<SEC-DOCUMENT>0000950103-15-001384-index.html : 20150223
<SEC-HEADER>0000950103-15-001384.hdr.sgml : 20150223
<ACCEPTANCE-DATETIME>20150223060238
ACCESSION NUMBER:		0000950103-15-001384
CONFORMED SUBMISSION TYPE:	SC TO-T/A
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20150223
DATE AS OF CHANGE:		20150223
GROUP MEMBERS:		KNIGHT NEWCO 2, INC.
GROUP MEMBERS:		SHIRE PHARMACEUTICAL HOLDINGS IRELAND LTD.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NPS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000890465
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				870439579
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC TO-T/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44877
		FILM NUMBER:		15637515

	BUSINESS ADDRESS:	
		STREET 1:		550 HILLS DRIVE
		CITY:			BEDMINSTER
		STATE:			NJ
		ZIP:			07921
		BUSINESS PHONE:		(908) 450-5300

	MAIL ADDRESS:	
		STREET 1:		550 HILLS DRIVE
		CITY:			BEDMINSTER
		STATE:			NJ
		ZIP:			07921

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Shire plc
		CENTRAL INDEX KEY:			0000936402
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC TO-T/A

	BUSINESS ADDRESS:	
		STREET 1:		HAMPSHIRE INTL BUSINESS PARK
		STREET 2:		CHINEHAM BASINGSTOKE
		CITY:			HAMPSHIRE ENGLAND RG
		STATE:			X0
		ZIP:			R924 8EP
		BUSINESS PHONE:		441256894000

	MAIL ADDRESS:	
		STREET 1:		HAMPSHIRE INTL BUSINESS PARK
		STREET 2:		CHINEHAM BASINGSTOKE
		CITY:			HAMPSHIRE ENGLAND RG
		STATE:			X0
		ZIP:			R924 8EP

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Shire Ltd.
		DATE OF NAME CHANGE:	20080523

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Shire plc
		DATE OF NAME CHANGE:	20051125

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHIRE PHARMACEUTICALS GROUP PLC
		DATE OF NAME CHANGE:	19980302
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC TO-T/A
<SEQUENCE>1
<FILENAME>dp53693_sctota.htm
<DESCRIPTION>FORM SC TO-T/A
<TEXT>
Document 1 - file: dp53693_sctota.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.A5XVI
<SEQUENCE>2
<FILENAME>dp53693_exa5xvi.htm
<DESCRIPTION>EX-(A)(5)(XVI)
<TEXT>
Document 2 - file: dp53693_exa5xvi.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>logo.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: logo.jpg

</DOCUMENT>
</SEC-DOCUMENT>