales	32.3	29.5
	____________	____________
Total product sales	1,423.2	1,308.1
	____________	____________

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Other Current Liabilities (Tables)

3 Months Ended

Mar. 31, 2015

Other Liabilities, Current [Abstract]

Schedule of Other Current Liabilities

	March 31,	December 31,
	2015	2014
	$’M	$’M
	_____________	_____________
Income taxes payable	25.8	16.2
Value added taxes	18.0	16.6
Contingent consideration payable	166.2	194.5
Other current liabilities	93.2	35.2
	_____________	_____________
	303.2	262.5
	_____________	_____________

XML

Consolidated Statements of Income (Parenthetical) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Intangible Assets (Excluding Goodwill) [Line Items]
Amortization of intangible assets	$ 88.3	$ 57.8
Impairment of unamortized intangible assets	0	166.0
Acquired Intellectual Property Rights
Intangible Assets (Excluding Goodwill) [Line Items]
Amortization of intangible assets	$ 88.3	$ 57.8

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Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2015

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

1.       Summary of Significant Accounting Policies

(a)       Basis of preparation

These interim financial statements of Shire plc and its subsidiaries (collectively “Shire” or the “Company”) and other financial information included in this Form 10-Q, are unaudited. They have been prepared in accordance with generally accepted accounting principles in the United States of America (“US GAAP”) and US Securities and Exchange Commission (“SEC”) regulations for interim reporting.

The balance sheet as at December 31, 2014 was derived from audited financial statements but does not include all disclosures required by US GAAP.

These interim financial statements should be read in conjunction with the consolidated financial statements and accompanying notes included in the Company's Annual Report on Form 10-K for the year to December 31, 2014.

Certain information and footnote disclosures normally included in financial statements prepared in accordance with US GAAP have been condensed or omitted from these interim financial statements. However, these interim financial statements include all adjustments, which are, in the opinion of management, necessary to fairly state the results of the interim period and the Company believes that the disclosures are adequate to make the information presented not misleading. Interim results are not necessarily indicative of results to be expected for the full year.

(b)       Use of estimates in interim financial statements

The preparation of interim financial statements, in conformity with US GAAP and SEC regulations, requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the consolidated financial statements and reported amounts of revenues and expenses during the reporting period. Estimates and assumptions are primarily made in relation to the valuation of intangible assets, sales deductions, income taxes (including provisions for uncertain tax positions and the realization of deferred tax assets), provisions for litigation and legal proceedings, contingent consideration receivable from product divestmentsandcontingent consideration payable in respect of business combinations and asset purchases. If actual results differ from the Company's estimates, or to the extent these estimates are adjusted in future periods, the Company's results of operations could either benefit from, or be adversely affected by, any such change in estimate.

(c)       New accounting pronouncements

Adopted during the period

Reporting Discontinued Operations and Disclosures of Disposals of Components of an Entity

In April 2014 the Financial Accounting Standard Board (“FASB”) issued guidance on the reporting of discontinued operations and disclosures of disposals of components of an entity. The amendments in this update revise the definition of discontinued operations by limiting discontinued operations reporting to disposals of components of an entity that represent strategic shifts that have (or will have) a major effect on an entity's operations and financial results. The guidance requires expanded disclosures for discontinued operations which provide users of financial statements with more information about the assets, liabilities, revenues, and expenses of discontinued operations. The guidance also requires an entity to disclose the pre-tax profit or loss of an individually significant component of an entity that does not qualify for discontinued operations reporting.

Shire adopted this guidance in the period, which will be effective for discontinued operations occurring after January 1, 2015. The adoption of this guidance did not impact the Company's consolidated financial position, results of operations or cash flows.

To be adopted in future periods

Revenue from Contracts with Customers

In May 2014 the FASB and the International Accounting Standards Board (together the “Accounting Standards Boards”) issued a new accounting standard that is intended to clarify and converge the financial reporting requirements for revenue from contracts with customers. The core principle of the standard is that an “entity recognizes revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services”. To achieve that core principle the Accounting Standard Boards developed a five-step model (as presented below) and related application guidance, which will replace most existing revenue recognition guidance in US GAAP.

Five-step model:

Step 1: Identify the contract(s) with a customer.

Step 2: Identify the performance obligations in the contract.

Step 3: Determine the transaction price.

Step 4: Allocate the transaction price to the performance obligations in the contract.

Step 5: Recognize revenue when (or as) the entity satisfies a performance obligation.

The Accounting Standards Boards also issued new qualitative and quantitative disclosure requirements as part of the new accounting standard which aims to enable financial statement users to understand the nature, amount, timing, and uncertainty of revenue and cash flows arising from contracts with customers.

In April 2015 the FASB proposed to defer the effective date of the guidance by one year. Based on this proposal, public entities would need to apply the new guidance for annual reporting periods beginning after December 15, 2017, and interim periods therein. The Company is currently evaluating the impact of adopting this guidance.

Elimination of Certain Financial Reporting Requirements, Including an Amendment to Variable Interest Entities (“VIEs”) Guidance in Topic 810, Consolidation

In June 2014 the FASB issued guidance on the reporting requirements for development stage entities. The amendments in this update simplify the existing guidance by removing all incremental financial reporting requirements for development stage entities. The amendments also eliminate an exception provided with respect to development stage entities in Topic 810, Consolidation, for determining whether an entity is a VIE on the basis of the amount of equity that is at risk. The elimination of the exception may change the consolidation analysis, consolidation decision, and disclosure requirements for a reporting entity that has an interest in an entity in the development stage. The guidance to eliminate the exception to the sufficiency-of-equity-at-risk criterion for development stage entities should be applied retrospectively for annual reporting periods beginning after December 15, 2015, and interim periods therein. Early application of both of these amendments is permitted for any annual reporting period or interim period for which the entity's financial statements have not yet been issued. The Company is currently evaluating the impact of adopting this guidance.

Disclosure of Uncertainties about an Entity's Ability to Continue as a Going Concern

In August 2014 the FASB issued guidance aboutmanagement's responsibilitytoevaluatewhetherthereissubstantialdoubtaboutanentity's ability tocontinueasagoingconcernandtoproviderelatedfootnotedisclosures. An entity's management should evaluate whether there are conditions or events, considered in the aggregate, that raise substantial doubt about the entity's ability to continue as a going concern within one year after the date that the financial statements are issued (or within one year after the date that the financial statements are available to be issued when applicable). Management's evaluation should be based on relevant conditions and events that are known and reasonably knowable at the date that the financial statements are issued (or available to be issued). Substantial doubt about an entity's ability to continue as a going concern exists when relevant conditions and events, considered in the aggregate, indicate that it is probable that the entity will be unable to meet its obligations as they become due within one year after the date that the financial statements are issued (or available to be issued). The term probable is used consistently with its use in Topic 450, Contingencies. The amendments in this update are effective for the annual period ending after December 15, 2016, and for annual periods and interim periods thereafter. Early application is permitted. The Company does not expect the adoption of this guidance to have a material effect on its consolidated financial position, results of operations and cash flows.

Amendments to the Consolidation Analysis

In February 2015 the FASB issued guidanceto respond to stakeholders' concerns about the current accounting for consolidation of certain legal entities. Financial statement users asserted that in certain situations in which consolidation is ultimately required, deconsolidated financial statements are necessary to better analyze the reporting entity's economic and operational results. Previously, the FASB issued an indefinite deferral for certain entities to partially address those concerns. However, the amendments in this guidance rescind that deferral and address those concerns by making changes to the consolidation guidance.

Under the amendments, all reporting entities are within the scope of Subtopic 810-10, Consolidation, including limited partnerships and similar legal entities, unless a scope exception applies. The presumption that a general partner controls a limited partnership has been eliminated. In addition, fees paid to decision makers that meet certain conditions no longer cause decision makers to consolidate a VIE in certain instances. The amendments place more emphasis in the consolidation evaluation on variable interests other than fee arrangements such as principal investment risk (for example, debt or equity interests), guarantees of the value of the assets or liabilities of the VIE, written put options on the assets of the VIE, or similar obligations, including some liquidity commitments or agreements (explicit or implicit). Additionally, the amendments reduce the extent to which related party arrangements cause an entity to be considered a primary beneficiary.

The amendments are effective for public business entities for fiscal years, and for interim periods therein, beginning after December 15, 2015. Early adoption is permitted, including adoption in an interim period. The Company does not expect the adoption of this guidance to have a material effect on its consolidated financial position, results of operations and cash flows.

Simplifying the Presentation of Debt Issuance Costs

In April 2015 the FASB issued guidancetosimplify the presentation of debt issuance costs. The guidance requires that debt issuance costs related to a recognized debt liability be presentedin the balance sheet as a directdeduction from the carrying amount of that debtliability, consistent with debt discounts. The recognition andmeasurementguidance for debt issuance costs are not affected by the amendments in this update. The amendments in this update are effective forfinancial statements issued for fiscal years beginning after December 15, 2015,and interim periods therein.

Early adoption of the amendments in this update is permitted for financial statements that have not been previously issued. An entity should apply the new guidance on a retrospective basis, wherein the balance sheet of each individual period presented should be adjusted to reflect the period-specific effects of applying the new guidance. Upon transition, an entity is required to comply with the applicable disclosures for a change in an accounting principle. The Company does not expect the adoption of this guidance to have a material effect on its consolidated financial position, results of operations and cash flows.

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Goodwill (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Goodwill [Line Items]
Goodwill arising on business acquired	$ 1,732.7	$ 1,536.6
Goodwill [Roll Forward]
As at January 1,	2,474.9	624.6
Acquisition	1,732.7	1,536.6
Foreign currency translation	(28.9)	0
As at March 31,	$ 4,178.7	$ 2,161.2

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Financial Instruments (Interest Rate and Credit Risks) (Details) (USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015 customer	Dec. 31, 2014
Interest rate risk
Average interest rate received on cash and liquid investments	less than 1% per annum.
Line of Credit Facility [Line Items]
Interest rate risk exposure	The Company has evaluated the interest rate risk on the RCF, the 2013 Facilities Agreement and the 2015 Facilitiy Agreement and considers the risks associated with floating interest rates on borrowings under its facilities as appropriate. A hypothetical one percentage point increase or decrease in the interest rates applicable to drawings under the 2013 Facilities Agreement, 2015 Facility Agreement and RCF at March 31, 2015 would increase interest expense by approximately $25 million per annum and would decrease the interest expense by approximately $5 million per annum.
Short-term borrowings	$ 2,570.2	$ 850.0
Accounts, Notes, Loans and Financing Receivable [Line Items]
Number of major external customers	3
Customer concentration risk
Accounts, Notes, Loans and Financing Receivable [Line Items]
Concentration risk percentage	47.00%
Government-owned or Supported Healthcare Providers | Italy
Accounts, Notes, Loans and Financing Receivable [Line Items]
Accounts receivable received	17.4
Government-owned or Supported Healthcare Providers | Spain
Accounts, Notes, Loans and Financing Receivable [Line Items]
Accounts receivable received	17.1
Revolving Credit Facility
Line of Credit Facility [Line Items]
Facilitiy agreement total amount	2,100
Short-term borrowings	845.0	0
2013 Facilities Agreement
Line of Credit Facility [Line Items]
Term loan facility	850
Facilitiy agreement total amount	2,600
Short-term borrowings	850.0	850.0
2015 Facility Agreement
Line of Credit Facility [Line Items]
Facilitiy agreement total amount	850
Short-term borrowings	$ 850.0	$ 0

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Fair Value Measurement

3 Months Ended

Mar. 31, 2015

Fair Value Disclosures [Abstract]

Fair Value Disclosures

18.       Fair value measurement

Assets and liabilities that are measured at fair value on a recurring basis

As at March 31, 2015 and December 31, 2014 the following financial assets and liabilities are measured at fair value on a recurring basis using quoted prices in active markets for identical assets (Level 1); significant other observable inputs (Level 2); and significant unobservable inputs (Level 3).

		Carrying value and Fair value
		Total	Level 1	Level 2	Level 3
At March 31, 2015		$'M	$'M	$'M	$'M
		____________	___________	___________	___________
Financial assets:
Available-for-sale securities(1)		26.4	26.4	-	-
Contingent consideration receivable (2)		15.0	-	-	15.0
Foreign exchange contracts		10.9	-	10.9	-
Financial liabilities:
Foreign exchange contracts		5.5	-	5.5	-
Contingent consideration payable(3)		724.0	-	-	724.0
		____________	___________	___________	___________
		Total	Level 1	Level 2	Level 3
At December 31, 2014		$'M	$'M	$'M	$'M
		____________	___________	___________	___________
Financial assets:
Available-for-sale securities(1)		13.1	13.1	-	-
Contingent consideration receivable (2)		15.9	-	-	15.9
Foreign exchange contracts		12.6	-	12.6	-
Financial liabilities:
Foreign exchange contracts		7.8	-	7.8	-
Contingent consideration payable(3)	1	629.9	-	-	629.9
		____________	___________	___________	___________

• Available-for-sale securities are included within Investments and Prepaid expenses and other current assetsin the consolidated

balance sheet.

(2)Contingent consideration receivable is included within Prepaid expenses and other current assets and Other non-current assets in the consolidated balance sheet.

(3)Contingent consideration payableis included within Other current liabilities and Other non-current liabilities in the consolidated balance sheet.

Certain estimates and judgments were required to develop the fair value amounts. The fair value amounts shown above are not necessarily indicative of the amounts that the Company would realize upon disposition, nor do they indicate the Company's intent or ability to dispose of the financial instrument.

The following methods and assumptions were used to estimate the fair value of each material class of financial instrument:

• Available-for-sale securities – the fair values of available-for-sale securities are estimated based on quoted market prices for those investments.
• Contingent consideration receivable – the fair value of the contingent consideration receivable has been estimated using the income approach (using a probability weighted discounted cash flow method).
• Foreign exchange contracts – the fair values of the swap and forward foreign exchange contracts have been determined using an income approach based on current market expectations about the future cash flows.
• Contingent consideration payable – the fair value of the contingent consideration payable has been estimated using the income approach (using a probability weighted discounted cash flow method).

Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs (Level 3)

The change in the fair value of the Company's contingent consideration receivable and payables, which are measured at fair value on a recurring basis using significant unobservable inputs (Level 3),are as follows:

Contingent consideration receivable
	2015	2014
	$'M	$'M
	____________	____________
Balance at January 1,	15.9	36.1
Initial recognition of contingent consideration receivable	-	33.6
Gain/(loss) recognized in the income statement (within Gain on sale of product rights) due to change in fair value during the period	5.2	(7.1)
Reclassification of amounts to Other receivables within Other current assets	(5.9)	(4.0)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)	(0.2)	0.8
Balance at March 31,	15.0	59.4
Contingent consideration payable
	2015	2014
	$'M	$'M
	____________	____________
Balance at January 1,	629.9	405.9
Initial recognition of contingent consideration payable	92.1	10.0
Change in fair value during the period with the corresponding adjustment recognized as a loss in the income statement (within Integration and acquisition costs)	2.4	(59.2)
Reclassification of amounts to Other current liabilities	(2.1)	(2.4)
Change in fair value during the period with corresponding adjustment to the associated intangible asset	(0.7)	(4.0)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)	2.4	-
Balance at March 31,	724.0	350.3

Of the $724.0million of contingent consideration payable as at March 31, 2015 $166.2 million is recorded within other current liabilities and $557.8million is recorded within other non-current liabilities in the Company's balance sheet.

Quantitative Information about Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs (Level 3)

Quantitative information about the Company's recurring Level 3 fair value measurements is included below:

Financial assets:	Fair Value at the Measurement Date
At March 31, 2015	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
	____________	___________	___________	___________
Contingent consideration receivable ("CCR")	15.0	Income approach (probability weighted discounted cash flow)	• Probability weightings applied to different sales scenarios • Future forecast consideration receivable based on contractual terms with purchaser • Assumed market participant discount rate	• 10 to 70% • $25 million to $33 million • 8.3% to 11.5%
	____________	____________	____________	____________
Financial liabilities:	Fair Value at the Measurement Date
At March 31, 2015	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
	____________	___________	___________	___________
Contingent consideration payable	724.0	Income approach (probability weighted discounted cash flow)	• Cumulative probability of milestones being achieved • Assumed market participant discount rate • Periods in which milestones are expected to be achieved • Forecast quarterly royalties payable on net sales of relevant products	• 4 to 95% • 0.6 to 11.8% • 2015 to 2030 • $0.2 to $7.6 million
	____________	____________	____________	____________

The Company re-measures the CCR (relating to contingent consideration due to the Company following divestment of certain of the Company's products) at fair value at each balance sheet date,with the fair value measurement based on forecast cash flows, over a number of scenarios which vary depending on the expected performance outcome of the products following divestment. The forecast cash flows under each of these differing outcomes have been included in probability weighted estimates used by the Company in determining the fair value of the CCR.

Contingent consideration payable represents future milestones the Company may be required to pay in conjunction with various business combinations and future royalties payable as a result of certain business combinations and licenses. The amount ultimately payable by Shire in relation to business combinations is dependent upon the achievement of specified future milestones, such as the achievement of certain future development, regulatory and sales milestones. The Company assesses the probability, and estimated timing, of these milestones being achieved and re-measures the related contingent consideration to fair value each balance sheet date. The amount of contingent consideration which may ultimately be payable by Shire in relation to future royalties is dependent upon future net sales of the relevant products over the life of the royalty term. The Company assesses the present value of forecast future net sales of the relevant products and re-measures the related contingent consideration to fair value each balance sheet date.

The fair value of the Company's contingent consideration receivable and payable could significantly increase or decrease due to changes in certain assumptions which underpin the fair value measurements. Each set of assumptions and milestones is specific to the individual contingent consideration receivable or payable. The assumptions include, among other things, the probability and expected timing of certain milestones being achieved, the forecast future net sales of the relevant products and related future royalties payable, the probability weightings applied to different sales scenarios of the Company's divested products and forecast future royalties receivable under scenarios developed by the Company, and the discount rates used to determine the present value of contingent future cash flows. The Company regularly reviews these assumptions, and makes adjustments to the fair value measurements as required by facts and circumstances.

The carrying amounts of other financial assets and liabilities materially approximate to their fair value either because of the short-term maturity of these amounts or because there have been no significant changes since the asset or liability was last re-measured to fair value on a non-recurring basis.

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Fair Value Measurement (Quantitative Information About Recurring and Non-recurring Level 3 Fair Value Measurements) (Details) (Recurring Basis, USD $) In Millions, unless otherwise specified	3 Months Ended
	Mar. 31, 2015
Contingent Consideration Payable | Minimum
Fair Value Inputs
Assumed market participant discount rate	0.60%
Cumulative probability of milestones being achieved	4.00%
Periods in which milestones are expected to be achieved	2015
Forecast quarterly royalties payable on net sales of relevant products	$ 0.2
Contingent Consideration Payable | Maximum
Fair Value Inputs
Assumed market participant discount rate	11.80%
Cumulative probability of milestones being achieved	95.00%
Periods in which milestones are expected to be achieved	2030
Forecast quarterly royalties payable on net sales of relevant products	7.6
Contingent Consideration Payable | Income approach (probability weighted discounted cash flow)
Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques [Line Items]
Liabilities	724.0
Contingent Consideration Receivable | Income approach (probability weighted discounted cash flow)
Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques [Line Items]
Assets	15.0
Contingent Consideration Receivable | Income approach (probability weighted discounted cash flow) | Minimum
Fair Value Inputs
Probability weightings applied to different sales scenarios	10.00%
Future forecast consideration receivable based on contractual terms with purchaser	25
Assumed market participant discount rate	8.30%
Contingent Consideration Receivable | Income approach (probability weighted discounted cash flow) | Maximum
Fair Value Inputs
Probability weightings applied to different sales scenarios	70.00%
Future forecast consideration receivable based on contractual terms with purchaser	$ 33
Assumed market participant discount rate	11.50%

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Goodwill (Tables)

3 Months Ended

Mar. 31, 2015

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of Acquired Goodwill

	March 31,	December 31,
	2015	2014
	$’M	$’M
	____________	____________
Goodwill arising on businesses acquired	4,178.7	2,474.9
	____________	____________

Schedule of Goodwill

	2015	2014
	$’M	$’M
	____________	____________
As at January 1,	2,474.9	624.6
Acquisitions	1,732.7	1,536.6
Foreign currency translation	(28.9)	-
	____________	____________
As at March 31,	4,178.7	2,161.2
	____________	____________

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Accounts Payable and Accrued Expenses

3 Months Ended

Mar. 31, 2015

Accounts Payable and Accrued Liabilities, Current [Abstract]

Accounts Payable and Accrued Expenses Disclosure

11.       Accounts payable and accrued expenses

	March 31,	December 31,
	2015	2014
	$’M	$’M
	________________	________________
Trade accounts payable and accrued purchases	384.1	247.7
Accrued rebates – Medicaid	555.9	563.9
Accrued rebates – Managed care	306.8	318.2
Sales return reserve	134.8	131.7
Accrued bonuses	72.6	150.7
Accrued employee compensation and benefits payable	174.0	109.1
R&D accruals	55.9	88.3
Other accrued expenses	307.5	299.8
	________________	________________
	1,991.6	1,909.4
	________________	________________